DK1794165T4 - Fremstilling af opiat-analgeticum ved reduktiv alkylering - Google Patents
Fremstilling af opiat-analgeticum ved reduktiv alkylering Download PDFInfo
- Publication number
- DK1794165T4 DK1794165T4 DK05782842.8T DK05782842T DK1794165T4 DK 1794165 T4 DK1794165 T4 DK 1794165T4 DK 05782842 T DK05782842 T DK 05782842T DK 1794165 T4 DK1794165 T4 DK 1794165T4
- Authority
- DK
- Denmark
- Prior art keywords
- reductive alkylation
- preparation
- opiate analgesic
- protected
- hydroxyl group
- Prior art date
Links
- 238000005932 reductive alkylation reaction Methods 0.000 title abstract 3
- 230000000202 analgesic effect Effects 0.000 title 1
- 229940127240 opiate Drugs 0.000 title 1
- 125000002887 hydroxy group Chemical group [H]O* 0.000 abstract 3
- UFHFLCQGNIYNRP-UHFFFAOYSA-N Hydrogen Chemical compound [H][H] UFHFLCQGNIYNRP-UHFFFAOYSA-N 0.000 abstract 1
- 125000003710 aryl alkyl group Chemical group 0.000 abstract 1
- 239000003054 catalyst Substances 0.000 abstract 1
- 150000001875 compounds Chemical class 0.000 abstract 1
- 229910052739 hydrogen Inorganic materials 0.000 abstract 1
- 239000001257 hydrogen Substances 0.000 abstract 1
- 150000002576 ketones Chemical class 0.000 abstract 1
- 238000004519 manufacturing process Methods 0.000 abstract 1
- 238000000034 method Methods 0.000 abstract 1
- 125000000999 tert-butyl group Chemical group [H]C([H])([H])C(*)(C([H])([H])[H])C([H])([H])[H] 0.000 abstract 1
Classifications
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D489/00—Heterocyclic compounds containing 4aH-8, 9 c- Iminoethano-phenanthro [4, 5-b, c, d] furan ring systems, e.g. derivatives of [4, 5-epoxy]-morphinan of the formula:
- C07D489/02—Heterocyclic compounds containing 4aH-8, 9 c- Iminoethano-phenanthro [4, 5-b, c, d] furan ring systems, e.g. derivatives of [4, 5-epoxy]-morphinan of the formula: with oxygen atoms attached in positions 3 and 6, e.g. morphine, morphinone
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D221/00—Heterocyclic compounds containing six-membered rings having one nitrogen atom as the only ring hetero atom, not provided for by groups C07D211/00 - C07D219/00
- C07D221/02—Heterocyclic compounds containing six-membered rings having one nitrogen atom as the only ring hetero atom, not provided for by groups C07D211/00 - C07D219/00 condensed with carbocyclic rings or ring systems
- C07D221/22—Bridged ring systems
- C07D221/28—Morphinans
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D489/00—Heterocyclic compounds containing 4aH-8, 9 c- Iminoethano-phenanthro [4, 5-b, c, d] furan ring systems, e.g. derivatives of [4, 5-epoxy]-morphinan of the formula:
- C07D489/06—Heterocyclic compounds containing 4aH-8, 9 c- Iminoethano-phenanthro [4, 5-b, c, d] furan ring systems, e.g. derivatives of [4, 5-epoxy]-morphinan of the formula: with a hetero atom directly attached in position 14
- C07D489/08—Oxygen atom
-
- Y—GENERAL TAGGING OF NEW TECHNOLOGICAL DEVELOPMENTS; GENERAL TAGGING OF CROSS-SECTIONAL TECHNOLOGIES SPANNING OVER SEVERAL SECTIONS OF THE IPC; TECHNICAL SUBJECTS COVERED BY FORMER USPC CROSS-REFERENCE ART COLLECTIONS [XRACs] AND DIGESTS
