PT1291429E - Variante de splicing da glutamina-frutose-6-fosfatoamidotransferase e seu produto de expressão - Google Patents
Variante de splicing da glutamina-frutose-6-fosfatoamidotransferase e seu produto de expressão Download PDFInfo
- Publication number
- PT1291429E PT1291429E PT01938602T PT01938602T PT1291429E PT 1291429 E PT1291429 E PT 1291429E PT 01938602 T PT01938602 T PT 01938602T PT 01938602 T PT01938602 T PT 01938602T PT 1291429 E PT1291429 E PT 1291429E
- Authority
- PT
- Portugal
- Prior art keywords
- gene
- expression product
- amino acid
- protein
- splice variant
- Prior art date
Links
- 230000014509 gene expression Effects 0.000 title abstract 4
- GSXOAOHZAIYLCY-UHFFFAOYSA-N D-F6P Natural products OCC(=O)C(O)C(O)C(O)COP(O)(O)=O GSXOAOHZAIYLCY-UHFFFAOYSA-N 0.000 title 1
- BGWGXPAPYGQALX-ARQDHWQXSA-N beta-D-fructofuranose 6-phosphate Chemical compound OC[C@@]1(O)O[C@H](COP(O)(O)=O)[C@@H](O)[C@@H]1O BGWGXPAPYGQALX-ARQDHWQXSA-N 0.000 title 1
- ZDXPYRJPNDTMRX-UHFFFAOYSA-N glutamine Natural products OC(=O)C(N)CCC(N)=O ZDXPYRJPNDTMRX-UHFFFAOYSA-N 0.000 title 1
- 108090000623 proteins and genes Proteins 0.000 abstract 8
- 102000004169 proteins and genes Human genes 0.000 abstract 3
- 125000003275 alpha amino acid group Chemical group 0.000 abstract 2
- 206010012601 diabetes mellitus Diseases 0.000 abstract 2
- 239000013604 expression vector Substances 0.000 abstract 2
- 238000003259 recombinant expression Methods 0.000 abstract 2
- 208000013016 Hypoglycemia Diseases 0.000 abstract 1
- 239000004480 active ingredient Substances 0.000 abstract 1
- 150000001413 amino acids Chemical class 0.000 abstract 1
- 239000003814 drug Substances 0.000 abstract 1
- 229940079593 drug Drugs 0.000 abstract 1
- 230000002218 hypoglycaemic effect Effects 0.000 abstract 1
- 230000007170 pathology Effects 0.000 abstract 1
- 102000040430 polynucleotide Human genes 0.000 abstract 1
- 108091033319 polynucleotide Proteins 0.000 abstract 1
- 239000002157 polynucleotide Substances 0.000 abstract 1
- 229920001184 polypeptide Polymers 0.000 abstract 1
- 230000002265 prevention Effects 0.000 abstract 1
- 230000003449 preventive effect Effects 0.000 abstract 1
- 102000004196 processed proteins & peptides Human genes 0.000 abstract 1
- 108090000765 processed proteins & peptides Proteins 0.000 abstract 1
- 230000001225 therapeutic effect Effects 0.000 abstract 1
Classifications
-
- C—CHEMISTRY; METALLURGY
- C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
- C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
- C12N15/00—Mutation or genetic engineering; DNA or RNA concerning genetic engineering, vectors, e.g. plasmids, or their isolation, preparation or purification; Use of hosts therefor
- C12N15/09—Recombinant DNA-technology
- C12N15/11—DNA or RNA fragments; Modified forms thereof; Non-coding nucleic acids having a biological activity
- C12N15/52—Genes encoding for enzymes or proenzymes
-
- C—CHEMISTRY; METALLURGY
- C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
- C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
- C12N9/00—Enzymes; Proenzymes; Compositions thereof; Processes for preparing, activating, inhibiting, separating or purifying enzymes
- C12N9/10—Transferases (2.)
