PT1971330E - Associação de derivados de triazina e sensibilizadores de insulina - Google Patents
Associação de derivados de triazina e sensibilizadores de insulina Download PDFInfo
- Publication number
- PT1971330E PT1971330E PT06829706T PT06829706T PT1971330E PT 1971330 E PT1971330 E PT 1971330E PT 06829706 T PT06829706 T PT 06829706T PT 06829706 T PT06829706 T PT 06829706T PT 1971330 E PT1971330 E PT 1971330E
- Authority
- PT
- Portugal
- Prior art keywords
- alkoxy
- alkyl
- amino
- optionally substituted
- pharmaceutical composition
- Prior art date
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- NOESYZHRGYRDHS-UHFFFAOYSA-N insulin Chemical compound N1C(=O)C(NC(=O)C(CCC(N)=O)NC(=O)C(CCC(O)=O)NC(=O)C(C(C)C)NC(=O)C(NC(=O)CN)C(C)CC)CSSCC(C(NC(CO)C(=O)NC(CC(C)C)C(=O)NC(CC=2C=CC(O)=CC=2)C(=O)NC(CCC(N)=O)C(=O)NC(CC(C)C)C(=O)NC(CCC(O)=O)C(=O)NC(CC(N)=O)C(=O)NC(CC=2C=CC(O)=CC=2)C(=O)NC(CSSCC(NC(=O)C(C(C)C)NC(=O)C(CC(C)C)NC(=O)C(CC=2C=CC(O)=CC=2)NC(=O)C(CC(C)C)NC(=O)C(C)NC(=O)C(CCC(O)=O)NC(=O)C(C(C)C)NC(=O)C(CC(C)C)NC(=O)C(CC=2NC=NC=2)NC(=O)C(CO)NC(=O)CNC2=O)C(=O)NCC(=O)NC(CCC(O)=O)C(=O)NC(CCCNC(N)=N)C(=O)NCC(=O)NC(CC=3C=CC=CC=3)C(=O)NC(CC=3C=CC=CC=3)C(=O)NC(CC=3C=CC(O)=CC=3)C(=O)NC(C(C)O)C(=O)N3C(CCC3)C(=O)NC(CCCCN)C(=O)NC(C)C(O)=O)C(=O)NC(CC(N)=O)C(O)=O)=O)NC(=O)C(C(C)CC)NC(=O)C(CO)NC(=O)C(C(C)O)NC(=O)C1CSSCC2NC(=O)C(CC(C)C)NC(=O)C(NC(=O)C(CCC(N)=O)NC(=O)C(CC(N)=O)NC(=O)C(NC(=O)C(N)CC=1C=CC=CC=1)C(C)C)CC1=CN=CN1 NOESYZHRGYRDHS-UHFFFAOYSA-N 0.000 title claims description 14
- 150000003918 triazines Chemical class 0.000 title claims description 10
- 102000004877 Insulin Human genes 0.000 title claims description 7
- 108090001061 Insulin Proteins 0.000 title claims description 7
- 229940125396 insulin Drugs 0.000 title claims description 7
- 231100000489 sensitizer Toxicity 0.000 title claims description 3
- -1 amino, hydroxy, thio Chemical group 0.000 claims description 81
- 125000003545 alkoxy group Chemical group 0.000 claims description 77
- 150000001875 compounds Chemical class 0.000 claims description 59
- 125000000217 alkyl group Chemical group 0.000 claims description 53
- 239000008194 pharmaceutical composition Substances 0.000 claims description 39
- 229910052736 halogen Inorganic materials 0.000 claims description 38
- 150000002367 halogens Chemical group 0.000 claims description 38
- 125000005915 C6-C14 aryl group Chemical group 0.000 claims description 33
- 229940122355 Insulin sensitizer Drugs 0.000 claims description 33
- 125000004093 cyano group Chemical group *C#N 0.000 claims description 33
- YASAKCUCGLMORW-UHFFFAOYSA-N Rosiglitazone Chemical compound C=1C=CC=NC=1N(C)CCOC(C=C1)=CC=C1CC1SC(=O)NC1=O YASAKCUCGLMORW-UHFFFAOYSA-N 0.000 claims description 32
- 125000002023 trifluoromethyl group Chemical group FC(F)(F)* 0.000 claims description 31
- 125000003282 alkyl amino group Chemical group 0.000 claims description 30
- 125000005914 C6-C14 aryloxy group Chemical group 0.000 claims description 27
- 125000003178 carboxy group Chemical group [H]OC(*)=O 0.000 claims description 26
- 125000002057 carboxymethyl group Chemical group [H]OC(=O)C([H])([H])[*] 0.000 claims description 26
- 125000006715 (C1-C5) alkylthio group Chemical group 0.000 claims description 22
- 239000000203 mixture Substances 0.000 claims description 19
- 208000001072 type 2 diabetes mellitus Diseases 0.000 claims description 18
- 229960004586 rosiglitazone Drugs 0.000 claims description 16
- 150000003839 salts Chemical class 0.000 claims description 16
- 125000005842 heteroatom Chemical group 0.000 claims description 15
- 229910052760 oxygen Inorganic materials 0.000 claims description 15
