AU2007247869B2 - T-cell vaccine - Google Patents
T-cell vaccine Download PDFInfo
- Publication number
- AU2007247869B2 AU2007247869B2 AU2007247869A AU2007247869A AU2007247869B2 AU 2007247869 B2 AU2007247869 B2 AU 2007247869B2 AU 2007247869 A AU2007247869 A AU 2007247869A AU 2007247869 A AU2007247869 A AU 2007247869A AU 2007247869 B2 AU2007247869 B2 AU 2007247869B2
- Authority
- AU
- Australia
- Prior art keywords
- cells
- plp
- mog
- autoreactive
- mbp
- Prior art date
- Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
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Classifications
-
- G—PHYSICS
- G01—MEASURING; TESTING
- G01N—INVESTIGATING OR ANALYSING MATERIALS BY DETERMINING THEIR CHEMICAL OR PHYSICAL PROPERTIES
- G01N33/00—Investigating or analysing materials by specific methods not covered by groups G01N1/00 - G01N31/00
- G01N33/48—Biological material, e.g. blood, urine; Haemocytometers
- G01N33/50—Chemical analysis of biological material, e.g. blood, urine; Testing involving biospecific ligand binding methods; Immunological testing
- G01N33/5005—Chemical analysis of biological material, e.g. blood, urine; Testing involving biospecific ligand binding methods; Immunological testing involving human or animal cells
- G01N33/5008—Chemical analysis of biological material, e.g. blood, urine; Testing involving biospecific ligand binding methods; Immunological testing involving human or animal cells for testing or evaluating the effect of chemical or biological compounds, e.g. drugs, cosmetics
- G01N33/5044—Chemical analysis of biological material, e.g. blood, urine; Testing involving biospecific ligand binding methods; Immunological testing involving human or animal cells for testing or evaluating the effect of chemical or biological compounds, e.g. drugs, cosmetics involving specific cell types
- G01N33/5047—Cells of the immune system
- G01N33/505—Cells of the immune system involving T-cells
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K39/00—Medicinal preparations containing antigens or antibodies
- A61K39/0005—Vertebrate antigens
- A61K39/0008—Antigens related to auto-immune diseases; Preparations to induce self-tolerance
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K40/00—Cellular immunotherapy
- A61K40/10—Cellular immunotherapy characterised by the cell type used
- A61K40/11—T-cells, e.g. tumour infiltrating lymphocytes [TIL] or regulatory T [Treg] cells; Lymphokine-activated killer [LAK] cells
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K40/00—Cellular immunotherapy
- A61K40/20—Cellular immunotherapy characterised by the effect or the function of the cells
- A61K40/22—Immunosuppressive or immunotolerising
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K40/00—Cellular immunotherapy
- A61K40/40—Cellular immunotherapy characterised by antigens that are targeted or presented by cells of the immune system
- A61K40/41—Vertebrate antigens
- A61K40/414—Nervous system antigens
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K40/00—Cellular immunotherapy
- A61K40/40—Cellular immunotherapy characterised by antigens that are targeted or presented by cells of the immune system
- A61K40/41—Vertebrate antigens
- A61K40/416—Antigens related to auto-immune diseases; Preparations to induce self-tolerance
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P25/00—Drugs for disorders of the nervous system
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- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P37/00—Drugs for immunological or allergic disorders
