CY1108227T1 - Τοπος ελαφρας αλυσιδας λ σε ποντικι - Google Patents
Τοπος ελαφρας αλυσιδας λ σε ποντικιInfo
- Publication number
- CY1108227T1 CY1108227T1 CY20081100796T CY081100796T CY1108227T1 CY 1108227 T1 CY1108227 T1 CY 1108227T1 CY 20081100796 T CY20081100796 T CY 20081100796T CY 081100796 T CY081100796 T CY 081100796T CY 1108227 T1 CY1108227 T1 CY 1108227T1
- Authority
- CY
- Cyprus
- Prior art keywords
- light chain
- mice
- lambda light
- place
- deleted
- Prior art date
Links
- 241000699670 Mus sp. Species 0.000 title abstract 2
- 238000011813 knockout mouse model Methods 0.000 abstract 2
- 238000004519 manufacturing process Methods 0.000 abstract 2
- 241000699666 Mus <mouse, genus> Species 0.000 abstract 1
- 230000008685 targeting Effects 0.000 abstract 1
Classifications
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- A—HUMAN NECESSITIES
- A01—AGRICULTURE; FORESTRY; ANIMAL HUSBANDRY; HUNTING; TRAPPING; FISHING
- A01K—ANIMAL HUSBANDRY; AVICULTURE; APICULTURE; PISCICULTURE; FISHING; REARING OR BREEDING ANIMALS, NOT OTHERWISE PROVIDED FOR; NEW BREEDS OF ANIMALS
- A01K67/00—Rearing or breeding animals, not otherwise provided for; New or modified breeds of animals
- A01K67/027—New or modified breeds of vertebrates
- A01K67/0275—Genetically modified vertebrates, e.g. transgenic
- A01K67/0276—Knock-out vertebrates
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07K—PEPTIDES
- C07K16/00—Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07K—PEPTIDES
- C07K16/00—Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies
- C07K16/06—Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies from serum
-
- A—HUMAN NECESSITIES
- A01—AGRICULTURE; FORESTRY; ANIMAL HUSBANDRY; HUNTING; TRAPPING; FISHING
- A01K—ANIMAL HUSBANDRY; AVICULTURE; APICULTURE; PISCICULTURE; FISHING; REARING OR BREEDING ANIMALS, NOT OTHERWISE PROVIDED FOR; NEW BREEDS OF ANIMALS
- A01K2217/00—Genetically modified animals
- A01K2217/05—Animals comprising random inserted nucleic acids (transgenic)
- A01K2217/054—Animals comprising random inserted nucleic acids (transgenic) inducing loss of function
- A01K2217/058—Animals comprising random inserted nucleic acids (transgenic) inducing loss of function due to expression of inhibitory nucleic acid, e.g. siRNA, antisense
-
- A—HUMAN NECESSITIES
- A01—AGRICULTURE; FORESTRY; ANIMAL HUSBANDRY; HUNTING; TRAPPING; FISHING
- A01K—ANIMAL HUSBANDRY; AVICULTURE; APICULTURE; PISCICULTURE; FISHING; REARING OR BREEDING ANIMALS, NOT OTHERWISE PROVIDED FOR; NEW BREEDS OF ANIMALS
- A01K2217/00—Genetically modified animals
- A01K2217/07—Animals genetically altered by homologous recombination
- A01K2217/075—Animals genetically altered by homologous recombination inducing loss of function, i.e. knock out
-
- A—HUMAN NECESSITIES
- A01—AGRICULTURE; FORESTRY; ANIMAL HUSBANDRY; HUNTING; TRAPPING; FISHING
- A01K—ANIMAL HUSBANDRY; AVICULTURE; APICULTURE; PISCICULTURE; FISHING; REARING OR BREEDING ANIMALS, NOT OTHERWISE PROVIDED FOR; NEW BREEDS OF ANIMALS
- A01K2227/00—Animals characterised by species
- A01K2227/10—Mammal
- A01K2227/105—Murine
-
- A—HUMAN NECESSITIES
- A01—AGRICULTURE; FORESTRY; ANIMAL HUSBANDRY; HUNTING; TRAPPING; FISHING
- A01K—ANIMAL HUSBANDRY; AVICULTURE; APICULTURE; PISCICULTURE; FISHING; REARING OR BREEDING ANIMALS, NOT OTHERWISE PROVIDED FOR; NEW BREEDS OF ANIMALS
- A01K2267/00—Animals characterised by purpose
- A01K2267/01—Animal expressing industrially exogenous proteins
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07K—PEPTIDES
