GB2471803B - Chemical process - Google Patents

Chemical process

Info

Publication number
GB2471803B
GB2471803B GB1017991A GB201017991A GB2471803B GB 2471803 B GB2471803 B GB 2471803B GB 1017991 A GB1017991 A GB 1017991A GB 201017991 A GB201017991 A GB 201017991A GB 2471803 B GB2471803 B GB 2471803B
Authority
GB
United Kingdom
Prior art keywords
chemical process
chemical
Prior art date
Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
Expired - Fee Related
Application number
GB1017991A
Other versions
GB2471803A (en
GB201017991D0 (en
Inventor
Harald Halvorsen
Ole Heine Kvernenes
Audun Heggelund
Anne Mette Nyg Rd
Original Assignee
Alpharma
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Alpharma filed Critical Alpharma
Priority to GB1017991A priority Critical patent/GB2471803B/en
Publication of GB201017991D0 publication Critical patent/GB201017991D0/en
Publication of GB2471803A publication Critical patent/GB2471803A/en
Application granted granted Critical
Publication of GB2471803B publication Critical patent/GB2471803B/en
Expired - Fee Related legal-status Critical Current
Anticipated expiration legal-status Critical

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D489/00—Heterocyclic compounds containing 4aH-8, 9 c- Iminoethano-phenanthro [4, 5-b, c, d] furan ring systems, e.g. derivatives of [4, 5-epoxy]-morphinan of the formula:
    • C07D489/06—Heterocyclic compounds containing 4aH-8, 9 c- Iminoethano-phenanthro [4, 5-b, c, d] furan ring systems, e.g. derivatives of [4, 5-epoxy]-morphinan of the formula: with a hetero atom directly attached in position 14
    • C07D489/08—Oxygen atom

Landscapes

  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
GB1017991A 2006-05-25 2006-05-25 Chemical process Expired - Fee Related GB2471803B (en)

Priority Applications (1)

Application Number Priority Date Filing Date Title
GB1017991A GB2471803B (en) 2006-05-25 2006-05-25 Chemical process

Applications Claiming Priority (2)

Application Number Priority Date Filing Date Title
GB0610385A GB2444052A (en) 2006-05-25 2006-05-25 Processes of preparing morphinan derivatives such as naltrexone and naloxone comprising O- and N-demethylation and reductive alkylation steps
GB1017991A GB2471803B (en) 2006-05-25 2006-05-25 Chemical process

Publications (3)

Publication Number Publication Date
GB201017991D0 GB201017991D0 (en) 2010-12-08
GB2471803A GB2471803A (en) 2011-01-12
GB2471803B true GB2471803B (en) 2011-02-16

Family

ID=36687714

Family Applications (2)

Application Number Title Priority Date Filing Date
GB0610385A Withdrawn GB2444052A (en) 2006-05-25 2006-05-25 Processes of preparing morphinan derivatives such as naltrexone and naloxone comprising O- and N-demethylation and reductive alkylation steps
GB1017991A Expired - Fee Related GB2471803B (en) 2006-05-25 2006-05-25 Chemical process

Family Applications Before (1)

Application Number Title Priority Date Filing Date
GB0610385A Withdrawn GB2444052A (en) 2006-05-25 2006-05-25 Processes of preparing morphinan derivatives such as naltrexone and naloxone comprising O- and N-demethylation and reductive alkylation steps

Country Status (1)

Country Link
GB (2) GB2444052A (en)

Families Citing this family (1)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
SK592017A3 (en) * 2017-07-04 2019-01-08 Saneca Pharmaceuticals A. S. Method for preparing morphinan compounds

Citations (5)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US3717643A (en) * 1967-05-04 1973-02-20 Sterling Drug Inc N-substituted-norapomorphines
US3905981A (en) * 1973-10-12 1975-09-16 Research Corp N-dealkylation of tertiary amines
GB2000137A (en) * 1977-06-21 1979-01-04 Warner Lambert Co 7,8-Dihydro-14-hydroxy-normorphine
EP0164290A1 (en) * 1984-05-25 1985-12-11 Sanofi S.A. Process for the dealkylation of alcaloids and intermediates
WO2006035195A1 (en) * 2004-09-30 2006-04-06 Johnson Matthey Public Limited Company Preparation of opiate analgesics by reductive alkylation

Patent Citations (5)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US3717643A (en) * 1967-05-04 1973-02-20 Sterling Drug Inc N-substituted-norapomorphines
US3905981A (en) * 1973-10-12 1975-09-16 Research Corp N-dealkylation of tertiary amines
GB2000137A (en) * 1977-06-21 1979-01-04 Warner Lambert Co 7,8-Dihydro-14-hydroxy-normorphine
EP0164290A1 (en) * 1984-05-25 1985-12-11 Sanofi S.A. Process for the dealkylation of alcaloids and intermediates
WO2006035195A1 (en) * 2004-09-30 2006-04-06 Johnson Matthey Public Limited Company Preparation of opiate analgesics by reductive alkylation

Non-Patent Citations (5)

* Cited by examiner, † Cited by third party
Title
Journal of Medicinal Chemistry Vol. 21, No. 4, 1978, pages 398-400 *
Journal of Organic Chemistry Vol. 49, No. 11, 1984, pages 2081-2082. *
Tetrahedron Vol.48, No. 32, 1992, pages 6709-6716. *
Yaoxue Xuebao Vol. 17, No. 7, 1982, pages 546-548. *
Zhongguo Yaowu Huaxue Zazhi Vol. 8, No. 2, 1998, pages 141-146. *

Also Published As

Publication number Publication date
GB2444052A (en) 2008-05-28
GB0610385D0 (en) 2006-07-05
GB2471803A (en) 2011-01-12
GB201017991D0 (en) 2010-12-08

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Legal Events

Date Code Title Description
PCNP Patent ceased through non-payment of renewal fee

Effective date: 20120525