PT1991680E - Sistema para a expressão de componentes ortogonais de tradução em células hospedeiras eubacterianas - Google Patents
Sistema para a expressão de componentes ortogonais de tradução em células hospedeiras eubacterianas Download PDFInfo
- Publication number
- PT1991680E PT1991680E PT77526010T PT07752601T PT1991680E PT 1991680 E PT1991680 E PT 1991680E PT 77526010 T PT77526010 T PT 77526010T PT 07752601 T PT07752601 T PT 07752601T PT 1991680 E PT1991680 E PT 1991680E
- Authority
- PT
- Portugal
- Prior art keywords
- expression
- host cells
- translation components
- orthogonal translation
- eubacterial host
- Prior art date
Links
- 241001112695 Clostridiales Species 0.000 title abstract 2
- 150000001413 amino acids Chemical class 0.000 abstract 2
- 229920001184 polypeptide Polymers 0.000 abstract 2
- 102000004196 processed proteins & peptides Human genes 0.000 abstract 2
- 108090000765 processed proteins & peptides Proteins 0.000 abstract 2
- 238000001727 in vivo Methods 0.000 abstract 1
- 238000000034 method Methods 0.000 abstract 1
- 239000000203 mixture Substances 0.000 abstract 1
- 239000013612 plasmid Substances 0.000 abstract 1
Classifications
-
- C—CHEMISTRY; METALLURGY
- C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
- C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
- C12N15/00—Mutation or genetic engineering; DNA or RNA concerning genetic engineering, vectors, e.g. plasmids, or their isolation, preparation or purification; Use of hosts therefor
- C12N15/09—Recombinant DNA-technology
- C12N15/63—Introduction of foreign genetic material using vectors; Vectors; Use of hosts therefor; Regulation of expression
- C12N15/74—Vectors or expression systems specially adapted for prokaryotic hosts other than E. coli, e.g. Lactobacillus, Micromonospora
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07K—PEPTIDES
- C07K14/00—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof
- C07K14/195—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from bacteria
- C07K14/24—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from bacteria from Enterobacteriaceae (F), e.g. Citrobacter, Serratia, Proteus, Providencia, Morganella, Yersinia
- C07K14/245—Escherichia (G)
-
- C—CHEMISTRY; METALLURGY
- C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
- C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
- C12N15/00—Mutation or genetic engineering; DNA or RNA concerning genetic engineering, vectors, e.g. plasmids, or their isolation, preparation or purification; Use of hosts therefor
- C12N15/09—Recombinant DNA-technology
-
- C—CHEMISTRY; METALLURGY
- C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
- C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
- C12N15/00—Mutation or genetic engineering; DNA or RNA concerning genetic engineering, vectors, e.g. plasmids, or their isolation, preparation or purification; Use of hosts therefor
- C12N15/09—Recombinant DNA-technology
- C12N15/10—Processes for the isolation, preparation or purification of DNA or RNA
-
- C—CHEMISTRY; METALLURGY
- C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
- C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
- C12N15/00—Mutation or genetic engineering; DNA or RNA concerning genetic engineering, vectors, e.g. plasmids, or their isolation, preparation or purification; Use of hosts therefor
- C12N15/09—Recombinant DNA-technology
- C12N15/63—Introduction of foreign genetic material using vectors; Vectors; Use of hosts therefor; Regulation of expression
- C12N15/70—Vectors or expression systems specially adapted for E. coli
-
- C—CHEMISTRY; METALLURGY
- C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
- C12P—FERMENTATION OR ENZYME-USING PROCESSES TO SYNTHESISE A DESIRED CHEMICAL COMPOUND OR COMPOSITION OR TO SEPARATE OPTICAL ISOMERS FROM A RACEMIC MIXTURE
