PT1471074E - Ensaios melhorados de diagnóstico imunológico utilizando agentes redutores - Google Patents
Ensaios melhorados de diagnóstico imunológico utilizando agentes redutores Download PDFInfo
- Publication number
- PT1471074E PT1471074E PT04103238T PT04103238T PT1471074E PT 1471074 E PT1471074 E PT 1471074E PT 04103238 T PT04103238 T PT 04103238T PT 04103238 T PT04103238 T PT 04103238T PT 1471074 E PT1471074 E PT 1471074E
- Authority
- PT
- Portugal
- Prior art keywords
- recombinant protein
- purification
- recombinant
- conformation
- proteins
- Prior art date
Links
Classifications
-
- G—PHYSICS
- G01—MEASURING; TESTING
- G01N—INVESTIGATING OR ANALYSING MATERIALS BY DETERMINING THEIR CHEMICAL OR PHYSICAL PROPERTIES
- G01N33/00—Investigating or analysing materials by specific methods not covered by groups G01N1/00 - G01N31/00
- G01N33/48—Biological material, e.g. blood, urine; Haemocytometers
- G01N33/50—Chemical analysis of biological material, e.g. blood, urine; Testing involving biospecific ligand binding methods; Immunological testing
- G01N33/53—Immunoassay; Biospecific binding assay; Materials therefor
- G01N33/573—Immunoassay; Biospecific binding assay; Materials therefor for enzymes or isoenzymes
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07K—PEPTIDES
- C07K14/00—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof
- C07K14/005—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from viruses
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P31/00—Antiinfectives, i.e. antibiotics, antiseptics, chemotherapeutics
- A61P31/12—Antivirals
- A61P31/14—Antivirals for RNA viruses
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P43/00—Drugs for specific purposes, not provided for in groups A61P1/00-A61P41/00
-
- C—CHEMISTRY; METALLURGY
- C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
- C12Q—MEASURING OR TESTING PROCESSES INVOLVING ENZYMES, NUCLEIC ACIDS OR MICROORGANISMS; COMPOSITIONS OR TEST PAPERS THEREFOR; PROCESSES OF PREPARING SUCH COMPOSITIONS; CONDITION-RESPONSIVE CONTROL IN MICROBIOLOGICAL OR ENZYMOLOGICAL PROCESSES
- C12Q1/00—Measuring or testing processes involving enzymes, nucleic acids or microorganisms; Compositions therefor; Processes of preparing such compositions
- C12Q1/70—Measuring or testing processes involving enzymes, nucleic acids or microorganisms; Compositions therefor; Processes of preparing such compositions involving virus or bacteriophage
- C12Q1/701—Specific hybridization probes
- C12Q1/706—Specific hybridization probes for hepatitis
- C12Q1/707—Specific hybridization probes for hepatitis non-A, non-B Hepatitis, excluding hepatitis D
-
- G—PHYSICS
- G01—MEASURING; TESTING
- G01N—INVESTIGATING OR ANALYSING MATERIALS BY DETERMINING THEIR CHEMICAL OR PHYSICAL PROPERTIES
- G01N33/00—Investigating or analysing materials by specific methods not covered by groups G01N1/00 - G01N31/00
- G01N33/48—Biological material, e.g. blood, urine; Haemocytometers
- G01N33/50—Chemical analysis of biological material, e.g. blood, urine; Testing involving biospecific ligand binding methods; Immunological testing
- G01N33/53—Immunoassay; Biospecific binding assay; Materials therefor
- G01N33/543—Immunoassay; Biospecific binding assay; Materials therefor with an insoluble carrier for immobilising immunochemicals
- G01N33/54306—Solid-phase reaction mechanisms
-
- G—PHYSICS
- G01—MEASURING; TESTING
