PT1930011E - Forma cristalina de ibandronato de sódio - Google Patents
Forma cristalina de ibandronato de sódio Download PDFInfo
- Publication number
- PT1930011E PT1930011E PT08002626T PT08002626T PT1930011E PT 1930011 E PT1930011 E PT 1930011E PT 08002626 T PT08002626 T PT 08002626T PT 08002626 T PT08002626 T PT 08002626T PT 1930011 E PT1930011 E PT 1930011E
- Authority
- PT
- Portugal
- Prior art keywords
- ibandronate
- sodium
- solution
- hours
- water
- Prior art date
Links
- 229960005236 ibandronic acid Drugs 0.000 title claims abstract description 130
- MPBVHIBUJCELCL-UHFFFAOYSA-N Ibandronate Chemical compound CCCCCN(C)CCC(O)(P(O)(O)=O)P(O)(O)=O MPBVHIBUJCELCL-UHFFFAOYSA-N 0.000 title abstract description 245
- 238000000634 powder X-ray diffraction Methods 0.000 claims abstract description 68
- 239000008194 pharmaceutical composition Substances 0.000 claims abstract description 14
- LXLBEOAZMZAZND-UHFFFAOYSA-M sodium;hydroxy-[1-hydroxy-3-[methyl(pentyl)amino]-1-phosphonopropyl]phosphinate Chemical compound [Na+].CCCCCN(C)CCC(O)(P(O)(O)=O)P(O)([O-])=O LXLBEOAZMZAZND-UHFFFAOYSA-M 0.000 claims description 116
- 238000010586 diagram Methods 0.000 abstract description 21
- HEMHJVSKTPXQMS-UHFFFAOYSA-M Sodium hydroxide Chemical compound [OH-].[Na+] HEMHJVSKTPXQMS-UHFFFAOYSA-M 0.000 description 180
- 239000000243 solution Substances 0.000 description 177
- LFQSCWFLJHTTHZ-UHFFFAOYSA-N Ethanol Chemical compound CCO LFQSCWFLJHTTHZ-UHFFFAOYSA-N 0.000 description 155
- XLYOFNOQVPJJNP-UHFFFAOYSA-N water Substances O XLYOFNOQVPJJNP-UHFFFAOYSA-N 0.000 description 151
- CSCPPACGZOOCGX-UHFFFAOYSA-N Acetone Chemical compound CC(C)=O CSCPPACGZOOCGX-UHFFFAOYSA-N 0.000 description 127
- WEVYAHXRMPXWCK-UHFFFAOYSA-N Acetonitrile Chemical compound CC#N WEVYAHXRMPXWCK-UHFFFAOYSA-N 0.000 description 111
- 238000010992 reflux Methods 0.000 description 106
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- 239000002002 slurry Substances 0.000 description 83
- 239000002244 precipitate Substances 0.000 description 82
- OKKJLVBELUTLKV-UHFFFAOYSA-N Methanol Chemical compound OC OKKJLVBELUTLKV-UHFFFAOYSA-N 0.000 description 81
- 239000007787 solid Substances 0.000 description 63
- KFZMGEQAYNKOFK-UHFFFAOYSA-N Isopropanol Chemical compound CC(C)O KFZMGEQAYNKOFK-UHFFFAOYSA-N 0.000 description 60
- 238000002411 thermogravimetry Methods 0.000 description 58
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- 238000000034 method Methods 0.000 description 52
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- 229940015872 ibandronate Drugs 0.000 description 45
- 238000003828 vacuum filtration Methods 0.000 description 41
- 230000004580 weight loss Effects 0.000 description 39
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- 239000002904 solvent Substances 0.000 description 36
- IAZDPXIOMUYVGZ-UHFFFAOYSA-N Dimethylsulphoxide Chemical compound CS(C)=O IAZDPXIOMUYVGZ-UHFFFAOYSA-N 0.000 description 34
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- 238000004519 manufacturing process Methods 0.000 description 29
- BTANRVKWQNVYAZ-UHFFFAOYSA-N butan-2-ol Chemical compound CCC(C)O BTANRVKWQNVYAZ-UHFFFAOYSA-N 0.000 description 27
- IJGRMHOSHXDMSA-UHFFFAOYSA-N Atomic nitrogen Chemical compound N#N IJGRMHOSHXDMSA-UHFFFAOYSA-N 0.000 description 18
- 238000010438 heat treatment Methods 0.000 description 15
- WYURNTSHIVDZCO-UHFFFAOYSA-N Tetrahydrofuran Chemical compound C1CCOC1 WYURNTSHIVDZCO-UHFFFAOYSA-N 0.000 description 14
