TR200101648T2 - İndirgeme ajanlarını kullanarak geliştirilen immünodiagnostik tahliller - Google Patents
İndirgeme ajanlarını kullanarak geliştirilen immünodiagnostik tahlillerInfo
- Publication number
- TR200101648T2 TR200101648T2 TR2001/01648T TR200101648T TR200101648T2 TR 200101648 T2 TR200101648 T2 TR 200101648T2 TR 2001/01648 T TR2001/01648 T TR 2001/01648T TR 200101648 T TR200101648 T TR 200101648T TR 200101648 T2 TR200101648 T2 TR 200101648T2
- Authority
- TR
- Turkey
- Prior art keywords
- purification
- sulfonated
- reducing agents
- solid phase
- relates
- Prior art date
Links
- 238000003556 assay Methods 0.000 title abstract 2
- 239000003638 chemical reducing agent Substances 0.000 title abstract 2
- 238000000746 purification Methods 0.000 abstract 3
- 102000007056 Recombinant Fusion Proteins Human genes 0.000 abstract 2
- 108010008281 Recombinant Fusion Proteins Proteins 0.000 abstract 2
- 239000007790 solid phase Substances 0.000 abstract 2
- VEXZGXHMUGYJMC-UHFFFAOYSA-M Chloride anion Chemical compound [Cl-] VEXZGXHMUGYJMC-UHFFFAOYSA-M 0.000 abstract 1
- 239000000427 antigen Substances 0.000 abstract 1
- 102000036639 antigens Human genes 0.000 abstract 1
- 108091007433 antigens Proteins 0.000 abstract 1
- 239000013592 cell lysate Substances 0.000 abstract 1
- XUJNEKJLAYXESH-UHFFFAOYSA-N cysteine Natural products SCC(N)C(O)=O XUJNEKJLAYXESH-UHFFFAOYSA-N 0.000 abstract 1
- 235000018417 cysteine Nutrition 0.000 abstract 1
- 230000009089 cytolysis Effects 0.000 abstract 1
- 239000003599 detergent Substances 0.000 abstract 1
- 230000008034 disappearance Effects 0.000 abstract 1
- 230000036039 immunity Effects 0.000 abstract 1
- 238000003018 immunoassay Methods 0.000 abstract 1
- 238000000034 method Methods 0.000 abstract 1
- 235000018102 proteins Nutrition 0.000 abstract 1
- 102000004169 proteins and genes Human genes 0.000 abstract 1
- 108090000623 proteins and genes Proteins 0.000 abstract 1
- 238000006277 sulfonation reaction Methods 0.000 abstract 1
- 208000024891 symptom Diseases 0.000 abstract 1
Classifications
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- G—PHYSICS
- G01—MEASURING; TESTING
- G01N—INVESTIGATING OR ANALYSING MATERIALS BY DETERMINING THEIR CHEMICAL OR PHYSICAL PROPERTIES
- G01N33/00—Investigating or analysing materials by specific methods not covered by groups G01N1/00 - G01N31/00
- G01N33/48—Biological material, e.g. blood, urine; Haemocytometers
- G01N33/50—Chemical analysis of biological material, e.g. blood, urine; Testing involving biospecific ligand binding methods; Immunological testing
- G01N33/53—Immunoassay; Biospecific binding assay; Materials therefor
- G01N33/573—Immunoassay; Biospecific binding assay; Materials therefor for enzymes or isoenzymes
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07K—PEPTIDES
- C07K14/00—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof
- C07K14/005—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from viruses
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P31/00—Antiinfectives, i.e. antibiotics, antiseptics, chemotherapeutics
- A61P31/12—Antivirals
- A61P31/14—Antivirals for RNA viruses
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P43/00—Drugs for specific purposes, not provided for in groups A61P1/00-A61P41/00
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- C—CHEMISTRY; METALLURGY