- HYAFETHFCAUJAY-UHFFFAOYSA-N pioglitazone Chemical compound N1=CC(CC)=CC=C1CCOC(C=C1)=CC=C1CC1C(=O)NC(=O)S1 HYAFETHFCAUJAY-UHFFFAOYSA-N 0.000 claims description 15
- 238000011282 treatment Methods 0.000 claims description 15
- 229910052717 sulfur Inorganic materials 0.000 claims description 14
- 125000000446 sulfanediyl group Chemical group *S* 0.000 claims description 13
- 239000000556 agonist Substances 0.000 claims description 11
- 206010012601 diabetes mellitus Diseases 0.000 claims description 11
- 125000003837 (C1-C20) alkyl group Chemical group 0.000 claims description 9
- 125000006552 (C3-C8) cycloalkyl group Chemical group 0.000 claims description 9
- GFICWFZTBXUVIG-UHFFFAOYSA-N 6-n,6-n,4-trimethyl-1,4-dihydro-1,3,5-triazine-2,6-diamine Chemical compound CC1N=C(N)NC(N(C)C)=N1 GFICWFZTBXUVIG-UHFFFAOYSA-N 0.000 claims description 9
- XZWYZXLIPXDOLR-UHFFFAOYSA-N metformin Chemical compound CN(C)C(=N)NC(N)=N XZWYZXLIPXDOLR-UHFFFAOYSA-N 0.000 claims description 8
- 229960003105 metformin Drugs 0.000 claims description 8
- 239000004480 active ingredient Substances 0.000 claims description 7
- 125000004432 carbon atom Chemical group C* 0.000 claims description 7
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- 125000004414 alkyl thio group Chemical group 0.000 claims description 6
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- 239000000843 powder Substances 0.000 claims description 6
- UFHFLCQGNIYNRP-UHFFFAOYSA-N Hydrogen Chemical compound [H][H] UFHFLCQGNIYNRP-UHFFFAOYSA-N 0.000 claims description 5
- 125000003342 alkenyl group Chemical group 0.000 claims description 5
- 229910052757 nitrogen Inorganic materials 0.000 claims description 5
- 238000002360 preparation method Methods 0.000 claims description 5
- 102000000536 PPAR gamma Human genes 0.000 claims description 4
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- 125000003118 aryl group Chemical group 0.000 claims description 4
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- 239000001257 hydrogen Substances 0.000 claims description 4
- 125000004433 nitrogen atom Chemical group N* 0.000 claims description 4
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- 125000003367 polycyclic group Chemical group 0.000 claims description 4
- GXPHKUHSUJUWKP-UHFFFAOYSA-N troglitazone Chemical compound C1CC=2C(C)=C(O)C(C)=C(C)C=2OC1(C)COC(C=C1)=CC=C1CC1SC(=O)NC1=O GXPHKUHSUJUWKP-UHFFFAOYSA-N 0.000 claims description 4
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- HBAQYPYDRFILMT-UHFFFAOYSA-N 8-[3-(1-cyclopropylpyrazol-4-yl)-1H-pyrazolo[4,3-d]pyrimidin-5-yl]-3-methyl-3,8-diazabicyclo[3.2.1]octan-2-one Chemical class C1(CC1)N1N=CC(=C1)C1=NNC2=C1N=C(N=C2)N1C2C(N(CC1CC2)C)=O HBAQYPYDRFILMT-UHFFFAOYSA-N 0.000 claims description 3
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- 125000002496 methyl group Chemical group [H]C([H])([H])* 0.000 claims description 3
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- 108010014905 Glycogen Synthase Kinase 3 Proteins 0.000 claims description 2
- OUYCCCASQSFEME-QMMMGPOBSA-N L-tyrosine Chemical compound OC(=O)[C@@H](N)CC1=CC=C(O)C=C1 OUYCCCASQSFEME-QMMMGPOBSA-N 0.000 claims description 2
- 208000017170 Lipid metabolism disease Diseases 0.000 claims description 2
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- 102000023984 PPAR alpha Human genes 0.000 claims description 2
- 102000004160 Phosphoric Monoester Hydrolases Human genes 0.000 claims description 2
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- 125000002252 acyl group Chemical group 0.000 claims description 2
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Classifications
