PT1411982E - Moduladores do ligando 1 glicoproteico da p-selectina - Google Patents
Moduladores do ligando 1 glicoproteico da p-selectina Download PDFInfo
- Publication number
- PT1411982E PT1411982E PT02733839T PT02733839T PT1411982E PT 1411982 E PT1411982 E PT 1411982E PT 02733839 T PT02733839 T PT 02733839T PT 02733839 T PT02733839 T PT 02733839T PT 1411982 E PT1411982 E PT 1411982E
- Authority
- PT
- Portugal
- Prior art keywords
- cell
- modulators
- selectin glycoprotein
- glycoprotein ligand
- induce
- Prior art date
Links
- 102100034925 P-selectin glycoprotein ligand 1 Human genes 0.000 title 1
- 108010054395 P-selectin ligand protein Proteins 0.000 title 1
- 210000001744 T-lymphocyte Anatomy 0.000 abstract 3
- 150000001875 compounds Chemical class 0.000 abstract 2
- 210000000822 natural killer cell Anatomy 0.000 abstract 2
- 208000023275 Autoimmune disease Diseases 0.000 abstract 1
- 102000008212 P-Selectin Human genes 0.000 abstract 1
- 108010035766 P-Selectin Proteins 0.000 abstract 1
- 230000033540 T cell apoptotic process Effects 0.000 abstract 1
- 206010052779 Transplant rejections Diseases 0.000 abstract 1
- 208000026935 allergic disease Diseases 0.000 abstract 1
- 210000004027 cell Anatomy 0.000 abstract 1
- 230000021633 leukocyte mediated immunity Effects 0.000 abstract 1
- 230000026762 natural killer cell apoptotic process Effects 0.000 abstract 1
Classifications
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07K—PEPTIDES
- C07K16/00—Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies
- C07K16/18—Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies against material from animals or humans
- C07K16/28—Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies against material from animals or humans against receptors, cell surface antigens or cell surface determinants
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K39/00—Medicinal preparations containing antigens or antibodies
- A61K39/395—Antibodies; Immunoglobulins; Immune serum, e.g. antilymphocytic serum
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P1/00—Drugs for disorders of the alimentary tract or the digestive system
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P1/00—Drugs for disorders of the alimentary tract or the digestive system
- A61P1/04—Drugs for disorders of the alimentary tract or the digestive system for ulcers, gastritis or reflux esophagitis, e.g. antacids, inhibitors of acid secretion, mucosal protectants
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P1/00—Drugs for disorders of the alimentary tract or the digestive system
- A61P1/16—Drugs for disorders of the alimentary tract or the digestive system for liver or gallbladder disorders, e.g. hepatoprotective agents, cholagogues, litholytics
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P11/00—Drugs for disorders of the respiratory system
- A61P11/06—Antiasthmatics
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P15/00—Drugs for genital or sexual disorders; Contraceptives
- A61P15/02—Drugs for genital or sexual disorders; Contraceptives for disorders of the vagina
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P17/00—Drugs for dermatological disorders
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P17/00—Drugs for dermatological disorders
- A61P17/06—Antipsoriatics
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P17/00—Drugs for dermatological disorders
- A61P17/12—Keratolytics, e.g. wart or anti-corn preparations
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P19/00—Drugs for skeletal disorders
- A61P19/02—Drugs for skeletal disorders for joint disorders, e.g. arthritis, arthrosis
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P21/00—Drugs for disorders of the muscular or neuromuscular system
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P25/00—Drugs for disorders of the nervous system
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P27/00—Drugs for disorders of the senses
- A61P27/02—Ophthalmic agents