- C12N9/1096—Transferases (2.) transferring nitrogenous groups (2.6)
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P3/00—Drugs for disorders of the metabolism
- A61P3/08—Drugs for disorders of the metabolism for glucose homeostasis
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P3/00—Drugs for disorders of the metabolism
- A61P3/08—Drugs for disorders of the metabolism for glucose homeostasis
- A61P3/10—Drugs for disorders of the metabolism for glucose homeostasis for hyperglycaemia, e.g. antidiabetics
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K48/00—Medicinal preparations containing genetic material which is inserted into cells of the living body to treat genetic diseases; Gene therapy
Landscapes
- Health & Medical Sciences (AREA)
- Life Sciences & Earth Sciences (AREA)
- Chemical & Material Sciences (AREA)
- Engineering & Computer Science (AREA)
- Genetics & Genomics (AREA)
- Bioinformatics & Cheminformatics (AREA)
- Organic Chemistry (AREA)
- Zoology (AREA)
- Wood Science & Technology (AREA)
- Diabetes (AREA)
- Biomedical Technology (AREA)
- General Health & Medical Sciences (AREA)
- Molecular Biology (AREA)
- General Engineering & Computer Science (AREA)
- Biotechnology (AREA)
- Medicinal Chemistry (AREA)
- Biochemistry (AREA)
- Microbiology (AREA)
- Emergency Medicine (AREA)
- Endocrinology (AREA)
- Hematology (AREA)
- Obesity (AREA)
- Chemical Kinetics & Catalysis (AREA)
- General Chemical & Material Sciences (AREA)
- Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
- Pharmacology & Pharmacy (AREA)
- Animal Behavior & Ethology (AREA)
- Public Health (AREA)
- Veterinary Medicine (AREA)
- Physics & Mathematics (AREA)
- Biophysics (AREA)
- Plant Pathology (AREA)
- Peptides Or Proteins (AREA)
- Micro-Organisms Or Cultivation Processes Thereof (AREA)
- Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)
- Enzymes And Modification Thereof (AREA)
- Preparation Of Compounds By Using Micro-Organisms (AREA)
- Measuring Or Testing Involving Enzymes Or Micro-Organisms (AREA)
- Investigating Or Analysing Biological Materials (AREA)
Applications Claiming Priority (2)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| JP2000176631 | 2000-06-13 | ||
| JP2000290679A JP4601143B2 (ja) | 2000-06-13 | 2000-09-25 | 新規酵素遺伝子およびその発現産物 |
Publications (1)
| Publication Number | Publication Date |
|---|---|
| PT1291429E true PT1291429E (pt) | 2008-12-15 |
Family
ID=26593812
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| PT01938602T PT1291429E (pt) | 2000-06-13 | 2001-06-12 | Variante de splicing da glutamina-frutose-6-fosfatoamidotransferase e seu produto de expressão |
Country Status (15)
| Country | Link |
|---|---|
| US (1) | US7091018B2 (cg-RX-API-DMAC7.html) |
| EP (1) | EP1291429B1 (cg-RX-API-DMAC7.html) |
| JP (1) | JP4601143B2 (cg-RX-API-DMAC7.html) |
| KR (1) | KR100882407B1 (cg-RX-API-DMAC7.html) |
| CN (1) | CN100390286C (cg-RX-API-DMAC7.html) |
| AR (1) | AR029130A1 (cg-RX-API-DMAC7.html) |
| AT (1) | ATE407212T1 (cg-RX-API-DMAC7.html) |
| AU (2) | AU2001264245B2 (cg-RX-API-DMAC7.html) |
| CA (1) | CA2412880C (cg-RX-API-DMAC7.html) |
| DE (1) | DE60135650D1 (cg-RX-API-DMAC7.html) |
