CL2008003185A1 - Procedure for the preparation of medetomidine that considers the coupling between a silyimidazole and a derivative of benzyl alcohol. - Google Patents

Procedure for the preparation of medetomidine that considers the coupling between a silyimidazole and a derivative of benzyl alcohol.

Info

Publication number
CL2008003185A1
CL2008003185A1 CL2008003185A CL2008003185A CL2008003185A1 CL 2008003185 A1 CL2008003185 A1 CL 2008003185A1 CL 2008003185 A CL2008003185 A CL 2008003185A CL 2008003185 A CL2008003185 A CL 2008003185A CL 2008003185 A1 CL2008003185 A1 CL 2008003185A1
Authority
CL
Chile
Prior art keywords
medetomidine
silyimidazole
considers
derivative
procedure
Prior art date
Application number
CL2008003185A
Other languages
Spanish (es)
Inventor
Rasik Somaiya
Muhammad Raza
Jonathan Cranke
Kristian Bragg
Original Assignee
Norbrook Lab Ltd
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Norbrook Lab Ltd filed Critical Norbrook Lab Ltd
Publication of CL2008003185A1 publication Critical patent/CL2008003185A1/en

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D233/00—Heterocyclic compounds containing 1,3-diazole or hydrogenated 1,3-diazole rings, not condensed with other rings
    • C07D233/54—Heterocyclic compounds containing 1,3-diazole or hydrogenated 1,3-diazole rings, not condensed with other rings having two double bonds between ring members or between ring members and non-ring members
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D233/00—Heterocyclic compounds containing 1,3-diazole or hydrogenated 1,3-diazole rings, not condensed with other rings
    • C07D233/54—Heterocyclic compounds containing 1,3-diazole or hydrogenated 1,3-diazole rings, not condensed with other rings having two double bonds between ring members or between ring members and non-ring members
    • C07D233/56—Heterocyclic compounds containing 1,3-diazole or hydrogenated 1,3-diazole rings, not condensed with other rings having two double bonds between ring members or between ring members and non-ring members with only hydrogen atoms or radicals containing only hydrogen and carbon atoms, attached to ring carbon atoms
    • C07D233/58—Heterocyclic compounds containing 1,3-diazole or hydrogenated 1,3-diazole rings, not condensed with other rings having two double bonds between ring members or between ring members and non-ring members with only hydrogen atoms or radicals containing only hydrogen and carbon atoms, attached to ring carbon atoms with only hydrogen atoms or radicals containing only hydrogen and carbon atoms, attached to ring nitrogen atoms
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P25/00—Drugs for disorders of the nervous system
    • A61P25/04—Centrally acting analgesics, e.g. opioids
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P25/00—Drugs for disorders of the nervous system
    • A61P25/20—Hypnotics; Sedatives
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P9/00—Drugs for disorders of the cardiovascular system
    • A61P9/12—Antihypertensives
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D233/00—Heterocyclic compounds containing 1,3-diazole or hydrogenated 1,3-diazole rings, not condensed with other rings
    • C07D233/54—Heterocyclic compounds containing 1,3-diazole or hydrogenated 1,3-diazole rings, not condensed with other rings having two double bonds between ring members or between ring members and non-ring members
    • C07D233/56—Heterocyclic compounds containing 1,3-diazole or hydrogenated 1,3-diazole rings, not condensed with other rings having two double bonds between ring members or between ring members and non-ring members with only hydrogen atoms or radicals containing only hydrogen and carbon atoms, attached to ring carbon atoms
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D233/00—Heterocyclic compounds containing 1,3-diazole or hydrogenated 1,3-diazole rings, not condensed with other rings
    • C07D233/54—Heterocyclic compounds containing 1,3-diazole or hydrogenated 1,3-diazole rings, not condensed with other rings having two double bonds between ring members or between ring members and non-ring members
    • C07D233/64—Heterocyclic compounds containing 1,3-diazole or hydrogenated 1,3-diazole rings, not condensed with other rings having two double bonds between ring members or between ring members and non-ring members with substituted hydrocarbon radicals attached to ring carbon atoms, e.g. histidine
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07F—ACYCLIC, CARBOCYCLIC OR HETEROCYCLIC COMPOUNDS CONTAINING ELEMENTS OTHER THAN CARBON, HYDROGEN, HALOGEN, OXYGEN, NITROGEN, SULFUR, SELENIUM OR TELLURIUM
    • C07F7/00—Compounds containing elements of Groups 4 or 14 of the Periodic Table
    • C07F7/02—Silicon compounds
    • C07F7/08—Compounds having one or more C—Si linkages
    • C07F7/0803—Compounds with Si-C or Si-Si linkages
    • C07F7/081—Compounds with Si-C or Si-Si linkages comprising at least one atom selected from the elements N, O, halogen, S, Se or Te
    • C07F7/0812—Compounds with Si-C or Si-Si linkages comprising at least one atom selected from the elements N, O, halogen, S, Se or Te comprising a heterocyclic ring

