PT1399559E - Locus da cadeia leve lambda de ratinho - Google Patents
Locus da cadeia leve lambda de ratinho Download PDFInfo
- Publication number
- PT1399559E PT1399559E PT02732970T PT02732970T PT1399559E PT 1399559 E PT1399559 E PT 1399559E PT 02732970 T PT02732970 T PT 02732970T PT 02732970 T PT02732970 T PT 02732970T PT 1399559 E PT1399559 E PT 1399559E
- Authority
- PT
- Portugal
- Prior art keywords
- light chain
- lambda light
- chain locus
- mouse
- mouse lambda
- Prior art date
Links
- 238000011813 knockout mouse model Methods 0.000 abstract 2
- 238000004519 manufacturing process Methods 0.000 abstract 2
- 241000699666 Mus <mouse, genus> Species 0.000 abstract 1
- 241000699670 Mus sp. Species 0.000 abstract 1
- 230000008685 targeting Effects 0.000 abstract 1
Classifications
-
- A—HUMAN NECESSITIES
- A01—AGRICULTURE; FORESTRY; ANIMAL HUSBANDRY; HUNTING; TRAPPING; FISHING
- A01K—ANIMAL HUSBANDRY; AVICULTURE; APICULTURE; PISCICULTURE; FISHING; REARING OR BREEDING ANIMALS, NOT OTHERWISE PROVIDED FOR; NEW BREEDS OF ANIMALS
- A01K67/00—Rearing or breeding animals, not otherwise provided for; New or modified breeds of animals
- A01K67/027—New or modified breeds of vertebrates
- A01K67/0275—Genetically modified vertebrates, e.g. transgenic
- A01K67/0276—Knock-out vertebrates
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07K—PEPTIDES
- C07K16/00—Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07K—PEPTIDES
- C07K16/00—Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies
- C07K16/06—Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies from serum
-
- A—HUMAN NECESSITIES
- A01—AGRICULTURE; FORESTRY; ANIMAL HUSBANDRY; HUNTING; TRAPPING; FISHING
- A01K—ANIMAL HUSBANDRY; AVICULTURE; APICULTURE; PISCICULTURE; FISHING; REARING OR BREEDING ANIMALS, NOT OTHERWISE PROVIDED FOR; NEW BREEDS OF ANIMALS
- A01K2217/00—Genetically modified animals
- A01K2217/05—Animals comprising random inserted nucleic acids (transgenic)
- A01K2217/054—Animals comprising random inserted nucleic acids (transgenic) inducing loss of function
- A01K2217/058—Animals comprising random inserted nucleic acids (transgenic) inducing loss of function due to expression of inhibitory nucleic acid, e.g. siRNA, antisense
-
- A—HUMAN NECESSITIES
- A01—AGRICULTURE; FORESTRY; ANIMAL HUSBANDRY; HUNTING; TRAPPING; FISHING
- A01K—ANIMAL HUSBANDRY; AVICULTURE; APICULTURE; PISCICULTURE; FISHING; REARING OR BREEDING ANIMALS, NOT OTHERWISE PROVIDED FOR; NEW BREEDS OF ANIMALS
- A01K2217/00—Genetically modified animals
- A01K2217/07—Animals genetically altered by homologous recombination
- A01K2217/075—Animals genetically altered by homologous recombination inducing loss of function, i.e. knock out
-
- A—HUMAN NECESSITIES
- A01—AGRICULTURE; FORESTRY; ANIMAL HUSBANDRY; HUNTING; TRAPPING; FISHING
