WO2000006087A3 - Uncoupling protein-2(hcp2): compositions and methods of use - Google Patents

Uncoupling protein-2(hcp2): compositions and methods of use Download PDF

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Publication number
WO2000006087A3
WO2000006087A3 PCT/US1999/017246 US9917246W WO0006087A3 WO 2000006087 A3 WO2000006087 A3 WO 2000006087A3 US 9917246 W US9917246 W US 9917246W WO 0006087 A3 WO0006087 A3 WO 0006087A3
Authority
WO
WIPO (PCT)
Prior art keywords
ucp2
methods
polypeptide
compositions
nucleic acids
Prior art date
Application number
PCT/US1999/017246
Other languages
French (fr)
Other versions
WO2000006087A2 (en
Inventor
Jin-Long Chen
M Catherine Amaral
Original Assignee
Tularik Inc
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Tularik Inc filed Critical Tularik Inc
Priority to AU52432/99A priority Critical patent/AU5243299A/en
Publication of WO2000006087A2 publication Critical patent/WO2000006087A2/en
Publication of WO2000006087A3 publication Critical patent/WO2000006087A3/en

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Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K14/00—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof
    • C07K14/435—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from animals; from humans
    • C07K14/46—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from animals; from humans from vertebrates
    • C07K14/47—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from animals; from humans from vertebrates from mammals
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K38/00—Medicinal preparations containing peptides

Abstract

The present invention relates generally to compositions and methods for the treatment of body weight disorders including, but not limited to, obesity. More specifically, the present invention relates to nucleic acids encoding a human UCP2 polypeptide; a human UCP2 polypeptide encoded by such nucleic acids; recombinant nucleic acid molecules containing nucleic acids encoding a human UCP2 polypeptide; cells containing such recombinant nucleic acid molecules; a method for producing human UCP2 polypeptides; and methods for detecting modulators of UCP2 gene expression and UCP2 polypeptide expression.
PCT/US1999/017246 1998-07-29 1999-07-29 Uncoupling protein-2(hcp2): compositions and methods of use WO2000006087A2 (en)

Priority Applications (1)

Application Number Priority Date Filing Date Title
AU52432/99A AU5243299A (en) 1998-07-29 1999-07-29 Uncoupling protein-2(hcp2): compositions and methods of use

Applications Claiming Priority (2)

Application Number Priority Date Filing Date Title
US12429398A 1998-07-29 1998-07-29
US09/124,293 1998-07-29

Publications (2)

Publication Number Publication Date
WO2000006087A2 WO2000006087A2 (en) 2000-02-10
WO2000006087A3 true WO2000006087A3 (en) 2000-05-11

Family

ID=22413984

Family Applications (1)

Application Number Title Priority Date Filing Date
PCT/US1999/017246 WO2000006087A2 (en) 1998-07-29 1999-07-29 Uncoupling protein-2(hcp2): compositions and methods of use

Country Status (3)

Country Link
US (1) US20020127600A1 (en)
AU (1) AU5243299A (en)
WO (1) WO2000006087A2 (en)

Families Citing this family (10)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US6670138B2 (en) * 2000-11-01 2003-12-30 Agy Therapeutics, Inc. Method of diagnosing ischemic stroke via UCP-2 detection
JP2004534742A (en) * 2001-03-30 2004-11-18 デヴェロゲン アクチエンゲゼルシャフト フュア エントヴィックルングスビオローギッシェ フォルシュング Modification of organelle metabolism by UNC-51-like kinase, ROMA1, or 2TM protein
US20050004056A1 (en) * 2001-12-04 2005-01-06 Martin Meise Ptp10d, tec protein tyrosine kinase and edtp homologous proteins involved in the regulation of energy homeostasis
EP1492553B1 (en) * 2002-03-14 2006-11-22 DeveloGen Aktiengesellschaft Cg8327 and srm involved in the regulation of energy homeostasis
AU2003274715A1 (en) * 2002-06-10 2003-12-22 Develogen Aktiengesellschaft Fur Entwicklungsbiologische Forschung L(2)44 dea, wunen-2, grapes, cg2221, cg1172, rutabaga, cg11940, facl involved in the regulation of energy homeostasis
ATE545428T1 (en) * 2002-12-16 2012-03-15 Develogen Ag PIK4CB IS INVOLVED IN THE REGULATION OF ENERGY METABOLISM
FR2866233B1 (en) * 2004-02-18 2008-02-08 Vincience DERMATOLOGICAL AND / OR COSMETIC COMPOSITION CONTAINING POLYPEPTIDES
FR2879924B1 (en) * 2004-12-23 2007-06-15 Soc Extraction Principes Actif SLIMMING COSMETIC COMPOSITION
EP2205249B1 (en) 2007-09-28 2018-11-07 Intrexon Corporation Therapeutic gene-switch constructs and bioreactors for the expression of biotherapeutic molecules, and uses thereof
EP2877602A4 (en) * 2012-06-05 2016-04-20 Medical Res Infrastructure & Health Services Fund Novel assay for monitoring glucose balance and oxidative stress

Citations (1)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US5741666A (en) * 1994-08-23 1998-04-21 Millennium Pharmaceuticals, Inc. Compositions and methods, for the treatment of body weight disorders, including obesity

Patent Citations (1)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US5741666A (en) * 1994-08-23 1998-04-21 Millennium Pharmaceuticals, Inc. Compositions and methods, for the treatment of body weight disorders, including obesity

Non-Patent Citations (2)

* Cited by examiner, † Cited by third party
Title
BATHGATE B. ET AL.: "Functional expression of the rat brown adipose tissue uncoupling protein in Saccharomyces cerevisiae", MOLECULAR MICROBIOLOGY,, vol. 6, no. 3, 1992, pages 363 - 370 *
BOSS O. ET AL.: "Uncoupling protein-3: a new member of the mitochondrial carrier family with tissue-specific expression", FEBS LETTERS,, vol. 408, 17 May 1997 (1997-05-17), pages 39 - 42 *

Also Published As

Publication number Publication date
AU5243299A (en) 2000-02-21
WO2000006087A2 (en) 2000-02-10
US20020127600A1 (en) 2002-09-12

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