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P27/00—Drugs for disorders of the senses
- A61P27/16—Otologicals
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P29/00—Non-central analgesic, antipyretic or antiinflammatory agents, e.g. antirheumatic agents; Non-steroidal antiinflammatory drugs [NSAID]
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P3/00—Drugs for disorders of the metabolism
- A61P3/08—Drugs for disorders of the metabolism for glucose homeostasis
- A61P3/10—Drugs for disorders of the metabolism for glucose homeostasis for hyperglycaemia, e.g. antidiabetics
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P35/00—Antineoplastic agents
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P35/00—Antineoplastic agents
- A61P35/02—Antineoplastic agents specific for leukemia
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P37/00—Drugs for immunological or allergic disorders
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P37/00—Drugs for immunological or allergic disorders
- A61P37/02—Immunomodulators
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P37/00—Drugs for immunological or allergic disorders
- A61P37/02—Immunomodulators
- A61P37/06—Immunosuppressants, e.g. drugs for graft rejection
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P37/00—Drugs for immunological or allergic disorders
- A61P37/08—Antiallergic agents
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P43/00—Drugs for specific purposes, not provided for in groups A61P1/00-A61P41/00
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P5/00—Drugs for disorders of the endocrine system
- A61P5/14—Drugs for disorders of the endocrine system of the thyroid hormones, e.g. T3, T4
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P7/00—Drugs for disorders of the blood or the extracellular fluid
- A61P7/04—Antihaemorrhagics; Procoagulants; Haemostatic agents; Antifibrinolytic agents
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P7/00—Drugs for disorders of the blood or the extracellular fluid
- A61P7/06—Antianaemics
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K39/00—Medicinal preparations containing antigens or antibodies
- A61K2039/505—Medicinal preparations containing antigens or antibodies comprising antibodies
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07K—PEPTIDES
- C07K2319/00—Fusion polypeptide
- C07K2319/30—Non-immunoglobulin-derived peptide or protein having an immunoglobulin constant or Fc region, or a fragment thereof, attached thereto
-
- G—PHYSICS
- G01—MEASURING; TESTING
- G01N—INVESTIGATING OR ANALYSING MATERIALS BY DETERMINING THEIR CHEMICAL OR PHYSICAL PROPERTIES
- G01N2500/00—Screening for compounds of potential therapeutic value
- G01N2500/10—Screening for compounds of potential therapeutic value involving cells
Landscapes
- Health & Medical Sciences (AREA)
- Chemical & Material Sciences (AREA)
- Organic Chemistry (AREA)
- Life Sciences & Earth Sciences (AREA)
- Medicinal Chemistry (AREA)
- General Health & Medical Sciences (AREA)
- Veterinary Medicine (AREA)
- Public Health (AREA)
- Animal Behavior & Ethology (AREA)
- Pharmacology & Pharmacy (AREA)
- Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
- General Chemical & Material Sciences (AREA)
- Chemical Kinetics & Catalysis (AREA)
- Bioinformatics & Cheminformatics (AREA)
- Engineering & Computer Science (AREA)
- Immunology (AREA)
- Diabetes (AREA)
- Hematology (AREA)
- Pulmonology (AREA)
- Endocrinology (AREA)
- Dermatology (AREA)
- Proteomics, Peptides & Aminoacids (AREA)
- Biochemistry (AREA)
- Physical Education & Sports Medicine (AREA)
- Neurology (AREA)
- Rheumatology (AREA)
- Molecular Biology (AREA)
- Genetics & Genomics (AREA)
- Orthopedic Medicine & Surgery (AREA)
- Biophysics (AREA)
- Obesity (AREA)
- Microbiology (AREA)
- Oncology (AREA)
- Gynecology & Obstetrics (AREA)
- Reproductive Health (AREA)
- Gastroenterology & Hepatology (AREA)
- Emergency Medicine (AREA)
- Neurosurgery (AREA)