- C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
- C12Q—MEASURING OR TESTING PROCESSES INVOLVING ENZYMES, NUCLEIC ACIDS OR MICROORGANISMS; COMPOSITIONS OR TEST PAPERS THEREFOR; PROCESSES OF PREPARING SUCH COMPOSITIONS; CONDITION-RESPONSIVE CONTROL IN MICROBIOLOGICAL OR ENZYMOLOGICAL PROCESSES
- C12Q1/00—Measuring or testing processes involving enzymes, nucleic acids or microorganisms; Compositions therefor; Processes of preparing such compositions
- C12Q1/70—Measuring or testing processes involving enzymes, nucleic acids or microorganisms; Compositions therefor; Processes of preparing such compositions involving virus or bacteriophage
- C12Q1/701—Specific hybridization probes
- C12Q1/706—Specific hybridization probes for hepatitis
- C12Q1/707—Specific hybridization probes for hepatitis non-A, non-B Hepatitis, excluding hepatitis D
-
- G—PHYSICS
- G01—MEASURING; TESTING
- G01N—INVESTIGATING OR ANALYSING MATERIALS BY DETERMINING THEIR CHEMICAL OR PHYSICAL PROPERTIES
- G01N33/00—Investigating or analysing materials by specific methods not covered by groups G01N1/00 - G01N31/00
- G01N33/48—Biological material, e.g. blood, urine; Haemocytometers
- G01N33/50—Chemical analysis of biological material, e.g. blood, urine; Testing involving biospecific ligand binding methods; Immunological testing
- G01N33/53—Immunoassay; Biospecific binding assay; Materials therefor
- G01N33/543—Immunoassay; Biospecific binding assay; Materials therefor with an insoluble carrier for immobilising immunochemicals
- G01N33/54306—Solid-phase reaction mechanisms
-
- G—PHYSICS
- G01—MEASURING; TESTING
- G01N—INVESTIGATING OR ANALYSING MATERIALS BY DETERMINING THEIR CHEMICAL OR PHYSICAL PROPERTIES
- G01N33/00—Investigating or analysing materials by specific methods not covered by groups G01N1/00 - G01N31/00
- G01N33/48—Biological material, e.g. blood, urine; Haemocytometers
- G01N33/50—Chemical analysis of biological material, e.g. blood, urine; Testing involving biospecific ligand binding methods; Immunological testing
- G01N33/53—Immunoassay; Biospecific binding assay; Materials therefor
- G01N33/543—Immunoassay; Biospecific binding assay; Materials therefor with an insoluble carrier for immobilising immunochemicals
- G01N33/54393—Improving reaction conditions or stability, e.g. by coating or irradiation of surface, by reduction of non-specific binding, by promotion of specific binding
-
- G—PHYSICS
- G01—MEASURING; TESTING
- G01N—INVESTIGATING OR ANALYSING MATERIALS BY DETERMINING THEIR CHEMICAL OR PHYSICAL PROPERTIES
- G01N33/00—Investigating or analysing materials by specific methods not covered by groups G01N1/00 - G01N31/00
- G01N33/48—Biological material, e.g. blood, urine; Haemocytometers
- G01N33/50—Chemical analysis of biological material, e.g. blood, urine; Testing involving biospecific ligand binding methods; Immunological testing
- G01N33/53—Immunoassay; Biospecific binding assay; Materials therefor
- G01N33/576—Immunoassay; Biospecific binding assay; Materials therefor for hepatitis
-
- G—PHYSICS
- G01—MEASURING; TESTING
- G01N—INVESTIGATING OR ANALYSING MATERIALS BY DETERMINING THEIR CHEMICAL OR PHYSICAL PROPERTIES
- G01N33/00—Investigating or analysing materials by specific methods not covered by groups G01N1/00 - G01N31/00
- G01N33/48—Biological material, e.g. blood, urine; Haemocytometers