- C07K2317/00—Immunoglobulins specific features
- C07K2317/50—Immunoglobulins specific features characterized by immunoglobulin fragments
- C07K2317/56—Immunoglobulins specific features characterized by immunoglobulin fragments variable (Fv) region, i.e. VH and/or VL
-
- C—CHEMISTRY; METALLURGY
- C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
- C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
- C12N2800/00—Nucleic acids vectors
- C12N2800/30—Vector systems comprising sequences for excision in presence of a recombinase, e.g. loxP or FRT
Landscapes
- Life Sciences & Earth Sciences (AREA)
- Chemical & Material Sciences (AREA)
- Health & Medical Sciences (AREA)
- Organic Chemistry (AREA)
- General Health & Medical Sciences (AREA)
- Environmental Sciences (AREA)
- Medicinal Chemistry (AREA)
- Biochemistry (AREA)
- Genetics & Genomics (AREA)
- Biophysics (AREA)
- Molecular Biology (AREA)
- Immunology (AREA)
- Proteomics, Peptides & Aminoacids (AREA)
- Zoology (AREA)
- Biodiversity & Conservation Biology (AREA)
- Animal Husbandry (AREA)
- Animal Behavior & Ethology (AREA)
- Veterinary Medicine (AREA)
- Biotechnology (AREA)
- Engineering & Computer Science (AREA)
- Peptides Or Proteins (AREA)
- Micro-Organisms Or Cultivation Processes Thereof (AREA)
- Ultra Sonic Daignosis Equipment (AREA)
- Preparation Of Compounds By Using Micro-Organisms (AREA)
- Inspection Of Paper Currency And Valuable Securities (AREA)
- Position Input By Displaying (AREA)
- Mechanical Coupling Of Light Guides (AREA)
- Investigating Or Analysing Biological Materials (AREA)
- Electrochromic Elements, Electrophoresis, Or Variable Reflection Or Absorption Elements (AREA)
- User Interface Of Digital Computer (AREA)
- Details Of Television Scanning (AREA)
Abstract
Η παρούσα εφεύρεση δίδει από μία πρώτη άποψη ένα ποντίκι στο οποίο ο τόπος της ελαφράς αλυσίδας λ (λάμδα) έχει σιγαστεί λειτουργικά. Σε μία εφαρμογή, ο τόπος ελαφράς αλυσίδας λ ποντικιού σιγάστηκε λειτουργικά με τη διαγραφή τμημάτων γονιδίων που κωδικοποιούν τον τόπο ελαφράς αλυσίδας λ. Σε μία περαιτέρω άποψη, παρήχθη ένα ποντίκι που περιέχει λειτουργικά σιγασμένους τόπους L αλυσίδας λ και κ (κάππα). Η εφεύρεση είναι χρήσιμη για την παραγωγή αντισωμάτων, για παράδειγμα ετερόλογων αντισωμάτων, συμπεριλαμβανομένων μόνο των αντισωμάτων βαρείας αλυσίδας.
Applications Claiming Priority (2)
Application Number | Priority Date | Filing Date | Title |
---|---|---|---|
GBGB0115256.0A GB0115256D0 (en) | 2001-06-21 | 2001-06-21 | Mouse light chain locus |
EP02732970.5A EP1399559B2 (en) | 2001-06-21 | 2002-06-21 | Mouse lambda light chain locus |
Publications (1)
Publication Number | Publication Date |
---|---|
CY1108227T1 true CY1108227T1 (el) | 2014-02-12 |
Family
ID=9917128
Family Applications (1)
Application Number | Title | Priority Date | Filing Date |
---|---|---|---|
CY20081100796T CY1108227T1 (el) | 2001-06-21 | 2008-07-30 | Τοπος ελαφρας αλυσιδας λ σε ποντικι |
Country Status (11)
Country | Link |
---|---|
US (4) | US7541513B2 (el) |
EP (2) | EP1956092A1 (el) |
AT (1) | ATE393826T1 (el) |
AU (1) | AU2002304460A1 (el) |
CY (1) | CY1108227T1 (el) |
DE (1) | DE60226322T3 (el) |
DK (1) | DK1399559T4 (el) |
ES (1) | ES2305245T5 (el) |
GB (2) | GB0115256D0 (el) |
PT (1) | PT1399559E (el) |
WO (1) | WO2003000737A2 (el) |
Families Citing this family (86)
Publication number | Priority date | Publication date | Assignee | Title |
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GB0110029D0 (en) | 2001-04-24 | 2001-06-13 | Grosveld Frank | Transgenic animal |