- Biomedical Technology (AREA)
- Transplantation (AREA)
Applications Claiming Priority (2)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| US31019601P | 2001-08-03 | 2001-08-03 | |
| US10/051,497 US7744888B2 (en) | 2001-08-03 | 2002-01-18 | Methods of modulating T cell or natural killer cell activity with anti-P-selectin glycoprotein ligand 1 antibodies |
Publications (1)
| Publication Number | Publication Date |
|---|---|
| PT1411982E true PT1411982E (pt) | 2008-12-24 |
Family
ID=26729479
Family Applications (2)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| PT02733839T PT1411982E (pt) | 2001-08-03 | 2002-03-13 | Moduladores do ligando 1 glicoproteico da p-selectina |
| PT08012718T PT1985634E (pt) | 2001-08-03 | 2002-03-13 | Anticorpo que se liga ao ligando 1 glicoproteico da pseletina (psgl-1) para utilização no tratamento de doença alérgica |
Family Applications After (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| PT08012718T PT1985634E (pt) | 2001-08-03 | 2002-03-13 | Anticorpo que se liga ao ligando 1 glicoproteico da pseletina (psgl-1) para utilização no tratamento de doença alérgica |
Country Status (19)
| Country | Link |
|---|---|
| US (3) | US7744888B2 (enExample) |
| EP (2) | EP1985634B1 (enExample) |
| JP (3) | JP4815101B2 (enExample) |
| KR (1) | KR100850731B1 (enExample) |
| CN (2) | CN101045161B (enExample) |
| AT (2) | ATE411045T1 (enExample) |
| AU (1) | AU2002305041B2 (enExample) |
| CA (1) | CA2428822C (enExample) |
| CY (2) | CY1108701T1 (enExample) |
| DE (1) | DE60229394D1 (enExample) |
| DK (2) | DK1985634T3 (enExample) |
| ES (2) | ES2376948T3 (enExample) |
| IL (4) | IL160168A0 (enExample) |
| MX (1) | MXPA04001047A (enExample) |
| NO (2) | NO333456B1 (enExample) |
| NZ (1) | NZ531199A (enExample) |
| PT (2) | PT1411982E (enExample) |
| TW (1) | TWI327070B (enExample) |
| WO (1) | WO2003013603A1 (enExample) |
Families Citing this family (23)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| US7744888B2 (en) | 2001-08-03 | 2010-06-29 | Abgenomics Cooperatief U.A. | Methods of modulating T cell or natural killer cell activity with anti-P-selectin glycoprotein ligand 1 antibodies |
| US20040116333A1 (en) | 2001-08-03 | 2004-06-17 | Rong-Hwa Lin | Modulators of P-selectin glycoprotein ligand 1 |
| BRPI0414402A (pt) * | 2003-09-15 | 2006-11-14 | Abgenomics Corp | moduladores de ligante 1 de glicoproteìna p-selectina |
| WO2005047320A2 (en) * | 2003-11-12 | 2005-05-26 | Wisconsin Alumni Research Foundation | Equine p-selection glycoprotein ligand-1 and uses thereof |
| AU2012201999C1 (en) * | 2004-05-10 | 2016-05-12 | Abgenomics Cooperatief U.A. | Antibodies |
| MY148646A (en) * | 2004-05-10 | 2013-05-15 | Abgenomics Cooperatief Ua | Anti-psgl-1 antibodies |
| RU2412945C2 (ru) * | 2004-05-11 | 2011-02-27 | Эбдженомикс Кооператиф У.А. | Эпитопы, индуцирующие гибель т-клеток |
| WO2007033959A2 (en) * | 2005-09-19 | 2007-03-29 | Vib Vzw | Use of p-selectin glycoprotein ligand 1 in modulation of hematogenous metastasis of lymphomas |
| US20070160601A1 (en) * | 2005-12-09 | 2007-07-12 | Angela Widom | Neutralizing antibodies against primate psgl-1 and uses therefor |
| JP2011524858A (ja) * | 2008-05-15 | 2011-09-08 | セレクシーズ ファーマスーティカルズ コーポレーション | 抗ｐｓｇｌ−１抗体並びにその同定及び使用方法 |
| ES2387156B1 (es) * | 2010-12-01 | 2013-07-04 | Universidad Autónoma de Madrid | Uso de psgl-1 para el tratamiento de enfermedades inflamatorias y autoinmunes |
| CN103732626A (zh) | 2011-06-13 | 2014-04-16 | 艾比吉诺米克斯合作公司 | 抗psgl-1抗体及其用途 |
| JP7240808B2 (ja) * | 2014-07-08 | 2023-03-16 | サンフォード バーナム プレビーズ メディカル ディスカバリー インスティテュート | Ｐｓｇｌ－１モジュレーターおよびその使用 |
| TWI753875B (zh) | 2016-01-08 | 2022-02-01 | 美商美國全心醫藥生技股份有限公司 | 四價抗psgl-1抗體及其用途 |
| US20170241415A1 (en) * | 2016-02-19 | 2017-08-24 | Muzan, Inc. | Sanitary check valve |
| EP3568159A4 (en) | 2017-01-11 | 2020-08-05 | Bristol-Myers Squibb Company | PSGL-1 ANTAGONISTS AND THEIR USES |
| CA3054067A1 (en) | 2017-03-14 | 2018-09-20 | Five Prime Therapeutics, Inc. | Antibodies binding to vista at acidic ph |