| DK (1) | DK1291429T3 (cg-RX-API-DMAC7.html) |
| ES (1) | ES2312442T3 (cg-RX-API-DMAC7.html) |
| PT (1) | PT1291429E (cg-RX-API-DMAC7.html) |
| TW (1) | TWI232883B (cg-RX-API-DMAC7.html) |
| WO (1) | WO2001096574A1 (cg-RX-API-DMAC7.html) |
Families Citing this family (5)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| AU2006262364A1 (en) * | 2005-06-20 | 2007-01-04 | Exelixis, Inc. | GFATs as modifiers of the Axin pathway and methods of use |
| US8106256B2 (en) * | 2005-10-05 | 2012-01-31 | Bayer Cropscience Ag | Methods and means for producing hyaluronan |
| BRPI0713331A2 (pt) * | 2006-06-30 | 2012-03-13 | Hokkaido System Science Co., Ltd. | composição para a transfecção de ácido nucléico |
| CN103301447B (zh) * | 2013-06-25 | 2014-12-31 | 哈尔滨医科大学 | DNA-PKcs在制备改变肿瘤细胞对MTX耐药性的药物中的应用 |
| CN112980914A (zh) * | 2019-12-12 | 2021-06-18 | 中国科学院大连化学物理研究所 | Gfpt1基因作为靶点在筛选抗肿瘤药物中的应用 |
Family Cites Families (5)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| WO1993021330A1 (en) * | 1992-04-22 | 1993-10-28 | Zymogenetics, Inc. | Human glutamine:fructose-6-phosphate amino-transferase |
| JPH1018683A (ja) * | 1996-06-29 | 1998-01-20 | Tesco Joho Center:Kk | 吊下扉のレール装置 |
| US5876713A (en) * | 1996-08-13 | 1999-03-02 | Takeda Chemical Industries Ltd | Glutamine: fructose-6-phosphate amidotransferase, its production and use |
| JP4175680B2 (ja) * | 1996-08-13 | 2008-11-05 | 武田薬品工業株式会社 | 新規タンパク質およびそのｄｎａ |
| WO2000037617A1 (en) * | 1998-12-22 | 2000-06-29 | G.D. Searle & Co. | Glutamine: fructose-6-phosphate aminotransferase ii enzyme and their encoding nucleic acids |
-
2000
- 2000-09-25 JP JP2000290679A patent/JP4601143B2/ja not_active Expired - Fee Related
-
2001
- 2001-06-12 AT AT01938602T patent/ATE407212T1/de active
- 2001-06-12 AR ARP010102776A patent/AR029130A1/es not_active Application Discontinuation
- 2001-06-12 ES ES01938602T patent/ES2312442T3/es not_active Expired - Lifetime
- 2001-06-12 DE DE60135650T patent/DE60135650D1/de not_active Expired - Lifetime
- 2001-06-12 CN CNB018111114A patent/CN100390286C/zh not_active Expired - Fee Related
- 2001-06-12 AU AU2001264245A patent/AU2001264245B2/en not_active Ceased
- 2001-06-12 US US10/297,599 patent/US7091018B2/en not_active Expired - Fee Related
- 2001-06-12 DK DK01938602T patent/DK1291429T3/da active
- 2001-06-12 WO PCT/JP2001/004941 patent/WO2001096574A1/ja not_active Ceased
- 2001-06-12 AU AU6424501A patent/AU6424501A/xx active Pending
- 2001-06-12 PT PT01938602T patent/PT1291429E/pt unknown
- 2001-06-12 EP EP01938602A patent/EP1291429B1/en not_active Expired - Lifetime
- 2001-06-12 CA CA2412880A patent/CA2412880C/en not_active Expired - Fee Related
- 2001-06-12 KR KR1020027016418A patent/KR100882407B1/ko not_active Expired - Fee Related
- 2001-10-16 TW TW090125551A patent/TWI232883B/zh not_active IP Right Cessation
Also Published As
| Publication number | Publication date |
|---|---|
| EP1291429A4 (en) | 2004-05-26 |
| EP1291429A1 (en) | 2003-03-12 |
| JP4601143B2 (ja) | 2010-12-22 |
| ATE407212T1 (de) | 2008-09-15 |
| CA2412880C (en) | 2010-05-04 |
| ES2312442T3 (es) | 2009-03-01 |
| CA2412880A1 (en) | 2002-12-13 |
| US20040132020A1 (en) | 2004-07-08 |
| WO2001096574A1 (en) | 2001-12-20 |