GB0115256D0 (en) * | 2001-06-21 | 2001-08-15 | Babraham Inst | Mouse light chain locus |
GB0228210D0 (en) * | 2002-12-03 | 2003-01-08 | Babraham Inst | Single chain antibodies |
US7141157B2 (en) * | 2003-03-11 | 2006-11-28 | Chevron U.S.A. Inc. | Blending of low viscosity Fischer-Tropsch base oils and Fischer-Tropsch derived bottoms or bright stock |
US8783257B2 (en) | 2004-02-23 | 2014-07-22 | Fisher & Paykel Healthcare Limited | Breathing assistance apparatus |
KR101151957B1 (ko) | 2004-07-22 | 2012-06-01 | 로저 킹돈 크레이그 | 결합 분자 |
DK3738636T3 (da) | 2006-07-14 | 2023-09-11 | Fisher & Paykel Healthcare Ltd | Åndedrætshjælpeapparat |
DK2602323T3 (en) | 2007-06-01 | 2018-04-16 | Open Monoclonal Tech Inc | Compositions and Methods for Inhibiting Endogenous Immunoglobin Genes and Producing Transgenic Human Idiotypic Antibodies |
US10258757B2 (en) | 2008-05-12 | 2019-04-16 | Fisher & Paykel Healthcare Limited | Patient interface and aspects thereof |
US10792451B2 (en) | 2008-05-12 | 2020-10-06 | Fisher & Paykel Healthcare Limited | Patient interface and aspects thereof |
US20100122358A1 (en) * | 2008-06-06 | 2010-05-13 | Crescendo Biologics Limited | H-Chain-only antibodies |
EP3889265A1 (en) | 2008-09-30 | 2021-10-06 | Ablexis, LLC | Transgenic mice for the production of chimeric antibodies |
JP5827127B2 (ja) | 2008-12-18 | 2015-12-02 | エラスムス・ユニヴァーシティ・メディカル・センター・ロッテルダム | ヒト化抗体を発現する非ヒトトランスジェニック動物及びその使用 |
GB0905023D0 (en) | 2009-03-24 | 2009-05-06 | Univ Erasmus Medical Ct | Binding molecules |
CN104131035A (zh) | 2009-12-10 | 2014-11-05 | 瑞泽恩制药公司 | 生产重链抗体的小鼠 |
KR102117771B1 (ko) | 2010-03-31 | 2020-06-02 | 아블렉시스, 엘엘씨 | 키메라 항체의 제조를 위한 비-인간 동물의 유전적 조작 |
NZ627119A (en) | 2010-06-22 | 2015-05-29 | Regeneron Pharma | Hybrid light chain mice |
US10793829B2 (en) | 2010-07-26 | 2020-10-06 | Trianni, Inc. | Transgenic mammals and methods of use thereof |
US10662256B2 (en) | 2010-07-26 | 2020-05-26 | Trianni, Inc. | Transgenic mammals and methods of use thereof |
CA2806233C (en) | 2010-07-26 | 2021-12-07 | Trianni, Inc. | Transgenic animals and methods of use |
EP3960865A1 (en) | 2010-08-02 | 2022-03-02 | Regeneron Pharmaceuticals, Inc. | Mice that make binding proteins comprising vl domains |
EP4070841A1 (en) | 2010-10-08 | 2022-10-12 | Fisher & Paykel Healthcare Limited | Breathing assistance apparatus |
WO2012063048A1 (en) | 2010-11-08 | 2012-05-18 | Kymab Limited | Cells & vertebrates for enhanced somatic hypermutation and class switch recombination |
ES2876306T3 (es) | 2011-04-15 | 2021-11-12 | Fisher & Paykel Healthcare Ltd | Interfaz que comprende una porción de puente nasal replegable en forma de onda |
US10603456B2 (en) | 2011-04-15 | 2020-03-31 | Fisher & Paykel Healthcare Limited | Interface comprising a nasal sealing portion |
EP2758534B1 (en) | 2011-09-19 | 2020-04-29 | Kymab Limited | Animals, repertoires & methods for the production of human antibodies |
EP4091442A1 (en) | 2011-09-19 | 2022-11-23 | Kymab Limited | Manipulation of immunoglobulin gene diversity and multi-antibody therapeutics |
WO2013045916A1 (en) | 2011-09-26 | 2013-04-04 | Kymab Limited | Chimaeric surrogate light chains (slc) comprising human vpreb |
GB2496375A (en) | 2011-10-28 | 2013-05-15 | Kymab Ltd | A non-human assay vertebrate comprising human antibody loci and human epitope knock-in, and uses thereof |
GB201122047D0 (en) | 2011-12-21 | 2012-02-01 | Kymab Ltd | Transgenic animals |
KR102038974B1 (ko) | 2011-12-20 | 2019-10-31 | 리제너론 파마슈티칼스 인코포레이티드 | 인간화 경쇄 마우스 |