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- 238000000113 differential scanning calorimetry Methods 0.000 description 12
- DGAQECJNVWCQMB-PUAWFVPOSA-M Ilexoside XXIX Chemical compound C[C@@H]1CC[C@@]2(CC[C@@]3(C(=CC[C@H]4[C@]3(CC[C@@H]5[C@@]4(CC[C@@H](C5(C)C)OS(=O)(=O)[O-])C)C)[C@@H]2[C@]1(C)O)C)C(=O)O[C@H]6[C@@H]([C@H]([C@@H]([C@H](O6)CO)O)O)O.[Na+] DGAQECJNVWCQMB-PUAWFVPOSA-M 0.000 description 11
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- KRKNYBCHXYNGOX-UHFFFAOYSA-N citric acid Chemical compound OC(=O)CC(O)(C(O)=O)CC(O)=O KRKNYBCHXYNGOX-UHFFFAOYSA-N 0.000 description 6
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Classifications
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- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K31/00—Medicinal preparations containing organic active ingredients
- A61K31/66—Phosphorus compounds
- A61K31/662—Phosphorus acids or esters thereof having P—C bonds, e.g. foscarnet, trichlorfon
- A61K31/663—Compounds having two or more phosphorus acid groups or esters thereof, e.g. clodronic acid, pamidronic acid
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- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07F—ACYCLIC, CARBOCYCLIC OR HETEROCYCLIC COMPOUNDS CONTAINING ELEMENTS OTHER THAN CARBON, HYDROGEN, HALOGEN, OXYGEN, NITROGEN, SULFUR, SELENIUM OR TELLURIUM
- C07F9/00—Compounds containing elements of Groups 5 or 15 of the Periodic Table
- C07F9/02—Phosphorus compounds
- C07F9/28—Phosphorus compounds with one or more P—C bonds
- C07F9/38—Phosphonic acids [RP(=O)(OH)2]; Thiophosphonic acids ; [RP(=X1)(X2H)2(X1, X2 are each independently O, S or Se)]
- C07F9/3804—Phosphonic acids [RP(=O)(OH)2]; Thiophosphonic acids ; [RP(=X1)(X2H)2(X1, X2 are each independently O, S or Se)] not used, see subgroups
- C07F9/3839—Polyphosphonic acids
- C07F9/3873—Polyphosphonic acids containing nitrogen substituent, e.g. N.....H or N-hydrocarbon group which can be substituted by halogen or nitro(so), N.....O, N.....S, N.....C(=X)- (X =O, S), N.....N, N...C(=X)...N (X =O, S)
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- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P19/00—Drugs for skeletal disorders
- A61P19/08—Drugs for skeletal disorders for bone diseases, e.g. rachitism, Paget's disease
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- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P19/00—Drugs for skeletal disorders
- A61P19/08—Drugs for skeletal disorders for bone diseases, e.g. rachitism, Paget's disease
- A61P19/10—Drugs for skeletal disorders for bone diseases, e.g. rachitism, Paget's disease for osteoporosis
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- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P3/00—Drugs for disorders of the metabolism
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- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P35/00—Antineoplastic agents
Landscapes
- Health & Medical Sciences (AREA)
- Chemical & Material Sciences (AREA)
- Organic Chemistry (AREA)
- Life Sciences & Earth Sciences (AREA)
- General Health & Medical Sciences (AREA)
- Public Health (AREA)
- Physical Education & Sports Medicine (AREA)
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Applications Claiming Priority (2)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| US60402604P | 2004-08-23 | 2004-08-23 | |
| US69086705P | 2005-06-16 | 2005-06-16 |
Publications (1)
| Publication Number | Publication Date |
|---|---|
