PT1794165E - Preparação de analgésicos opiáceos por alquilação redutiva - Google Patents
Preparação de analgésicos opiáceos por alquilação redutiva Download PDFInfo
- Publication number
- PT1794165E PT1794165E PT05782842T PT05782842T PT1794165E PT 1794165 E PT1794165 E PT 1794165E PT 05782842 T PT05782842 T PT 05782842T PT 05782842 T PT05782842 T PT 05782842T PT 1794165 E PT1794165 E PT 1794165E
- Authority
- PT
- Portugal
- Prior art keywords
- reductive alkylation
- preparation
- opiate analgesics
- protected
- hydroxyl group
- Prior art date
Links
- 238000005932 reductive alkylation reaction Methods 0.000 title abstract 3
- 229940035676 analgesics Drugs 0.000 title 1
- 239000000730 antalgic agent Substances 0.000 title 1
- 229940127240 opiate Drugs 0.000 title 1
- 125000002887 hydroxy group Chemical group [H]O* 0.000 abstract 3
- UFHFLCQGNIYNRP-UHFFFAOYSA-N Hydrogen Chemical compound [H][H] UFHFLCQGNIYNRP-UHFFFAOYSA-N 0.000 abstract 1
- 125000003710 aryl alkyl group Chemical group 0.000 abstract 1
- 239000003054 catalyst Substances 0.000 abstract 1
- 150000001875 compounds Chemical class 0.000 abstract 1
- 229910052739 hydrogen Inorganic materials 0.000 abstract 1
- 239000001257 hydrogen Substances 0.000 abstract 1
- 150000002576 ketones Chemical class 0.000 abstract 1
- 238000004519 manufacturing process Methods 0.000 abstract 1
- 238000000034 method Methods 0.000 abstract 1
- 125000000999 tert-butyl group Chemical group [H]C([H])([H])C(*)(C([H])([H])[H])C([H])([H])[H] 0.000 abstract 1
Classifications
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D489/00—Heterocyclic compounds containing 4aH-8, 9 c- Iminoethano-phenanthro [4, 5-b, c, d] furan ring systems, e.g. derivatives of [4, 5-epoxy]-morphinan of the formula:
- C07D489/02—Heterocyclic compounds containing 4aH-8, 9 c- Iminoethano-phenanthro [4, 5-b, c, d] furan ring systems, e.g. derivatives of [4, 5-epoxy]-morphinan of the formula: with oxygen atoms attached in positions 3 and 6, e.g. morphine, morphinone
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D221/00—Heterocyclic compounds containing six-membered rings having one nitrogen atom as the only ring hetero atom, not provided for by groups C07D211/00 - C07D219/00
- C07D221/02—Heterocyclic compounds containing six-membered rings having one nitrogen atom as the only ring hetero atom, not provided for by groups C07D211/00 - C07D219/00 condensed with carbocyclic rings or ring systems
- C07D221/22—Bridged ring systems
- C07D221/28—Morphinans
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D489/00—Heterocyclic compounds containing 4aH-8, 9 c- Iminoethano-phenanthro [4, 5-b, c, d] furan ring systems, e.g. derivatives of [4, 5-epoxy]-morphinan of the formula:
- C07D489/06—Heterocyclic compounds containing 4aH-8, 9 c- Iminoethano-phenanthro [4, 5-b, c, d] furan ring systems, e.g. derivatives of [4, 5-epoxy]-morphinan of the formula: with a hetero atom directly attached in position 14
- C07D489/08—Oxygen atom
-
- Y—GENERAL TAGGING OF NEW TECHNOLOGICAL DEVELOPMENTS; GENERAL TAGGING OF CROSS-SECTIONAL TECHNOLOGIES SPANNING OVER SEVERAL SECTIONS OF THE IPC; TECHNICAL SUBJECTS COVERED BY FORMER USPC CROSS-REFERENCE ART COLLECTIONS [XRACs] AND DIGESTS
