DK1794165T3 - Fremstilling af opiat-analgeticum ved reduktiv alkylering - Google Patents

Fremstilling af opiat-analgeticum ved reduktiv alkylering

Info

Publication number
DK1794165T3
DK1794165T3 DK05782842.8T DK05782842T DK1794165T3 DK 1794165 T3 DK1794165 T3 DK 1794165T3 DK 05782842 T DK05782842 T DK 05782842T DK 1794165 T3 DK1794165 T3 DK 1794165T3
Authority
DK
Denmark
Prior art keywords
reductive alkylation
preparation
opiate analgesic
protected
hydroxyl group
Prior art date
Application number
DK05782842.8T
Other languages
English (en)
Other versions
DK1794165T4 (da
Inventor
Neil John Goodwin
Melville Mitchell
Neil Kenneth Thomson
George Scott Wilson
Maureen Joan Young
Original Assignee
Johnson Matthey Plc
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Family has litigation
First worldwide family litigation filed litigation Critical https://patents.darts-ip.com/?family=33427785&utm_source=google_patent&utm_medium=platform_link&utm_campaign=public_patent_search&patent=DK1794165(T3) "Global patent litigation dataset” by Darts-ip is licensed under a Creative Commons Attribution 4.0 International License.
Application filed by Johnson Matthey Plc filed Critical Johnson Matthey Plc
Publication of DK1794165T3 publication Critical patent/DK1794165T3/da
Application granted granted Critical
Publication of DK1794165T4 publication Critical patent/DK1794165T4/da

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D489/00—Heterocyclic compounds containing 4aH-8, 9 c- Iminoethano-phenanthro [4, 5-b, c, d] furan ring systems, e.g. derivatives of [4, 5-epoxy]-morphinan of the formula:
    • C07D489/02—Heterocyclic compounds containing 4aH-8, 9 c- Iminoethano-phenanthro [4, 5-b, c, d] furan ring systems, e.g. derivatives of [4, 5-epoxy]-morphinan of the formula: with oxygen atoms attached in positions 3 and 6, e.g. morphine, morphinone
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D221/00—Heterocyclic compounds containing six-membered rings having one nitrogen atom as the only ring hetero atom, not provided for by groups C07D211/00 - C07D219/00
    • C07D221/02—Heterocyclic compounds containing six-membered rings having one nitrogen atom as the only ring hetero atom, not provided for by groups C07D211/00 - C07D219/00 condensed with carbocyclic rings or ring systems
    • C07D221/22—Bridged ring systems
    • C07D221/28—Morphinans
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D489/00—Heterocyclic compounds containing 4aH-8, 9 c- Iminoethano-phenanthro [4, 5-b, c, d] furan ring systems, e.g. derivatives of [4, 5-epoxy]-morphinan of the formula:
    • C07D489/06—Heterocyclic compounds containing 4aH-8, 9 c- Iminoethano-phenanthro [4, 5-b, c, d] furan ring systems, e.g. derivatives of [4, 5-epoxy]-morphinan of the formula: with a hetero atom directly attached in position 14
    • C07D489/08—Oxygen atom
    • Y—GENERAL TAGGING OF NEW TECHNOLOGICAL DEVELOPMENTS; GENERAL TAGGING OF CROSS-SECTIONAL TECHNOLOGIES SPANNING OVER SEVERAL SECTIONS OF THE IPC; TECHNICAL SUBJECTS COVERED BY FORMER USPC CROSS-REFERENCE ART COLLECTIONS [XRACs] AND DIGESTS
    • Y02—TECHNOLOGIES OR APPLICATIONS FOR MITIGATION OR ADAPTATION AGAINST CLIMATE CHANGE
    • Y02P—CLIMATE CHANGE MITIGATION TECHNOLOGIES IN THE PRODUCTION OR PROCESSING OF GOODS
    • Y02P20/00—Technologies relating to chemical industry
    • Y02P20/50—Improvements relating to the production of bulk chemicals
    • Y02P20/55—Design of synthesis routes, e.g. reducing the use of auxiliary or protecting groups

Landscapes

  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Organic Low-Molecular-Weight Compounds And Preparation Thereof (AREA)
  • Low-Molecular Organic Synthesis Reactions Using Catalysts (AREA)
DK05782842.8T 2004-09-30 2005-09-14 Fremstilling af opiat-analgeticum ved reduktiv alkylering DK1794165T4 (da)

Applications Claiming Priority (2)

Application Number Priority Date Filing Date Title
GBGB0421687.5A GB0421687D0 (en) 2004-09-30 2004-09-30 Preparation of opiate analgesics
PCT/GB2005/003547 WO2006035195A1 (en) 2004-09-30 2005-09-14 Preparation of opiate analgesics by reductive alkylation

