PT1284998E - Eptideos imunogenicos sinteticos mas nao-amiloidogenicos homologos a beta-amiloides, destinados a induzir uma reaccao imunitaria contra os beta-amiloides e os depositos amiloides - Google Patents
Eptideos imunogenicos sinteticos mas nao-amiloidogenicos homologos a beta-amiloides, destinados a induzir uma reaccao imunitaria contra os beta-amiloides e os depositos amiloidesInfo
- Publication number
- PT1284998E PT1284998E PT01941526T PT01941526T PT1284998E PT 1284998 E PT1284998 E PT 1284998E PT 01941526 T PT01941526 T PT 01941526T PT 01941526 T PT01941526 T PT 01941526T PT 1284998 E PT1284998 E PT 1284998E
- Authority
- PT
- Portugal
- Prior art keywords
- amyloid
- beta
- immunogenic
- synthetic
- amyloogogenic
- Prior art date
Links
Classifications
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07K—PEPTIDES
- C07K14/00—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof
- C07K14/435—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from animals; from humans
- C07K14/46—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from animals; from humans from vertebrates
- C07K14/47—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from animals; from humans from vertebrates from mammals
- C07K14/4701—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from animals; from humans from vertebrates from mammals not used
- C07K14/4711—Alzheimer's disease; Amyloid plaque core protein
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P25/00—Drugs for disorders of the nervous system
- A61P25/28—Drugs for disorders of the nervous system for treating neurodegenerative disorders of the central nervous system, e.g. nootropic agents, cognition enhancers, drugs for treating Alzheimer's disease or other forms of dementia
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P3/00—Drugs for disorders of the metabolism
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P37/00—Drugs for immunological or allergic disorders
- A61P37/02—Immunomodulators
- A61P37/04—Immunostimulants
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07K—PEPTIDES
- C07K16/00—Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies
- C07K16/18—Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies against material from animals or humans
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K39/00—Medicinal preparations containing antigens or antibodies
-
- Y—GENERAL TAGGING OF NEW TECHNOLOGICAL DEVELOPMENTS; GENERAL TAGGING OF CROSS-SECTIONAL TECHNOLOGIES SPANNING OVER SEVERAL SECTIONS OF THE IPC; TECHNICAL SUBJECTS COVERED BY FORMER USPC CROSS-REFERENCE ART COLLECTIONS [XRACs] AND DIGESTS
- Y02—TECHNOLOGIES OR APPLICATIONS FOR MITIGATION OR ADAPTATION AGAINST CLIMATE CHANGE
- Y02A—TECHNOLOGIES FOR ADAPTATION TO CLIMATE CHANGE
- Y02A50/00—TECHNOLOGIES FOR ADAPTATION TO CLIMATE CHANGE in human health protection, e.g. against extreme weather
- Y02A50/30—Against vector-borne diseases, e.g. mosquito-borne, fly-borne, tick-borne or waterborne diseases whose impact is exacerbated by climate change
Landscapes
- Health & Medical Sciences (AREA)
- Chemical & Material Sciences (AREA)
- Organic Chemistry (AREA)
- Life Sciences & Earth Sciences (AREA)
- General Health & Medical Sciences (AREA)
- Medicinal Chemistry (AREA)
- Engineering & Computer Science (AREA)
- Immunology (AREA)
- Biophysics (AREA)
- Genetics & Genomics (AREA)
- Proteomics, Peptides & Aminoacids (AREA)
- Molecular Biology (AREA)
- Biochemistry (AREA)
- Bioinformatics & Cheminformatics (AREA)
- Biomedical Technology (AREA)
- Neurology (AREA)
- Pharmacology & Pharmacy (AREA)
- Veterinary Medicine (AREA)
- Public Health (AREA)
- Animal Behavior & Ethology (AREA)
- Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
- General Chemical & Material Sciences (AREA)
- Chemical Kinetics & Catalysis (AREA)
- Neurosurgery (AREA)
