WO2011050152A3 - Site-specific modification of proteins - Google Patents

Site-specific modification of proteins Download PDF

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Publication number
WO2011050152A3
WO2011050152A3 PCT/US2010/053523 US2010053523W WO2011050152A3 WO 2011050152 A3 WO2011050152 A3 WO 2011050152A3 US 2010053523 W US2010053523 W US 2010053523W WO 2011050152 A3 WO2011050152 A3 WO 2011050152A3
Authority
WO
WIPO (PCT)
Prior art keywords
proteins
site
specific modification
modification
specific
Prior art date
Application number
PCT/US2010/053523
Other languages
French (fr)
Other versions
WO2011050152A2 (en
Inventor
Philip A. Cole
Rong Huang
You-Sang Hwang
Original Assignee
The Johns Hopkins University
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by The Johns Hopkins University filed Critical The Johns Hopkins University
Publication of WO2011050152A2 publication Critical patent/WO2011050152A2/en
Publication of WO2011050152A3 publication Critical patent/WO2011050152A3/en

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Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K16/00—Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P39/00—General protective or antinoxious agents
    • A61P39/02—Antidotes
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K1/00—General methods for the preparation of peptides, i.e. processes for the organic chemical preparation of peptides or proteins of any length
    • C07K1/107—General methods for the preparation of peptides, i.e. processes for the organic chemical preparation of peptides or proteins of any length by chemical modification of precursor peptides
    • C07K1/113—General methods for the preparation of peptides, i.e. processes for the organic chemical preparation of peptides or proteins of any length by chemical modification of precursor peptides without change of the primary structure
    • C07K1/1133—General methods for the preparation of peptides, i.e. processes for the organic chemical preparation of peptides or proteins of any length by chemical modification of precursor peptides without change of the primary structure by redox-reactions involving cystein/cystin side chains

Abstract

Methods and compositions for site-specific modification of amino acids, peptides, polypeptides and proteins are disclosed.
PCT/US2010/053523 2009-10-21 2010-10-21 Site-specific modification of proteins WO2011050152A2 (en)

Applications Claiming Priority (2)

Application Number Priority Date Filing Date Title
US25368809P 2009-10-21 2009-10-21
US61/253,688 2009-10-21

Publications (2)

Publication Number Publication Date
WO2011050152A2 WO2011050152A2 (en) 2011-04-28
WO2011050152A3 true WO2011050152A3 (en) 2011-09-09

Family

ID=43900956

Family Applications (1)

Application Number Title Priority Date Filing Date
PCT/US2010/053523 WO2011050152A2 (en) 2009-10-21 2010-10-21 Site-specific modification of proteins

Country Status (1)

Country Link
WO (1) WO2011050152A2 (en)

Families Citing this family (1)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
CN114621312B (en) * 2022-03-24 2022-11-15 陕西师范大学 Selective modification method of oligopeptide alkyl side chain

Citations (4)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US4025503A (en) * 1973-07-07 1977-05-24 Basf Aktiengesellschaft Manufacture of aziridinecarboxylic acid esters
US5037752A (en) * 1987-10-09 1991-08-06 Monsanto Company Modified tissue plasminogen activator substituted at cysteine-73 and lysine-277
WO2002028884A1 (en) * 2000-10-04 2002-04-11 University Of Medicine And Dentistry Of New Jersey Site-specific protein modification
US20030186890A1 (en) * 2000-07-03 2003-10-02 Synt:Em S.A. Amphipathic linear peptides and formulations containing said peptides

Patent Citations (4)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US4025503A (en) * 1973-07-07 1977-05-24 Basf Aktiengesellschaft Manufacture of aziridinecarboxylic acid esters
US5037752A (en) * 1987-10-09 1991-08-06 Monsanto Company Modified tissue plasminogen activator substituted at cysteine-73 and lysine-277
US20030186890A1 (en) * 2000-07-03 2003-10-02 Synt:Em S.A. Amphipathic linear peptides and formulations containing said peptides
WO2002028884A1 (en) * 2000-10-04 2002-04-11 University Of Medicine And Dentistry Of New Jersey Site-specific protein modification

Also Published As

Publication number Publication date
WO2011050152A2 (en) 2011-04-28

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