| PT1930011E true PT1930011E (pt) | 2011-09-16 |
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Family Applications (2)
| Application Number | Title | Priority Date | Filing Date |
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| PT08002626T PT1930011E (pt) | 2004-08-23 | 2005-08-23 | Forma cristalina de ibandronato de sódio |
| PT05791142T PT1713489E (pt) | 2004-08-23 | 2005-08-23 | Forma cristalina de ibandronato de sódio e processos para a sua preparação |
Family Applications After (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| PT05791142T PT1713489E (pt) | 2004-08-23 | 2005-08-23 | Forma cristalina de ibandronato de sódio e processos para a sua preparação |
Country Status (12)
| Country | Link |
|---|---|
| US (1) | US7563918B2 (enExample) |
| EP (2) | EP1930011B1 (enExample) |
| JP (1) | JP4559431B2 (enExample) |
| KR (2) | KR20070043043A (enExample) |
| CN (1) | CN101022812A (enExample) |
| AT (2) | ATE520406T1 (enExample) |
| CA (1) | CA2576659A1 (enExample) |
| DE (2) | DE202005021414U1 (enExample) |
| ES (1) | ES2358269T3 (enExample) |
| IL (1) | IL181298A (enExample) |
| PT (2) | PT1930011E (enExample) |
| WO (1) | WO2006024024A2 (enExample) |
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| Publication number | Priority date | Publication date | Assignee | Title |
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| AR045637A1 (es) | 2003-09-12 | 2005-11-02 | Amgen Inc | Formulacion de disolucion rapida de un compuesto activo frente a los receptores de calcio |
| LT2662380T (lt) * | 2005-02-01 | 2019-03-12 | Atnahs Pharma Uk Limited | Ibandronato polimorfo a medicininis panaudojimas |
| EP2610261A1 (en) | 2005-02-01 | 2013-07-03 | F. Hoffmann-La Roche AG | Ibandronate polymorph B |
| WO2007074475A2 (en) * | 2005-12-27 | 2007-07-05 | Natco Pharma Limited | Novel polymorphic forms of ibandronate |
| WO2008014510A2 (en) * | 2006-07-28 | 2008-01-31 | Dr. Reddy's Laboratories Limited | Crystalline form a of ibandronic acid and process for the preparation |
| WO2008060609A1 (en) * | 2006-11-16 | 2008-05-22 | Teva Pharmaceutical Industries Ltd. | Crystalline forms of ibandronate sodium |
| CA2570949A1 (en) * | 2006-12-12 | 2008-06-12 | Apotex Pharmachem Inc. | Ibandronate sodium propylene glycol solvate and processes for the preparation thereof |
| EP2144919B1 (en) | 2007-04-11 | 2015-12-02 | F. Hoffmann-La Roche AG | Multi step synthesis of ibandronate |
| AU2008242788A1 (en) * | 2007-04-19 | 2008-10-30 | Dr. Reddy's Laboratories Ltd. | Ibandronate sodium polymorphs |
| WO2009020483A1 (en) * | 2007-08-09 | 2009-02-12 | Teva Pharmaceutical Industries Ltd. | Crystalline forms of ibandronate sodium |
| EP2128166A1 (en) | 2008-05-20 | 2009-12-02 | Chemo Ibérica, S.A. | Polymorphic forms of Ibandronate sodium and processes for preparation thereof |
| WO2009053445A2 (en) * | 2007-10-26 | 2009-04-30 | Chemo Ibérica, S.A. | Polymorphic forms of ibandronate sodium and processes for preparation thereof |
| US20090118239A1 (en) * | 2007-11-05 | 2009-05-07 | Teva Pharmaceutical Industries Ltd. | Amorphous and crystalline forms of ibandronate disodium |
| EP2180003A1 (en) | 2008-10-21 | 2010-04-28 | Zentiva, k.s. | Preparation of ibandronate trisodium |
| MX339194B (es) | 2009-02-13 | 2016-05-16 | Boehringer Ingelheim Int | Composicion farmaceutica que comprende un inhibidor de sglt2, un inhibidor de dpp-iv y opcionalmente otro agente antidiabetico, y usos de la misma. |