GB2502127A (en) | 2012-05-17 | 2013-11-20 | Kymab Ltd | Multivalent antibodies and in vivo methods for their production |
WO2013144567A1 (en) | 2012-03-28 | 2013-10-03 | Kymab Limited | Transgenic non-human vertebrate for the expression of class - switched, fully human, antibodies |
US9980470B2 (en) | 2013-03-14 | 2018-05-29 | Erasmus University Medical Center | Antibody production |
WO2014141192A1 (en) * | 2013-03-15 | 2014-09-18 | Erasmus University Medical Center | Generation of heavy chain-only antibodies |
EP3119194B1 (en) | 2014-03-21 | 2021-04-28 | Regeneron Pharmaceuticals, Inc. | Non-human animals that make single domain binding proteins |
BR112016021679A2 (pt) | 2014-03-21 | 2018-12-04 | Regeneron Pharmaceuticals, Inc. | proteína de ligação ao antígeno, métodos de produção de uma proteína de ligação ao antígeno e de identificação de uma ou mais proteínas de ligação ao antígeno, hibridoma, ácido nucleico, célula, e, animal não humano geneticamente modificado. |
AU2014409276A1 (en) | 2014-10-22 | 2017-04-06 | Crescendo Biologics Limited | Transgenic mice |
GB201500461D0 (en) | 2015-01-12 | 2015-02-25 | Cresendo Biolog Ltd | Therapeutic molecules |
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KR20200104342A (ko) | 2017-12-22 | 2020-09-03 | 테네오바이오, 인코포레이티드 | Cd22에 결합하는 중쇄 항체 |
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JP7439046B2 (ja) | 2018-07-20 | 2024-02-27 | テネオツー・インコーポレイテッド | Cd19に結合する重鎖抗体 |
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GB201818460D0 (en) | 2018-11-13 | 2018-12-26 | Crescendo Biologics Ltd | Single domain antibodies that bind human serum albumin |
KR20210133234A (ko) | 2019-02-18 | 2021-11-05 | 바이오사이토젠 파마슈티컬스 (베이징) 컴퍼니 리미티드 | 인간화 면역글로불린 유전자좌를 갖는 유전적으로 변형된 비-인간 동물 |
CR20210500A (es) | 2019-04-05 | 2021-11-05 | Teneobio Inc | Anticuerpos de cadena pesada que se unen al psma |
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IL293751A (en) | 2019-12-18 | 2022-08-01 | Teneofour Inc | Heavy chain antibodies that bind to cd38 |
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IL298632A (en) | 2020-06-02 | 2023-01-01 | Biocytogen Pharmaceuticals Beijing Co Ltd | Non-human animals genetically modified with a common light chain immunoglobulin locus |
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TW202233684A (zh) | 2020-11-18 | 2022-09-01 | 美商泰尼歐生物公司 | 結合於葉酸受體α之重鏈抗體 |
WO2022183074A2 (en) | 2021-02-25 | 2022-09-01 | Teneobio, Inc. | Anti-psma antibodies and car-t structures |
CA3211142A1 (en) | 2021-02-26 | 2022-09-01 | Teneobio, Inc. | Anti-muc1-c antibodies and car-t structures |
TW202304994A (zh) | 2021-04-02 | 2023-02-01 | 美商泰尼歐生物公司 | 促效性抗il-2r抗體及使用方法 |
CA3214283A1 (en) | 2021-04-06 | 2022-10-13 | Teneobio, Inc. | Anti-cd19 antibodies and car-t structures |
WO2022221698A1 (en) | 2021-04-16 | 2022-10-20 | Teneobio, Inc. | Anti-cd20 antibodies and car-t structures |
WO2022271987A1 (en) | 2021-06-23 | 2022-12-29 | TeneoFour, Inc. | Anti-cd38 antibodies and epitopes of same |
WO2023004197A1 (en) | 2021-07-23 | 2023-01-26 | Teneoten, Inc. | Heavy chain antibodies binding to hepatitis b surface antigen |
GB202205589D0 (en) | 2022-04-14 | 2022-06-01 | Crescendo Biologics Ltd | Mesothelin binders |
WO2023199069A1 (en) | 2022-04-14 | 2023-10-19 | Crescendo Biologics Limited | Chimeric antigen receptor that binds mesothelin |
WO2024077044A1 (en) | 2022-10-05 | 2024-04-11 | Amgen Inc. | Combination therapies comprising t-cell redirecting therapies and agonistic anti-il-2r antibodies or fragments thereof |