- A01K—ANIMAL HUSBANDRY; AVICULTURE; APICULTURE; PISCICULTURE; FISHING; REARING OR BREEDING ANIMALS, NOT OTHERWISE PROVIDED FOR; NEW BREEDS OF ANIMALS
- A01K2227/00—Animals characterised by species
- A01K2227/10—Mammal
- A01K2227/105—Murine
-
- A—HUMAN NECESSITIES
- A01—AGRICULTURE; FORESTRY; ANIMAL HUSBANDRY; HUNTING; TRAPPING; FISHING
- A01K—ANIMAL HUSBANDRY; AVICULTURE; APICULTURE; PISCICULTURE; FISHING; REARING OR BREEDING ANIMALS, NOT OTHERWISE PROVIDED FOR; NEW BREEDS OF ANIMALS
- A01K2267/00—Animals characterised by purpose
- A01K2267/01—Animal expressing industrially exogenous proteins
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07K—PEPTIDES
- C07K2317/00—Immunoglobulins specific features
- C07K2317/50—Immunoglobulins specific features characterized by immunoglobulin fragments
- C07K2317/56—Immunoglobulins specific features characterized by immunoglobulin fragments variable (Fv) region, i.e. VH and/or VL
-
- C—CHEMISTRY; METALLURGY
- C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
- C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
- C12N2800/00—Nucleic acids vectors
- C12N2800/30—Vector systems comprising sequences for excision in presence of a recombinase, e.g. loxP or FRT
Landscapes
- Life Sciences & Earth Sciences (AREA)
- Chemical & Material Sciences (AREA)
- Health & Medical Sciences (AREA)
- Organic Chemistry (AREA)
- General Health & Medical Sciences (AREA)
- Environmental Sciences (AREA)
- Medicinal Chemistry (AREA)
- Biochemistry (AREA)
- Genetics & Genomics (AREA)
- Biophysics (AREA)
- Molecular Biology (AREA)
- Immunology (AREA)
- Proteomics, Peptides & Aminoacids (AREA)
- Zoology (AREA)
- Animal Husbandry (AREA)
- Animal Behavior & Ethology (AREA)
- Veterinary Medicine (AREA)
- Biotechnology (AREA)
- Engineering & Computer Science (AREA)
- Biodiversity & Conservation Biology (AREA)
- Peptides Or Proteins (AREA)
- Micro-Organisms Or Cultivation Processes Thereof (AREA)
- Ultra Sonic Daignosis Equipment (AREA)
- Preparation Of Compounds By Using Micro-Organisms (AREA)
- Inspection Of Paper Currency And Valuable Securities (AREA)
- Position Input By Displaying (AREA)
- User Interface Of Digital Computer (AREA)
- Electrochromic Elements, Electrophoresis, Or Variable Reflection Or Absorption Elements (AREA)
- Investigating Or Analysing Biological Materials (AREA)
- Mechanical Coupling Of Light Guides (AREA)
- Details Of Television Scanning (AREA)
Applications Claiming Priority (1)
Application Number | Priority Date | Filing Date | Title |
---|---|---|---|
GBGB0115256.0A GB0115256D0 (en) | 2001-06-21 | 2001-06-21 | Mouse light chain locus |
Publications (1)
Publication Number | Publication Date |
---|---|
PT1399559E true PT1399559E (pt) | 2008-07-29 |
Family
ID=9917128
Family Applications (1)
Application Number | Title | Priority Date | Filing Date |
---|---|---|---|
PT02732970T PT1399559E (pt) | 2001-06-21 | 2002-06-21 | Locus da cadeia leve lambda de ratinho |