- Toxicology (AREA)
- Gastroenterology & Hepatology (AREA)
- Zoology (AREA)
- Diabetes (AREA)
- Psychiatry (AREA)
- Obesity (AREA)
- Hematology (AREA)
- Hospice & Palliative Care (AREA)
- Peptides Or Proteins (AREA)
- Medicines Containing Antibodies Or Antigens For Use As Internal Diagnostic Agents (AREA)
- Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)
- Preparation Of Compounds By Using Micro-Organisms (AREA)
- Acyclic And Carbocyclic Compounds In Medicinal Compositions (AREA)
- Medicines Containing Material From Animals Or Micro-Organisms (AREA)
Applications Claiming Priority (1)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| US20557800P | 2000-05-22 | 2000-05-22 |
Publications (1)
| Publication Number | Publication Date |
|---|---|
| PT1284998E true PT1284998E (pt) | 2005-06-30 |
Family
ID=22762767
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| PT01941526T PT1284998E (pt) | 2000-05-22 | 2001-05-22 | Eptideos imunogenicos sinteticos mas nao-amiloidogenicos homologos a beta-amiloides, destinados a induzir uma reaccao imunitaria contra os beta-amiloides e os depositos amiloides |
Country Status (14)
| Country | Link |
|---|---|
| US (3) | US6713450B2 (enExample) |
| EP (1) | EP1284998B1 (enExample) |
| JP (1) | JP2003534351A (enExample) |
| CN (1) | CN1249085C (enExample) |
| AT (1) | ATE286072T1 (enExample) |
| AU (2) | AU2001274873B2 (enExample) |
| CA (1) | CA2408925A1 (enExample) |
| DE (1) | DE60108111T2 (enExample) |
| ES (1) | ES2238049T3 (enExample) |
| IL (2) | IL152625A0 (enExample) |
| NZ (1) | NZ521939A (enExample) |
| PT (1) | PT1284998E (enExample) |
| WO (1) | WO2001090182A2 (enExample) |
| ZA (1) | ZA200207992B (enExample) |
Families Citing this family (73)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| US6923964B1 (en) | 1997-12-02 | 2005-08-02 | Neuralab Limited | Active immunization of AScr for prion disorders |
| US7588766B1 (en) | 2000-05-26 | 2009-09-15 | Elan Pharma International Limited | Treatment of amyloidogenic disease |
| US6743427B1 (en) | 1997-12-02 | 2004-06-01 | Neuralab Limited | Prevention and treatment of amyloidogenic disease |
| US7790856B2 (en) | 1998-04-07 | 2010-09-07 | Janssen Alzheimer Immunotherapy | Humanized antibodies that recognize beta amyloid peptide |
| US6913745B1 (en) | 1997-12-02 | 2005-07-05 | Neuralab Limited | Passive immunization of Alzheimer's disease |
| US7179892B2 (en) * | 2000-12-06 | 2007-02-20 | Neuralab Limited | Humanized antibodies that recognize beta amyloid peptide |
| US7964192B1 (en) | 1997-12-02 | 2011-06-21 | Janssen Alzheimer Immunotherapy | Prevention and treatment of amyloidgenic disease |
| US6750324B1 (en) | 1997-12-02 | 2004-06-15 | Neuralab Limited | Humanized and chimeric N-terminal amyloid beta-antibodies |
| US6761888B1 (en) | 2000-05-26 | 2004-07-13 | Neuralab Limited | Passive immunization treatment of Alzheimer's disease |
| TWI239847B (en) * | 1997-12-02 | 2005-09-21 | Elan Pharm Inc | N-terminal fragment of Abeta peptide and an adjuvant for preventing and treating amyloidogenic disease |
| US20080050367A1 (en) * | 1998-04-07 | 2008-02-28 | Guriq Basi | Humanized antibodies that recognize beta amyloid peptide |
| US6787523B1 (en) * | 1997-12-02 | 2004-09-07 | Neuralab Limited | Prevention and treatment of amyloidogenic disease |
| US20030147882A1 (en) * | 1998-05-21 | 2003-08-07 | Alan Solomon | Methods for amyloid removal using anti-amyloid antibodies |
| US7148324B1 (en) * | 1998-12-14 | 2006-12-12 | Dendreon Corporation | Compositions and methods for enhancement of major histocompatibility complex class I restricted antigen presentation |
| US6787637B1 (en) | 1999-05-28 | 2004-09-07 | Neuralab Limited | N-Terminal amyloid-β antibodies |
| UA81216C2 (en) | 1999-06-01 | 2007-12-25 | Prevention and treatment of amyloid disease | |