- Y02—TECHNOLOGIES OR APPLICATIONS FOR MITIGATION OR ADAPTATION AGAINST CLIMATE CHANGE
- Y02P—CLIMATE CHANGE MITIGATION TECHNOLOGIES IN THE PRODUCTION OR PROCESSING OF GOODS
- Y02P20/00—Technologies relating to chemical industry
- Y02P20/50—Improvements relating to the production of bulk chemicals
- Y02P20/55—Design of synthesis routes, e.g. reducing the use of auxiliary or protecting groups
Landscapes
- Chemical & Material Sciences (AREA)
- Organic Chemistry (AREA)
- Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
- Organic Low-Molecular-Weight Compounds And Preparation Thereof (AREA)
- Low-Molecular Organic Synthesis Reactions Using Catalysts (AREA)
Applications Claiming Priority (2)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| GBGB0421687.5A GB0421687D0 (en) | 2004-09-30 | 2004-09-30 | Preparation of opiate analgesics |
| PCT/GB2005/003547 WO2006035195A1 (en) | 2004-09-30 | 2005-09-14 | Preparation of opiate analgesics by reductive alkylation |
Publications (2)
| Publication Number | Publication Date |
|---|---|
| DK1794165T3 DK1794165T3 (da) | 2010-03-08 |
| DK1794165T4 true DK1794165T4 (da) | 2020-07-13 |
Family
ID=33427785
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| DK05782842.8T DK1794165T4 (da) | 2004-09-30 | 2005-09-14 | Fremstilling af opiat-analgeticum ved reduktiv alkylering |
Country Status (13)
| Country | Link |
|---|---|
| US (2) | US8119803B2 (da) |
| EP (1) | EP1794165B2 (da) |
| CN (1) | CN101027307B (da) |
| AT (1) | ATE428715T1 (da) |
| AU (1) | AU2005288728B2 (da) |
| DE (1) | DE602005013986D1 (da) |
| DK (1) | DK1794165T4 (da) |
| ES (1) | ES2322486T5 (da) |
| GB (1) | GB0421687D0 (da) |
| PL (1) | PL1794165T5 (da) |
| PT (1) | PT1794165E (da) |
| WO (1) | WO2006035195A1 (da) |
| ZA (1) | ZA200701784B (da) |
Families Citing this family (37)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| WO2007137785A2 (en) * | 2006-05-25 | 2007-12-06 | Alpharma (Bermuda) Investments Ltd | Process useful in the preparation of morphinan antagonists |
| GB2444052A (en) * | 2006-05-25 | 2008-05-28 | Alpharma Aps | Processes of preparing morphinan derivatives such as naltrexone and naloxone comprising O- and N-demethylation and reductive alkylation steps |
| GB2471801B (en) * | 2006-05-25 | 2011-02-16 | Alpharma | Process useful in the preparation of morphine antagonists |
| GB2471800B (en) * | 2006-05-25 | 2011-03-09 | Alpharma | Preparation of N-alkylated morphinans by reduction of an iminium group |
| KR100780932B1 (ko) * | 2006-05-30 | 2007-11-30 | 엠텍비젼 주식회사 | 컬러 보간 방법 및 장치 |
| AU2008207580B2 (en) | 2007-05-04 | 2011-04-14 | SpecGx LLC | Improved process for the preparation of 6-alpha-hydroxy-N-alkylated opiates |
| US8962841B2 (en) * | 2007-06-29 | 2015-02-24 | Brock University | Methods for one-pot N-demethylation/N-functionalization of morphine and tropane alkaloids |
| NZ582668A (en) * | 2007-07-17 | 2012-02-24 | Mallinckrodt Llc | Preparation of n-alkylated opiates by reductive amination |
| EP2112152A1 (en) | 2008-04-22 | 2009-10-28 | GPC Biotech AG | Dihydropteridinones as Plk Inhibitors |
| WO2010039220A1 (en) | 2008-09-30 | 2010-04-08 | Mallinckrodt Inc. | Processes for the production of buprenorphine with reduced impurity formation |
