PT1443328E - Doseamento de cobalamina - Google Patents
Doseamento de cobalamina Download PDFInfo
- Publication number
- PT1443328E PT1443328E PT04009702T PT04009702T PT1443328E PT 1443328 E PT1443328 E PT 1443328E PT 04009702 T PT04009702 T PT 04009702T PT 04009702 T PT04009702 T PT 04009702T PT 1443328 E PT1443328 E PT 1443328E
- Authority
- PT
- Portugal
- Prior art keywords
- holo
- ligand
- cobalamin
- transcobalamin
- assay method
- Prior art date
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- FDJOLVPMNUYSCM-WZHZPDAFSA-L cobalt(3+);[(2r,3s,4r,5s)-5-(5,6-dimethylbenzimidazol-1-yl)-4-hydroxy-2-(hydroxymethyl)oxolan-3-yl] [(2r)-1-[3-[(1r,2r,3r,4z,7s,9z,12s,13s,14z,17s,18s,19r)-2,13,18-tris(2-amino-2-oxoethyl)-7,12,17-tris(3-amino-3-oxopropyl)-3,5,8,8,13,15,18,19-octamethyl-2 Chemical compound [Co+3].N#[C-].N([C@@H]([C@]1(C)[N-]\C([C@H]([C@@]1(CC(N)=O)C)CCC(N)=O)=C(\C)/C1=N/C([C@H]([C@@]1(CC(N)=O)C)CCC(N)=O)=C\C1=N\C([C@H](C1(C)C)CCC(N)=O)=C/1C)[C@@H]2CC(N)=O)=C\1[C@]2(C)CCC(=O)NC[C@@H](C)OP([O-])(=O)O[C@H]1[C@@H](O)[C@@H](N2C3=CC(C)=C(C)C=C3N=C2)O[C@@H]1CO FDJOLVPMNUYSCM-WZHZPDAFSA-L 0.000 title claims abstract description 122
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- WTFXARWRTYJXII-UHFFFAOYSA-N iron(2+);iron(3+);oxygen(2-) Chemical compound [O-2].[O-2].[O-2].[O-2].[Fe+2].[Fe+3].[Fe+3] WTFXARWRTYJXII-UHFFFAOYSA-N 0.000 description 1
- 230000002427 irreversible effect Effects 0.000 description 1
- 238000002955 isolation Methods 0.000 description 1
- 210000003734 kidney Anatomy 0.000 description 1
- 238000002372 labelling Methods 0.000 description 1
- 238000012332 laboratory investigation Methods 0.000 description 1
- 230000000670 limiting effect Effects 0.000 description 1
- HWYHZTIRURJOHG-UHFFFAOYSA-N luminol Chemical compound O=C1NNC(=O)C2=C1C(N)=CC=C2 HWYHZTIRURJOHG-UHFFFAOYSA-N 0.000 description 1
- 210000002540 macrophage Anatomy 0.000 description 1
- 238000004519 manufacturing process Methods 0.000 description 1
- 238000004949 mass spectrometry Methods 0.000 description 1
- 231100001016 megaloblastic anemia Toxicity 0.000 description 1
- 230000007102 metabolic function Effects 0.000 description 1
- 239000002207 metabolite Substances 0.000 description 1
- 229910052751 metal Inorganic materials 0.000 description 1
- 239000002184 metal Substances 0.000 description 1
- 150000002739 metals Chemical class 0.000 description 1
- 229930182817 methionine Natural products 0.000 description 1
- JEWJRMKHSMTXPP-BYFNXCQMSA-M methylcobalamin Chemical compound C[Co+]N([C@]1([H])[C@H](CC(N)=O)[C@]\2(CCC(=O)NC[C@H](C)OP(O)(=O)OC3[C@H]([C@H](O[C@@H]3CO)N3C4=CC(C)=C(C)C=C4N=C3)O)C)C/2=C(C)\C([C@H](C/2(C)C)CCC(N)=O)=N\C\2=C\C([C@H]([C@@]/2(CC(N)=O)C)CCC(N)=O)=N\C\2=C(C)/C2=N[C@]1(C)[C@@](C)(CC(N)=O)[C@@H]2CCC(N)=O JEWJRMKHSMTXPP-BYFNXCQMSA-M 0.000 description 1
- 235000007672 methylcobalamin Nutrition 0.000 description 1
- 239000011585 methylcobalamin Substances 0.000 description 1
- 239000011325 microbead Substances 0.000 description 1
- 238000002816 microbial assay Methods 0.000 description 1
- 230000002906 microbiologic effect Effects 0.000 description 1
- 230000000926 neurological effect Effects 0.000 description 1
- 150000004893 oxazines Chemical class 0.000 description 1
- 230000036961 partial effect Effects 0.000 description 1