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- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K31/00—Medicinal preparations containing organic active ingredients
- A61K31/33—Heterocyclic compounds
- A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
- A61K31/53—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with three nitrogens as the only ring hetero atoms, e.g. chlorazanil, melamine
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D251/00—Heterocyclic compounds containing 1,3,5-triazine rings
- C07D251/02—Heterocyclic compounds containing 1,3,5-triazine rings not condensed with other rings
- C07D251/12—Heterocyclic compounds containing 1,3,5-triazine rings not condensed with other rings having three double bonds between ring members or between ring members and non-ring members
- C07D251/26—Heterocyclic compounds containing 1,3,5-triazine rings not condensed with other rings having three double bonds between ring members or between ring members and non-ring members with only hetero atoms directly attached to ring carbon atoms
- C07D251/40—Nitrogen atoms
- C07D251/48—Two nitrogen atoms
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- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K31/00—Medicinal preparations containing organic active ingredients
- A61K31/16—Amides, e.g. hydroxamic acids
- A61K31/165—Amides, e.g. hydroxamic acids having aromatic rings, e.g. colchicine, atenolol, progabide
- A61K31/166—Amides, e.g. hydroxamic acids having aromatic rings, e.g. colchicine, atenolol, progabide having the carbon of a carboxamide group directly attached to the aromatic ring, e.g. procainamide, procarbazine, metoclopramide, labetalol
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- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K31/00—Medicinal preparations containing organic active ingredients
- A61K31/33—Heterocyclic compounds
- A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
- A61K31/41—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having five-membered rings with two or more ring hetero atoms, at least one of which being nitrogen, e.g. tetrazole
- A61K31/42—Oxazoles
- A61K31/422—Oxazoles not condensed and containing further heterocyclic rings
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K31/00—Medicinal preparations containing organic active ingredients
- A61K31/33—Heterocyclic compounds
- A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
- A61K31/435—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with one nitrogen as the only ring hetero atom
- A61K31/44—Non condensed pyridines; Hydrogenated derivatives thereof
- A61K31/4427—Non condensed pyridines; Hydrogenated derivatives thereof containing further heterocyclic ring systems
- A61K31/4439—Non condensed pyridines; Hydrogenated derivatives thereof containing further heterocyclic ring systems containing a five-membered ring with nitrogen as a ring hetero atom, e.g. omeprazole
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- A—HUMAN NECESSITIES
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- A61P3/10—Drugs for disorders of the metabolism for glucose homeostasis for hyperglycaemia, e.g. antidiabetics
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- A61P5/48—Drugs for disorders of the endocrine system of the pancreatic hormones
- A61P5/50—Drugs for disorders of the endocrine system of the pancreatic hormones for increasing or potentiating the activity of insulin
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Landscapes
- Health & Medical Sciences (AREA)
- Chemical & Material Sciences (AREA)
- Pharmacology & Pharmacy (AREA)
- Veterinary Medicine (AREA)
- Public Health (AREA)
