GB0720891D0 - Chemical process - Google Patents

Chemical process

Info

Publication number
GB0720891D0
GB0720891D0 GBGB0720891.1A GB0720891A GB0720891D0 GB 0720891 D0 GB0720891 D0 GB 0720891D0 GB 0720891 A GB0720891 A GB 0720891A GB 0720891 D0 GB0720891 D0 GB 0720891D0
Authority
GB
United Kingdom
Prior art keywords
chemical process
chemical
Prior art date
Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
Granted
Application number
GBGB0720891.1A
Other versions
GB2453982B (en
GB2453982A (en
Current Assignee (The listed assignees may be inaccurate. Google has not performed a legal analysis and makes no representation or warranty as to the accuracy of the list.)
Norbrook Laboratories Ltd
Original Assignee
Norbrook Laboratories Ltd
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Norbrook Laboratories Ltd filed Critical Norbrook Laboratories Ltd
Priority to GB0720891A priority Critical patent/GB2453982B/en
Publication of GB0720891D0 publication Critical patent/GB0720891D0/en
Priority to ARP080104589A priority patent/AR068952A1/en
Priority to UY31415A priority patent/UY31415A1/en
Priority to PE2008001820A priority patent/PE20091088A1/en
Priority to CL2008003185A priority patent/CL2008003185A1/en
Priority to PCT/GB2008/003613 priority patent/WO2009053709A1/en
Publication of GB2453982A publication Critical patent/GB2453982A/en
Application granted granted Critical
Publication of GB2453982B publication Critical patent/GB2453982B/en
Expired - Fee Related legal-status Critical Current
Anticipated expiration legal-status Critical

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D233/00—Heterocyclic compounds containing 1,3-diazole or hydrogenated 1,3-diazole rings, not condensed with other rings
    • C07D233/54—Heterocyclic compounds containing 1,3-diazole or hydrogenated 1,3-diazole rings, not condensed with other rings having two double bonds between ring members or between ring members and non-ring members
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D233/00—Heterocyclic compounds containing 1,3-diazole or hydrogenated 1,3-diazole rings, not condensed with other rings
    • C07D233/54—Heterocyclic compounds containing 1,3-diazole or hydrogenated 1,3-diazole rings, not condensed with other rings having two double bonds between ring members or between ring members and non-ring members
    • C07D233/56—Heterocyclic compounds containing 1,3-diazole or hydrogenated 1,3-diazole rings, not condensed with other rings having two double bonds between ring members or between ring members and non-ring members with only hydrogen atoms or radicals containing only hydrogen and carbon atoms, attached to ring carbon atoms
    • C07D233/58—Heterocyclic compounds containing 1,3-diazole or hydrogenated 1,3-diazole rings, not condensed with other rings having two double bonds between ring members or between ring members and non-ring members with only hydrogen atoms or radicals containing only hydrogen and carbon atoms, attached to ring carbon atoms with only hydrogen atoms or radicals containing only hydrogen and carbon atoms, attached to ring nitrogen atoms
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P25/00—Drugs for disorders of the nervous system
    • A61P25/04—Centrally acting analgesics, e.g. opioids
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P25/00—Drugs for disorders of the nervous system
    • A61P25/20—Hypnotics; Sedatives
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P9/00—Drugs for disorders of the cardiovascular system
    • A61P9/12—Antihypertensives
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D233/00—Heterocyclic compounds containing 1,3-diazole or hydrogenated 1,3-diazole rings, not condensed with other rings
    • C07D233/54—Heterocyclic compounds containing 1,3-diazole or hydrogenated 1,3-diazole rings, not condensed with other rings having two double bonds between ring members or between ring members and non-ring members
    • C07D233/56—Heterocyclic compounds containing 1,3-diazole or hydrogenated 1,3-diazole rings, not condensed with other rings having two double bonds between ring members or between ring members and non-ring members with only hydrogen atoms or radicals containing only hydrogen and carbon atoms, attached to ring carbon atoms
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D233/00—Heterocyclic compounds containing 1,3-diazole or hydrogenated 1,3-diazole rings, not condensed with other rings
    • C07D233/54—Heterocyclic compounds containing 1,3-diazole or hydrogenated 1,3-diazole rings, not condensed with other rings having two double bonds between ring members or between ring members and non-ring members
    • C07D233/64—Heterocyclic compounds containing 1,3-diazole or hydrogenated 1,3-diazole rings, not condensed with other rings having two double bonds between ring members or between ring members and non-ring members with substituted hydrocarbon radicals attached to ring carbon atoms, e.g. histidine
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07F—ACYCLIC, CARBOCYCLIC OR HETEROCYCLIC COMPOUNDS CONTAINING ELEMENTS OTHER THAN CARBON, HYDROGEN, HALOGEN, OXYGEN, NITROGEN, SULFUR, SELENIUM OR TELLURIUM
    • C07F7/00—Compounds containing elements of Groups 4 or 14 of the Periodic Table
    • C07F7/02—Silicon compounds
    • C07F7/08—Compounds having one or more C—Si linkages
    • C07F7/0803—Compounds with Si-C or Si-Si linkages
    • C07F7/081—Compounds with Si-C or Si-Si linkages comprising at least one atom selected from the elements N, O, halogen, S, Se or Te
    • C07F7/0812—Compounds with Si-C or Si-Si linkages comprising at least one atom selected from the elements N, O, halogen, S, Se or Te comprising a heterocyclic ring

