DE602005025977D1 - Kristalline form des ibandronat-natriums und herstellungsverfahren dafür - Google Patents

Kristalline form des ibandronat-natriums und herstellungsverfahren dafür

Info

Publication number
DE602005025977D1
DE602005025977D1 DE602005025977T DE602005025977T DE602005025977D1 DE 602005025977 D1 DE602005025977 D1 DE 602005025977D1 DE 602005025977 T DE602005025977 T DE 602005025977T DE 602005025977 T DE602005025977 T DE 602005025977T DE 602005025977 D1 DE602005025977 D1 DE 602005025977D1
Authority
DE
Germany
Prior art keywords
ibandronate sodium
crystalline form
manufacturing
ray
crystalline
Prior art date
Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
Active
Application number
DE602005025977T
Other languages
English (en)
Inventor
Revital Lifshitz-Liron
Thomas Bayer
Judith Aronhime
Current Assignee (The listed assignees may be inaccurate. Google has not performed a legal analysis and makes no representation or warranty as to the accuracy of the list.)
Teva Pharmaceutical Industries Ltd
Original Assignee
Teva Pharmaceutical Industries Ltd
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Family has litigation
First worldwide family litigation filed litigation Critical https://patents.darts-ip.com/?family=35968334&utm_source=google_patent&utm_medium=platform_link&utm_campaign=public_patent_search&patent=DE602005025977(D1) "Global patent litigation dataset” by Darts-ip is licensed under a Creative Commons Attribution 4.0 International License.
Application filed by Teva Pharmaceutical Industries Ltd filed Critical Teva Pharmaceutical Industries Ltd
Publication of DE602005025977D1 publication Critical patent/DE602005025977D1/de
Active legal-status Critical Current
Anticipated expiration legal-status Critical

Links

Classifications

    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/66—Phosphorus compounds
    • A61K31/662—Phosphorus acids or esters thereof having P—C bonds, e.g. foscarnet, trichlorfon
    • A61K31/663—Compounds having two or more phosphorus acid groups or esters thereof, e.g. clodronic acid, pamidronic acid
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07F—ACYCLIC, CARBOCYCLIC OR HETEROCYCLIC COMPOUNDS CONTAINING ELEMENTS OTHER THAN CARBON, HYDROGEN, HALOGEN, OXYGEN, NITROGEN, SULFUR, SELENIUM OR TELLURIUM
    • C07F9/00—Compounds containing elements of Groups 5 or 15 of the Periodic Table
    • C07F9/02—Phosphorus compounds
    • C07F9/28—Phosphorus compounds with one or more P—C bonds
    • C07F9/38—Phosphonic acids [RP(=O)(OH)2]; Thiophosphonic acids ; [RP(=X1)(X2H)2(X1, X2 are each independently O, S or Se)]
    • C07F9/3804—Phosphonic acids [RP(=O)(OH)2]; Thiophosphonic acids ; [RP(=X1)(X2H)2(X1, X2 are each independently O, S or Se)] not used, see subgroups
    • C07F9/3839—Polyphosphonic acids
    • C07F9/3873—Polyphosphonic acids containing nitrogen substituent, e.g. N.....H or N-hydrocarbon group which can be substituted by halogen or nitro(so), N.....O, N.....S, N.....C(=X)- (X =O, S), N.....N, N...C(=X)...N (X =O, S)
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P19/00—Drugs for skeletal disorders
    • A61P19/08—Drugs for skeletal disorders for bone diseases, e.g. rachitism, Paget's disease
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P19/00—Drugs for skeletal disorders
    • A61P19/08—Drugs for skeletal disorders for bone diseases, e.g. rachitism, Paget's disease
    • A61P19/10—Drugs for skeletal disorders for bone diseases, e.g. rachitism, Paget's disease for osteoporosis
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P3/00—Drugs for disorders of the metabolism
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P35/00—Antineoplastic agents