- G01N33/50—Chemical analysis of biological material, e.g. blood, urine; Testing involving biospecific ligand binding methods; Immunological testing
- G01N33/53—Immunoassay; Biospecific binding assay; Materials therefor
- G01N33/576—Immunoassay; Biospecific binding assay; Materials therefor for hepatitis
- G01N33/5767—Immunoassay; Biospecific binding assay; Materials therefor for hepatitis non-A, non-B hepatitis
-
- C—CHEMISTRY; METALLURGY
- C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
- C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
- C12N2770/00—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA ssRNA viruses positive-sense
- C12N2770/00011—Details
- C12N2770/24011—Flaviviridae
- C12N2770/24211—Hepacivirus, e.g. hepatitis C virus, hepatitis G virus
- C12N2770/24222—New viral proteins or individual genes, new structural or functional aspects of known viral proteins or genes
Landscapes
- Health & Medical Sciences (AREA)
- Life Sciences & Earth Sciences (AREA)
- Chemical & Material Sciences (AREA)
- Immunology (AREA)
- Engineering & Computer Science (AREA)
- Molecular Biology (AREA)
- Urology & Nephrology (AREA)
- Hematology (AREA)
- Biomedical Technology (AREA)
- General Health & Medical Sciences (AREA)
- Biochemistry (AREA)
- Medicinal Chemistry (AREA)
- Organic Chemistry (AREA)
- Biotechnology (AREA)
- Microbiology (AREA)
- Analytical Chemistry (AREA)
- Physics & Mathematics (AREA)
- Food Science & Technology (AREA)
- General Physics & Mathematics (AREA)
- Cell Biology (AREA)
- Communicable Diseases (AREA)
- Pathology (AREA)
- Chemical Kinetics & Catalysis (AREA)
- Proteomics, Peptides & Aminoacids (AREA)
- Virology (AREA)
- Zoology (AREA)
- Genetics & Genomics (AREA)
- Wood Science & Technology (AREA)
- Biophysics (AREA)
- Bioinformatics & Cheminformatics (AREA)
- Pharmacology & Pharmacy (AREA)
- Veterinary Medicine (AREA)
- Public Health (AREA)
- Animal Behavior & Ethology (AREA)
- Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
- General Chemical & Material Sciences (AREA)
- General Engineering & Computer Science (AREA)
- Gastroenterology & Hepatology (AREA)
- Oncology (AREA)
- Peptides Or Proteins (AREA)
Abstract
Mevcut bulus; kati faz bagisiklik tahlili (immünoassay) ile ilgili olup, bahsedilen kati faz üzerinde, indirgeyici bir ajanin varliginda, bir antijenden olusmaktadir. Bunun yaninda, mevcut bulus; sistein içeren, rekombinant olarak tanimlanan bir proteini saflastirmak için bir metot ile ilgili olup, asagidaki basamaklardan en az 2, tersihen 3 veya 4'ü ve hatta daha çok da, tercihen tümünden olusmaktadir: (a) bir lisatin rekombinant tasiyici canli hücrelerinden sülfonasyonu veya guanidinyum klorürün varliginda, rekombinant tasiyici canli hücrelerinin belirtilerinin giderek kaybolmasi (lisis), arkasindan da hücre lisatinin sülfonasyonu, (b) tercihen, hücre kalintilarinin uzaklastirilmasindan sonra, bir zvitteryonik deterjan ile muamele, (c) rekombinant proteinin sülfonasyonlu versiyonunun saflastirilmasi veya ardisik olarak gerçeklestirilen zvitteryonik deterjanin uzaklastirilmasi ile, sülfonasyonlu rekombinant proteinin saflastirilmasi olup, bahsedilen saflastirma islemi, DEVAMI VAR.
Applications Claiming Priority (1)
Application Number | Priority Date | Filing Date | Title |
---|---|---|---|
EP98870087 | 1998-04-17 |