| US8273887B2 (en) * | 2008-09-30 | 2012-09-25 | Mallinckrodt Llc | Processes for synthesis of opiate alkaloid derivatives |
| NZ607842A (en) * | 2008-09-30 | 2013-12-20 | Mallinckrodt Llc | Processes for the selective amination of ketomorphinans |
| AU2010216150B2 (en) * | 2009-02-17 | 2015-05-14 | Mallinckrodt Llc | Process for the reductive alkylation of normorphinans |
| US8946419B2 (en) | 2009-02-23 | 2015-02-03 | Mallinckrodt Llc | (+)-6-hydroxy-morphinan or (+)-6-amino-morphinan derivatives |
| PL2440562T3 (pl) * | 2009-06-11 | 2017-07-31 | Mallinckrodt Llc | Otrzymywanie 6-alfa-amino-N-podstawionych morfinanów w wyniku katalitycznego przeniesienia wodoru |
| ES2465066T3 (es) * | 2009-06-11 | 2014-06-05 | Mallinckrodt Llc | Aminación reductora de 6-ceto-normorfinanos por transferencia de hidrógeno catalítica |
| GB0914338D0 (en) | 2009-08-17 | 2009-09-30 | Johnson Matthey Plc | Improved process |
| MX2013013634A (es) | 2011-06-09 | 2013-12-12 | Mallinckrodt Llc | Aminacion reductiva de 6-ceto-morfinanos por transfrencia catalitica de hidrogeno. |
| JP2014526467A (ja) | 2011-09-08 | 2014-10-06 | マリンクロッド エルエルシー | 中間体の単離なしでのアルカロイドの調製 |
| US9315514B2 (en) | 2012-08-27 | 2016-04-19 | Rhodes Technologies | 1,3-dioxanomorphides and 1,3-dioxanocodides |
| US8937084B2 (en) | 2012-12-14 | 2015-01-20 | Purdue Pharma L.P. | Nitrogen containing morphinan derivatives and the use thereof |
| ES2621305T3 (es) | 2012-12-14 | 2017-07-03 | Purdue Pharma Lp | Morfinanos espirocíclicos y su uso |
| CA2894963A1 (en) | 2012-12-14 | 2014-06-19 | Purdue Pharma L.P. | Pyridonemorphinan analogs and biological activity on opioid receptors |
| TW201441199A (zh) | 2012-12-28 | 2014-11-01 | Purdue Pharma Lp | 經取代之嗎啡喃類及其用途 |
| WO2014102587A1 (en) | 2012-12-28 | 2014-07-03 | Purdue Pharma L.P. | 7,8-cyclicmorphinan analogs |
| US9834562B2 (en) | 2012-12-31 | 2017-12-05 | Rhodes Technologies | 7 beta-substituted 6a, 14a-ethenomorphinans and 7beta-substituted 6a, 14a-ethanomorphinans |
| GB201313915D0 (en) | 2013-08-02 | 2013-09-18 | Johnson Matthey Plc | Process |
| WO2015066443A1 (en) | 2013-11-01 | 2015-05-07 | Mallinckrodt Llc | Convenient preparation of n-substituted morphinan-6-ols from morphinan-6-ones |
| ES2784690T3 (es) | 2013-12-05 | 2020-09-29 | Univ Bath | Nuevos compuestos opioides y sus usos |
| EP3087079B1 (en) | 2013-12-26 | 2019-04-03 | Purdue Pharma LP | Opioid receptor modulating oxabicyclo[2.2.2]octane morphinans |
| US9340542B2 (en) | 2013-12-26 | 2016-05-17 | Purdue Pharma L.P. | Propellane-based compounds and the use thereof |
| WO2015097548A1 (en) | 2013-12-26 | 2015-07-02 | Purdue Pharma L.P. | 7-beta-alkyl analogs of orvinols |
| WO2015097547A1 (en) | 2013-12-26 | 2015-07-02 | Purdue Pharma L.P. | 10-substituted morphinan hydantoins |
| WO2015102682A1 (en) | 2013-12-30 | 2015-07-09 | Purdue Pharma L.P. | Pyridone-sulfone morphinan analogs as opioid receptor ligands |
| MA41125A (fr) | 2014-12-05 | 2017-10-10 | Purdue Pharma Lp | Dérivés de 6.7-cyclomorphinane et leur utilisation |