- 230000007170 pathology Effects 0.000 description 1
- 239000008188 pellet Substances 0.000 description 1
- 239000008363 phosphate buffer Substances 0.000 description 1
- 108060006184 phycobiliprotein Proteins 0.000 description 1
- 239000000049 pigment Substances 0.000 description 1
- 230000008884 pinocytosis Effects 0.000 description 1
- 229920000642 polymer Polymers 0.000 description 1
- 239000000256 polyoxyethylene sorbitan monolaurate Substances 0.000 description 1
- 235000010486 polyoxyethylene sorbitan monolaurate Nutrition 0.000 description 1
- 150000004032 porphyrins Chemical class 0.000 description 1
- 239000002244 precipitate Substances 0.000 description 1
- 238000001556 precipitation Methods 0.000 description 1
- 238000004393 prognosis Methods 0.000 description 1
- 210000000512 proximal kidney tubule Anatomy 0.000 description 1
- 125000000168 pyrrolyl group Chemical group 0.000 description 1
- 230000002285 radioactive effect Effects 0.000 description 1
- 230000008707 rearrangement Effects 0.000 description 1
- 230000009467 reduction Effects 0.000 description 1
- 230000002829 reductive effect Effects 0.000 description 1
- 229920005989 resin Polymers 0.000 description 1
- 239000011347 resin Substances 0.000 description 1
- 230000004044 response Effects 0.000 description 1
- PYWVYCXTNDRMGF-UHFFFAOYSA-N rhodamine B Chemical compound [Cl-].C=12C=CC(=[N+](CC)CC)C=C2OC2=CC(N(CC)CC)=CC=C2C=1C1=CC=CC=C1C(O)=O PYWVYCXTNDRMGF-UHFFFAOYSA-N 0.000 description 1
- 229940043267 rhodamine b Drugs 0.000 description 1
- 239000002336 ribonucleotide Substances 0.000 description 1
- 125000002652 ribonucleotide group Chemical group 0.000 description 1
- 238000002821 scintillation proximity assay Methods 0.000 description 1
- 229910021487 silica fume Inorganic materials 0.000 description 1
- 239000000741 silica gel Substances 0.000 description 1
- 229910002027 silica gel Inorganic materials 0.000 description 1
- 239000011780 sodium chloride Substances 0.000 description 1
- 241000894007 species Species 0.000 description 1
- 210000002784 stomach Anatomy 0.000 description 1
- 230000004206 stomach function Effects 0.000 description 1
- VNOYUJKHFWYWIR-ITIYDSSPSA-N succinyl-CoA Chemical compound O[C@@H]1[C@H](OP(O)(O)=O)[C@@H](COP(O)(=O)OP(O)(=O)OCC(C)(C)[C@@H](O)C(=O)NCCC(=O)NCCSC(=O)CCC(O)=O)O[C@H]1N1C2=NC=NC(N)=C2N=C1 VNOYUJKHFWYWIR-ITIYDSSPSA-N 0.000 description 1
- 239000000725 suspension Substances 0.000 description 1
- 208000024891 symptom Diseases 0.000 description 1
- 238000003786 synthesis reaction Methods 0.000 description 1
- 238000012360 testing method Methods 0.000 description 1
- 238000002560 therapeutic procedure Methods 0.000 description 1
- 150000004897 thiazines Chemical class 0.000 description 1
- 150000005075 thioxanthenes Chemical class 0.000 description 1
- 230000009466 transformation Effects 0.000 description 1
- 150000003918 triazines Chemical class 0.000 description 1
- LENZDBCJOHFCAS-UHFFFAOYSA-N tris Chemical compound OCC(N)(CO)CO LENZDBCJOHFCAS-UHFFFAOYSA-N 0.000 description 1
- 210000004881 tumor cell Anatomy 0.000 description 1
- 241001148471 unidentified anaerobic bacterium Species 0.000 description 1
- 210000002438 upper gastrointestinal tract Anatomy 0.000 description 1
- 235000019156 vitamin B Nutrition 0.000 description 1
- 239000011720 vitamin B Substances 0.000 description 1