Publications (2)

Publication Number Publication Date
DK1794165T3 true DK1794165T3 (da) 2010-03-08
DK1794165T4 DK1794165T4 (da) 2020-07-13

Family

ID=33427785

Family Applications (1)

Application Number Title Priority Date Filing Date
DK05782842.8T DK1794165T4 (da) 2004-09-30 2005-09-14 Fremstilling af opiat-analgeticum ved reduktiv alkylering

Country Status (13)

Country Link
US (2) US8119803B2 (da)
EP (1) EP1794165B2 (da)
CN (1) CN101027307B (da)
AT (1) ATE428715T1 (da)
AU (1) AU2005288728B2 (da)
DE (1) DE602005013986D1 (da)
DK (1) DK1794165T4 (da)
ES (1) ES2322486T5 (da)
GB (1) GB0421687D0 (da)
PL (1) PL1794165T5 (da)
PT (1) PT1794165E (da)
WO (1) WO2006035195A1 (da)
ZA (1) ZA200701784B (da)

Families Citing this family (37)

* Cited by examiner, † Cited by third party
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GB2438399A (en) * 2006-05-25 2007-11-28 Alpharma Aps Preparation of N-alkylated morphinans by reduction of an iminium group
GB2471803B (en) * 2006-05-25 2011-02-16 Alpharma Chemical process
GB2471801B (en) * 2006-05-25 2011-02-16 Alpharma Process useful in the preparation of morphine antagonists
EP2032579A2 (en) * 2006-05-25 2009-03-11 Alpharma (Bermuda) Investments Ltd Process useful in the preparation of morphinan antagonists
KR100780932B1 (ko) * 2006-05-30 2007-11-30 엠텍비젼 주식회사 컬러 보간 방법 및 장치
DE602008004245D1 (de) 2007-05-04 2011-02-10 Mallinckrodt Inc Verbessertes verfahren zur herstellung von 6-alpha-hydroxy-n-alkylierten opiaten
US8962841B2 (en) * 2007-06-29 2015-02-24 Brock University Methods for one-pot N-demethylation/N-functionalization of morphine and tropane alkaloids
EP2167505B1 (en) * 2007-07-17 2012-11-28 Mallinckrodt LLC Preparation of n-alkylated opiates by reductive amination
EP2112152A1 (en) 2008-04-22 2009-10-28 GPC Biotech AG Dihydropteridinones as Plk Inhibitors
AU2009300390B2 (en) 2008-09-30 2015-05-14 SpecGx LLC Processes for the production of buprenorphine with reduced impurity formation
AU2009300392B2 (en) * 2008-09-30 2014-10-23 SpecGx LLC Processes for the selective amination of ketomorphinans
ES2529057T3 (es) * 2008-09-30 2015-02-16 Mallinckrodt Inc. Procedimientos para la hidrogenación de derivados de alcaloides opiáceos
EP2398808B1 (en) * 2009-02-17 2013-11-20 Mallinckrodt LLC Process for the reductive alkylation of normorphinans
US8946419B2 (en) 2009-02-23 2015-02-03 Mallinckrodt Llc (+)-6-hydroxy-morphinan or (+)-6-amino-morphinan derivatives
US8471023B2 (en) * 2009-06-11 2013-06-25 Mallinckrodt Llc Reductive amination of 6-keto normorphinans by catalytic hydrogen transfer
WO2010144641A1 (en) * 2009-06-11 2010-12-16 Mallinckrodt Inc. Preparation of 6-alpha-amino n-substituted morphinans by catalytic hydrogen transfer
GB0914338D0 (en) 2009-08-17 2009-09-30 Johnson Matthey Plc Improved process
ES2698408T3 (es) 2011-06-09 2019-02-04 SpecGx LLC Aminación reductora de 6-ceto morfinanos por transferencia de hidrógeno catalítico
EP2753622B1 (en) * 2011-09-08 2016-01-20 Mallinckrodt LLC Production of alkaloids without the isolation of intermediates
US9315514B2 (en) 2012-08-27 2016-04-19 Rhodes Technologies 1,3-dioxanomorphides and 1,3-dioxanocodides
JP6163210B2 (ja) 2012-12-14 2017-07-12 パーデュー、ファーマ、リミテッド、パートナーシップ 窒素含有モルフィナン誘導体およびその使用
TW201434837A (zh) 2012-12-14 2014-09-16 Purdue Pharma Lp 螺環嗎啡喃及其用途
US8980906B2 (en) 2012-12-14 2015-03-17 Purdue Pharma L.P. Pyridonemorphinan analogs and biological activity on opioid receptors
JP6159416B2 (ja) 2012-12-28 2017-07-05 パーデュー、ファーマ、リミテッド、パートナーシップ ７，８−環式モルフィナン類似体
CA2896202A1 (en) 2012-12-28 2014-07-03 Purdue Pharma L.P. Substituted morphinans and the use thereof
JP6181770B2 (ja) 2012-12-31 2017-08-16 ローズ テクノロジーズ ７β−置換６α，１４α−エテノモルフィナンおよび７β−置換６α，１４α−エタノモルフィナンを調製するための方法
GB201313915D0 (en) 2013-08-02 2013-09-18 Johnson Matthey Plc Process
WO2015066443A1 (en) 2013-11-01 2015-05-07 Mallinckrodt Llc Convenient preparation of n-substituted morphinan-6-ols from morphinan-6-ones
US9969746B2 (en) 2013-12-05 2018-05-15 The University Of Bath Opioid compounds and their uses
EP3087078B1 (en) 2013-12-26 2019-05-15 Purdue Pharma LP 7-beta-alkyl analogs of orvinols
US9994571B2 (en) 2013-12-26 2018-06-12 Purdue Pharma L.P. 10-substituted morphinan hydantoins
EP3087079B1 (en) 2013-12-26 2019-04-03 Purdue Pharma LP Opioid receptor modulating oxabicyclo[2.2.2]octane morphinans
US9340542B2 (en) 2013-12-26 2016-05-17 Purdue Pharma L.P. Propellane-based compounds and the use thereof
US9902726B2 (en) 2013-12-30 2018-02-27 Purdue Pharma L.P. Pyridone-sulfone morphinan analogs as opioid receptor ligands
MA41125A (fr) 2014-12-05 2017-10-10 Purdue Pharma Lp Dérivés de 6.7-cyclomorphinane et leur utilisation
MX2019007327A (es) 2016-12-23 2019-09-02 Minoryx Therapeutics S L Proceso para preparar 5-[[4-[2-[5-(1-hidroxietil)-2-piridinil] etoxi]fenil]metil]-2,4-tiazolidindiona y sus sales.
EP3755704A1 (en) 2018-02-23 2020-12-30 Rhodes Technologies Inc. Novel opioid compounds and uses thereof