Country Status (11)
Country | Link |
---|---|
US (4) | US7541513B2 (pt) |
EP (2) | EP1956092A1 (pt) |
AT (1) | ATE393826T1 (pt) |
AU (1) | AU2002304460A1 (pt) |
CY (1) | CY1108227T1 (pt) |
DE (1) | DE60226322T3 (pt) |
DK (1) | DK1399559T4 (pt) |
ES (1) | ES2305245T5 (pt) |
GB (2) | GB0115256D0 (pt) |
PT (1) | PT1399559E (pt) |
WO (1) | WO2003000737A2 (pt) |
Families Citing this family (87)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
GB0110029D0 (en) | 2001-04-24 | 2001-06-13 | Grosveld Frank | Transgenic animal |
GB0115256D0 (en) | 2001-06-21 | 2001-08-15 | Babraham Inst | Mouse light chain locus |
GB0228210D0 (en) * | 2002-12-03 | 2003-01-08 | Babraham Inst | Single chain antibodies |
US7141157B2 (en) * | 2003-03-11 | 2006-11-28 | Chevron U.S.A. Inc. | Blending of low viscosity Fischer-Tropsch base oils and Fischer-Tropsch derived bottoms or bright stock |
US8783257B2 (en) | 2004-02-23 | 2014-07-22 | Fisher & Paykel Healthcare Limited | Breathing assistance apparatus |
SI2311874T1 (sl) | 2004-07-22 | 2017-12-29 | Erasmus University Medical Center Rotterdam Department of Cell Biology and Genetics | Vezavne molekule |
DK3689407T3 (da) | 2006-07-14 | 2021-11-22 | Fisher & Paykel Healthcare Ltd | Apparat til vejrtrækningshjælp |
AU2008259939B2 (en) | 2007-06-01 | 2014-03-13 | Open Monoclonal Technology, Inc. | Compositions and methods for inhibiting endogenous immunoglobulin genes and producing transgenic human idiotype antibodies |
US10792451B2 (en) | 2008-05-12 | 2020-10-06 | Fisher & Paykel Healthcare Limited | Patient interface and aspects thereof |
US10258757B2 (en) | 2008-05-12 | 2019-04-16 | Fisher & Paykel Healthcare Limited | Patient interface and aspects thereof |
US20100122358A1 (en) * | 2008-06-06 | 2010-05-13 | Crescendo Biologics Limited | H-Chain-only antibodies |
LT2346994T (lt) | 2008-09-30 | 2022-03-10 | Ablexis, Llc | Knock-in pelė, skirta chimerinių antikūnų gamybai |
JP5827127B2 (ja) | 2008-12-18 | 2015-12-02 | エラスムス・ユニヴァーシティ・メディカル・センター・ロッテルダム | ヒト化抗体を発現する非ヒトトランスジェニック動物及びその使用 |
GB0905023D0 (en) | 2009-03-24 | 2009-05-06 | Univ Erasmus Medical Ct | Binding molecules |
ES2595376T3 (es) | 2009-12-10 | 2016-12-29 | Regeneron Pharmaceuticals, Inc. | Ratones que producen anticuerpos de cadena pesada |
LT3248462T (lt) | 2010-03-31 | 2024-05-27 | Ablexis, Llc | Pelių genų inžinerija, skirta chimerinių antikūnų gamybai |
BR112012032991B1 (pt) | 2010-06-22 | 2021-08-10 | Regeneron Pharmaceuticals, Inc | Método para preparar um anticorpo que se liga a um antígeno de interesse |
US10793829B2 (en) | 2010-07-26 | 2020-10-06 | Trianni, Inc. | Transgenic mammals and methods of use thereof |
US10881084B2 (en) | 2010-07-26 | 2021-01-05 | Trianni, Inc | Transgenic animals and methods of use |
US10662256B2 (en) | 2010-07-26 | 2020-05-26 | Trianni, Inc. | Transgenic mammals and methods of use thereof |