- C12P21/00—Preparation of peptides or proteins
- C12P21/02—Preparation of peptides or proteins having a known sequence of two or more amino acids, e.g. glutathione
Landscapes
- Health & Medical Sciences (AREA)
- Life Sciences & Earth Sciences (AREA)
- Chemical & Material Sciences (AREA)
- Genetics & Genomics (AREA)
- Organic Chemistry (AREA)
- Engineering & Computer Science (AREA)
- Zoology (AREA)
- Wood Science & Technology (AREA)
- Bioinformatics & Cheminformatics (AREA)
- General Engineering & Computer Science (AREA)
- Biotechnology (AREA)
- Biomedical Technology (AREA)
- General Health & Medical Sciences (AREA)
- Biochemistry (AREA)
- Molecular Biology (AREA)
- Biophysics (AREA)
- Microbiology (AREA)
- Physics & Mathematics (AREA)
- Plant Pathology (AREA)
- Proteomics, Peptides & Aminoacids (AREA)
- Medicinal Chemistry (AREA)
- Gastroenterology & Hepatology (AREA)
- Chemical Kinetics & Catalysis (AREA)
- General Chemical & Material Sciences (AREA)
- Crystallography & Structural Chemistry (AREA)
- Micro-Organisms Or Cultivation Processes Thereof (AREA)
- Preparation Of Compounds By Using Micro-Organisms (AREA)
Applications Claiming Priority (3)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| US78097306P | 2006-03-09 | 2006-03-09 | |
| US78349706P | 2006-03-17 | 2006-03-17 | |
| US85533606P | 2006-10-29 | 2006-10-29 |
Publications (1)
| Publication Number | Publication Date |
|---|---|
| PT1991680E true PT1991680E (pt) | 2013-10-30 |
Family
ID=38475556
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| PT77526010T PT1991680E (pt) | 2006-03-09 | 2007-03-07 | Sistema para a expressão de componentes ortogonais de tradução em células hospedeiras eubacterianas |
Country Status (14)
| Country | Link |
|---|---|
| US (3) | US7960141B2 (https=) |
| EP (1) | EP1991680B1 (https=) |
| JP (1) | JP5589186B2 (https=) |
| KR (1) | KR20080106430A (https=) |
| CN (1) | CN101400796B (https=) |
| AU (1) | AU2007223830A1 (https=) |
| BR (1) | BRPI0709935A2 (https=) |
| CA (1) | CA2638763A1 (https=) |
| ES (1) | ES2432391T3 (https=) |
| IL (1) | IL193394A0 (https=) |
| MX (1) | MX2008011470A (https=) |
| PL (1) | PL1991680T3 (https=) |
| PT (1) | PT1991680E (https=) |
| WO (1) | WO2007103490A2 (https=) |
Families Citing this family (28)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| WO2002085923A2 (en) * | 2001-04-19 | 2002-10-31 | The Scripps Research Institute | In vivo incorporation of unnatural amino acids |
| MXPA05003978A (es) * | 2002-10-16 | 2005-06-22 | Scripps Research Inst | Sintesis de glicoproteinas. |
| JP5642916B2 (ja) | 2003-04-17 | 2014-12-17 | ザ スクリプス リサーチ インスティテュート | 真核遺伝コードの拡張 |
| EP1649004A4 (en) * | 2003-07-07 | 2008-04-09 | Scripps Research Inst | COMPOSITIONS WITH PAIRS OF ORTHOGONAL LYSYL-TRNA AND AMINOACYL-TRNA-SYNTHETASE AND USES THEREOF |
| US20080171317A1 (en) * | 2004-09-22 | 2008-07-17 | The Scripps Research Institute | Site-Specific Labeling of Proteins for Nmr Studies |
| CN101048506B (zh) | 2004-10-27 | 2013-06-26 | 斯克利普斯研究院 | 体内掺入非天然氨基酸的正交翻译组分 |
| KR20080106430A (ko) | 2006-03-09 | 2008-12-05 | 더 스크립스 리서치 인스티튜트 | 진정 세균 숙주 세포 내에서의 직교형 번역 성분의 발현을 위한 시스템 |
| WO2007109035A2 (en) | 2006-03-16 | 2007-09-27 | The Scripps Research Institute | Genetically programmed expression of proteins containing the unnatural amino acid phenylselenocysteine |
| AU2007267950B2 (en) | 2006-05-23 | 2012-08-16 | The Scripps Research Institute | Genetically encoded fluorescent coumarin amino acids |
| JP5385143B2 (ja) | 2006-09-21 | 2014-01-08 | ザ スクリプス リサーチ インスティチュート | 真正細菌における選択的に硫酸化された蛋白質の遺伝的にプログラムされた発現 |
| WO2008073184A2 (en) | 2006-10-18 | 2008-06-19 | The Scripps Research Institute | Genetic incorporation of unnatural amino acids into proteins in mammalian cells |