| DK1291429T3 (da) | 2009-01-19 |
| DE60135650D1 (de) | 2008-10-16 |
| TWI232883B (en) | 2005-05-21 |
| KR20030011868A (ko) | 2003-02-11 |
| CN1436239A (zh) | 2003-08-13 |
| JP2002065284A (ja) | 2002-03-05 |
| US7091018B2 (en) | 2006-08-15 |
| KR100882407B1 (ko) | 2009-02-05 |
| CN100390286C (zh) | 2008-05-28 |
| EP1291429B1 (en) | 2008-09-03 |
| AU2001264245B2 (en) | 2006-04-27 |
| AU6424501A (en) | 2001-12-24 |
| AR029130A1 (es) | 2003-06-04 |
Similar Documents
| Publication | Publication Date | Title |
|---|---|---|
| RU2353625C2 (ru) | Миметики человеческого глюканоподобного пептида-1 и их применение в лечении диабета и родственных состояний | |
| AU2017367173B2 (en) | New compounds as peptidic trigonal GLP1/glucagon/GIP receptor agonists | |
| NO20050998L (no) | DNA som koder for et biologisk aktivt fragment av baktericid/premeabilitetsokende protein fremgangsmate for fremstilling av dette, samt farmasoytisk preparat inneholdende dette | |
| MD2311F2 (en) | Obesity polypeptides, immunogenic fragment, analogue, human analogue and reduced human analogue, isolated molecule of nucleic acid, DNA molecule, detectable marked molecule of nucleic acid, vectors containing said DNA molecule, monoclonal antibody, polyclonal antibody and pharmaceutical composition for reduction of the animals body weight | |
| ATE140969T1 (de) | Il-3 mit zusätzlichen cysteinresten und chemische modifikationen davon | |
| ATE146219T1 (de) | Polypeptid | |
| WO2001092497A3 (en) | Human pancreatic islet glucose-6-phosphatase | |
| WO2015061351A1 (en) | Chimeric fibroblast growth factor (fgf) 2/fgf1 peptides and methods of use | |
| AU8748198A (en) | Carcinostatic agents | |
| WO2003038112B1 (en) | A composition and method to alter lean body mass and bone properties in a subject | |
| DE60135650D1 (de) | Amidotransferase und dessen expressionsprodukt | |
| EP1279744A3 (en) | Identification and use of molecules implicated in pain | |
| EP1284297A3 (en) | Identification and use of molecules implicated in pain | |
| EP1279677A4 (en) | GD3 MIMETIC PEPTIDES | |
| BR0318594A (pt) | proteìna recombinante que possui um efeito anticancerìgeno, seu gene de codificação e usos desta | |
| WO2000006087A3 (en) | Uncoupling protein-2(hcp2): compositions and methods of use | |
| ATE327321T1 (de) | Zyklische depsipeptid-synthasen, deren gene und system zur massenproduktion von zyklischen depsipeptiden | |
| AU2957099A (en) | Novel physiologically active peptides and utilization thereof | |
| WO2001049711A3 (en) | Nucleic acids encoding (poly)peptides having chips activity | |
| EP0824149A3 (en) | Glutamine: fructose-6-phosphate amidotransferase (GFAT), its production and use | |
| PT659883E (pt) | Proteina p140 e adn que a codifica | |
| RU97104072A (ru) | Модуляторы веса тела, соответствующие нуклеиновые кислоты и протеины, а также их применение для диагностических и терапевтических целей | |
| Lee et al. | Cooperative activity of subunits of human ferritin heteropolymers in Escherichia coli | |
| WO2003057827A3 (en) | Insulin-responsive dna binding protein-1 and methods to regulate insulin-responsive genes | |
| WO2006063800A8 (en) | Cloning of honey bee allergen |