| PE20210290A1 (es) | 2018-03-21 | 2021-02-11 | Five Prime Therapeutics Inc | ANTICUERPOS DE UNION A VISTA A pH ACIDO |
| BR112021000303A2 (pt) | 2018-07-11 | 2021-04-13 | Five Prime Therapeutics, Inc. | Anticorpos que se ligam a vista em ph ácido |
| CN112740043A (zh) | 2018-07-20 | 2021-04-30 | 皮埃尔法布雷医药公司 | Vista受体 |
| CN114158275A (zh) * | 2019-05-03 | 2022-03-08 | 香港大学 | 腹膜转移细胞的检测和分离方法 |
| WO2020247371A1 (en) * | 2019-06-04 | 2020-12-10 | Verseau Therapeutics, Inc. | Anti-psgl-1 compositions and methods for modulating myeloid cell inflammatory phenotypes and uses thereof |
| WO2025168211A1 (en) * | 2023-02-10 | 2025-08-14 | Novo Nordisk A/S | P-selectin peptide ligands |
Family Cites Families (31)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| US2002A (en) * | 1841-03-12 | Tor and planter for plowing | ||
| US4376110A (en) | 1980-08-04 | 1983-03-08 | Hybritech, Incorporated | Immunometric assays using monoclonal antibodies |
| US4946778A (en) | 1987-09-21 | 1990-08-07 | Genex Corporation | Single polypeptide chain binding molecules |
| US4704692A (en) | 1986-09-02 | 1987-11-03 | Ladner Robert C | Computer based system and method for determining and displaying possible chemical structures for converting double- or multiple-chain polypeptides to single-chain polypeptides |
| US5378464A (en) | 1989-03-08 | 1995-01-03 | Board Of Regents Of The University Of Oklahoma | Modulation of inflammatory responses by administration of GMP-140 or antibody to GMP-140 |
| US5464778A (en) | 1989-03-08 | 1995-11-07 | Board Of Regents Of The University Of Oklahoma | Glycoprotein ligand for P-selectin and methods of use thereof |
| US5690933A (en) * | 1989-05-31 | 1997-11-25 | Glaxo Wellcome Inc. | Monoclonal antibodies for inducing tolerance |
| US5545806A (en) | 1990-08-29 | 1996-08-13 | Genpharm International, Inc. | Ransgenic non-human animals for producing heterologous antibodies |
| CA2089661C (en) | 1990-08-29 | 2007-04-03 | Nils Lonberg | Transgenic non-human animals capable of producing heterologous antibodies |
| US5709859A (en) | 1991-01-24 | 1998-01-20 | Bristol-Myers Squibb Company | Mixed specificity fusion proteins |
| US6309639B1 (en) | 1991-02-05 | 2001-10-30 | The Board Of Regents Of The University Of Oklahoma | Method for inhibiting an inflammatory response using antibodies to P-selectin glycoprotein ligand |
| US6124267A (en) | 1991-02-05 | 2000-09-26 | Southpac Trust Internationals, Inc. | O-glycan inhibitors of selectin mediated inflammation derived from PSGL-1 |
| US5972625A (en) | 1991-05-06 | 1999-10-26 | The Regents Of The University Of California | Assays for inhibitors of leukocyte adhesion |
| US5843707A (en) | 1992-10-23 | 1998-12-01 | Genetics Institute, Inc. | Nucleic acid encoding a novel P-selectin ligand protein |
| WO1994014836A1 (en) | 1992-12-18 | 1994-07-07 | Centocor, Inc. | Peptide inhibitors of selectin binding |
| NZ261991A (en) | 1993-01-25 | 1998-04-27 | Dana Farber Cancer Inst Inc | Chimeric l and p selectin made by exchange of domains, uses thereof |
| WO1995014787A1 (en) | 1993-11-22 | 1995-06-01 | Centocor, Inc. | Peptide inhibitors of selecting binding |
| US5686426A (en) | 1994-11-17 | 1997-11-11 | Bristol-Myers Squibb Company | Dicarboxymethylated glycolipid derivatives as cell adhesion inhibitors |
| WO1997006176A2 (en) | 1995-08-03 | 1997-02-20 | Board Of Regents Of The University Of Oklahoma | Peptide and o-glycan inhibitors of selectin mediated inflammation |
| JPH09227410A (ja) | 1996-02-21 | 1997-09-02 | Sumitomo Pharmaceut Co Ltd | 臓器移植拒絶反応の抑制剤 |
| WO1999043353A2 (en) | 1998-02-26 | 1999-09-02 | Boehringer Ingelheim Pharmaceuticals, Inc. | Combination anti-selectin and immunosuppressant therapy |
| CA2347119A1 (en) | 1998-10-30 | 2000-05-11 | Genetics Institute, Inc. | Inhibition of differentiation of cytotoxic t-cells by p-selectin ligand (psgl) antagonists |
| JP2005503756A (ja) | 2000-12-29 | 2005-02-10 | サビエント ファーマシューティカルズ，インコーポレイティド | 硫酸化部分を含むエピトープを含む単離分子、当該エピトープに対する抗体、及びその使用 |