| US9192316B2 (en) | 2009-05-15 | 2015-11-24 | Nox Medical | Systems and methods using flexible capacitive electrodes for measuring biosignals |
| WO2011016738A1 (en) | 2009-08-05 | 2011-02-10 | Zaklady Farmaceutyczne Polpharma Sa | A process for the synthesis of 1-hydroxy-3-(n-methylpentylamino) propylidene bisphosphonic acid monosodium salt, monohydrate |
| EP3351249A1 (en) | 2010-01-27 | 2018-07-25 | VIIV Healthcare Company | Antiviral therapy |
| US9059532B2 (en) | 2010-06-25 | 2015-06-16 | Nox Medical | Biometric belt connector |
| KR101907434B1 (ko) | 2010-09-03 | 2018-10-12 | 발네바 오스트리아 게엠베하 | C. 디피실의 a 독소 및 b 독소 단백질의 분리된 폴리펩타이드 및 이의 용도 |
| AR085689A1 (es) | 2011-03-07 | 2013-10-23 | Boehringer Ingelheim Int | Composiciones farmaceuticas de metformina, linagliptina y un inhibidor de sglt-2 |
| WO2013179305A1 (en) * | 2012-06-01 | 2013-12-05 | Hetero Research Foundation | Ibandronate sodium solid dispersion |
| WO2014170909A2 (en) | 2013-04-01 | 2014-10-23 | Hetero Research Foundation | Process for pomalidomide |
| US10588550B2 (en) | 2013-11-06 | 2020-03-17 | Nox Medical | Method, apparatus, and system for measuring respiratory effort |
| TWI665190B (zh) | 2013-11-15 | 2019-07-11 | 阿克比治療有限公司 | ｛［５－（３－氯苯基）－３－羥基吡啶－２－羰基］胺基｝乙酸之固體型式，其組合物及用途 |
| US10869619B2 (en) | 2016-08-19 | 2020-12-22 | Nox Medical | Method, apparatus, and system for measuring respiratory effort of a subject |
| US11896386B2 (en) | 2017-06-02 | 2024-02-13 | Nox Medical Ehf | Coherence-based method, apparatus, and system for identifying corresponding signals of a physiological study |
| US11602282B2 (en) | 2017-09-08 | 2023-03-14 | Nox Medical Ehf | System and method for non-invasively determining an internal component of respiratory effort |
Family Cites Families (22)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| DE3623397A1 (de) | 1986-07-11 | 1988-01-14 | Boehringer Mannheim Gmbh | Neue diphosphonsaeurederivate, verfahren zu deren herstellung und diese verbindungen enthaltende arzneimittel |
| JP2639721B2 (ja) | 1988-12-27 | 1997-08-13 | 富士重工業株式会社 | 内燃機関の燃焼室 |
| US5652227A (en) * | 1995-01-30 | 1997-07-29 | Teronen; Olli Pekka | Inhibition of the degradation of connective tissue matrix protein components in mammals |
| DE19637890A1 (de) * | 1996-09-17 | 1998-03-19 | Max Planck Gesellschaft | Biphosphonat-Liposomen |
| DE19828450A1 (de) * | 1998-06-26 | 1999-12-30 | Hassan Jomaa | Bisphosphonsäuren und deren Derivate enthaltende Arzneimittel zur Prophylaxe und zur Behandlung von Autoimmunkrankheiten sowie von Allergien |
| EP0998933A1 (de) * | 1998-10-09 | 2000-05-10 | Boehringer Mannheim Gmbh | Verfahren zur Herstellung von bisphosphonathaltigen pharmazeutischen Zusammensetzungen zur oralen Applikation |
| EP0998932A1 (de) * | 1998-10-09 | 2000-05-10 | Boehringer Mannheim Gmbh | Feste pharmazeutische Darreichungsform enthaltend Diphosphonsäure oder deren Salze und Verfahren zu ihrer Herstellung |
| EP1178810B8 (en) * | 1999-05-21 | 2005-07-27 | Novartis AG | Use of bisphosphonic acids for treating angiogenesis |
| US6677320B2 (en) * | 2000-01-20 | 2004-01-13 | Hoffmann-La Roches Inc. | Parenteral bisphosphonate composition with improved local tolerance |
| KR100492110B1 (ko) * | 2000-05-05 | 2005-06-02 | 에프. 호프만-라 로슈 아게 | 비스포스폰산 또는 그의 염을 포함하는 피하 투여용겔-유사 약학 조성물 |
| DK1296689T3 (da) * | 2000-06-20 | 2005-11-28 | Novartis Ag | Fremgangsmåde til indgivelse af bisphosphonater |
| GB0029111D0 (en) * | 2000-11-29 | 2001-01-10 | Novartis Ag | Organic compounds |