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P37/00—Drugs for immunological or allergic disorders
- A61P37/02—Immunomodulators
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P37/00—Drugs for immunological or allergic disorders
- A61P37/02—Immunomodulators
- A61P37/04—Immunostimulants
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P37/00—Drugs for immunological or allergic disorders
- A61P37/02—Immunomodulators
- A61P37/06—Immunosuppressants, e.g. drugs for graft rejection
-
- C—CHEMISTRY; METALLURGY
- C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
- C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
- C12N5/00—Undifferentiated human, animal or plant cells, e.g. cell lines; Tissues; Cultivation or maintenance thereof; Culture media therefor
- C12N5/06—Animal cells or tissues; Human cells or tissues
- C12N5/0602—Vertebrate cells
- C12N5/0634—Cells from the blood or the immune system
- C12N5/0636—T lymphocytes
Landscapes
- Health & Medical Sciences (AREA)
- Life Sciences & Earth Sciences (AREA)
- Immunology (AREA)
- Engineering & Computer Science (AREA)
- General Health & Medical Sciences (AREA)
- Chemical & Material Sciences (AREA)
- Veterinary Medicine (AREA)
- Public Health (AREA)
- Animal Behavior & Ethology (AREA)
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- Bioinformatics & Cheminformatics (AREA)
- Epidemiology (AREA)
- Organic Chemistry (AREA)
- Medicinal Chemistry (AREA)
- Cell Biology (AREA)
- Pharmacology & Pharmacy (AREA)
- Hematology (AREA)
- Biotechnology (AREA)
- Microbiology (AREA)
- General Chemical & Material Sciences (AREA)
- Chemical Kinetics & Catalysis (AREA)
- Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
- Wood Science & Technology (AREA)
- Genetics & Genomics (AREA)
- Zoology (AREA)
- Biochemistry (AREA)
- Molecular Biology (AREA)
- Urology & Nephrology (AREA)
- Tropical Medicine & Parasitology (AREA)
- General Engineering & Computer Science (AREA)
- Analytical Chemistry (AREA)
- Food Science & Technology (AREA)
- General Physics & Mathematics (AREA)
- Pathology (AREA)
- Rheumatology (AREA)
- Mycology (AREA)
- Toxicology (AREA)
- Physics & Mathematics (AREA)
- Neurosurgery (AREA)
- Transplantation (AREA)
Priority Applications (1)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| AU2013204973A AU2013204973A1 (en) | 2006-05-05 | 2013-04-12 | T-cell vaccine |
Applications Claiming Priority (5)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| US74661106P | 2006-05-05 | 2006-05-05 | |
| US60/746,611 | 2006-05-05 | ||
| US74790306P | 2006-05-22 | 2006-05-22 | |
| US60/747,903 | 2006-05-22 | ||
| PCT/US2007/068304 WO2007131210A2 (en) | 2006-05-05 | 2007-05-04 | T-cell vaccine |
Related Child Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| AU2013204973A Division AU2013204973A1 (en) | 2006-05-05 | 2013-04-12 | T-cell vaccine |
Publications (2)
| Publication Number | Publication Date |
|---|---|
| AU2007247869A1 AU2007247869A1 (en) | 2007-11-15 |
| AU2007247869B2 true AU2007247869B2 (en) | 2013-11-21 |
Family
ID=38668612
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| AU2007247869A Ceased AU2007247869B2 (en) | 2006-05-05 | 2007-05-04 | T-cell vaccine |
Country Status (12)
| Country | Link |
|---|---|
| US (1) | US20100003228A1 (enExample) |
| EP (3) | EP2016414B1 (enExample) |
| JP (3) | JP2009536036A (enExample) |
| AU (1) | AU2007247869B2 (enExample) |
| CA (1) | CA2651328A1 (enExample) |