| US20040001839A1 (en) * | 2000-12-29 | 2004-01-01 | Avigdor Levanon | Multimers - isolated molecules comprising epitopes containing sulfated moieties, antibodies to such epitopes, and uses thereof |
| US20040002450A1 (en) * | 2000-12-29 | 2004-01-01 | Janette Lazarovits | Y17 - isolated molecules comprising epitopes containing sulfated moieties, antibodies to such epitopes, and uses thereof |
| US20040116333A1 (en) * | 2001-08-03 | 2004-06-17 | Rong-Hwa Lin | Modulators of P-selectin glycoprotein ligand 1 |
| US7744888B2 (en) * | 2001-08-03 | 2010-06-29 | Abgenomics Cooperatief U.A. | Methods of modulating T cell or natural killer cell activity with anti-P-selectin glycoprotein ligand 1 antibodies |
| US20050152906A1 (en) * | 2003-06-30 | 2005-07-14 | Avigdor Levanon | Specific human antibodies |
| MY148646A (en) | 2004-05-10 | 2013-05-15 | Abgenomics Cooperatief Ua | Anti-psgl-1 antibodies |
| RU2412945C2 (ru) | 2004-05-11 | 2011-02-27 | Эбдженомикс Кооператиф У.А. | Эпитопы, индуцирующие гибель т-клеток |
| CN103732626A (zh) | 2011-06-13 | 2014-04-16 | 艾比吉诺米克斯合作公司 | 抗psgl-1抗体及其用途 |
-
2002
- 2002-01-18 US US10/051,497 patent/US7744888B2/en not_active Expired - Fee Related
- 2002-03-13 AU AU2002305041A patent/AU2002305041B2/en not_active Ceased
- 2002-03-13 CA CA2428822A patent/CA2428822C/en not_active Expired - Lifetime
- 2002-03-13 DK DK08012718.6T patent/DK1985634T3/da active
- 2002-03-13 PT PT02733839T patent/PT1411982E/pt unknown
- 2002-03-13 JP JP2003518607A patent/JP4815101B2/ja not_active Expired - Fee Related
- 2002-03-13 ES ES08012718T patent/ES2376948T3/es not_active Expired - Lifetime
- 2002-03-13 DK DK02733839T patent/DK1411982T3/da active
- 2002-03-13 NZ NZ531199A patent/NZ531199A/en not_active IP Right Cessation
- 2002-03-13 CN CN200710003904XA patent/CN101045161B/zh not_active Expired - Fee Related
- 2002-03-13 MX MXPA04001047A patent/MXPA04001047A/es active IP Right Grant
- 2002-03-13 DE DE60229394T patent/DE60229394D1/de not_active Expired - Lifetime
- 2002-03-13 IL IL16016802A patent/IL160168A0/xx active IP Right Grant
- 2002-03-13 PT PT08012718T patent/PT1985634E/pt unknown
- 2002-03-13 AT AT02733839T patent/ATE411045T1/de active
- 2002-03-13 CN CNB028029844A patent/CN1304051C/zh not_active Expired - Fee Related
- 2002-03-13 AT AT08012718T patent/ATE531734T1/de active
- 2002-03-13 KR KR1020047001711A patent/KR100850731B1/ko not_active Expired - Fee Related
- 2002-03-13 EP EP08012718A patent/EP1985634B1/en not_active Expired - Lifetime
- 2002-03-13 ES ES02733839T patent/ES2316569T3/es not_active Expired - Lifetime
- 2002-03-13 WO PCT/US2002/007498 patent/WO2003013603A1/en not_active Ceased
- 2002-03-13 EP EP02733839A patent/EP1411982B1/en not_active Expired - Lifetime
- 2002-04-10 TW TW091107216A patent/TWI327070B/zh not_active IP Right Cessation
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2004
- 2004-02-02 IL IL160168A patent/IL160168A/en unknown
- 2004-02-02 NO NO20040460A patent/NO333456B1/no not_active IP Right Cessation
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2008
- 2008-03-07 JP JP2008058501A patent/JP2008260759A/ja not_active Abandoned
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2009
- 2009-01-13 CY CY20091100020T patent/CY1108701T1/el unknown
- 2009-06-29 US US12/494,018 patent/US8298540B2/en not_active Expired - Fee Related
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2010
- 2010-02-18 IL IL204030A patent/IL204030A/en active IP Right Grant
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2011
- 2011-01-11 IL IL210557A patent/IL210557A0/en unknown
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2012
- 2012-02-01 CY CY20121100115T patent/CY1112966T1/el unknown
- 2012-02-03 JP JP2012022511A patent/JP2012092144A/ja active Pending
- 2012-09-14 US US13/616,749 patent/US8557579B2/en not_active Expired - Fee Related
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2013
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