| JP2002332235A (ja) * | 2001-02-01 | 2002-11-22 | Riderway Corp | 骨疾患治療用液体医薬組成物 |
| ITMI20020908A1 (it) | 2002-04-29 | 2003-10-29 | Chemi Spa | Processo di preparazione di sodio alendronato |
| BR0308901A (pt) * | 2002-05-10 | 2005-01-04 | Hoffmann La Roche | ácidos bisfosfÈnicos para tratamento e prevenção de osteoporose |
| WO2003099992A2 (en) * | 2002-05-17 | 2003-12-04 | Wyeth | Injectable solid hyaluronic acid carriers for delivery of osteogenic proteins |
| ES2530791T3 (es) * | 2002-12-20 | 2015-03-05 | Hoffmann La Roche | Formulación de ibandronato de altas dosis |
| US7723542B2 (en) * | 2003-12-23 | 2010-05-25 | Trifarma S.P.A. | Process for the preparation of alkyl- and aryl-diphosphonic acids and salts thereof |
| MX2007000087A (es) * | 2004-06-23 | 2007-11-06 | Teva Pharma | Acido ibandronico solido y cristalino. |
| EP2610261A1 (en) | 2005-02-01 | 2013-07-03 | F. Hoffmann-La Roche AG | Ibandronate polymorph B |
| LT2662380T (lt) | 2005-02-01 | 2019-03-12 | Atnahs Pharma Uk Limited | Ibandronato polimorfo a medicininis panaudojimas |
| WO2007074475A2 (en) | 2005-12-27 | 2007-07-05 | Natco Pharma Limited | Novel polymorphic forms of ibandronate |
-
2005
- 2005-08-23 ES ES05791142T patent/ES2358269T3/es not_active Expired - Lifetime
- 2005-08-23 JP JP2006536948A patent/JP4559431B2/ja not_active Expired - Lifetime
- 2005-08-23 EP EP08002626A patent/EP1930011B1/en not_active Expired - Lifetime
- 2005-08-23 AT AT08002626T patent/ATE520406T1/de not_active IP Right Cessation
- 2005-08-23 AT AT05791142T patent/ATE495747T1/de not_active IP Right Cessation
- 2005-08-23 KR KR1020077005922A patent/KR20070043043A/ko not_active Ceased
- 2005-08-23 CA CA002576659A patent/CA2576659A1/en not_active Abandoned
- 2005-08-23 PT PT08002626T patent/PT1930011E/pt unknown
- 2005-08-23 WO PCT/US2005/030500 patent/WO2006024024A2/en not_active Ceased
- 2005-08-23 CN CNA2005800285039A patent/CN101022812A/zh active Pending
- 2005-08-23 EP EP05791142A patent/EP1713489B1/en not_active Revoked
- 2005-08-23 PT PT05791142T patent/PT1713489E/pt unknown
- 2005-08-23 DE DE202005021414U patent/DE202005021414U1/de not_active Expired - Lifetime
- 2005-08-23 KR KR1020097022363A patent/KR20090120011A/ko not_active Ceased
- 2005-08-23 DE DE602005025977T patent/DE602005025977D1/de not_active Expired - Lifetime
-
2006
- 2006-12-22 US US11/644,568 patent/US7563918B2/en not_active Expired - Fee Related
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2007
- 2007-02-13 IL IL181298A patent/IL181298A/en not_active IP Right Cessation
Also Published As
| Publication number | Publication date |
|---|---|
| CA2576659A1 (en) | 2006-03-02 |
| ATE520406T1 (de) | 2011-09-15 |
| DE202005021414U1 (de) | 2008-03-20 |
| WO2006024024A3 (en) | 2006-06-29 |
| WO2006024024A2 (en) | 2006-03-02 |
| ES2358269T3 (es) | 2011-05-09 |
| KR20090120011A (ko) | 2009-11-23 |
| EP1930011B1 (en) | 2011-08-17 |
| EP1930011A2 (en) | 2008-06-11 |
| CN101022812A (zh) | 2007-08-22 |
| KR20070043043A (ko) | 2007-04-24 |
| EP1713489A2 (en) | 2006-10-25 |
| EP1930011A3 (en) | 2008-06-18 |
| US7563918B2 (en) | 2009-07-21 |
| DE602005025977D1 (de) | 2011-03-03 |
| JP2007512237A (ja) | 2007-05-17 |
| IL181298A (en) | 2011-04-28 |
| US20070179119A1 (en) | 2007-08-02 |
| IL181298A0 (en) | 2007-07-04 |
| EP1713489B1 (en) | 2011-01-19 |
| JP4559431B2 (ja) | 2010-10-06 |
| ATE495747T1 (de) | 2011-02-15 |
| PT1713489E (pt) | 2011-03-03 |
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