Publications (1)
Publication Number | Publication Date |
---|---|
TR200101648T2 true TR200101648T2 (tr) | 2002-06-21 |
Family
ID=8237028
Family Applications (4)
Application Number | Title | Priority Date | Filing Date |
---|---|---|---|
TR2000/03024T TR200003024T2 (tr) | 1998-04-17 | 1999-04-15 | İndirgeme ajanlarını kullanarak geliştirilen immünodiagnostik tahliller. |
TR2001/01648T TR200101648T2 (tr) | 1998-04-17 | 1999-04-15 | İndirgeme ajanlarını kullanarak geliştirilen immünodiagnostik tahliller |
TR2002/02213T TR200202213T2 (tr) | 1998-04-17 | 1999-04-15 | İndirgeme ajanlarını kullanarak geliştirilen immünodiagnostik tahliller |
TR2001/01647T TR200101647T2 (tr) | 1998-04-17 | 1999-04-15 | İndirgeme ajanlarını kullanarak geliştirilen immünodiagnostik tahliller. |
Family Applications Before (1)
Application Number | Title | Priority Date | Filing Date |
---|---|---|---|
TR2000/03024T TR200003024T2 (tr) | 1998-04-17 | 1999-04-15 | İndirgeme ajanlarını kullanarak geliştirilen immünodiagnostik tahliller. |
Family Applications After (2)
Application Number | Title | Priority Date | Filing Date |
---|---|---|---|
TR2002/02213T TR200202213T2 (tr) | 1998-04-17 | 1999-04-15 | İndirgeme ajanlarını kullanarak geliştirilen immünodiagnostik tahliller |
TR2001/01647T TR200101647T2 (tr) | 1998-04-17 | 1999-04-15 | İndirgeme ajanlarını kullanarak geliştirilen immünodiagnostik tahliller. |
Country Status (22)
Country | Link |
---|---|
US (1) | US7935490B2 (tr) |
EP (2) | EP1071955B2 (tr) |
JP (2) | JP2002512370A (tr) |
KR (1) | KR20010042807A (tr) |
CN (1) | CN1305589A (tr) |
AT (2) | ATE278960T1 (tr) |
AU (1) | AU751362B2 (tr) |
BR (1) | BRPI9909678B8 (tr) |
CA (2) | CA2324970C (tr) |
CY (1) | CY1108424T1 (tr) |
CZ (1) | CZ298268B6 (tr) |
DE (2) | DE69920895T3 (tr) |
DK (2) | DK1471074T3 (tr) |
ES (2) | ES2230851T5 (tr) |
HK (1) | HK1036653A1 (tr) |
HU (1) | HUP0101719A3 (tr) |
IL (1) | IL138791A0 (tr) |
PL (1) | PL343469A1 (tr) |
PT (2) | PT1071955E (tr) |
TR (4) | TR200003024T2 (tr) |
WO (1) | WO1999054735A1 (tr) |
ZA (1) | ZA200005445B (tr) |
Families Citing this family (23)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
WO1999067285A1 (en) * | 1998-06-24 | 1999-12-29 | Innogenetics N.V. | Particles of hcv envelope proteins: use for vaccination |
US7022830B2 (en) | 2000-08-17 | 2006-04-04 | Tripep Ab | Hepatitis C virus codon optimized non-structural NS3/4A fusion gene |
US6960569B2 (en) * | 2000-08-17 | 2005-11-01 | Tripep Ab | Hepatitis C virus non-structural NS3/4A fusion gene |
US7314925B2 (en) * | 2001-04-24 | 2008-01-01 | Innogenetics N.V. | Constructs and methods for expression of recombinant HCV envelope proteins |
JP2004108914A (ja) * | 2002-09-18 | 2004-04-08 | Kudo Norio | コラーゲンの測定方法 |
CA2504711A1 (en) * | 2002-11-08 | 2004-05-21 | Innogenetics N.V. | Hcv vaccine compositions comprising e1 and ns3 peptides |
US20050014136A1 (en) * | 2003-05-28 | 2005-01-20 | Innogenetics N.V. | Modified HCV NS5 |
DE602004029707D1 (de) * | 2003-10-28 | 2010-12-02 | Advanced Life Science Inst Inc | Verfahren zum nachweis von hepatitis-c-virus |
EP2041572A1 (en) * | 2006-07-07 | 2009-04-01 | Pall Corporation | Use of denaturing agents during affinity capture |
AU2008276488A1 (en) * | 2007-07-16 | 2009-01-22 | Pfizer Inc. | Methods of improving a genomic marker index of dairy animals and products |