Landscapes

  • Health & Medical Sciences (AREA)
  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • General Health & Medical Sciences (AREA)
  • Public Health (AREA)
  • Physical Education & Sports Medicine (AREA)
  • Medicinal Chemistry (AREA)
  • Veterinary Medicine (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Animal Behavior & Ethology (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • General Chemical & Material Sciences (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Rheumatology (AREA)
  • Engineering & Computer Science (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Orthopedic Medicine & Surgery (AREA)
  • Molecular Biology (AREA)
  • Biochemistry (AREA)
  • Hematology (AREA)
  • Obesity (AREA)
  • Diabetes (AREA)
  • Epidemiology (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Analysing Materials By The Use Of Radiation (AREA)
  • Secondary Cells (AREA)
  • Silicates, Zeolites, And Molecular Sieves (AREA)
  • Medicines Containing Antibodies Or Antigens For Use As Internal Diagnostic Agents (AREA)
  • Crystals, And After-Treatments Of Crystals (AREA)
  • Artificial Filaments (AREA)
  • Organic Low-Molecular-Weight Compounds And Preparation Thereof (AREA)
  • Nitrogen Condensed Heterocyclic Rings (AREA)
  • Liquid Crystal Substances (AREA)
  • Battery Electrode And Active Subsutance (AREA)
DE602005025977T 2004-08-23 2005-08-23 Kristalline form des ibandronat-natriums und herstellungsverfahren dafür Active DE602005025977D1 (de)

Applications Claiming Priority (3)

Application Number Priority Date Filing Date Title
US60402604P 2004-08-23 2004-08-23
US69086705P 2005-06-16 2005-06-16
PCT/US2005/030500 WO2006024024A2 (en) 2004-08-23 2005-08-23 Solid and crystalline ibandronate sodium and processes for preparation thereof

Publications (1)

Publication Number Publication Date
DE602005025977D1 true DE602005025977D1 (de) 2011-03-03

Family

ID=35968334

Family Applications (2)

Application Number Title Priority Date Filing Date
DE602005025977T Active DE602005025977D1 (de) 2004-08-23 2005-08-23 Kristalline form des ibandronat-natriums und herstellungsverfahren dafür
DE202005021414U Expired - Lifetime DE202005021414U1 (de) 2004-08-23 2005-08-23 Festes und kristallines Ibandronat-Natrium

Family Applications After (1)

Application Number Title Priority Date Filing Date
DE202005021414U Expired - Lifetime DE202005021414U1 (de) 2004-08-23 2005-08-23 Festes und kristallines Ibandronat-Natrium

Country Status (12)

Country Link
US (1) US7563918B2 (de)
EP (2) EP1713489B1 (de)
JP (1) JP4559431B2 (de)
KR (2) KR20090120011A (de)
CN (1) CN101022812A (de)
AT (2) ATE520406T1 (de)
CA (1) CA2576659A1 (de)
DE (2) DE602005025977D1 (de)
ES (1) ES2358269T3 (de)
IL (1) IL181298A (de)
PT (2) PT1930011E (de)
WO (1) WO2006024024A2 (de)