KR102434557B1 (ko) | 2010-08-02 | 2022-08-23 | 리제너론 파아마슈티컬스, 인크. | Vl 도메인을 포함하는 결합 단백질을 생성하는 마우스 |
EP4070841A1 (en) | 2010-10-08 | 2022-10-12 | Fisher & Paykel Healthcare Limited | Breathing assistance apparatus |
EP2638155A1 (en) | 2010-11-08 | 2013-09-18 | Kymab Limited | Cells & vertebrates for enhanced somatic hypermutation and class switch recombination |
CA2833106C (en) | 2011-04-15 | 2019-08-27 | Fisher & Paykel Healthcare Limited | Interface comprising a rolling nasal bridge portion |
US10603456B2 (en) | 2011-04-15 | 2020-03-31 | Fisher & Paykel Healthcare Limited | Interface comprising a nasal sealing portion |
JP2014531452A (ja) | 2011-09-19 | 2014-11-27 | カイマブ・リミテッド | 動物、レパートリーおよび方法 |
JP2014533930A (ja) | 2011-09-19 | 2014-12-18 | カイマブ・リミテッド | 免疫グロブリン遺伝子多様性の操作およびマルチ抗体治療薬 |
EP2761008A1 (en) | 2011-09-26 | 2014-08-06 | Kymab Limited | Chimaeric surrogate light chains (slc) comprising human vpreb |
GB2496375A (en) | 2011-10-28 | 2013-05-15 | Kymab Ltd | A non-human assay vertebrate comprising human antibody loci and human epitope knock-in, and uses thereof |
GB201122047D0 (en) | 2011-12-21 | 2012-02-01 | Kymab Ltd | Transgenic animals |
MX356429B (es) | 2011-12-20 | 2018-05-29 | Regeneron Pharma | Ratones con cadena ligera humanizada. |
SG11201405059XA (en) | 2012-03-28 | 2014-09-26 | Kymab Ltd | Transgenic non-human vertebrate for the expression of class - switched, fully human, antibodies |
GB2502127A (en) | 2012-05-17 | 2013-11-20 | Kymab Ltd | Multivalent antibodies and in vivo methods for their production |
PL2967012T3 (pl) | 2013-03-14 | 2021-04-19 | Erasmus University Medical Center Rotterdam | Transgeniczne ssaki inne niż człowiek do wytwarzania przeciwciał |
US10993420B2 (en) * | 2013-03-15 | 2021-05-04 | Erasmus University Medical Center | Production of heavy chain only antibodies in transgenic mammals |
US20150266976A1 (en) | 2014-03-21 | 2015-09-24 | Regeneron Pharmaceuticals, Inc. | Vl antigen binding proteins exhibiting distinct binding characteristics |
KR20210088756A (ko) | 2014-03-21 | 2021-07-14 | 리제너론 파마슈티칼스 인코포레이티드 | 단일 도메인 결합 단백질을 생산하는 비-인간 동물 |
AU2014409276A1 (en) | 2014-10-22 | 2017-04-06 | Crescendo Biologics Limited | Transgenic mice |
GB201500464D0 (en) | 2015-01-12 | 2015-02-25 | Crescendo Biolog Ltd | Method of producing optimised therapeutic molecules |
GB201500461D0 (en) | 2015-01-12 | 2015-02-25 | Cresendo Biolog Ltd | Therapeutic molecules |
JP2018508224A (ja) | 2015-03-19 | 2018-03-29 | リジェネロン・ファーマシューティカルズ・インコーポレイテッドRegeneron Pharmaceuticals, Inc. | 抗原を結合する軽鎖可変領域を選択する非ヒト動物 |
WO2017095939A1 (en) | 2015-12-03 | 2017-06-08 | Trianni, Inc. | Enhanced immunoglobulin diversity |
US11236174B2 (en) | 2016-01-12 | 2022-02-01 | Crescendo Biologics Limited | Therapeutic molecules |
AU2017213633B2 (en) | 2016-02-04 | 2023-08-03 | Trianni, Inc. | Enhanced production of immunoglobulins |