Family Cites Families (13)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
GB8823869D0 (en) | 1988-10-12 | 1988-11-16 | Medical Res Council | Production of antibodies |
US6673986B1 (en) * | 1990-01-12 | 2004-01-06 | Abgenix, Inc. | Generation of xenogeneic antibodies |
US6300129B1 (en) * | 1990-08-29 | 2001-10-09 | Genpharm International | Transgenic non-human animals for producing heterologous antibodies |
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WO1994002602A1 (en) * | 1992-07-24 | 1994-02-03 | Cell Genesys, Inc. | Generation of xenogeneic antibodies |
KR100654645B1 (ko) * | 1995-04-27 | 2007-04-04 | 아브게닉스, 인크. | 면역화된 제노마우스 유래의 인간 항체 |
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IL154751A0 (en) | 2000-08-03 | 2003-10-31 | Humanized antibodies, recombination vectors, transgenic vectors and methods for the preparation of humanized antibodies from transgenic animals | |
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GB0115256D0 (en) * | 2001-06-21 | 2001-08-15 | Babraham Inst | Mouse light chain locus |
DK1399484T3 (da) | 2001-06-28 | 2010-11-08 | Domantis Ltd | Dobbelt-specifik ligand og anvendelse af denne |
GB0228210D0 (en) | 2002-12-03 | 2003-01-08 | Babraham Inst | Single chain antibodies |
-
2001
- 2001-06-21 GB GBGB0115256.0A patent/GB0115256D0/en not_active Ceased
-
2002
- 2002-06-21 PT PT02732970T patent/PT1399559E/pt unknown
- 2002-06-21 DK DK02732970.5T patent/DK1399559T4/en active
- 2002-06-21 ES ES02732970.5T patent/ES2305245T5/es not_active Expired - Lifetime
- 2002-06-21 US US10/481,395 patent/US7541513B2/en not_active Expired - Fee Related
- 2002-06-21 DE DE60226322.0T patent/DE60226322T3/de not_active Expired - Lifetime
- 2002-06-21 AT AT02732970T patent/ATE393826T1/de active
- 2002-06-21 EP EP20080008171 patent/EP1956092A1/en not_active Withdrawn
- 2002-06-21 AU AU2002304460A patent/AU2002304460A1/en not_active Abandoned
- 2002-06-21 GB GB0400676A patent/GB2392672B/en not_active Expired - Lifetime
- 2002-06-21 EP EP02732970.5A patent/EP1399559B2/en not_active Expired - Lifetime
- 2002-06-21 WO PCT/GB2002/002867 patent/WO2003000737A2/en active IP Right Grant
-
2008
- 2008-07-30 CY CY20081100796T patent/CY1108227T1/el unknown
-
2009
- 2009-06-01 US US12/476,087 patent/US8367888B2/en not_active Expired - Fee Related
-
2012
- 2012-10-17 US US13/654,007 patent/US9439405B2/en not_active Expired - Lifetime
-
2016
- 2016-08-08 US US15/230,564 patent/US10194645B2/en not_active Expired - Lifetime
Also Published As
Publication number | Publication date |
---|---|
US20050060763A1 (en) | 2005-03-17 |
EP1399559A2 (en) | 2004-03-24 |
US20170049083A1 (en) | 2017-02-23 |
EP1399559B2 (en) | 2015-09-02 |
DE60226322T2 (de) | 2009-07-09 |
US8367888B2 (en) | 2013-02-05 |
GB0115256D0 (en) | 2001-08-15 |
GB0400676D0 (en) | 2004-02-18 |
EP1399559B1 (en) | 2008-04-30 |
ES2305245T3 (es) | 2008-11-01 |
DK1399559T4 (en) | 2015-12-14 |
PT1399559E (pt) | 2008-07-29 |
ATE393826T1 (de) | 2008-05-15 |
US20130046079A1 (en) | 2013-02-21 |
EP1956092A1 (en) | 2008-08-13 |
GB2392672B (en) | 2005-05-11 |
GB2392672A (en) | 2004-03-10 |
US7541513B2 (en) | 2009-06-02 |
DK1399559T3 (da) | 2008-08-25 |
WO2003000737A2 (en) | 2003-01-03 |
DE60226322D1 (de) | 2008-06-12 |
AU2002304460A1 (en) | 2003-01-08 |
DE60226322T3 (de) | 2016-03-03 |
ES2305245T5 (es) | 2015-12-11 |
US20110093961A1 (en) | 2011-04-21 |
US9439405B2 (en) | 2016-09-13 |
WO2003000737A3 (en) | 2003-09-25 |
US10194645B2 (en) | 2019-02-05 |
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