Landscapes

  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • Health & Medical Sciences (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • General Health & Medical Sciences (AREA)
  • Veterinary Medicine (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • General Chemical & Material Sciences (AREA)
  • Medicinal Chemistry (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Engineering & Computer Science (AREA)
  • Animal Behavior & Ethology (AREA)
  • Public Health (AREA)
  • Biomedical Technology (AREA)
  • Neurology (AREA)
  • Neurosurgery (AREA)
  • Heart & Thoracic Surgery (AREA)
  • Cardiology (AREA)
  • Pain & Pain Management (AREA)
  • Anesthesiology (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Saccharide Compounds (AREA)
  • Organic Low-Molecular-Weight Compounds And Preparation Thereof (AREA)
  • Plural Heterocyclic Compounds (AREA)
GB0720891A 2007-10-24 2007-10-24 Chemical process for the preparation of Medetomidine Expired - Fee Related GB2453982B (en)

Priority Applications (6)

Application Number Priority Date Filing Date Title
GB0720891A GB2453982B (en) 2007-10-24 2007-10-24 Chemical process for the preparation of Medetomidine
ARP080104589A AR068952A1 (en) 2007-10-24 2008-10-22 PROCEDURE FOR THE PREPARATION OF MEDETOMIDINE
UY31415A UY31415A1 (en) 2007-10-24 2008-10-22 PROCEDURE FOR THE PREPARATION OF MEDETOMIDINE
PE2008001820A PE20091088A1 (en) 2007-10-24 2008-10-23 PROCESS FOR THE PREPARATION OF MEDETOMIDINE
CL2008003185A CL2008003185A1 (en) 2007-10-24 2008-10-24 Procedure for the preparation of medetomidine that considers the coupling between a silyimidazole and a derivative of benzyl alcohol.
PCT/GB2008/003613 WO2009053709A1 (en) 2007-10-24 2008-10-24 Process for the preparation of medetomidine

Applications Claiming Priority (1)

Application Number Priority Date Filing Date Title
GB0720891A GB2453982B (en) 2007-10-24 2007-10-24 Chemical process for the preparation of Medetomidine

Publications (3)

Publication Number Publication Date
GB0720891D0 true GB0720891D0 (en) 2007-12-05
GB2453982A GB2453982A (en) 2009-04-29
GB2453982B GB2453982B (en) 2009-09-16

Family

ID=38829878

Family Applications (1)

Application Number Title Priority Date Filing Date
GB0720891A Expired - Fee Related GB2453982B (en) 2007-10-24 2007-10-24 Chemical process for the preparation of Medetomidine

Country Status (6)

Country Link
AR (1) AR068952A1 (en)
CL (1) CL2008003185A1 (en)
GB (1) GB2453982B (en)
PE (1) PE20091088A1 (en)
UY (1) UY31415A1 (en)
WO (1) WO2009053709A1 (en)

Cited By (1)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
CN114671811A (en) * 2022-04-14 2022-06-28 南京正科医药股份有限公司 Racemization recovery method of dexmedetomidine resolution byproduct

Families Citing this family (10)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
CN101921234B (en) * 2009-06-12 2012-05-30 中国中化股份有限公司 Method for preparing dexmedetomidine
WO2011070069A1 (en) 2009-12-09 2011-06-16 I-Tech Ab Process for preparation of medetomidine
WO2013014428A1 (en) * 2011-07-22 2013-01-31 Cambrex Karlskoga Ab New processes for preparing 4-substituted imidazoles
EP2847173B1 (en) 2012-05-08 2015-12-30 Lonza Ltd Method for preparation of medetomidine
PL2847157T3 (en) 2012-05-08 2016-04-29 Lonza Ag Method for preparation of 2-(2,3-dimethylphenyl)-1-propanal
WO2012172119A2 (en) * 2012-05-08 2012-12-20 Lonza Ltd Method for the preparation of medetomidine
CN104245678B (en) 2012-06-28 2016-02-24 隆萨有限公司 The method of medetomidine is prepared with monochloroacetone
KR101537203B1 (en) 2012-06-28 2015-07-22 론자 아게 (론자 엘티디.) Method for preparation of 2-(2,3-dimethylphenyl)-1-propanal with chloroacetone
CN106588777A (en) * 2015-10-16 2017-04-26 江苏开元医药化工有限公司 Industrial preparation method of dexmedetomidine hydrochloride
WO2023182903A1 (en) 2022-03-22 2023-09-28 Общество с ограниченной ответственностью "ВИК-здоровье животных" Method for producing medetomidine and its derivatives

Family Cites Families (1)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
GB2101114B (en) * 1981-07-10 1985-05-22 Farmos Group Ltd Substituted imidazole derivatives and their preparation and use

Cited By (1)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
CN114671811A (en) * 2022-04-14 2022-06-28 南京正科医药股份有限公司 Racemization recovery method of dexmedetomidine resolution byproduct

Also Published As

Publication number Publication date
UY31415A1 (en) 2009-05-29
GB2453982B (en) 2009-09-16
CL2008003185A1 (en) 2009-03-06
GB2453982A (en) 2009-04-29
AR068952A1 (en) 2009-12-16
WO2009053709A1 (en) 2009-04-30
PE20091088A1 (en) 2009-07-20

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