AU2008300011A1 (en) * | 2007-09-12 | 2009-03-19 | Pfizer, Inc. | Methods of using genetic markers and related epistatic interactions |
CN101883869A (zh) * | 2007-10-03 | 2010-11-10 | 美国辉瑞有限公司 | 有角牛和无角牛的遗传标志及其相关方法 |
JP2011505872A (ja) * | 2007-12-17 | 2011-03-03 | ファイザー・インク | 乳用動物および乳用生産物の遺伝的プロフィールを改良する方法 |
CN102089662B (zh) * | 2008-07-16 | 2015-05-27 | 雷迪奥米特医学公司 | 高容量固相 |
CN102081018A (zh) * | 2009-11-30 | 2011-06-01 | 希森美康株式会社 | 样品的预处理方法及hcv的免疫测定方法 |
FR2984328B1 (fr) | 2011-12-20 | 2016-12-30 | Bio-Rad Innovations | Procede de detection d'une infection par le virus de l'hepatite c |
JP6821562B2 (ja) * | 2014-10-29 | 2021-01-27 | アボット・ラボラトリーズAbbott Laboratories | Ns3捕捉ペプチドを使用して対象の抗hcv抗体を検出するアッセイ |
CN109870581B (zh) * | 2017-12-04 | 2021-05-04 | 厦门万泰凯瑞生物技术有限公司 | 一种定量检测HBsAg的试剂盒及方法 |
CN109678954B (zh) * | 2018-12-29 | 2022-01-07 | 山东莱博生物科技有限公司 | 一对能够特异性识别hcv ns3蛋白的单克隆抗体及其应用 |
CN110988362B (zh) * | 2019-12-20 | 2023-11-14 | 迈克生物股份有限公司 | 抗组蛋白抗体测定试剂、试剂盒及其使用方法 |
CN112225783B (zh) * | 2020-09-16 | 2021-08-31 | 东莞市朋志生物科技有限公司 | Hcv重组抗原及其突变体 |
CN112285361B (zh) * | 2020-09-27 | 2023-12-05 | 中国人民解放军空军军医大学 | 排除抗-cd38单克隆抗体药物对抗人球蛋白检测干扰的试剂 |
CN113219169B (zh) * | 2021-05-22 | 2021-12-17 | 北京金诺百泰生物技术有限公司 | 生物检测用封闭剂及其制备方法、包被板及应用该包被板的试剂盒 |
Family Cites Families (21)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
EP0139526A2 (en) * | 1983-10-20 | 1985-05-02 | Warner-Lambert Company | An insolubilized stable specific binding protein |
US4616078A (en) * | 1985-04-08 | 1986-10-07 | Eli Lilly And Company | Process for purifying proinsulin-like materials |
CA1340877C (en) * | 1987-12-28 | 2000-01-18 | Takashi Sugiyama | Elastase inhibitory polypeptide and process for production thereof by recombinant gene technology |
ATE92633T1 (de) | 1988-05-11 | 1993-08-15 | Abbott Lab | Verfahren zur erhoehung der spezifizitaet in kompetitiven immuntests. |
US4923967A (en) * | 1988-09-26 | 1990-05-08 | Eli Lilly And Company | Purification and refolding of recombinant proteins |
US6194140B1 (en) * | 1990-04-04 | 2001-02-27 | Chiron Corporation | HCV NS3 protein fragments having helicase activity and improved solubility |
EP0527788B1 (en) | 1990-04-04 | 2004-06-30 | Chiron Corporation | Hepatitis c virus protease |
US5606031A (en) * | 1990-04-06 | 1997-02-25 | Lile; Jack | Production and purification of biologically active recombinant neurotrophic protein in bacteria |
UA40572C2 (uk) * | 1991-06-24 | 2001-08-15 | Чірон Корпорейшн | Поліпептид, що містить укорочену послідовність вірусу гепатиту с, ізольований епітоп, реагент для імуноаналізу на вірус гепатиту с (варіанти), спосіб виявлення наявності антитіл (варіанти) |
JP3225468B2 (ja) | 1992-08-28 | 2001-11-05 | ダイナボット株式会社 | 抗体測定用試薬 |
DE69435023T2 (de) | 1993-04-27 | 2008-09-11 | N.V. Innogenetics S.A. | Sequenzen der genotype des hepatitis-c-virus sowie ihre verwendung als arzneimittel und diagnostika |
EP0725824B1 (en) | 1993-11-04 | 2003-04-09 | Innogenetics N.V. | Immunodominant human t-cell epitopes of hepatitis c virus |
ES2167372T3 (es) | 1994-06-23 | 2002-05-16 | Energy Answers Corp | Sistema para la obtencion de productos derivados de la ceniza y de energia a partir de residuos rechazados. |
US6150134A (en) * | 1994-07-29 | 2000-11-21 | Innogenetics, N.V. | Purified hepatitis C virus envelope proteins for diagnostic and therapeutic use |
