ATE407212T1 - Spleissvariante der glutamine fructose-6- phosphate amidotransferase und dessen expressionsprodukt - Google Patents

Spleissvariante der glutamine fructose-6- phosphate amidotransferase und dessen expressionsprodukt

Info

Publication number
ATE407212T1
ATE407212T1 AT01938602T AT01938602T ATE407212T1 AT E407212 T1 ATE407212 T1 AT E407212T1 AT 01938602 T AT01938602 T AT 01938602T AT 01938602 T AT01938602 T AT 01938602T AT E407212 T1 ATE407212 T1 AT E407212T1
Authority
AT
Austria
Prior art keywords
expression product
splicing variant
phosphate amidotransferase
glutamine fructose
fructose
Prior art date
Application number
AT01938602T
Other languages
English (en)
Inventor
Tsutomu Fujiwara
Takashi Okamoto
Masashi Niimi
Hiroyuki Kyushiki
Yasuchika Yamamoto
Atsunori Ueyama
Original Assignee
Otsuka Pharma Co Ltd
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Otsuka Pharma Co Ltd filed Critical Otsuka Pharma Co Ltd
Application granted granted Critical
Publication of ATE407212T1 publication Critical patent/ATE407212T1/de

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
    • C12N15/00—Mutation or genetic engineering; DNA or RNA concerning genetic engineering, vectors, e.g. plasmids, or their isolation, preparation or purification; Use of hosts therefor
    • C12N15/09—Recombinant DNA-technology
    • C12N15/11—DNA or RNA fragments; Modified forms thereof; Non-coding nucleic acids having a biological activity
    • C12N15/52—Genes encoding for enzymes or proenzymes
    • C—CHEMISTRY; METALLURGY
    • C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
    • C12N9/00—Enzymes; Proenzymes; Compositions thereof; Processes for preparing, activating, inhibiting, separating or purifying enzymes
    • C12N9/10—Transferases (2.)
    • C12N9/1096—Transferases (2.) transferring nitrogenous groups (2.6)
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P3/00—Drugs for disorders of the metabolism
    • A61P3/08—Drugs for disorders of the metabolism for glucose homeostasis
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P3/00—Drugs for disorders of the metabolism
    • A61P3/08—Drugs for disorders of the metabolism for glucose homeostasis
    • A61P3/10—Drugs for disorders of the metabolism for glucose homeostasis for hyperglycaemia, e.g. antidiabetics
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K48/00—Medicinal preparations containing genetic material which is inserted into cells of the living body to treat genetic diseases; Gene therapy

Landscapes

  • Health & Medical Sciences (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Chemical & Material Sciences (AREA)
  • Engineering & Computer Science (AREA)
  • Genetics & Genomics (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Organic Chemistry (AREA)
  • Zoology (AREA)
  • Wood Science & Technology (AREA)
  • Diabetes (AREA)
  • Biomedical Technology (AREA)
  • General Health & Medical Sciences (AREA)
  • Molecular Biology (AREA)
  • General Engineering & Computer Science (AREA)
  • Biotechnology (AREA)
  • Medicinal Chemistry (AREA)
  • Biochemistry (AREA)
  • Microbiology (AREA)
  • Emergency Medicine (AREA)
  • Endocrinology (AREA)
  • Hematology (AREA)
  • Obesity (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • General Chemical & Material Sciences (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Animal Behavior & Ethology (AREA)
  • Public Health (AREA)
  • Veterinary Medicine (AREA)
  • Physics & Mathematics (AREA)
  • Biophysics (AREA)
  • Plant Pathology (AREA)
  • Peptides Or Proteins (AREA)
  • Micro-Organisms Or Cultivation Processes Thereof (AREA)
  • Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)
  • Enzymes And Modification Thereof (AREA)
  • Preparation Of Compounds By Using Micro-Organisms (AREA)
  • Measuring Or Testing Involving Enzymes Or Micro-Organisms (AREA)
  • Investigating Or Analysing Biological Materials (AREA)
AT01938602T 2000-06-13 2001-06-12 Spleissvariante der glutamine fructose-6- phosphate amidotransferase und dessen expressionsprodukt ATE407212T1 (de)