- G01N—INVESTIGATING OR ANALYSING MATERIALS BY DETERMINING THEIR CHEMICAL OR PHYSICAL PROPERTIES
- G01N33/00—Investigating or analysing materials by specific methods not covered by groups G01N1/00 - G01N31/00
- G01N33/48—Biological material, e.g. blood, urine; Haemocytometers
- G01N33/50—Chemical analysis of biological material, e.g. blood, urine; Testing involving biospecific ligand binding methods; Immunological testing
- G01N33/53—Immunoassay; Biospecific binding assay; Materials therefor
- G01N33/543—Immunoassay; Biospecific binding assay; Materials therefor with an insoluble carrier for immobilising immunochemicals
- G01N33/54393—Improving reaction conditions or stability, e.g. by coating or irradiation of surface, by reduction of non-specific binding, by promotion of specific binding
-
- G—PHYSICS
- G01—MEASURING; TESTING
- G01N—INVESTIGATING OR ANALYSING MATERIALS BY DETERMINING THEIR CHEMICAL OR PHYSICAL PROPERTIES
- G01N33/00—Investigating or analysing materials by specific methods not covered by groups G01N1/00 - G01N31/00
- G01N33/48—Biological material, e.g. blood, urine; Haemocytometers
- G01N33/50—Chemical analysis of biological material, e.g. blood, urine; Testing involving biospecific ligand binding methods; Immunological testing
- G01N33/53—Immunoassay; Biospecific binding assay; Materials therefor
- G01N33/576—Immunoassay; Biospecific binding assay; Materials therefor for hepatitis
-
- G—PHYSICS
- G01—MEASURING; TESTING
- G01N—INVESTIGATING OR ANALYSING MATERIALS BY DETERMINING THEIR CHEMICAL OR PHYSICAL PROPERTIES
- G01N33/00—Investigating or analysing materials by specific methods not covered by groups G01N1/00 - G01N31/00
- G01N33/48—Biological material, e.g. blood, urine; Haemocytometers
- G01N33/50—Chemical analysis of biological material, e.g. blood, urine; Testing involving biospecific ligand binding methods; Immunological testing
- G01N33/53—Immunoassay; Biospecific binding assay; Materials therefor
- G01N33/576—Immunoassay; Biospecific binding assay; Materials therefor for hepatitis
- G01N33/5767—Immunoassay; Biospecific binding assay; Materials therefor for hepatitis non-A, non-B hepatitis
-
- C—CHEMISTRY; METALLURGY
- C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
- C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
- C12N2770/00—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA ssRNA viruses positive-sense
- C12N2770/00011—Details
- C12N2770/24011—Flaviviridae
- C12N2770/24211—Hepacivirus, e.g. hepatitis C virus, hepatitis G virus
- C12N2770/24222—New viral proteins or individual genes, new structural or functional aspects of known viral proteins or genes
Landscapes
- Health & Medical Sciences (AREA)
- Life Sciences & Earth Sciences (AREA)
- Chemical & Material Sciences (AREA)
- Immunology (AREA)
- Engineering & Computer Science (AREA)
- Molecular Biology (AREA)
- Biomedical Technology (AREA)
- Hematology (AREA)
- Urology & Nephrology (AREA)
- General Health & Medical Sciences (AREA)
- Medicinal Chemistry (AREA)
- Biochemistry (AREA)
- Organic Chemistry (AREA)
- Biotechnology (AREA)
- Microbiology (AREA)
- Analytical Chemistry (AREA)
- Physics & Mathematics (AREA)
- General Physics & Mathematics (AREA)
- Food Science & Technology (AREA)
- Pathology (AREA)
- Cell Biology (AREA)
- Communicable Diseases (AREA)
- Proteomics, Peptides & Aminoacids (AREA)
- Chemical Kinetics & Catalysis (AREA)
- Virology (AREA)
- Wood Science & Technology (AREA)