EP3471773A4 (en) | 2016-06-21 | 2020-07-08 | Teneobio, Inc. | ANTIBODIES BINDING CD3 |
GB201612043D0 (en) | 2016-07-11 | 2016-08-24 | Crescendo Biologics Ltd | Composition for treatment of disorders |
US20190225671A1 (en) | 2016-08-24 | 2019-07-25 | Teneobio, Inc. | Transgenic non-human animals producing modified heavy chain-only antibodies |
PT4050034T (pt) | 2016-09-14 | 2024-05-27 | Teneoone Inc | Anticorpos de ligação a cd3 |
US20230137351A1 (en) | 2016-11-14 | 2023-05-04 | Amgen Inc. | Bispecific or biparatopic antigen binding proteins and uses thereof |
IL300729A (en) | 2016-12-21 | 2023-04-01 | Teneobio Inc | Anti-BCMA antibodies containing only heavy chains |
JP7183163B2 (ja) | 2017-01-06 | 2022-12-05 | クレシェンド・バイオロジックス・リミテッド | プログラム細胞死(pd-1)に対するシングルドメイン抗体 |
SG11201906540WA (en) | 2017-01-19 | 2019-08-27 | Open Monoclonal Tech Inc | Human antibodies from transgenic rodents with multiple heavy chain immunoglobulin loci |
USD824020S1 (en) | 2017-02-23 | 2018-07-24 | Fisher & Paykel Healthcare Limited | Cushion assembly for breathing mask assembly |
USD823455S1 (en) | 2017-02-23 | 2018-07-17 | Fisher & Paykel Healthcare Limited | Cushion assembly for breathing mask assembly |
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IL271194B2 (en) | 2017-06-20 | 2024-10-01 | Teneobio Inc | Anti-BCMA antibodies containing only heavy chains |
GB201711068D0 (en) | 2017-07-10 | 2017-08-23 | Crescendo Biologics Ltd | Therapeutic molecules binding PSMA |
KR20200044094A (ko) | 2017-09-13 | 2020-04-28 | 테네오바이오, 인코포레이티드 | 엑토효소에 결합하는 중쇄 항체 |
KR20200083574A (ko) | 2017-11-13 | 2020-07-08 | 크레센도 바이오로직스 리미티드 | Cd137 및 psma에 결합하는 분자 |
WO2019126756A1 (en) | 2017-12-22 | 2019-06-27 | Teneobio, Inc. | Heavy chain antibodies binding to cd22 |
GB201802573D0 (en) | 2018-02-16 | 2018-04-04 | Crescendo Biologics Ltd | Therapeutic molecules that bind to LAG3 |
SG11202011597RA (en) | 2018-07-20 | 2020-12-30 | Teneobio Inc | Heavy chain antibodies binding to cd19 |
GB2576914A (en) | 2018-09-06 | 2020-03-11 | Kymab Ltd | Antigen-binding molecules comprising unpaired variable domains produced in mammals |
JP2022505445A (ja) | 2018-10-26 | 2022-01-14 | テネオバイオ, インコーポレイテッド | Cd38に結合する重鎖抗体 |
GB201818460D0 (en) | 2018-11-13 | 2018-12-26 | Crescendo Biologics Ltd | Single domain antibodies that bind human serum albumin |
CN117099741A (zh) | 2019-02-18 | 2023-11-24 | 百奥赛图(北京)医药科技股份有限公司 | 具有人源化免疫球蛋白基因座的经遗传修饰的非人动物 |
CN113710707B (zh) | 2019-04-05 | 2024-05-31 | 特尼奥生物股份有限公司 | 结合于psma的重链抗体 |
SG11202111671QA (en) | 2019-05-15 | 2021-11-29 | Crescendo Biologics Ltd | Binding molecules |
MX2021015337A (es) | 2019-06-14 | 2022-01-18 | Teneobio Inc | Anticuerpos multiespecificos de cadena pesada que se unen a cd22 y cd3. |
GB201914468D0 (en) | 2019-10-07 | 2019-11-20 | Crescendo Biologics Ltd | Binding Molecules |