- General Health & Medical Sciences (AREA)
- Animal Behavior & Ethology (AREA)
- Medicinal Chemistry (AREA)
- Life Sciences & Earth Sciences (AREA)
- Organic Chemistry (AREA)
- Engineering & Computer Science (AREA)
- Bioinformatics & Cheminformatics (AREA)
- General Chemical & Material Sciences (AREA)
- Chemical Kinetics & Catalysis (AREA)
- Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
- Epidemiology (AREA)
- Diabetes (AREA)
- Obesity (AREA)
- Hematology (AREA)
- Urology & Nephrology (AREA)
- Cardiology (AREA)
- Heart & Thoracic Surgery (AREA)
- Endocrinology (AREA)
- Emergency Medicine (AREA)
- Vascular Medicine (AREA)
- Ophthalmology & Optometry (AREA)
- Biomedical Technology (AREA)
- Neurology (AREA)
- Neurosurgery (AREA)
- Child & Adolescent Psychology (AREA)
- Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
- Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)
Applications Claiming Priority (1)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| FR0600344A FR2896159B1 (fr) | 2006-01-13 | 2006-01-13 | Combinaison de derives de triazine et d'agents sensibilisateurs a l'insuline. |
Publications (1)
| Publication Number | Publication Date |
|---|---|
| PT1971330E true PT1971330E (pt) | 2010-09-09 |
Family
ID=36654309
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| PT06829706T PT1971330E (pt) | 2006-01-13 | 2006-12-18 | Associação de derivados de triazina e sensibilizadores de insulina |
Country Status (22)
| Country | Link |
|---|---|
| US (2) | US8791115B2 (enExample) |
| EP (1) | EP1971330B1 (enExample) |
| JP (1) | JP5249782B2 (enExample) |
| KR (2) | KR20140033498A (enExample) |
| CN (1) | CN101355933A (enExample) |
| AR (1) | AR059032A1 (enExample) |
| AT (1) | ATE476179T1 (enExample) |
| AU (1) | AU2006334734B2 (enExample) |
| BR (1) | BRPI0620985B8 (enExample) |
| CA (1) | CA2640897C (enExample) |
| CY (1) | CY1110789T1 (enExample) |
| DE (1) | DE602006016014D1 (enExample) |
| DK (1) | DK1971330T3 (enExample) |
| EA (1) | EA015576B1 (enExample) |
| ES (1) | ES2347177T3 (enExample) |
| FR (1) | FR2896159B1 (enExample) |
| IL (1) | IL192558A (enExample) |
| PL (1) | PL1971330T3 (enExample) |
| PT (1) | PT1971330E (enExample) |
| SI (1) | SI1971330T1 (enExample) |
| WO (1) | WO2007079917A2 (enExample) |
| ZA (1) | ZA200806947B (enExample) |
Families Citing this family (11)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| FR2896159B1 (fr) * | 2006-01-13 | 2008-09-12 | Merck Sante Soc Par Actions Si | Combinaison de derives de triazine et d'agents sensibilisateurs a l'insuline. |
| JP5667985B2 (ja) * | 2008-12-12 | 2015-02-12 | ポクセル | インスリンとトリアジンの組合せ及び糖尿病を治療するためのその使用 |
| CA2745854A1 (en) * | 2008-12-12 | 2010-06-17 | Daniel Cravo | Tetrahydrotriazine compounds for treating diseases associated with ampk activity |
| FR2948027A1 (fr) * | 2009-07-17 | 2011-01-21 | Merck Sante Sas | Derives amines de dihydro-1,3,5-triazine pour leur utilisation dans le traitement des maladies associees a une ischemie et/ou une reperfusion |
| FR2948026B1 (fr) * | 2009-07-17 | 2011-12-02 | Merck Sante Sas | Derives amines de dihydro-1,3,5-triazine |
| TWI436768B (zh) * | 2010-06-09 | 2014-05-11 | Poxel | 第２型糖尿病之治療 |
| KR20120011667A (ko) | 2010-07-29 | 2012-02-08 | 광주과학기술원 | 당뇨병 치료제의 스크리닝 방법 |
| KR101271218B1 (ko) * | 2012-12-07 | 2013-06-07 | 광주과학기술원 | 당뇨병 치료제의 스크리닝 방법 |
| JP2020536121A (ja) | 2017-10-02 | 2020-12-10 | ポクセルＰｏｘｅｌ | 駆出率が保持された心不全を治療する方法 |
| CA3102412A1 (en) | 2018-06-06 | 2019-12-12 | Metavant Sciences Gmbh | Methods of treating subjects having diabetes with chronic kidney disease |
| WO2019238647A1 (en) | 2018-06-14 | 2019-12-19 | Poxel | Film-coated tablet comprising a triazine derivative for use in the treatment of diabetes |