DE4428705A1 (de) | 1994-08-12 | 1996-02-15 | Boehringer Mannheim Gmbh | Rekombinantes Antigen aus der NS3-Region des Hepatitis C Virus |
JPH0862219A (ja) | 1994-08-19 | 1996-03-08 | Dainabotsuto Kk | 還元型抗原に対する抗体アッセイ試薬及びそれを使用した測定方法 |
EP1076092A3 (en) | 1994-10-21 | 2001-03-28 | Innogenetics N.V. | Sequences of hepatitis C virus type10 and their use as prophylactic, therapeutic and diagnostic agents |
US5705330A (en) | 1995-04-14 | 1998-01-06 | Abbott Laboratories | Chemiluminescent immunoassay for antibody detection |
US5616460A (en) * | 1995-06-07 | 1997-04-01 | Abbott Laboratories | Buffer composition for reagents for immunoassay |
DE69734776T2 (de) | 1996-05-24 | 2006-08-17 | Chiron Corp. (N.D.Ges.D. Staates Delaware), Emeryville | Fusionsprotein mit multiplen Epitopen |
JP4163756B2 (ja) * | 1997-01-13 | 2008-10-08 | ローム アンド ハース エレクトロニック マテリアルズ シーエムピー ホウルディングス インコーポレイテッド | ホトリソグラフィーによって形成された表面パターンを有するポリマー研磨パッド及びこれに関する方法 |
-
1999
- 1999-04-15 TR TR2000/03024T patent/TR200003024T2/tr unknown
- 1999-04-15 IL IL13879199A patent/IL138791A0/xx unknown
- 1999-04-15 ES ES99920678T patent/ES2230851T5/es not_active Expired - Lifetime
- 1999-04-15 ES ES04103238T patent/ES2310701T3/es not_active Expired - Lifetime
- 1999-04-15 CA CA002324970A patent/CA2324970C/en not_active Expired - Lifetime
- 1999-04-15 DE DE69920895T patent/DE69920895T3/de not_active Expired - Lifetime
- 1999-04-15 EP EP99920678A patent/EP1071955B2/en not_active Expired - Lifetime
- 1999-04-15 AT AT99920678T patent/ATE278960T1/de active
- 1999-04-15 CA CA2658218A patent/CA2658218C/en not_active Expired - Lifetime
- 1999-04-15 PT PT99920678T patent/PT1071955E/pt unknown
- 1999-04-15 DK DK04103238T patent/DK1471074T3/da active
- 1999-04-15 CN CN99807283A patent/CN1305589A/zh active Pending
- 1999-04-15 TR TR2001/01648T patent/TR200101648T2/tr unknown
- 1999-04-15 TR TR2002/02213T patent/TR200202213T2/tr unknown
- 1999-04-15 DE DE69939132T patent/DE69939132D1/de not_active Expired - Lifetime
- 1999-04-15 BR BRPI9909678A patent/BRPI9909678B8/pt not_active IP Right Cessation
- 1999-04-15 HU HU0101719A patent/HUP0101719A3/hu unknown
- 1999-04-15 PL PL99343469A patent/PL343469A1/xx unknown
- 1999-04-15 AT AT04103238T patent/ATE401340T1/de active
- 1999-04-15 CZ CZ20003819A patent/CZ298268B6/cs not_active IP Right Cessation
- 1999-04-15 KR KR1020007011555A patent/KR20010042807A/ko not_active Application Discontinuation
- 1999-04-15 AU AU38171/99A patent/AU751362B2/en not_active Expired
- 1999-04-15 WO PCT/EP1999/002547 patent/WO1999054735A1/en active IP Right Grant
- 1999-04-15 PT PT04103238T patent/PT1471074E/pt unknown
- 1999-04-15 JP JP2000545027A patent/JP2002512370A/ja active Pending
- 1999-04-15 DK DK99920678T patent/DK1071955T4/da active
- 1999-04-15 EP EP04103238A patent/EP1471074B1/en not_active Expired - Lifetime
- 1999-04-15 TR TR2001/01647T patent/TR200101647T2/tr unknown
-
2000
- 2000-10-05 ZA ZA200005445A patent/ZA200005445B/en unknown
-
2001
- 2001-07-31 HK HK01105349A patent/HK1036653A1/xx not_active IP Right Cessation
-
2005
- 2005-01-05 JP JP2005000767A patent/JP3974620B2/ja not_active Expired - Lifetime
-
2006
- 2006-08-02 US US11/497,259 patent/US7935490B2/en not_active Expired - Fee Related
-
2008
- 2008-10-16 CY CY20081101157T patent/CY1108424T1/el unknown
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