- Y02—TECHNOLOGIES OR APPLICATIONS FOR MITIGATION OR ADAPTATION AGAINST CLIMATE CHANGE
- Y02P—CLIMATE CHANGE MITIGATION TECHNOLOGIES IN THE PRODUCTION OR PROCESSING OF GOODS
- Y02P20/00—Technologies relating to chemical industry
- Y02P20/50—Improvements relating to the production of bulk chemicals
- Y02P20/55—Design of synthesis routes, e.g. reducing the use of auxiliary or protecting groups
Landscapes
- Chemical & Material Sciences (AREA)
- Organic Chemistry (AREA)
- Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
- Organic Low-Molecular-Weight Compounds And Preparation Thereof (AREA)
- Low-Molecular Organic Synthesis Reactions Using Catalysts (AREA)
Applications Claiming Priority (1)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| GBGB0421687.5A GB0421687D0 (en) | 2004-09-30 | 2004-09-30 | Preparation of opiate analgesics |
Publications (1)
| Publication Number | Publication Date |
|---|---|
| PT1794165E true PT1794165E (pt) | 2009-05-06 |
Family
ID=33427785
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| PT05782842T PT1794165E (pt) | 2004-09-30 | 2005-09-14 | Preparação de analgésicos opiáceos por alquilação redutiva |
Country Status (13)
| Country | Link |
|---|---|
| US (2) | US8119803B2 (pt) |
| EP (1) | EP1794165B2 (pt) |
| CN (1) | CN101027307B (pt) |
| AT (1) | ATE428715T1 (pt) |
| AU (1) | AU2005288728B2 (pt) |
| DE (1) | DE602005013986D1 (pt) |
| DK (1) | DK1794165T4 (pt) |
| ES (1) | ES2322486T5 (pt) |
| GB (1) | GB0421687D0 (pt) |
| PL (1) | PL1794165T5 (pt) |
| PT (1) | PT1794165E (pt) |
| WO (1) | WO2006035195A1 (pt) |
| ZA (1) | ZA200701784B (pt) |
Families Citing this family (37)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| GB2444052A (en) * | 2006-05-25 | 2008-05-28 | Alpharma Aps | Processes of preparing morphinan derivatives such as naltrexone and naloxone comprising O- and N-demethylation and reductive alkylation steps |
| GB2471800B (en) * | 2006-05-25 | 2011-03-09 | Alpharma | Preparation of N-alkylated morphinans by reduction of an iminium group |
| GB2438401A (en) * | 2006-05-25 | 2007-11-28 | Alpharma Aps | Preparation of morphinan derivatives comprising N-demethylation, reductive amination and O-demethylation steps |
| AU2007267362B2 (en) * | 2006-05-25 | 2011-08-11 | Alpharma (Bermuda) Investments Ltd | Process useful in the preparation of morphinan antagonists |
| KR100780932B1 (ko) * | 2006-05-30 | 2007-11-30 | 엠텍비젼 주식회사 | 컬러 보간 방법 및 장치 |
| MX2008013842A (es) | 2007-05-04 | 2009-03-06 | Mallinckrodt Inc | Proceso mejorado para la preparacion de opiatos 6-alfa-hidroxi-n-alquilados. |
| US8962841B2 (en) | 2007-06-29 | 2015-02-24 | Brock University | Methods for one-pot N-demethylation/N-functionalization of morphine and tropane alkaloids |
| EP2167505B1 (en) | 2007-07-17 | 2012-11-28 | Mallinckrodt LLC | Preparation of n-alkylated opiates by reductive amination |
| EP2112152A1 (en) | 2008-04-22 | 2009-10-28 | GPC Biotech AG | Dihydropteridinones as Plk Inhibitors |
| NZ592005A (en) * | 2008-09-30 | 2013-03-28 | Mallinckrodt Llc | Process for the preparation of a N-alkylated ketomorphinan by selective catalytiC hydrogen transfer reduction |