Family Cites Families (12)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| US6288095B1 (en) * | 1987-09-04 | 2001-09-11 | Beecham Group P.L.C. | Compounds |
| US5885980A (en) * | 1996-06-25 | 1999-03-23 | Enrique G. Gutierrez | Composition and method for treating diabetes |
| US6011049A (en) | 1997-02-19 | 2000-01-04 | Warner-Lambert Company | Combinations for diabetes |
| TW200514783A (en) | 1999-09-22 | 2005-05-01 | Bristol Myers Squibb Co | Substituted acid derivatives useful as antiodiabetic and antiobesity agents and method |
| AR030920A1 (es) | 1999-11-16 | 2003-09-03 | Smithkline Beecham Plc | Composiciones farmaceuticas para el tratamiento de la diabetes mellitus y condiciones asociadas con la diabetes mellitus, y procedimientos para preparar dichas composiciones |
| FR2804113B1 (fr) * | 2000-01-26 | 2004-06-18 | Lipha | Derives animes de dihydro-1,3,5-triazine et leurs applications en therapeutique |
| AU2001257456B2 (en) * | 2000-05-01 | 2006-02-09 | Aeropharm Technology, Inc. | A core formulation |
| FR2853650B1 (fr) * | 2003-04-10 | 2006-07-07 | Merck Sante Sas | Procede de dedoublement d'amines utiles pour le traitement de desordres associes au syndrome d'insulino-resistance |
| TW200526678A (en) * | 2003-08-01 | 2005-08-16 | Janssen Pharmaceutica Nv | Substituted indole-O-glucosides |
| FR2863484B1 (fr) * | 2003-12-11 | 2007-04-13 | Oreal | Utilisation de composes capables d'agir sur la voie metabolique controlee par la dopachrome tautomerase trp-2 comme agent protecteur des melanocytes du follicule pileux et applications |
| EP1841414A1 (en) * | 2003-12-31 | 2007-10-10 | Alpharma, Inc. | Rosiglitazone and metformin formulations |
| FR2896159B1 (fr) * | 2006-01-13 | 2008-09-12 | Merck Sante Soc Par Actions Si | Combinaison de derives de triazine et d'agents sensibilisateurs a l'insuline. |
-
2006
- 2006-01-13 FR FR0600344A patent/FR2896159B1/fr not_active Expired - Fee Related
- 2006-12-18 EA EA200801676A patent/EA015576B1/ru not_active IP Right Cessation
- 2006-12-18 BR BRPI0620985A patent/BRPI0620985B8/pt not_active IP Right Cessation
- 2006-12-18 PT PT06829706T patent/PT1971330E/pt unknown
- 2006-12-18 EP EP06829706A patent/EP1971330B1/en active Active
- 2006-12-18 DE DE602006016014T patent/DE602006016014D1/de active Active
- 2006-12-18 AU AU2006334734A patent/AU2006334734B2/en not_active Ceased
- 2006-12-18 DK DK06829706.8T patent/DK1971330T3/da active
- 2006-12-18 CA CA2640897A patent/CA2640897C/en not_active Expired - Fee Related
- 2006-12-18 PL PL06829706T patent/PL1971330T3/pl unknown
- 2006-12-18 AT AT06829706T patent/ATE476179T1/de active
- 2006-12-18 JP JP2008549783A patent/JP5249782B2/ja active Active
- 2006-12-18 WO PCT/EP2006/012185 patent/WO2007079917A2/en not_active Ceased
- 2006-12-18 KR KR1020147002582A patent/KR20140033498A/ko not_active Ceased
- 2006-12-18 ES ES06829706T patent/ES2347177T3/es active Active
- 2006-12-18 CN CNA2006800509443A patent/CN101355933A/zh active Pending
- 2006-12-18 KR KR20087019624A patent/KR101482685B1/ko not_active Expired - Fee Related
- 2006-12-18 SI SI200630793T patent/SI1971330T1/sl unknown
- 2006-12-18 US US12/160,664 patent/US8791115B2/en active Active
-
2007
- 2007-01-12 AR ARP070100138A patent/AR059032A1/es unknown
-
2008
- 2008-07-01 IL IL192558A patent/IL192558A/en active IP Right Grant
- 2008-08-12 ZA ZA200806947A patent/ZA200806947B/xx unknown
-
2010
- 2010-09-16 CY CY20101100840T patent/CY1110789T1/el unknown
-
2013
- 2013-10-25 US US14/063,530 patent/US20140050786A1/en not_active Abandoned
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