| DK (2) | DK2016414T3 (enExample) |
| ES (2) | ES2552667T3 (enExample) |
| IL (1) | IL195115A (enExample) |
| NZ (1) | NZ572644A (enExample) |
| PL (2) | PL2016414T3 (enExample) |
| PT (2) | PT2016414E (enExample) |
| WO (1) | WO2007131210A2 (enExample) |
Families Citing this family (7)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| PL398077A1 (pl) * | 2012-02-10 | 2012-08-27 | Krzysztof Selmaj | Kompozycja farmaceutyczna oraz zastosowanie kompozycji do wytwarzania leku, do podawania naskórnego, do leczenia stwardnienia rozsianego |
| GB201300684D0 (en) * | 2013-01-15 | 2013-02-27 | Apitope Int Nv | Peptide |
| CN105992950A (zh) * | 2013-12-19 | 2016-10-05 | 欧普萨治疗股份有限公司 | T 细胞表位表达谱分析、制备 t 细胞组合物以及治疗疾病的方法 |
| KR101503341B1 (ko) * | 2014-03-12 | 2015-03-18 | 국립암센터 | 자가암항원 특이적 cd8+ t 세포의 분리 및 증식방법 |
| WO2016037123A2 (en) | 2014-09-05 | 2016-03-10 | Opexa Therapeutics, Inc. | Compositions and methods for treating b cell mediated autoimmune disorders |
| US10231033B1 (en) | 2014-09-30 | 2019-03-12 | Apple Inc. | Synchronizing out-of-band content with a media stream |
| AU2018206015B2 (en) | 2017-01-06 | 2019-05-30 | Eutilex Co., Ltd. | Anti-human 4-1 BB antibodies and use thereof |
Family Cites Families (68)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| JPS5852225A (ja) * | 1981-09-22 | 1983-03-28 | Mitsui Pharmaceut Inc | 脱髄疾患治療剤 |
| US5766920A (en) * | 1982-08-11 | 1998-06-16 | Cellcor, Inc. | Ex vivo activation of immune cells |
| US4550086A (en) * | 1983-02-16 | 1985-10-29 | Dana-Farber Cancer Institute, Inc. | Monoclonal antibodies that recognize human T cells |
| IL69686A (en) * | 1983-09-11 | 1988-03-31 | Yeda Res & Dev | Compositions containing cell membrane proteins and process for their preparation |
| US4608365A (en) * | 1984-03-30 | 1986-08-26 | University Of Southern California | Treatment of neurologic functions |
| US4677061A (en) * | 1984-10-19 | 1987-06-30 | Genetic Systems Corporation | T-cell lymphocyte subset monitoring of immunologic disease |
| US4902680A (en) * | 1984-10-29 | 1990-02-20 | Chaovanee Aroonsakul | Treating central nervous system diseases |
| US4898857A (en) * | 1984-10-29 | 1990-02-06 | Chaovanee Aroonsakul | Treating control nervous system diseases |
| US4898856A (en) * | 1984-10-29 | 1990-02-06 | Chaovanee Aroonsakul | Method for treating central nervous system diseases |
| US4897389A (en) * | 1984-10-29 | 1990-01-30 | Chaovanee Aroonsakul | Treating central nervous system diseases |
| CA1296622C (en) * | 1986-08-12 | 1992-03-03 | Jeffrey E. Anderson | Method and apparatus for automated assessment of the immunoregulatory status of the mononuclear leukocyte immune system |
| US5849298A (en) * | 1987-06-24 | 1998-12-15 | Autoimmune Inc. | Treatment of multiple sclerosis by oral administration of bovine myelin |
| US5039660A (en) * | 1988-03-02 | 1991-08-13 | Endocon, Inc. | Partially fused peptide pellet |
| US5242687A (en) * | 1989-03-15 | 1993-09-07 | Tkb Associates Limited Partnership | Method of reducing cellular immune response involving T-cells using CD8-bearing antigen presenting cells |
| US5861164A (en) * | 1989-03-21 | 1999-01-19 | The Immune Response Corporation | Vaccination against diseases resulting from pathogenic responses by specific T cell populations |
| US6007815A (en) * | 1989-03-21 | 1999-12-28 | The Immune Response Corporation | Anti-idiotype vaccination against diseases resulting from pathogenic responses by specific T cell populations |