| WO2009059056A2 (en) * | 2007-11-02 | 2009-05-07 | The Scripps Research Institute | A genetically encoded boronate amino acid |
| CN101939410A (zh) | 2007-12-11 | 2011-01-05 | 斯克利普斯研究院 | 甲基营养酵母菌巴斯德毕赤酵母中的体内非天然氨基酸表达 |
| EP2249865A4 (en) * | 2008-02-08 | 2012-04-04 | Scripps Research Inst | BREAKING IMMUNOLOGICAL TOLERANCE WITH A GENETICALLY ENCODED UNNATURAL AMINO ACID |
| AU2009296267B2 (en) | 2008-09-26 | 2013-10-31 | Ambrx, Inc. | Non-natural amino acid replication-dependent microorganisms and vaccines |
| US20090197339A1 (en) * | 2008-12-10 | 2009-08-06 | The Scripps Research Institute | In vivo unnatural amino acid expression in the methylotrophic yeast pichia pastoris |
| US8609383B2 (en) | 2008-12-10 | 2013-12-17 | The Scripps Research Institute | Production of carrier-peptide conjugates using chemically reactive unnatural amino acids |
| EA030886B1 (ru) * | 2010-08-17 | 2018-10-31 | Амбркс, Инк. | Модифицированные полипептиды релаксина, содержащие некодируемую в природе аминокислоту, связанную с полимером, и их применение |
| KR20160027219A (ko) | 2012-05-23 | 2016-03-09 | 에프. 호프만-라 로슈 아게 | 내배엽 및 간세포를 수득하고 사용하는 조성물 및 방법 |
| UY35368A (es) | 2013-03-08 | 2014-10-31 | Irm Llc | Péptidos y composiciones para el tratamiento de daño articular |
| EP3021942A4 (en) | 2013-07-19 | 2017-04-19 | The Regents of The University of California | Milk fat globule epidermal growth factor 8 regulates fatty acid uptake |
| JP2020500020A (ja) | 2016-11-14 | 2020-01-09 | ノバルティス アーゲー | 融合誘導性タンパク質ｍｉｎｉｏｎに関連する組成物、方法、および治療上の使用 |
| KR20240045351A (ko) | 2016-11-14 | 2024-04-05 | 노파르티스 아게 | 연골 손상 및 관절염 치료 방법 및 조성물 |
| PE20191716A1 (es) | 2017-02-08 | 2019-12-05 | Bristol Myers Squibb Co | Polipeptidos de relaxina modificada que comprenden un mejorador farmacocinetico y sus usos |
| CA3157470A1 (en) * | 2019-11-05 | 2021-05-14 | Neil Butler | Biosynthesis of para-nitro-l-phenylalanine |
| CN111304234A (zh) * | 2020-02-27 | 2020-06-19 | 江南大学 | 一种适用于枯草芽孢杆菌的非天然氨基酸利用工具 |
| CN113322267B (zh) * | 2021-03-15 | 2024-01-05 | 天津大学 | 系统在提高非天然氨基酸的插入效率中的应用 |
| WO2024091824A1 (en) | 2022-10-26 | 2024-05-02 | Ada Forsyth Institute, Inc. | Differentiation and reprogramming of chondrocyte |
Family Cites Families (24)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| US5024939A (en) | 1987-07-09 | 1991-06-18 | Genentech, Inc. | Transient expression system for producing recombinant protein |
| JP2002526103A (ja) | 1998-10-08 | 2002-08-20 | アストラゼネカ・アクチエボラーグ | 微細組み立てセル注入器 |
| ATE556149T1 (de) | 1999-02-23 | 2012-05-15 | Caliper Life Sciences Inc | Manipulation von mikropartikeln in mikrofluidischen systemen |
| WO2002085923A2 (en) | 2001-04-19 | 2002-10-31 | The Scripps Research Institute | In vivo incorporation of unnatural amino acids |
| US8220494B2 (en) | 2002-09-25 | 2012-07-17 | California Institute Of Technology | Microfluidic large scale integration |
| MXPA05003978A (es) | 2002-10-16 | 2005-06-22 | Scripps Research Inst | Sintesis de glicoproteinas. |
| JP4444113B2 (ja) | 2002-10-16 | 2010-03-31 | ザ スクリップス リサーチ インスティテュート | ケトアミノ酸の部位特異的蛋白質組込み方法 |
| CA2508939A1 (en) | 2002-12-22 | 2004-07-15 | The Scripps Research Institute | Protein arrays |
| JP5642916B2 (ja) | 2003-04-17 | 2014-12-17 | ザ スクリプス リサーチ インスティテュート | 真核遺伝コードの拡張 |
| EP2410331B1 (en) | 2003-06-18 | 2015-09-23 | The Scripps Research Institute | Aminoacyl-tRNA synthetase for aminoacylation tRNA with unnatural amino acids |
| EP1649004A4 (en) | 2003-07-07 | 2008-04-09 | Scripps Research Inst | COMPOSITIONS WITH PAIRS OF ORTHOGONAL LYSYL-TRNA AND AMINOACYL-TRNA-SYNTHETASE AND USES THEREOF |
| US20060160175A1 (en) | 2003-07-07 | 2006-07-20 | The Scripps Research Institute | Compositions of orthogonal leucyl-trna and aminoacyl-trna synthetase pairs and uses thereof |