- Biophysics (AREA)
- Genetics & Genomics (AREA)
- Zoology (AREA)
- Bioinformatics & Cheminformatics (AREA)
- General Engineering & Computer Science (AREA)
- Veterinary Medicine (AREA)
- Public Health (AREA)
- Animal Behavior & Ethology (AREA)
- Pharmacology & Pharmacy (AREA)
- Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
- Gastroenterology & Hepatology (AREA)
- General Chemical & Material Sciences (AREA)
- Oncology (AREA)
- Peptides Or Proteins (AREA)
Applications Claiming Priority (1)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| EP98870087 | 1998-04-17 |
Publications (1)
| Publication Number | Publication Date |
|---|---|
| PT1471074E true PT1471074E (pt) | 2008-10-23 |
Family
ID=8237028
Family Applications (2)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| PT04103238T PT1471074E (pt) | 1998-04-17 | 1999-04-15 | Ensaios melhorados de diagnóstico imunológico utilizando agentes redutores |
| PT99920678T PT1071955E (pt) | 1998-04-17 | 1999-04-15 | Ensaios melhorados de diagnostico imunologico utilizando agentes redutores |
Family Applications After (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| PT99920678T PT1071955E (pt) | 1998-04-17 | 1999-04-15 | Ensaios melhorados de diagnostico imunologico utilizando agentes redutores |
Country Status (22)
| Country | Link |
|---|---|
| US (1) | US7935490B2 (pt) |
| EP (2) | EP1071955B2 (pt) |
| JP (2) | JP2002512370A (pt) |
| KR (1) | KR20010042807A (pt) |
| CN (1) | CN1305589A (pt) |
| AT (2) | ATE401340T1 (pt) |
| AU (1) | AU751362B2 (pt) |
| BR (1) | BRPI9909678B8 (pt) |
| CA (2) | CA2658218C (pt) |
| CY (1) | CY1108424T1 (pt) |
| CZ (1) | CZ298268B6 (pt) |
| DE (2) | DE69920895T3 (pt) |
| DK (2) | DK1071955T4 (pt) |
| ES (2) | ES2230851T5 (pt) |
| HK (1) | HK1036653A1 (pt) |
| HU (1) | HUP0101719A3 (pt) |
| IL (1) | IL138791A0 (pt) |
| PL (1) | PL343469A1 (pt) |
| PT (2) | PT1471074E (pt) |
| TR (4) | TR200202213T2 (pt) |
| WO (1) | WO1999054735A1 (pt) |
| ZA (1) | ZA200005445B (pt) |
Families Citing this family (24)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| DK1090033T4 (da) * | 1998-06-24 | 2008-03-31 | Innogenetics Nv | Partikler af HCV-kappeproteiner: Anvendelse til vaccination |
| ATE375804T1 (de) * | 2000-08-17 | 2007-11-15 | Tripep Ab | Ribavirin-enthaltende vakzine |
| US7022830B2 (en) | 2000-08-17 | 2006-04-04 | Tripep Ab | Hepatitis C virus codon optimized non-structural NS3/4A fusion gene |
| AR035867A1 (es) * | 2001-04-24 | 2004-07-21 | Innogenetics Nv | Una particula semejante a un virus hcv formada por una proteina de envoltura de hcv, un metodo para formar dicha particula, un medicamento que la contiene, una vacuna, un metodo de deteccion, un kit de diagnostico, el uso de cepas de hansenula o saccharomyces para la expresion de una proteina hcv, e |
| JP2004108914A (ja) * | 2002-09-18 | 2004-04-08 | Kudo Norio | コラーゲンの測定方法 |
| EP1558283A2 (en) * | 2002-11-08 | 2005-08-03 | Innogenetics N.V. | Hcv vaccine compositions comprising e1 and ns3 peptides |
| US20050014136A1 (en) * | 2003-05-28 | 2005-01-20 | Innogenetics N.V. | Modified HCV NS5 |
| EP1691198B1 (en) * | 2003-10-28 | 2010-10-20 | Advanced Life Science Institute, Inc. | Method of detecting hepatitis c virus |
| CA2657223A1 (en) * | 2006-07-07 | 2008-01-10 | Pall Corporation | Use of denaturing agents during affinity capture |
| CA2693941A1 (en) * | 2007-07-16 | 2009-01-22 | Pfizer Inc. | Methods of improving a genomic marker index of dairy animals and products |