MX2022007613A (es) | 2019-12-18 | 2022-07-19 | Teneofour Inc | Union de anticuerpos de cadena pesada a cd38. |
PE20230431A1 (es) | 2020-04-29 | 2023-03-08 | Teneobio Inc | Anticuerpos de cadena pesada multiespecificos con regiones constantes de cadena pesada modificadas |
WO2021222578A1 (en) | 2020-04-29 | 2021-11-04 | Teneobio, Inc. | Multispecific heavy chain antibodies with modified heavy chain constant regions |
TW202210510A (zh) | 2020-05-27 | 2022-03-16 | 美商健生生物科技公司 | 包含cd3抗原結合域之蛋白質及其用途 |
CN115667532A (zh) | 2020-06-02 | 2023-01-31 | 百奥赛图(北京)医药科技股份有限公司 | 具有共有轻链免疫球蛋白基因座的经遗传修饰的非人动物 |
MX2022016342A (es) | 2020-06-30 | 2023-01-24 | Teneobio Inc | Union de anticuerpos multiespecificos a bcma. |
TW202233684A (zh) | 2020-11-18 | 2022-09-01 | 美商泰尼歐生物公司 | 結合於葉酸受體α之重鏈抗體 |
CN117500835A (zh) | 2021-02-25 | 2024-02-02 | 特尼奥生物股份有限公司 | 抗psma抗体及car-t结构 |
JP2024508808A (ja) | 2021-02-26 | 2024-02-28 | テネオバイオ, インコーポレイテッド | 抗muc1-c抗体及びcar-t構造 |
TW202304994A (zh) | 2021-04-02 | 2023-02-01 | 美商泰尼歐生物公司 | 促效性抗il-2r抗體及使用方法 |
AU2022255709A1 (en) | 2021-04-06 | 2023-09-28 | Teneobio, Inc. | Anti-cd19 antibodies and car-t structures |
PE20240656A1 (es) | 2021-04-16 | 2024-04-04 | Teneobio Inc | Anticuerpos anti-cd20 y estructuras car-t |
WO2022271987A1 (en) | 2021-06-23 | 2022-12-29 | TeneoFour, Inc. | Anti-cd38 antibodies and epitopes of same |
WO2023004197A1 (en) | 2021-07-23 | 2023-01-26 | Teneoten, Inc. | Heavy chain antibodies binding to hepatitis b surface antigen |
GB202205589D0 (en) | 2022-04-14 | 2022-06-01 | Crescendo Biologics Ltd | Mesothelin binders |
WO2023199069A1 (en) | 2022-04-14 | 2023-10-19 | Crescendo Biologics Limited | Chimeric antigen receptor that binds mesothelin |
WO2024077044A1 (en) | 2022-10-05 | 2024-04-11 | Amgen Inc. | Combination therapies comprising t-cell redirecting therapies and agonistic anti-il-2r antibodies or fragments thereof |
Family Cites Families (13)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
GB8823869D0 (en) | 1988-10-12 | 1988-11-16 | Medical Res Council | Production of antibodies |
US6673986B1 (en) * | 1990-01-12 | 2004-01-06 | Abgenix, Inc. | Generation of xenogeneic antibodies |
US5770429A (en) | 1990-08-29 | 1998-06-23 | Genpharm International, Inc. | Transgenic non-human animals capable of producing heterologous antibodies |
US6300129B1 (en) * | 1990-08-29 | 2001-10-09 | Genpharm International | Transgenic non-human animals for producing heterologous antibodies |
CA2140638C (en) * | 1992-07-24 | 2010-05-04 | Raju Kucherlapati | Generation of xenogeneic antibodies |
EP1709970A1 (en) | 1995-04-27 | 2006-10-11 | Abgenix, Inc. | Human antibodies against EGFR, derived from immunized xenomice |
GB9823930D0 (en) * | 1998-11-03 | 1998-12-30 | Babraham Inst | Murine expression of human ig\ locus |