| WO2005007624A2 (en) | 2003-07-07 | 2005-01-27 | The Scripps Research Institute | Compositions of orthogonal glutamyl-trna and aminoacyl trna synthetase pairs and uses thereof |
| PT1687401E (pt) | 2003-10-14 | 2013-02-26 | Scripps Research Inst | Incorporação de aminoácidos activos em oxidação-redução específica do local em proteínas |
| US7741071B2 (en) | 2003-12-18 | 2010-06-22 | The Scripps Research Institute | Selective incorporation of 5-hydroxytryptophan into proteins in mammalian cells |
| JP2008500050A (ja) * | 2004-05-25 | 2008-01-10 | ザ スクリップス リサーチ インスティテュート | 結晶構造決定のための重原子含有非天然アミノ酸の部位特異的蛋白質組込み |
| AU2005286722B2 (en) | 2004-09-21 | 2010-12-02 | The Scripps Research Institute | In vivo incorporation of alkynyl amino acids into proteins in eubacteria |
| US20090181858A1 (en) | 2004-09-21 | 2009-07-16 | The Scripps Research Institute | Adding photoregulated amino acids to the genetic code |
| US20080171317A1 (en) | 2004-09-22 | 2008-07-17 | The Scripps Research Institute | Site-Specific Labeling of Proteins for Nmr Studies |
| JP2008516637A (ja) | 2004-10-20 | 2008-05-22 | ザ スクリップス リサーチ インスティテュート | 真正細菌へのｎ−アセチルガラクトサミンアミノ酸のインビボ部位特異的組込み |
| CN101048506B (zh) | 2004-10-27 | 2013-06-26 | 斯克利普斯研究院 | 体内掺入非天然氨基酸的正交翻译组分 |
| BRPI0617191A2 (pt) | 2005-10-12 | 2011-07-19 | Scripps Research Inst | modificação pós-traducional de polipeptìdeos expressos em fagos |
| KR20080106430A (ko) | 2006-03-09 | 2008-12-05 | 더 스크립스 리서치 인스티튜트 | 진정 세균 숙주 세포 내에서의 직교형 번역 성분의 발현을 위한 시스템 |
| WO2007109035A2 (en) | 2006-03-16 | 2007-09-27 | The Scripps Research Institute | Genetically programmed expression of proteins containing the unnatural amino acid phenylselenocysteine |
-
2007
- 2007-03-07 KR KR1020087022447A patent/KR20080106430A/ko not_active Ceased
- 2007-03-07 JP JP2008558393A patent/JP5589186B2/ja not_active Expired - Fee Related
- 2007-03-07 WO PCT/US2007/005914 patent/WO2007103490A2/en not_active Ceased
- 2007-03-07 BR BRPI0709935-5A patent/BRPI0709935A2/pt not_active Application Discontinuation
- 2007-03-07 AU AU2007223830A patent/AU2007223830A1/en not_active Abandoned
- 2007-03-07 CA CA002638763A patent/CA2638763A1/en not_active Abandoned
- 2007-03-07 US US11/715,672 patent/US7960141B2/en active Active
- 2007-03-07 PT PT77526010T patent/PT1991680E/pt unknown
- 2007-03-07 PL PL07752601T patent/PL1991680T3/pl unknown
- 2007-03-07 CN CN2007800084039A patent/CN101400796B/zh not_active Expired - Fee Related
- 2007-03-07 MX MX2008011470A patent/MX2008011470A/es active IP Right Grant
- 2007-03-07 US US12/224,773 patent/US8198044B2/en active Active
- 2007-03-07 EP EP07752601.0A patent/EP1991680B1/en not_active Not-in-force
- 2007-03-07 ES ES07752601T patent/ES2432391T3/es active Active
-
2008
- 2008-08-12 IL IL193394A patent/IL193394A0/en unknown
-
2012
- 2012-05-10 US US13/468,736 patent/US8357512B2/en not_active Expired - Fee Related
Also Published As
| Publication number | Publication date |
|---|---|
| BRPI0709935A2 (pt) | 2011-08-02 |
| CN101400796B (zh) | 2013-03-27 |
| US20120252067A1 (en) | 2012-10-04 |
| US8357512B2 (en) | 2013-01-22 |
| US7960141B2 (en) | 2011-06-14 |
| JP2009529328A (ja) | 2009-08-20 |
| KR20080106430A (ko) | 2008-12-05 |
| IL193394A0 (en) | 2009-09-22 |
| EP1991680A4 (en) | 2009-10-21 |
| MX2008011470A (es) | 2008-09-24 |
| CA2638763A1 (en) | 2007-09-13 |
| WO2007103490A2 (en) | 2007-09-13 |
| US20090181429A1 (en) | 2009-07-16 |
| CN101400796A (zh) | 2009-04-01 |
| JP5589186B2 (ja) | 2014-09-17 |
| AU2007223830A1 (en) | 2007-09-13 |
| EP1991680A2 (en) | 2008-11-19 |
| WO2007103490A3 (en) | 2008-06-12 |
| US20070281335A1 (en) | 2007-12-06 |
| PL1991680T3 (pl) | 2014-01-31 |
| US8198044B2 (en) | 2012-06-12 |
| EP1991680B1 (en) | 2013-08-21 |
| ES2432391T3 (es) | 2013-12-03 |
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