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DK1663182T4 (da) 2003-09-12 2020-02-17 Amgen Inc Hurtigt opløsende formulering af cinacalcet HCI
US7582789B2 (en) 2005-02-01 2009-09-01 Hoffmann-La Roche Inc. Ibandronate polymorph
ES2712644T3 (es) * 2005-02-01 2019-05-14 Atnahs Pharma Uk Ltd Uso médico del polimorfo A de Ibandronato
WO2007074475A2 (en) * 2005-12-27 2007-07-05 Natco Pharma Limited Novel polymorphic forms of ibandronate
EP2046342A4 (de) * 2006-07-28 2011-05-04 Reddys Lab Ltd Dr Kristalline form a von ibandronsäure und herstellungsverfahren dafür
TW200829256A (en) 2006-11-16 2008-07-16 Teva Pharma Crystalline forms of ibandronate sodium
CA2570949A1 (en) 2006-12-12 2008-06-12 Apotex Pharmachem Inc. Ibandronate sodium propylene glycol solvate and processes for the preparation thereof
BRPI0809548A8 (pt) 2007-04-11 2018-10-16 Hoffmann La Roche processo para a preparação do sal ácido- (mono-hidratado)-3- (n-metil-n-pentil) amino-1-hidroxipropano-1, 1-difosfônico monossódico
US20100125149A1 (en) 2007-04-19 2010-05-20 Dr. Reddy's Laboratories Ltd. Ibandronate sodium polymorphs
WO2009020483A1 (en) * 2007-08-09 2009-02-12 Teva Pharmaceutical Industries Ltd. Crystalline forms of ibandronate sodium
ES2428699T3 (es) * 2007-10-26 2013-11-08 Chemo Ibérica, S.A. Formas polimórficas de ibandronato de sodio y procedimientos para la preparación del mismo
EP2128166A1 (de) 2008-05-20 2009-12-02 Chemo Ibérica, S.A. Polymorphe Ibandronat-Natrium-Formen und Verfahren zu ihrer Herstellung
US20090118239A1 (en) * 2007-11-05 2009-05-07 Teva Pharmaceutical Industries Ltd. Amorphous and crystalline forms of ibandronate disodium
EP2180003A1 (de) 2008-10-21 2010-04-28 Zentiva, k.s. Herstellung von Trinatriumbandronat
CN104906582A (zh) 2009-02-13 2015-09-16 勃林格殷格翰国际有限公司 包含sglt2抑制剂、dpp-iv抑制剂和任选的另一种抗糖尿病药的药物组合物及其用途
WO2010131267A1 (en) 2009-05-15 2010-11-18 Nox Medical System and methods using flexible capacitive electrodes for measuring biosignals
WO2011016738A1 (en) 2009-08-05 2011-02-10 Zaklady Farmaceutyczne Polpharma Sa A process for the synthesis of 1-hydroxy-3-(n-methylpentylamino) propylidene bisphosphonic acid monosodium salt, monohydrate
KR20170078868A (ko) 2010-01-27 2017-07-07 비이브 헬쓰케어 컴퍼니 항바이러스 치료
DK2584962T3 (da) 2010-06-25 2014-09-29 Nox Medical Ehf Biometrisk bæltekonnektor
LT2753352T (lt) 2010-09-03 2017-05-25 Valneva Austria Gmbh Išskirtas toksino a ir toksino b baltymų polipeptidas iš c. difficile ir jo panaudojimas
AR085689A1 (es) 2011-03-07 2013-10-23 Boehringer Ingelheim Int Composiciones farmaceuticas de metformina, linagliptina y un inhibidor de sglt-2
WO2013179305A1 (en) * 2012-06-01 2013-12-05 Hetero Research Foundation Ibandronate sodium solid dispersion
WO2014170909A2 (en) 2013-04-01 2014-10-23 Hetero Research Foundation Process for pomalidomide
EP3065638B1 (de) 2013-11-06 2024-01-10 Nox Medical ehf. Verfahren, vorrichtung und system zur messung einer atemanstrengung
TWI665190B (zh) 2013-11-15 2019-07-11 阿克比治療有限公司 ｛［５－（３－氯苯基）－３－羥基吡啶－２－羰基］胺基｝乙酸之固體型式，其組合物及用途
EP3500155B1 (de) 2016-08-19 2024-10-02 Nox Medical Verfahren, system und computerprogramm zur messung der atemanstrengung einer person
EP3629893A1 (de) 2017-06-02 2020-04-08 Nox Medical ehf. Kohärenzbasiertes verfahren, vorrichtung und system zur identifizierung von entsprechenden signalen einer physiologischen untersuchung
WO2019049097A1 (en) 2017-09-08 2019-03-14 Nox Medical Ehf SYSTEM AND METHOD FOR NON-INVASIVE DETERMINATION OF AN INTERNAL COMPONENT OF RESPIRATORY EFFORT