| US6221352B1 (en) * | 1989-03-21 | 2001-04-24 | The Immune Response Corporation | Method of preventing the proliferation of Vβ14 or Vβ17-Expressing T cells |
| US6207645B1 (en) * | 1989-03-21 | 2001-03-27 | The Immune Response Corporation | Vaccination and methods against diseases resulting from pathogenic responses by specific T cell populations |
| US5837246A (en) * | 1989-03-21 | 1998-11-17 | The Immune Response Corporation | Vaccination and methods against diseases resulting from pathogenic responses by specific T cell populations |
| US5612035A (en) * | 1989-03-21 | 1997-03-18 | The Immune Response Corporation | Vaccination against diseases resulting from pathogenic responses by specific T cell populations |
| US5776459A (en) * | 1989-07-19 | 1998-07-07 | Connetics Corporation | TCR V beta 5 peptides |
| US5614192A (en) * | 1989-07-19 | 1997-03-25 | Connective Therapeutics, Inc. | T cell receptor peptides as therapeutics for immune-related disease |
| US5298396A (en) * | 1989-11-15 | 1994-03-29 | National Jewish Center For Immunology And Respiratory Medicine | Method for identifying T cells disease involved in autoimmune disease |
| WO1992001044A1 (en) * | 1990-07-06 | 1992-01-23 | Allergene, Inc. | Mouse/human heterohybrid cell line el41 and methods for the production of human monoclonal antibodies |
| US5668117A (en) * | 1991-02-22 | 1997-09-16 | Shapiro; Howard K. | Methods of treating neurological diseases and etiologically related symptomology using carbonyl trapping agents in combination with previously known medicaments |
| US5211952A (en) * | 1991-04-12 | 1993-05-18 | University Of Southern California | Contraceptive methods and formulations for use therein |
| US6083503A (en) * | 1991-08-28 | 2000-07-04 | The United States Of America As Represented By The Department Of Health And Human Services | Interleukin-2 stimulated T lymphocyte cell death for the treatment of autoimmune diseases, allergic responses, and graft rejection |
| US5480895A (en) * | 1991-09-27 | 1996-01-02 | New York Society For The Relief Of The Ruptured And Crippled, Maintaining The Hospital For Special Surgery | Method of producing antibodies to a restricted population of T lymphocytes, antibodies produced therefrom and methods of use thereof |
| US5545716A (en) * | 1992-09-08 | 1996-08-13 | University Of Florida | Superantigen agonist and antagonist peptides |
| WO1994020120A1 (en) * | 1993-03-12 | 1994-09-15 | Cellcor, Inc. | In vitro assay measuring degree of activation of immune cells |
| US5494899A (en) * | 1993-04-07 | 1996-02-27 | Oklahoma Medical Research Foundation | Selective regulation of B lymphocyte precursors by hormones |
| IL110787A0 (en) * | 1993-08-27 | 1994-11-11 | Sandoz Ag | Biodegradable polymer, its preparation and pharmaceutical composition containing it |
| JPH09510437A (ja) * | 1993-12-28 | 1997-10-21 | カイロン ミモトープス プロプライエトリー リミテッド | Ｔ細胞エピトープ |
| US5552300A (en) * | 1994-01-13 | 1996-09-03 | T Cell Sciences, Inc. | T cell antigen receptor V region proteins and methods of preparation thereof |
| US6410518B1 (en) * | 1994-05-31 | 2002-06-25 | Isis Pharmaceuticals, Inc. | Antisense oligonucleotide inhibition of raf gene expression |
| US5723503A (en) * | 1994-09-28 | 1998-03-03 | Thomas Jefferson University | Biological treatment for rheumatoid arthritis |
| US5674487A (en) * | 1994-09-28 | 1997-10-07 | Univ Jefferson | Method for treating autoimmune diseases |
| US6033661A (en) * | 1995-06-07 | 2000-03-07 | Thomas Jefferson University | Composition and method for allogenetic mononuclear cell immunotherapy |