Applications Claiming Priority (2)

Application Number Priority Date Filing Date Title
JP2000176631 2000-06-13
JP2000290679A JP4601143B2 (ja) 2000-06-13 2000-09-25 新規酵素遺伝子およびその発現産物

Publications (1)

Publication Number Publication Date
ATE407212T1 true ATE407212T1 (de) 2008-09-15

Family

ID=26593812

Family Applications (1)

Application Number Title Priority Date Filing Date
AT01938602T ATE407212T1 (de) 2000-06-13 2001-06-12 Spleissvariante der glutamine fructose-6- phosphate amidotransferase und dessen expressionsprodukt

Country Status (15)

Country Link
US (1) US7091018B2 (de)
EP (1) EP1291429B1 (de)
JP (1) JP4601143B2 (de)
KR (1) KR100882407B1 (de)
CN (1) CN100390286C (de)
AR (1) AR029130A1 (de)
AT (1) ATE407212T1 (de)
AU (2) AU6424501A (de)
CA (1) CA2412880C (de)
DE (1) DE60135650D1 (de)
DK (1) DK1291429T3 (de)
ES (1) ES2312442T3 (de)
PT (1) PT1291429E (de)
TW (1) TWI232883B (de)
WO (1) WO2001096574A1 (de)

Families Citing this family (5)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
CA2612143A1 (en) * 2005-06-20 2007-01-04 Exelixis, Inc. Gfats as modifiers of the axin pathway and methods of use
JP2009509557A (ja) * 2005-10-05 2009-03-12 バイエル・クロップサイエンス・アーゲー 改善されたヒアルロン酸産生方法および手段
KR101430773B1 (ko) * 2006-06-30 2014-08-18 홋카이도 시스테무 사이엔스 가부시키가이샤 핵산 도입용 조성물
CN103301447B (zh) * 2013-06-25 2014-12-31 哈尔滨医科大学 DNA-PKcs在制备改变肿瘤细胞对MTX耐药性的药物中的应用
CN112980914A (zh) * 2019-12-12 2021-06-18 中国科学院大连化学物理研究所 Gfpt1基因作为靶点在筛选抗肿瘤药物中的应用

Family Cites Families (5)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
WO1993021330A1 (en) * 1992-04-22 1993-10-28 Zymogenetics, Inc. Human glutamine:fructose-6-phosphate amino-transferase
JPH1018683A (ja) * 1996-06-29 1998-01-20 Tesco Joho Center:Kk 吊下扉のレール装置
JP4175680B2 (ja) * 1996-08-13 2008-11-05 武田薬品工業株式会社 新規タンパク質およびそのｄｎａ
US5876713A (en) * 1996-08-13 1999-03-02 Takeda Chemical Industries Ltd Glutamine: fructose-6-phosphate amidotransferase, its production and use
AU2216300A (en) * 1998-12-22 2000-07-12 G.D. Searle & Co. Glutamine: fructose-6-phosphate aminotransferase ii enzyme and their encoding nucleic acids

Also Published As

Publication number Publication date
EP1291429A1 (de) 2003-03-12
CA2412880A1 (en) 2002-12-13
TWI232883B (en) 2005-05-21
WO2001096574A1 (fr) 2001-12-20
AU6424501A (en) 2001-12-24
EP1291429B1 (de) 2008-09-03
EP1291429A4 (de) 2004-05-26
DK1291429T3 (da) 2009-01-19
AU2001264245B2 (en) 2006-04-27
DE60135650D1 (de) 2008-10-16
CN100390286C (zh) 2008-05-28
AR029130A1 (es) 2003-06-04
CN1436239A (zh) 2003-08-13
KR20030011868A (ko) 2003-02-11
ES2312442T3 (es) 2009-03-01
CA2412880C (en) 2010-05-04
PT1291429E (pt) 2008-12-15
JP2002065284A (ja) 2002-03-05
KR100882407B1 (ko) 2009-02-05
US20040132020A1 (en) 2004-07-08
JP4601143B2 (ja) 2010-12-22
US7091018B2 (en) 2006-08-15

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