- 229940046001 vitamin b complex Drugs 0.000 description 1
- 239000011534 wash buffer Substances 0.000 description 1
- 125000001834 xanthenyl group Chemical class C1=CC=CC=2OC3=CC=CC=C3C(C12)* 0.000 description 1
Classifications
-
- G—PHYSICS
- G01—MEASURING; TESTING
- G01N—INVESTIGATING OR ANALYSING MATERIALS BY DETERMINING THEIR CHEMICAL OR PHYSICAL PROPERTIES
- G01N33/00—Investigating or analysing materials by specific methods not covered by groups G01N1/00 - G01N31/00
- G01N33/48—Biological material, e.g. blood, urine; Haemocytometers
- G01N33/50—Chemical analysis of biological material, e.g. blood, urine; Testing involving biospecific ligand binding methods; Immunological testing
- G01N33/82—Chemical analysis of biological material, e.g. blood, urine; Testing involving biospecific ligand binding methods; Immunological testing involving vitamins or their receptors
-
- G—PHYSICS
- G01—MEASURING; TESTING
- G01N—INVESTIGATING OR ANALYSING MATERIALS BY DETERMINING THEIR CHEMICAL OR PHYSICAL PROPERTIES
- G01N33/00—Investigating or analysing materials by specific methods not covered by groups G01N1/00 - G01N31/00
- G01N33/48—Biological material, e.g. blood, urine; Haemocytometers
- G01N33/50—Chemical analysis of biological material, e.g. blood, urine; Testing involving biospecific ligand binding methods; Immunological testing
- G01N33/53—Immunoassay; Biospecific binding assay; Materials therefor
- G01N33/543—Immunoassay; Biospecific binding assay; Materials therefor with an insoluble carrier for immobilising immunochemicals
- G01N33/54313—Immunoassay; Biospecific binding assay; Materials therefor with an insoluble carrier for immobilising immunochemicals the carrier being characterised by its particulate form
- G01N33/54326—Magnetic particles
Landscapes
- Life Sciences & Earth Sciences (AREA)
- Health & Medical Sciences (AREA)
- Engineering & Computer Science (AREA)
- Molecular Biology (AREA)
- Biomedical Technology (AREA)
- Chemical & Material Sciences (AREA)
- Hematology (AREA)
- Immunology (AREA)
- Urology & Nephrology (AREA)
- General Physics & Mathematics (AREA)
- Microbiology (AREA)
- Cell Biology (AREA)
- Food Science & Technology (AREA)
- Medicinal Chemistry (AREA)
- Physics & Mathematics (AREA)
- Analytical Chemistry (AREA)
- Biochemistry (AREA)
- General Health & Medical Sciences (AREA)
- Biotechnology (AREA)
- Pathology (AREA)
- Investigating Or Analysing Biological Materials (AREA)
- Peptides Or Proteins (AREA)
- Measuring Or Testing Involving Enzymes Or Micro-Organisms (AREA)
- Investigating Or Analysing Materials By The Use Of Chemical Reactions (AREA)
- Ultra Sonic Daignosis Equipment (AREA)
- Lubrication Of Internal Combustion Engines (AREA)
- Measurement And Recording Of Electrical Phenomena And Electrical Characteristics Of The Living Body (AREA)
- Cable Accessories (AREA)
- Liquid Developers In Electrophotography (AREA)
- Mechanical Treatment Of Semiconductor (AREA)
- Devices For Conveying Motion By Means Of Endless Flexible Members (AREA)
- Measuring And Recording Apparatus For Diagnosis (AREA)
- Medicines Containing Material From Animals Or Micro-Organisms (AREA)
- Analysing Materials By The Use Of Radiation (AREA)
- Preparation Of Compounds By Using Micro-Organisms (AREA)
- Medicines Containing Antibodies Or Antigens For Use As Internal Diagnostic Agents (AREA)