| US6096314A (en) * | 1994-10-07 | 2000-08-01 | Yeda Research And Development Co. Ltd. | Peptides and pharmaceutical compositions comprising them |
| EP1172376A1 (en) * | 1994-11-18 | 2002-01-16 | Neurocrine Biosciences, Inc. | Peptide analogues at position 91 of human myelin basic protein for treatment of multiple sclerosis |
| FR2727117A1 (fr) * | 1994-11-18 | 1996-05-24 | Geffard Michel | Utilisation de conjugues de la polylysine pour la preparation de medicaments utiles dans le traitement des maladies neurodegeneratives et des affections degeneratives a caractere autoimmun |
| US6218166B1 (en) * | 1994-12-09 | 2001-04-17 | John Wayne Cancer Institute | Adjuvant incorporation into antigen carrying cells: compositions and methods |
| US5874531A (en) * | 1995-03-07 | 1999-02-23 | President And Fellows Of Harvard College | Identification of self and non-self antigens implicated autoimmune disease |
| US5869057A (en) * | 1995-06-07 | 1999-02-09 | Rock; Edwin P. | Recombinant vaccines to break self-tolerance |
| SE9502921D0 (sv) * | 1995-08-23 | 1995-08-23 | Astra Ab | New compounds |
| US5739307A (en) * | 1995-08-28 | 1998-04-14 | Washington University | Polynucleotide encoding neurturin neurotrophic factor |
| US5716946A (en) * | 1996-02-13 | 1998-02-10 | Wisconsin Alumni Research Foundation | Multiple sclerosis treatment |
| US5750356A (en) * | 1996-05-31 | 1998-05-12 | Anergen, Inc. | Method for monitoring T cell reactivity |
| US5849886A (en) * | 1996-07-10 | 1998-12-15 | Oy Aboatech Ab | Extraction of myelin basic protein |
| US20010031253A1 (en) * | 1996-07-24 | 2001-10-18 | Gruenberg Micheal L. | Autologous immune cell therapy: cell compositions, methods and applications to treatment of human disease |
| US6130087A (en) * | 1996-10-07 | 2000-10-10 | Fordham University | Methods for generating cytotoxic T cells in vitro |
| KR20000049096A (ko) * | 1996-10-11 | 2000-07-25 | 린다 에스. 스티븐슨 | 혼합 림프구와 조합된 종양세포를 사용하는 암 면역요법 |
| US6054292A (en) * | 1997-07-18 | 2000-04-25 | Incyte Pharmaceuticals, Inc. | T-cell receptor protein |
| US20020009448A1 (en) * | 1997-09-19 | 2002-01-24 | Leslie P. Weiner | T-cell vaccination for the treatment of multiple sclerosis |
| US20020072493A1 (en) * | 1998-05-19 | 2002-06-13 | Yeda Research And Development Co. Ltd. | Activated T cells, nervous system-specific antigens and their uses |
| US20020001841A1 (en) * | 1998-06-26 | 2002-01-03 | Keld Kaltoft | Continuous t-cell lines |
| AU774952B2 (en) * | 1999-02-23 | 2004-07-15 | Baylor College Of Medicine | T cell receptor Vbeta-Dbeta-Jbeta sequence and methods for its detection |
| US6187750B1 (en) * | 1999-08-25 | 2001-02-13 | Everyoung Technologies, Inc. | Method of hormone treatment for patients with symptoms consistent with multiple sclerosis |
| US6746670B2 (en) * | 2000-08-15 | 2004-06-08 | Schering Corporation | Regulatory T cells; methods |
| SI1311542T1 (sl) * | 2000-08-21 | 2009-02-28 | Apitope Technology Bristol Ltd | Tolerogenski peptidi |
| JP2004535785A (ja) * | 2000-11-22 | 2004-12-02 | ディアデクサス インコーポレーテッド | 乳房特異的遺伝子およびタンパク質に関する組成物および方法 |
| US20030078347A1 (en) * | 2001-08-28 | 2003-04-24 | General Electric Company | Triazine compounds, polymers comprising triazine structural units, and method |
| US7658926B2 (en) * | 2001-09-14 | 2010-02-09 | Opexa Pharmaceuticals, Inc. | Autologous T-cell vaccines materials and methods |
| EP1444330A1 (en) * | 2001-11-07 | 2004-08-11 | Kirin Beer Kabushiki Kaisha | Expansion of t cells in vitro and expanded t cell populations |