Family Cites Families (8)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
GB1136214A (en) 1965-06-15 1968-12-11 Reckitt & Sons Ltd Thebaine and oripavine derivatives
US3332950A (en) 1963-03-23 1967-07-25 Endo Lab 14-hydroxydihydronormorphinone derivatives
US3717643A (en) * 1967-05-04 1973-02-20 Sterling Drug Inc N-substituted-norapomorphines
DE2107989A1 (de) * 1971-02-19 1972-09-07 Boehringer Sohn Ingelheim N-(Furyl-methy])-morphinane, deren Säureadditionssalze sowie Verfahren zu deren Herstellung
US4082744A (en) * 1973-05-08 1978-04-04 Nihon Iyakuhin Kogyo Co., Ltd. 4-benzazonine derivatives and process for preparation thereof
US4190601A (en) † 1978-05-31 1980-02-26 Union Carbide Corporation Production of tertiary amines by reductive alkylation
IE52502B1 (en) † 1981-03-27 1987-11-25 Wyeth John & Brother Ltd Morpholines
US5869669A (en) * 1996-07-26 1999-02-09 Penick Corporation Preparation of 14-hydroxynormorphinones from normorphinone dienol acylates

Also Published As

Publication number Publication date
ES2322486T5 (es) 2021-02-05
US20080045715A1 (en) 2008-02-21
US20120046466A9 (en) 2012-02-23
US8318937B2 (en) 2012-11-27
ATE428715T1 (de) 2009-05-15
AU2005288728B2 (en) 2012-05-03
CN101027307A (zh) 2007-08-29
CN101027307B (zh) 2011-12-21
ZA200701784B (en) 2008-11-26
GB0421687D0 (en) 2004-11-03
PT1794165E (pt) 2009-05-06
DE602005013986D1 (de) 2009-05-28
US20110144341A1 (en) 2011-06-16
DK1794165T4 (da) 2020-07-13
ES2322486T3 (es) 2009-06-22
EP1794165B2 (en) 2020-04-29
WO2006035195A1 (en) 2006-04-06
US8119803B2 (en) 2012-02-21
AU2005288728A1 (en) 2006-04-06
EP1794165A1 (en) 2007-06-13
PL1794165T5 (pl) 2020-11-16
PL1794165T3 (pl) 2009-09-30
EP1794165B1 (en) 2009-04-15

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