- Glass Compositions (AREA)
- Polyamides (AREA)
Applications Claiming Priority (1)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| GBGB9820473.8A GB9820473D0 (en) | 1998-09-18 | 1998-09-18 | Assay |
Publications (1)
| Publication Number | Publication Date |
|---|---|
| PT1443328E true PT1443328E (pt) | 2007-06-11 |
Family
ID=10839158
Family Applications (2)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| PT04009702T PT1443328E (pt) | 1998-09-18 | 1999-09-20 | Doseamento de cobalamina |
| PT99947642T PT1114323E (pt) | 1998-09-18 | 1999-09-20 | Ensaio de cobalamina |
Family Applications After (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| PT99947642T PT1114323E (pt) | 1998-09-18 | 1999-09-20 | Ensaio de cobalamina |
Country Status (22)
| Country | Link |
|---|---|
| US (1) | US7279283B1 (enExample) |
| EP (2) | EP1443328B1 (enExample) |
| JP (1) | JP4394285B2 (enExample) |
| KR (2) | KR100781014B1 (enExample) |
| CN (2) | CN1322330C (enExample) |
| AT (2) | ATE363076T1 (enExample) |
| AU (1) | AU761498B2 (enExample) |
| BR (1) | BR9913770A (enExample) |
| CA (1) | CA2344193C (enExample) |
| CY (1) | CY1106688T1 (enExample) |
| CZ (2) | CZ298381B6 (enExample) |
| DE (2) | DE69936154T2 (enExample) |
| DK (1) | DK1443328T3 (enExample) |
| ES (2) | ES2234299T3 (enExample) |
| GB (1) | GB9820473D0 (enExample) |
| HU (1) | HU228077B1 (enExample) |
| MX (1) | MXPA01002591A (enExample) |
| NO (2) | NO327771B1 (enExample) |
| NZ (1) | NZ510766A (enExample) |
| PL (2) | PL201360B1 (enExample) |
| PT (2) | PT1443328E (enExample) |
| WO (1) | WO2000017659A1 (enExample) |
Families Citing this family (9)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| GB0016460D0 (en) * | 2000-07-04 | 2000-08-23 | Axis Shield Asa | Assay |
| GB0109925D0 (en) * | 2001-04-23 | 2001-06-13 | Axis Shield Asa | Method |
| KR101449340B1 (ko) | 2012-11-06 | 2014-10-13 | 현대자동차주식회사 | 고내열 흡차음재의 제조방법 |
| CN104198598B (zh) * | 2014-07-15 | 2016-03-16 | 汤臣倍健股份有限公司 | 一种维生素b12的测定方法 |
| CN106841017B (zh) * | 2017-01-22 | 2019-05-07 | 耐斯检测技术服务有限公司 | 一种评价辐照或热处理对钴胺素-蛋白结合体影响的方法 |
| CN106693443A (zh) * | 2017-01-23 | 2017-05-24 | 北京美正生物科技有限公司 | 一种维生素b12适配体亲和柱及其制备方法和用途 |
| WO2021030166A1 (en) * | 2019-08-09 | 2021-02-18 | Siemens Healthcare Diagnostics Inc. | Anti-hog tcn1 monoclonal antibodies and methods of production and use thereof |
| EP4220152A4 (en) * | 2020-12-18 | 2024-12-25 | Chugai Seiyaku Kabushiki Kaisha | METHOD FOR MEASURING THE RELATIVE FU RATIO BY DYNAMIC ANALYSIS |
| CN113189252A (zh) * | 2021-04-19 | 2021-07-30 | 中国医学科学院北京协和医院 | 一种总钴胺素和氰钴胺的检测方法及其检测试剂盒和应用 |
Family Cites Families (12)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| US4273757A (en) * | 1977-06-02 | 1981-06-16 | Yissum Research Development Company | Determination of transcobalamins |
| US4332785A (en) * | 1980-04-09 | 1982-06-01 | University Patents, Inc. | Immunoassay for measurement of reticulocytes, and immunoreactive reagents for use therein |
| CA1180273A (en) * | 1981-06-22 | 1985-01-02 | Technicon Instruments Corporation | Assay of vitamin b in12 xx |
| US4680273A (en) * | 1985-07-29 | 1987-07-14 | Victor Herbert | Assay for vitamin B12 deficiency |
| US5457055A (en) * | 1986-11-20 | 1995-10-10 | The University Of Colorado Foundation | Diagnostic method for cobalamin deficiency |