| CA2738761C (en) | 2008-09-30 | 2019-10-29 | Mallinckrodt Inc. | Processes for the production of buprenorphine with reduced impurity formation |
| EP2342206B1 (en) * | 2008-09-30 | 2014-11-12 | Mallinckrodt LLC | Processes for the hydrogenation of opiate alkaloid derivatives |
| US8431701B2 (en) * | 2009-02-17 | 2013-04-30 | Mallinckrodt Llc | Process for the reductive alkylation of normorphinans |
| US8946419B2 (en) | 2009-02-23 | 2015-02-03 | Mallinckrodt Llc | (+)-6-hydroxy-morphinan or (+)-6-amino-morphinan derivatives |
| CN102803267A (zh) | 2009-06-11 | 2012-11-28 | 马林克罗特有限公司 | 通过催化氢转移的6-α-氨基N-取代的吗啡喃的制备 |
| PL2440561T3 (pl) * | 2009-06-11 | 2014-09-30 | SpecGx LLC | Redukcyjne aminowanie 6-keto-normorfinanow przez katalityczne przeniesienie wodoru |
| GB0914338D0 (en) | 2009-08-17 | 2009-09-30 | Johnson Matthey Plc | Improved process |
| BR112013031420A2 (pt) | 2011-06-09 | 2016-08-16 | Mallinckrodt Llc | "processo para preparar um 6-amino morfinano, composição que o compreende e composição compreendendo um composto intermediário" |
| JP2014526467A (ja) | 2011-09-08 | 2014-10-06 | マリンクロッド エルエルシー | 中間体の単離なしでのアルカロイドの調製 |
| US9315514B2 (en) | 2012-08-27 | 2016-04-19 | Rhodes Technologies | 1,3-dioxanomorphides and 1,3-dioxanocodides |
| US8987287B2 (en) | 2012-12-14 | 2015-03-24 | Purdue Pharma L.P. | Spirocyclic morphinans and their use |
| TW201434836A (zh) | 2012-12-14 | 2014-09-16 | Purdue Pharma Lp | 包含氮之嗎啡喃衍生物及其用途 |
| EP2931724B1 (en) | 2012-12-14 | 2017-01-25 | Purdue Pharma LP | Pyridonemorphinan analogs and biological activity on opioid receptors |
| US8957084B2 (en) | 2012-12-28 | 2015-02-17 | Purdue Pharma L.P. | 7,8-cyclicmorphinan analogs |
| TW201441199A (zh) | 2012-12-28 | 2014-11-01 | Purdue Pharma Lp | 經取代之嗎啡喃類及其用途 |
| ES2748803T3 (es) | 2012-12-31 | 2020-03-18 | Rhodes Tech | Procedimiento para preparar 6,14-etenomorfinanos sustituidos en 7, 6,14-etanomorfinanos sustituidos en 7 |
| GB201313915D0 (en) | 2013-08-02 | 2013-09-18 | Johnson Matthey Plc | Process |
| PL3063152T3 (pl) | 2013-11-01 | 2020-01-31 | SpecGx LLC | Dogodne wytwarzanie n-podstawionych morfinan-6-oli z morfinan-6-onów |
| ES2784690T3 (es) | 2013-12-05 | 2020-09-29 | Univ Bath | Nuevos compuestos opioides y sus usos |
| EP3087073B1 (en) | 2013-12-26 | 2018-07-04 | Purdue Pharma LP | 10-substituted morphinan hydantoins |
| EP3087079B1 (en) | 2013-12-26 | 2019-04-03 | Purdue Pharma LP | Opioid receptor modulating oxabicyclo[2.2.2]octane morphinans |
| WO2015097546A1 (en) | 2013-12-26 | 2015-07-02 | Purdue Pharma L.P. | Propellane-based compounds and their use as opioid receptor modulators |
| US9988392B2 (en) | 2013-12-26 | 2018-06-05 | Purdue Pharma L.P. | 7-beta-alkyl analogs of orvinols |
| US9902726B2 (en) | 2013-12-30 | 2018-02-27 | Purdue Pharma L.P. | Pyridone-sulfone morphinan analogs as opioid receptor ligands |
| MA41125A (fr) | 2014-12-05 | 2017-10-10 | Purdue Pharma Lp | Dérivés de 6.7-cyclomorphinane et leur utilisation |
| SI3559010T1 (sl) | 2016-12-23 | 2022-10-28 | Minoryx Therapeutics S. L. | Postopek za pripravo 5-((4-(2-(5-(1-hidroksietil)-2-piridinil)etoksi) fenil)metil)-2,4-tiazolidindiona in soli le-tega |