| US20050181459A1 (en) * | 2002-06-11 | 2005-08-18 | Matthew Baker | Method for mapping and eliminating T cell epitopes |
| CA2542668C (en) * | 2003-10-17 | 2014-04-29 | Baylor College Of Medicine | A method for increasing cd8+ cytotoxic t cell reponses and for treating multiple sclerosis |
| CN101711861A (zh) * | 2003-10-31 | 2010-05-26 | 不列颠哥伦比亚大学 | 细菌毒力因子及其用途 |
| WO2005074579A2 (en) * | 2004-02-02 | 2005-08-18 | Mixture Sciences, Inc. | Peptide mixtures with immunomodulatory activity |
-
2007
- 2007-05-04 PT PT77973477T patent/PT2016414E/pt unknown
- 2007-05-04 AU AU2007247869A patent/AU2007247869B2/en not_active Ceased
- 2007-05-04 JP JP2009510114A patent/JP2009536036A/ja not_active Withdrawn
- 2007-05-04 EP EP07797347.7A patent/EP2016414B1/en not_active Not-in-force
- 2007-05-04 PT PT111886768T patent/PT2420833E/pt unknown
- 2007-05-04 ES ES11188676.8T patent/ES2552667T3/es active Active
- 2007-05-04 NZ NZ572644A patent/NZ572644A/en not_active IP Right Cessation
- 2007-05-04 CA CA002651328A patent/CA2651328A1/en not_active Abandoned
- 2007-05-04 EP EP13187264.0A patent/EP2712623A1/en not_active Withdrawn
- 2007-05-04 ES ES07797347T patent/ES2553192T3/es active Active
- 2007-05-04 EP EP11188676.8A patent/EP2420833B1/en not_active Not-in-force
- 2007-05-04 PL PL07797347T patent/PL2016414T3/pl unknown
- 2007-05-04 DK DK07797347.7T patent/DK2016414T3/en active
- 2007-05-04 US US12/299,585 patent/US20100003228A1/en not_active Abandoned
- 2007-05-04 WO PCT/US2007/068304 patent/WO2007131210A2/en not_active Ceased
- 2007-05-04 PL PL11188676T patent/PL2420833T3/pl unknown
- 2007-05-04 DK DK11188676.8T patent/DK2420833T3/en active
-
2008
- 2008-11-04 IL IL195115A patent/IL195115A/en not_active IP Right Cessation
-
2013
- 2013-08-06 JP JP2013163134A patent/JP6000205B2/ja not_active Expired - Fee Related
-
2016
- 2016-01-12 JP JP2016003678A patent/JP2016053090A/ja not_active Withdrawn
Non-Patent Citations (8)
| Title |
|---|
| ACHIRON, A. et al., Clinical Immunology, 2004, vol. 113, pages 155-160 * |
| MEDAER, R. et al., Lancet, 1995, vol. 346, pages 807-808 * |
| TEJADA-SIMON, M. V. et al., International Immunology, 2000, vol. 12, no. 12, pages 1641-1650 * |
| VAN DER AA, A. et al., Clinical Exp. Immunology, 2003, vol. 131, pages 155-168 * |
| VERGELLI, M. et al., Journal of Neuroscience Research, 2001, vol. 66, pages 517-524 * |
| ZHANG, J. Z. et al., Journal of Molecular Medicine, 1996, vol. 74, pages 653-652 * |
| ZHANG, J. Z. et al., Journal of Neurology, 2002, vol. 249, pages 212-218 * |
| ZHANG, J. Z. et al., Science, 1993, vol. 261, pages 1451-1454 * |
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| EP2016414B1 (en) | 2015-09-02 |
| JP6000205B2 (ja) | 2016-09-28 |
| PT2016414E (pt) | 2015-11-24 |
| DK2420833T3 (en) | 2015-12-07 |
| JP2013252142A (ja) | 2013-12-19 |
| CA2651328A1 (en) | 2007-11-15 |
| PL2420833T3 (pl) | 2016-03-31 |
| PL2016414T3 (pl) | 2016-01-29 |
| JP2016053090A (ja) | 2016-04-14 |
| JP2009536036A (ja) | 2009-10-08 |
| WO2007131210A2 (en) | 2007-11-15 |
| EP2420833A1 (en) | 2012-02-22 |
| ES2552667T3 (es) | 2015-12-01 |
| PT2420833E (pt) | 2015-11-24 |
| DK2016414T3 (en) | 2015-12-07 |
| IL195115A0 (en) | 2009-09-22 |
| EP2016414A2 (en) | 2009-01-21 |
| ES2553192T3 (es) | 2015-12-04 |
| WO2007131210A3 (en) | 2008-10-30 |
| AU2007247869A1 (en) | 2007-11-15 |
| EP2016414A4 (en) | 2009-08-12 |
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