IL154751A0 (en) | 2000-08-03 | 2003-10-31 | Humanized antibodies, recombination vectors, transgenic vectors and methods for the preparation of humanized antibodies from transgenic animals | |
US6596541B2 (en) | 2000-10-31 | 2003-07-22 | Regeneron Pharmaceuticals, Inc. | Methods of modifying eukaryotic cells |
GB0110029D0 (en) * | 2001-04-24 | 2001-06-13 | Grosveld Frank | Transgenic animal |
GB0115256D0 (en) * | 2001-06-21 | 2001-08-15 | Babraham Inst | Mouse light chain locus |
DK1399484T3 (da) | 2001-06-28 | 2010-11-08 | Domantis Ltd | Dobbelt-specifik ligand og anvendelse af denne |
GB0228210D0 (en) | 2002-12-03 | 2003-01-08 | Babraham Inst | Single chain antibodies |
-
2001
- 2001-06-21 GB GBGB0115256.0A patent/GB0115256D0/en not_active Ceased
-
2002
- 2002-06-21 US US10/481,395 patent/US7541513B2/en not_active Expired - Fee Related
- 2002-06-21 ES ES02732970.5T patent/ES2305245T5/es not_active Expired - Lifetime
- 2002-06-21 AU AU2002304460A patent/AU2002304460A1/en not_active Abandoned
- 2002-06-21 WO PCT/GB2002/002867 patent/WO2003000737A2/en active IP Right Grant
- 2002-06-21 PT PT02732970T patent/PT1399559E/pt unknown
- 2002-06-21 EP EP20080008171 patent/EP1956092A1/en not_active Withdrawn
- 2002-06-21 AT AT02732970T patent/ATE393826T1/de active
- 2002-06-21 DE DE60226322.0T patent/DE60226322T3/de not_active Expired - Lifetime
- 2002-06-21 EP EP02732970.5A patent/EP1399559B2/en not_active Expired - Lifetime
- 2002-06-21 DK DK02732970.5T patent/DK1399559T4/en active
- 2002-06-21 GB GB0400676A patent/GB2392672B/en not_active Expired - Lifetime
-
2008
- 2008-07-30 CY CY20081100796T patent/CY1108227T1/el unknown
-
2009
- 2009-06-01 US US12/476,087 patent/US8367888B2/en not_active Expired - Fee Related
-
2012
- 2012-10-17 US US13/654,007 patent/US9439405B2/en not_active Expired - Fee Related
-
2016
- 2016-08-08 US US15/230,564 patent/US10194645B2/en not_active Expired - Lifetime
Also Published As
Publication number | Publication date |
---|---|
US9439405B2 (en) | 2016-09-13 |
US7541513B2 (en) | 2009-06-02 |
US10194645B2 (en) | 2019-02-05 |
ES2305245T5 (es) | 2015-12-11 |
AU2002304460A1 (en) | 2003-01-08 |
DK1399559T4 (en) | 2015-12-14 |
EP1956092A1 (en) | 2008-08-13 |
GB2392672B (en) | 2005-05-11 |
US8367888B2 (en) | 2013-02-05 |
ATE393826T1 (de) | 2008-05-15 |
DE60226322T2 (de) | 2009-07-09 |
US20130046079A1 (en) | 2013-02-21 |
GB0400676D0 (en) | 2004-02-18 |
GB0115256D0 (en) | 2001-08-15 |
ES2305245T3 (es) | 2008-11-01 |
DK1399559T3 (da) | 2008-08-25 |
EP1399559B1 (en) | 2008-04-30 |
US20050060763A1 (en) | 2005-03-17 |
US20170049083A1 (en) | 2017-02-23 |
DE60226322D1 (de) | 2008-06-12 |
GB2392672A (en) | 2004-03-10 |
WO2003000737A3 (en) | 2003-09-25 |
CY1108227T1 (el) | 2014-02-12 |
US20110093961A1 (en) | 2011-04-21 |
EP1399559A2 (en) | 2004-03-24 |
WO2003000737A2 (en) | 2003-01-03 |
DE60226322T3 (de) | 2016-03-03 |
EP1399559B2 (en) | 2015-09-02 |
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