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DE3623397A1 (de) * 1986-07-11 1988-01-14 Boehringer Mannheim Gmbh Neue diphosphonsaeurederivate, verfahren zu deren herstellung und diese verbindungen enthaltende arzneimittel
JP2639721B2 (ja) 1988-12-27 1997-08-13 富士重工業株式会社 内燃機関の燃焼室
US5652227A (en) * 1995-01-30 1997-07-29 Teronen; Olli Pekka Inhibition of the degradation of connective tissue matrix protein components in mammals
DE19637890A1 (de) * 1996-09-17 1998-03-19 Max Planck Gesellschaft Biphosphonat-Liposomen
DE19828450A1 (de) * 1998-06-26 1999-12-30 Hassan Jomaa Bisphosphonsäuren und deren Derivate enthaltende Arzneimittel zur Prophylaxe und zur Behandlung von Autoimmunkrankheiten sowie von Allergien
EP0998933A1 (de) * 1998-10-09 2000-05-10 Boehringer Mannheim Gmbh Verfahren zur Herstellung von bisphosphonathaltigen pharmazeutischen Zusammensetzungen zur oralen Applikation
EP0998932A1 (de) * 1998-10-09 2000-05-10 Boehringer Mannheim Gmbh Feste pharmazeutische Darreichungsform enthaltend Diphosphonsäure oder deren Salze und Verfahren zu ihrer Herstellung
BR0010808A (pt) * 1999-05-21 2002-08-27 Novartis Ag Composições farmacêuticas e usos
US6677320B2 (en) * 2000-01-20 2004-01-13 Hoffmann-La Roches Inc. Parenteral bisphosphonate composition with improved local tolerance
CA2407747C (en) * 2000-05-05 2008-03-11 F. Hoffmann-La Roche Ag Gel-like pharmaceutical composition for subcutaneous administration comprising bisphosphonic acids or their salts
NZ523086A (en) * 2000-06-20 2007-07-27 Novartis Ag Method of administering bisphosphonates
GB0029111D0 (en) * 2000-11-29 2001-01-10 Novartis Ag Organic compounds
EP1228761A3 (de) * 2001-02-01 2003-01-15 Riderway Corporation Flüssige pharmazeutische Zusammensetzung zur Behandlung von Knochenerkrankungen
ITMI20020908A1 (it) 2002-04-29 2003-10-29 Chemi Spa Processo di preparazione di sodio alendronato
KR20120065435A (ko) * 2002-05-10 2012-06-20 에프. 호프만-라 로슈 아게 골다공증 치료 및 예방용 비스포스폰산
MXPA04011337A (es) * 2002-05-17 2005-07-01 Wyeth Corp Portadores de acido hialuronico solidos y susceptibles de ser inyectados para la liberacion de proteinas osteogenicas.
BR0309691A (pt) * 2002-12-20 2005-08-02 Hoffmann La Roche Formulação de ibandronato em alta dose
DE602004032577D1 (de) * 2003-12-23 2011-06-16 Alchymars S P A Amorphe Form das Natriumsalzes der Ibandronsäure
WO2006002348A2 (en) * 2004-06-23 2006-01-05 Teva Pharmaceutical Industies Ltd. Solid and crystalline ibandronic acid
US7582789B2 (en) 2005-02-01 2009-09-01 Hoffmann-La Roche Inc. Ibandronate polymorph
ES2712644T3 (es) 2005-02-01 2019-05-14 Atnahs Pharma Uk Ltd Uso médico del polimorfo A de Ibandronato
WO2007074475A2 (en) 2005-12-27 2007-07-05 Natco Pharma Limited Novel polymorphic forms of ibandronate

Also Published As

Publication number Publication date
ATE495747T1 (de) 2011-02-15
EP1930011A3 (de) 2008-06-18
EP1713489B1 (de) 2011-01-19
IL181298A0 (en) 2007-07-04
EP1930011A2 (de) 2008-06-11
DE202005021414U1 (de) 2008-03-20
IL181298A (en) 2011-04-28
WO2006024024A3 (en) 2006-06-29
CA2576659A1 (en) 2006-03-02
JP4559431B2 (ja) 2010-10-06
PT1930011E (pt) 2011-09-16
EP1713489A2 (de) 2006-10-25
PT1713489E (pt) 2011-03-03
EP1930011B1 (de) 2011-08-17
KR20070043043A (ko) 2007-04-24
KR20090120011A (ko) 2009-11-23
WO2006024024A2 (en) 2006-03-02
ES2358269T3 (es) 2011-05-09
US20070179119A1 (en) 2007-08-02
US7563918B2 (en) 2009-07-21
CN101022812A (zh) 2007-08-22
JP2007512237A (ja) 2007-05-17
ATE520406T1 (de) 2011-09-15

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