| BRPI0816776A2 (pt) * | 2007-09-12 | 2019-09-24 | Pfizer | métodos para usar marcadores genéticos e interações epistáticas relacionadas |
| BRPI0818300A2 (pt) * | 2007-10-03 | 2017-05-09 | Pfizer | marcadores genéticos para gado com chifres e sem chifres e processos relacionados |
| BRPI0820777A2 (pt) * | 2007-12-17 | 2015-06-16 | Pfizer | Métodos para melhorar os perfis genéticos de animais leiteiros e produtos |
| WO2010006604A1 (en) * | 2008-07-16 | 2010-01-21 | Radiometer Medical Aps | High capacity solid phase |
| CN102081018A (zh) * | 2009-11-30 | 2011-06-01 | 希森美康株式会社 | 样品的预处理方法及hcv的免疫测定方法 |
| FR2984328B1 (fr) | 2011-12-20 | 2016-12-30 | Bio-Rad Innovations | Procede de detection d'une infection par le virus de l'hepatite c |
| EP3213083B1 (en) | 2014-10-29 | 2020-08-19 | Abbott Laboratories | Subject anti-hcv antibody detection assays employing ns3 capture peptides |
| CN109870581B (zh) * | 2017-12-04 | 2021-05-04 | 厦门万泰凯瑞生物技术有限公司 | 一种定量检测HBsAg的试剂盒及方法 |
| CN109678954B (zh) * | 2018-12-29 | 2022-01-07 | 山东莱博生物科技有限公司 | 一对能够特异性识别hcv ns3蛋白的单克隆抗体及其应用 |
| CN110988362B (zh) * | 2019-12-20 | 2023-11-14 | 迈克生物股份有限公司 | 抗组蛋白抗体测定试剂、试剂盒及其使用方法 |
| CN112225783B (zh) * | 2020-09-16 | 2021-08-31 | 东莞市朋志生物科技有限公司 | Hcv重组抗原及其突变体 |
| CN112285361B (zh) * | 2020-09-27 | 2023-12-05 | 中国人民解放军空军军医大学 | 排除抗-cd38单克隆抗体药物对抗人球蛋白检测干扰的试剂 |
| CN113219169B (zh) * | 2021-05-22 | 2021-12-17 | 北京金诺百泰生物技术有限公司 | 生物检测用封闭剂及其制备方法、包被板及应用该包被板的试剂盒 |
| CN115112897A (zh) * | 2021-12-10 | 2022-09-27 | 中山大学附属第八医院（深圳福田） | 一种用于鉴别抗体检测生物学假阳性的方法 |
Family Cites Families (21)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| EP0139526A2 (en) * | 1983-10-20 | 1985-05-02 | Warner-Lambert Company | An insolubilized stable specific binding protein |
| US4616078A (en) * | 1985-04-08 | 1986-10-07 | Eli Lilly And Company | Process for purifying proinsulin-like materials |
| CA1340877C (en) * | 1987-12-28 | 2000-01-18 | Takashi Sugiyama | Elastase inhibitory polypeptide and process for production thereof by recombinant gene technology |
| ATE92633T1 (de) | 1988-05-11 | 1993-08-15 | Abbott Lab | Verfahren zur erhoehung der spezifizitaet in kompetitiven immuntests. |
| US4923967A (en) * | 1988-09-26 | 1990-05-08 | Eli Lilly And Company | Purification and refolding of recombinant proteins |
| US6194140B1 (en) * | 1990-04-04 | 2001-02-27 | Chiron Corporation | HCV NS3 protein fragments having helicase activity and improved solubility |
| IE911129A1 (en) | 1990-04-04 | 1991-10-09 | Chiron Corp | Hepatitis c virus protease |
| US5606031A (en) * | 1990-04-06 | 1997-02-25 | Lile; Jack | Production and purification of biologically active recombinant neurotrophic protein in bacteria |
| RO117329B1 (ro) * | 1991-06-24 | 2002-01-30 | Chiron Corp Emeryville | Polipeptide care contin o secventa a virusului hepatitei c |
| JP3225468B2 (ja) | 1992-08-28 | 2001-11-05 | ダイナボット株式会社 | 抗体測定用試薬 |
| ATE373093T1 (de) | 1993-04-27 | 2007-09-15 | Innogenetics Nv | Sequenzen der genotype des hepatitis-c-virus sowie ihre verwendung als arzneimitteln und diagnostika |
| EP0979867A3 (en) | 1993-11-04 | 2007-06-13 | Innogenetics N.V. | Immunodominant human T-cell epitopes of hepatitis C virus |
| ES2167372T3 (es) | 1994-06-23 | 2002-05-16 | Energy Answers Corp | Sistema para la obtencion de productos derivados de la ceniza y de energia a partir de residuos rechazados. |