Landscapes

  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • Health & Medical Sciences (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • General Health & Medical Sciences (AREA)
  • Veterinary Medicine (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • General Chemical & Material Sciences (AREA)
  • Medicinal Chemistry (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Engineering & Computer Science (AREA)
  • Animal Behavior & Ethology (AREA)
  • Public Health (AREA)
  • Biomedical Technology (AREA)
  • Neurology (AREA)
  • Neurosurgery (AREA)
  • Heart & Thoracic Surgery (AREA)
  • Cardiology (AREA)
  • Pain & Pain Management (AREA)
  • Anesthesiology (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Organic Low-Molecular-Weight Compounds And Preparation Thereof (AREA)
  • Plural Heterocyclic Compounds (AREA)
  • Saccharide Compounds (AREA)

Abstract

Procedimiento para preparar medetomidina que comprende hacer reaccionar alcohol 2,3-dimetil-metilbencilico con n-trimetilsililimidazol.A process for preparing medetomidine which comprises reacting 2,3-dimethyl-methylbenzyl alcohol with n-trimethylsilylimidazole.

CL2008003185A 2007-10-24 2008-10-24 Procedure for the preparation of medetomidine that considers the coupling between a silyimidazole and a derivative of benzyl alcohol. CL2008003185A1 (en)

Applications Claiming Priority (1)

Application Number Priority Date Filing Date Title
GB0720891A GB2453982B (en) 2007-10-24 2007-10-24 Chemical process for the preparation of Medetomidine

Publications (1)

Publication Number Publication Date
CL2008003185A1 true CL2008003185A1 (en) 2009-03-06

Family

ID=38829878

Family Applications (1)

Application Number Title Priority Date Filing Date
CL2008003185A CL2008003185A1 (en) 2007-10-24 2008-10-24 Procedure for the preparation of medetomidine that considers the coupling between a silyimidazole and a derivative of benzyl alcohol.

Country Status (6)

Country Link
AR (1) AR068952A1 (en)
CL (1) CL2008003185A1 (en)
GB (1) GB2453982B (en)
PE (1) PE20091088A1 (en)
UY (1) UY31415A1 (en)
WO (1) WO2009053709A1 (en)

Families Citing this family (11)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
CN101921234B (en) * 2009-06-12 2012-05-30 中国中化股份有限公司 Method for preparing dexmedetomidine
CN102753532B (en) * 2009-12-09 2015-05-13 I-技术有限公司 Process for preparation of medetomidine
IN2014DN00144A (en) 2011-07-22 2015-05-22 Cambrex Karlskoga Ab
SG11201405611SA (en) 2012-05-08 2014-11-27 Lonza Ag Method for preparation of 2-(2,3-dimethylphenyl)-1-propanal
WO2012172119A2 (en) * 2012-05-08 2012-12-20 Lonza Ltd Method for the preparation of medetomidine
IN2014DN07983A (en) * 2012-05-08 2015-05-01 Lonza Ag
US9156793B2 (en) * 2012-06-28 2015-10-13 Lonza Ltd. Method for preparation of medetomidine with chloroacetone
KR101537203B1 (en) 2012-06-28 2015-07-22 론자 아게 (론자 엘티디.) Method for preparation of 2-(2,3-dimethylphenyl)-1-propanal with chloroacetone
CN106588777A (en) * 2015-10-16 2017-04-26 江苏开元医药化工有限公司 Industrial preparation method of dexmedetomidine hydrochloride
CN117295718A (en) 2022-03-22 2023-12-26 维科-兹多洛夫希沃特尼赫有限责任公司 Method for preparing medetomidine and derivative thereof
CN114671811A (en) * 2022-04-14 2022-06-28 南京正科医药股份有限公司 Racemization recovery method of dexmedetomidine resolution byproduct

Family Cites Families (1)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
GB2101114B (en) * 1981-07-10 1985-05-22 Farmos Group Ltd Substituted imidazole derivatives and their preparation and use

Also Published As

Publication number Publication date
AR068952A1 (en) 2009-12-16
GB0720891D0 (en) 2007-12-05
UY31415A1 (en) 2009-05-29
GB2453982A (en) 2009-04-29
WO2009053709A1 (en) 2009-04-30
PE20091088A1 (en) 2009-07-20
GB2453982B (en) 2009-09-16

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