| MX2019007327A (es) | 2016-12-23 | 2019-09-02 | Minoryx Therapeutics S L | Proceso para preparar 5-[[4-[2-[5-(1-hidroxietil)-2-piridinil] etoxi]fenil]metil]-2,4-tiazolidindiona y sus sales. |
| AU2019224127B2 (en) | 2018-02-23 | 2021-12-09 | Rhodes Technologies | Novel opioid compounds and uses thereof |
Family Cites Families (8)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| GB1136214A (en) † | 1965-06-15 | 1968-12-11 | Reckitt & Sons Ltd | Thebaine and oripavine derivatives |
| US3332950A (en) | 1963-03-23 | 1967-07-25 | Endo Lab | 14-hydroxydihydronormorphinone derivatives |
| US3717643A (en) * | 1967-05-04 | 1973-02-20 | Sterling Drug Inc | N-substituted-norapomorphines |
| DE2107989A1 (de) * | 1971-02-19 | 1972-09-07 | Boehringer Sohn Ingelheim | N-(Furyl-methy])-morphinane, deren Säureadditionssalze sowie Verfahren zu deren Herstellung |
| US4082744A (en) * | 1973-05-08 | 1978-04-04 | Nihon Iyakuhin Kogyo Co., Ltd. | 4-benzazonine derivatives and process for preparation thereof |
| US4190601A (en) | 1978-05-31 | 1980-02-26 | Union Carbide Corporation | Production of tertiary amines by reductive alkylation |
| IE52502B1 (en) † | 1981-03-27 | 1987-11-25 | Wyeth John & Brother Ltd | Morpholines |
| US5869669A (en) † | 1996-07-26 | 1999-02-09 | Penick Corporation | Preparation of 14-hydroxynormorphinones from normorphinone dienol acylates |
-
2004
- 2004-09-30 GB GBGB0421687.5A patent/GB0421687D0/en not_active Ceased
-
2005
- 2005-09-14 DK DK05782842.8T patent/DK1794165T4/da active
- 2005-09-14 US US11/628,210 patent/US8119803B2/en active Active
- 2005-09-14 PT PT05782842T patent/PT1794165E/pt unknown
- 2005-09-14 EP EP05782842.8A patent/EP1794165B2/en active Active
- 2005-09-14 AU AU2005288728A patent/AU2005288728B2/en active Active
- 2005-09-14 DE DE602005013986T patent/DE602005013986D1/de active Active
- 2005-09-14 AT AT05782842T patent/ATE428715T1/de active
- 2005-09-14 WO PCT/GB2005/003547 patent/WO2006035195A1/en active Application Filing
- 2005-09-14 CN CN2005800326607A patent/CN101027307B/zh active Active
- 2005-09-14 PL PL05782842T patent/PL1794165T5/pl unknown
- 2005-09-14 ES ES05782842T patent/ES2322486T5/es active Active
-
2007
- 2007-02-28 ZA ZA2007/01784A patent/ZA200701784B/en unknown
-
2011
- 2011-02-18 US US13/030,652 patent/US8318937B2/en active Active
Also Published As
| Publication number | Publication date |
|---|---|
| PT1794165E (pt) | 2009-05-06 |
| US8318937B2 (en) | 2012-11-27 |
| GB0421687D0 (en) | 2004-11-03 |
| ES2322486T3 (es) | 2009-06-22 |
| EP1794165B1 (en) | 2009-04-15 |
| ATE428715T1 (de) | 2009-05-15 |
| AU2005288728B2 (en) | 2012-05-03 |
| AU2005288728A1 (en) | 2006-04-06 |
| DK1794165T3 (da) | 2010-03-08 |
| ES2322486T5 (es) | 2021-02-05 |
| DE602005013986D1 (de) | 2009-05-28 |
| PL1794165T5 (pl) | 2020-11-16 |
| ZA200701784B (en) | 2008-11-26 |
| WO2006035195A1 (en) | 2006-04-06 |
| CN101027307B (zh) | 2011-12-21 |
| EP1794165A1 (en) | 2007-06-13 |
| US8119803B2 (en) | 2012-02-21 |
| CN101027307A (zh) | 2007-08-29 |
| US20080045715A1 (en) | 2008-02-21 |
| US20120046466A9 (en) | 2012-02-23 |
| PL1794165T3 (pl) | 2009-09-30 |
| US20110144341A1 (en) | 2011-06-16 |
| EP1794165B2 (en) | 2020-04-29 |
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