| CA3091826A1 (en) | 2018-02-23 | 2019-08-29 | Rhodes Technologies | Novel opioid compounds and uses thereof |
Family Cites Families (8)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| GB1136214A (en) | 1965-06-15 | 1968-12-11 | Reckitt & Sons Ltd | Thebaine and oripavine derivatives |
| US3332950A (en) | 1963-03-23 | 1967-07-25 | Endo Lab | 14-hydroxydihydronormorphinone derivatives |
| US3717643A (en) * | 1967-05-04 | 1973-02-20 | Sterling Drug Inc | N-substituted-norapomorphines |
| DE2107989A1 (de) * | 1971-02-19 | 1972-09-07 | Boehringer Sohn Ingelheim | N-(Furyl-methy])-morphinane, deren Säureadditionssalze sowie Verfahren zu deren Herstellung |
| US4082744A (en) * | 1973-05-08 | 1978-04-04 | Nihon Iyakuhin Kogyo Co., Ltd. | 4-benzazonine derivatives and process for preparation thereof |
| US4190601A (en) † | 1978-05-31 | 1980-02-26 | Union Carbide Corporation | Production of tertiary amines by reductive alkylation |
| IE52502B1 (en) † | 1981-03-27 | 1987-11-25 | Wyeth John & Brother Ltd | Morpholines |
| US5869669A (en) * | 1996-07-26 | 1999-02-09 | Penick Corporation | Preparation of 14-hydroxynormorphinones from normorphinone dienol acylates |
-
2004
- 2004-09-30 GB GBGB0421687.5A patent/GB0421687D0/en not_active Ceased
-
2005
- 2005-09-14 PL PL05782842T patent/PL1794165T5/pl unknown
- 2005-09-14 DK DK05782842.8T patent/DK1794165T4/da active
- 2005-09-14 ES ES05782842T patent/ES2322486T5/es active Active
- 2005-09-14 AT AT05782842T patent/ATE428715T1/de active
- 2005-09-14 EP EP05782842.8A patent/EP1794165B2/en active Active
- 2005-09-14 AU AU2005288728A patent/AU2005288728B2/en active Active
- 2005-09-14 CN CN2005800326607A patent/CN101027307B/zh active Active
- 2005-09-14 US US11/628,210 patent/US8119803B2/en active Active
- 2005-09-14 PT PT05782842T patent/PT1794165E/pt unknown
- 2005-09-14 DE DE602005013986T patent/DE602005013986D1/de active Active
- 2005-09-14 WO PCT/GB2005/003547 patent/WO2006035195A1/en active Application Filing
-
2007
- 2007-02-28 ZA ZA2007/01784A patent/ZA200701784B/en unknown
-
2011
- 2011-02-18 US US13/030,652 patent/US8318937B2/en active Active
Also Published As
| Publication number | Publication date |
|---|---|
| AU2005288728B2 (en) | 2012-05-03 |
| US8119803B2 (en) | 2012-02-21 |
| AU2005288728A1 (en) | 2006-04-06 |
| ZA200701784B (en) | 2008-11-26 |
| DK1794165T3 (da) | 2010-03-08 |
| EP1794165B1 (en) | 2009-04-15 |
| PL1794165T5 (pl) | 2020-11-16 |
| DK1794165T4 (da) | 2020-07-13 |
| EP1794165B2 (en) | 2020-04-29 |
| US20110144341A1 (en) | 2011-06-16 |
| DE602005013986D1 (de) | 2009-05-28 |
| WO2006035195A1 (en) | 2006-04-06 |
| EP1794165A1 (en) | 2007-06-13 |
| ES2322486T3 (es) | 2009-06-22 |
| CN101027307B (zh) | 2011-12-21 |
| GB0421687D0 (en) | 2004-11-03 |
| PL1794165T3 (pl) | 2009-09-30 |
| CN101027307A (zh) | 2007-08-29 |
| US8318937B2 (en) | 2012-11-27 |
| US20080045715A1 (en) | 2008-02-21 |
| ES2322486T5 (es) | 2021-02-05 |
| US20120046466A9 (en) | 2012-02-23 |
| ATE428715T1 (de) | 2009-05-15 |
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