| US5374560A (en) * | 1989-04-03 | 1994-12-20 | The University Of Colorado, Inc. | Method for screening and distinguishing between cobalamin and folic acid deficiency based on assay for cystathionine and 2-methylcitric acid |
| DE3900650A1 (de) * | 1989-01-11 | 1990-07-12 | Boehringer Mannheim Gmbh | Vitamin-b12-bestimmung |
| US5506109A (en) | 1989-06-26 | 1996-04-09 | Bayer Corporation | Vitamin B12 assay |
| US5310656A (en) | 1989-06-26 | 1994-05-10 | Tritech Partners | Vitamin B12 assay |
| EP0479929B1 (en) * | 1989-06-26 | 1994-04-13 | Tritech Partners | Vitamin b12 assay |
| JPH07508174A (ja) * | 1992-05-08 | 1995-09-14 | レセプタジェン コーポレイション | ビタミンｂ１２／トランスコバラミン２レセプターに対する抗−レセプター剤 |
| AU4484997A (en) * | 1996-09-18 | 1998-04-14 | Thomas F. Brennan | Compositions containing cobalamin and amino acids |
-
1998
- 1998-09-18 GB GBGB9820473.8A patent/GB9820473D0/en not_active Ceased
-
1999
- 1999-09-20 PT PT04009702T patent/PT1443328E/pt unknown
- 1999-09-20 AU AU61026/99A patent/AU761498B2/en not_active Ceased
- 1999-09-20 WO PCT/GB1999/003127 patent/WO2000017659A1/en not_active Ceased
- 1999-09-20 AT AT04009702T patent/ATE363076T1/de active
- 1999-09-20 PL PL382436A patent/PL201360B1/pl unknown
- 1999-09-20 EP EP04009702A patent/EP1443328B1/en not_active Expired - Lifetime
- 1999-09-20 KR KR1020017003485A patent/KR100781014B1/ko not_active Expired - Lifetime
- 1999-09-20 ES ES99947642T patent/ES2234299T3/es not_active Expired - Lifetime
- 1999-09-20 PT PT99947642T patent/PT1114323E/pt unknown
- 1999-09-20 BR BR9913770-4A patent/BR9913770A/pt not_active IP Right Cessation
- 1999-09-20 KR KR1020047014817A patent/KR100646305B1/ko not_active Expired - Lifetime
- 1999-09-20 DE DE69936154T patent/DE69936154T2/de not_active Expired - Lifetime
- 1999-09-20 CZ CZ20023143A patent/CZ298381B6/cs not_active IP Right Cessation
- 1999-09-20 CN CNB2004100055424A patent/CN1322330C/zh not_active Expired - Fee Related
- 1999-09-20 AT AT99947642T patent/ATE283490T1/de active
- 1999-09-20 DE DE69922225T patent/DE69922225T2/de not_active Expired - Lifetime
- 1999-09-20 CN CNB998110396A patent/CN1148580C/zh not_active Expired - Fee Related
- 1999-09-20 JP JP2000571269A patent/JP4394285B2/ja not_active Expired - Lifetime
- 1999-09-20 DK DK04009702T patent/DK1443328T3/da active
- 1999-09-20 NZ NZ510766A patent/NZ510766A/en not_active IP Right Cessation
- 1999-09-20 PL PL347104A patent/PL198095B1/pl unknown
- 1999-09-20 ES ES04009702T patent/ES2287607T3/es not_active Expired - Lifetime
- 1999-09-20 EP EP99947642A patent/EP1114323B1/en not_active Expired - Lifetime
- 1999-09-20 HU HU0103532A patent/HU228077B1/hu not_active IP Right Cessation
- 1999-09-20 CZ CZ20010975A patent/CZ298310B6/cs not_active IP Right Cessation
- 1999-09-20 MX MXPA01002591A patent/MXPA01002591A/es not_active IP Right Cessation
- 1999-09-20 CA CA002344193A patent/CA2344193C/en not_active Expired - Lifetime
-
2000
- 2000-10-04 US US09/679,043 patent/US7279283B1/en not_active Expired - Lifetime
-
2001
- 2001-03-16 NO NO20011353A patent/NO327771B1/no not_active IP Right Cessation
-
2007
- 2007-07-02 CY CY20071100864T patent/CY1106688T1/el unknown
-
2008
- 2008-08-21 NO NO20083610A patent/NO331074B1/no not_active IP Right Cessation
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