| DK0721505T4 (da) * | 1994-07-29 | 2006-08-14 | Innogenetics Nv | Rensede hepatitis C-virus-kappeproteiner til diagnostisk og terapeutisk anvendelse |
| DE4428705A1 (de) | 1994-08-12 | 1996-02-15 | Boehringer Mannheim Gmbh | Rekombinantes Antigen aus der NS3-Region des Hepatitis C Virus |
| JPH0862219A (ja) | 1994-08-19 | 1996-03-08 | Dainabotsuto Kk | 還元型抗原に対する抗体アッセイ試薬及びそれを使用した測定方法 |
| US7129337B1 (en) | 1994-10-21 | 2006-10-31 | Innogenetics N.V. | Sequences of hepatitis C virus genotypes and their use as prophylactic, therapeutic and diagnostic agents |
| US5705330A (en) | 1995-04-14 | 1998-01-06 | Abbott Laboratories | Chemiluminescent immunoassay for antibody detection |
| US5616460A (en) | 1995-06-07 | 1997-04-01 | Abbott Laboratories | Buffer composition for reagents for immunoassay |
| ES2251028T3 (es) | 1996-05-24 | 2006-04-16 | Chiron Corporation | Proteina de fusion de epitopos multiples. |
| KR100487455B1 (ko) * | 1997-01-13 | 2005-05-09 | 롬 앤드 하스 일렉트로닉 머티리얼스 씨엠피 홀딩스, 인코포레이티드 | 사진석판술에 의해 유도된 표면 패턴(들)이 있는 연마용 중합체 패드 및 이에 관련된 방법 |
-
1999
- 1999-04-15 AU AU38171/99A patent/AU751362B2/en not_active Expired
- 1999-04-15 EP EP99920678A patent/EP1071955B2/en not_active Expired - Lifetime
- 1999-04-15 KR KR1020007011555A patent/KR20010042807A/ko not_active Application Discontinuation
- 1999-04-15 DE DE69920895T patent/DE69920895T3/de not_active Expired - Lifetime
- 1999-04-15 CA CA2658218A patent/CA2658218C/en not_active Expired - Lifetime
- 1999-04-15 JP JP2000545027A patent/JP2002512370A/ja active Pending
- 1999-04-15 IL IL13879199A patent/IL138791A0/xx unknown
- 1999-04-15 AT AT04103238T patent/ATE401340T1/de active
- 1999-04-15 HU HU0101719A patent/HUP0101719A3/hu unknown
- 1999-04-15 AT AT99920678T patent/ATE278960T1/de active
- 1999-04-15 CZ CZ20003819A patent/CZ298268B6/cs not_active IP Right Cessation
- 1999-04-15 PT PT04103238T patent/PT1471074E/pt unknown
- 1999-04-15 DK DK99920678T patent/DK1071955T4/da active
- 1999-04-15 CN CN99807283A patent/CN1305589A/zh active Pending
- 1999-04-15 ES ES99920678T patent/ES2230851T5/es not_active Expired - Lifetime
- 1999-04-15 TR TR2002/02213T patent/TR200202213T2/xx unknown
- 1999-04-15 TR TR2001/01647T patent/TR200101647T2/xx unknown
- 1999-04-15 DE DE69939132T patent/DE69939132D1/de not_active Expired - Lifetime
- 1999-04-15 PT PT99920678T patent/PT1071955E/pt unknown
- 1999-04-15 EP EP04103238A patent/EP1471074B1/en not_active Expired - Lifetime
- 1999-04-15 PL PL99343469A patent/PL343469A1/xx unknown
- 1999-04-15 TR TR2001/01648T patent/TR200101648T2/xx unknown
- 1999-04-15 BR BRPI9909678A patent/BRPI9909678B8/pt not_active IP Right Cessation
- 1999-04-15 ES ES04103238T patent/ES2310701T3/es not_active Expired - Lifetime
- 1999-04-15 DK DK04103238T patent/DK1471074T3/da active
- 1999-04-15 TR TR2000/03024T patent/TR200003024T2/xx unknown
- 1999-04-15 CA CA002324970A patent/CA2324970C/en not_active Expired - Lifetime
- 1999-04-15 WO PCT/EP1999/002547 patent/WO1999054735A1/en active IP Right Grant
-
2000
- 2000-10-05 ZA ZA200005445A patent/ZA200005445B/en unknown
-
2001
- 2001-07-31 HK HK01105349A patent/HK1036653A1/xx not_active IP Right Cessation
-
2005
- 2005-01-05 JP JP2005000767A patent/JP3974620B2/ja not_active Expired - Lifetime
-
2006
- 2006-08-02 US US11/497,259 patent/US7935490B2/en not_active Expired - Fee Related
-
2008
- 2008-10-16 CY CY20081101157T patent/CY1108424T1/el unknown
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