| ES2248283T3 (es) * | 2000-02-21 | 2006-03-16 | Pharmexa A/S | Nuevo procedimiento para reducir los niveles de amiloide. |
| CZ20022748A3 (cs) * | 2000-02-21 | 2004-03-17 | Pharmexa A/S | Nová metoda regulace obsahu amyloidu |
| WO2002003911A2 (en) | 2000-07-07 | 2002-01-17 | Lars Lannfelt | Prevention and treatment of alzheimer's disease |
| US7700751B2 (en) | 2000-12-06 | 2010-04-20 | Janssen Alzheimer Immunotherapy | Humanized antibodies that recognize β-amyloid peptide |
| TWI255272B (en) * | 2000-12-06 | 2006-05-21 | Guriq Basi | Humanized antibodies that recognize beta amyloid peptide |
| US7097837B2 (en) * | 2001-02-19 | 2006-08-29 | Pharmexa A/S | Synthetic vaccine agents |
| US20040191264A1 (en) * | 2001-02-19 | 2004-09-30 | Nielsen Klaus Gregorius | Synthetic vaccine agents |
| US6815175B2 (en) | 2001-03-16 | 2004-11-09 | Cornell Research Foundation, Inc. | Anti-amyloid peptide antibody based diagnosis and treatment of a neurological disease or disorder |
| WO2002074931A2 (en) * | 2001-03-20 | 2002-09-26 | University Of Chicago | Inhibitors and disassemblers of fibrillogenesis |
| MY144532A (en) * | 2001-08-20 | 2011-09-30 | Lundbeck & Co As H | Novel method for down-regulation of amyloid |
| EP1572894B1 (en) * | 2001-11-21 | 2016-04-13 | New York University | Synthetic immunogenic but non-deposit-forming polypeptides and peptides homologous to amyloid beta, prion protein, amylin, alpha synuclein, or polyglutamine repeats for induction of an immune response thereto |
| MY139983A (en) * | 2002-03-12 | 2009-11-30 | Janssen Alzheimer Immunotherap | Humanized antibodies that recognize beta amyloid peptide |
| AU2003256578A1 (en) * | 2002-07-17 | 2004-02-02 | Intellect Neurosciences, Inc. | Peptides and methods of screening immunogenic peptide vaccines against alzheimer's disease |
| EP1560850A2 (en) * | 2002-11-14 | 2005-08-10 | Adherex Technologies, Inc. | Compounds and methods for modulating desmosomal and atypical cadherin-mediated cell adhesion |
| WO2004056318A2 (en) | 2002-12-19 | 2004-07-08 | New York University | Method for treating amyloid disease |
| DE10303974A1 (de) | 2003-01-31 | 2004-08-05 | Abbott Gmbh & Co. Kg | Amyloid-β(1-42)-Oligomere, Verfahren zu deren Herstellung und deren Verwendung |
| GB0310270D0 (en) * | 2003-05-03 | 2003-06-11 | Univ Edinburgh | Biomolecular devices |
| TWI374893B (en) | 2003-05-30 | 2012-10-21 | Janssen Alzheimer Immunotherap | Humanized antibodies that recognize beta amyloid peptide |
| AR047062A1 (es) | 2003-12-17 | 2006-01-04 | Wyeth Corp | Conjugados portadores de peptidos inmunogenicos a beta y metodos para producirlos |
| SE0401601D0 (sv) | 2004-06-21 | 2004-06-21 | Bioarctic Neuroscience Ab | Protofibril specific antibodies and uses thereof |
| BRPI0516279A (pt) * | 2004-10-06 | 2008-09-02 | Hiroshi Mori | proteìna amilóide variante humana, peptìdeo, gene humano, mrna. cdna sintetizado, anticorpo, método de diagnóstico de doenças amilóides, método para classificação de um componente do agente terapêutico para as doenças amilóides, e fármaco anti-doença amilóide |
| EP1838349A1 (en) * | 2004-12-15 | 2007-10-03 | Neuralab, Ltd. | Amyloid beta antibodies for use in improving cognition |
| TW200635607A (en) * | 2004-12-15 | 2006-10-16 | Elan Pharm Inc | Humanized Aβ antibodies for use in improving cognition |
| WO2006066049A2 (en) | 2004-12-15 | 2006-06-22 | Neuralab Limited | Humanized antibodies that recognize beta amyloid peptide |
| CA2607004C (en) | 2005-05-05 | 2016-01-26 | Sensient Flavors Inc. | Production of beta-glucans and mannans |
| CN117903302A (zh) | 2005-11-30 | 2024-04-19 | Abbvie 公司 | 抗-Aβ球聚体抗体,其相关产品,生产所述抗体的方法,所述抗体的应用以及使用方法 |
| PT1976877E (pt) * | 2005-11-30 | 2014-04-29 | Abbvie Inc | Anticorpos monoclonais contra proteína beta-amilóide e suas utilizações |
| RU2429244C2 (ru) | 2006-03-23 | 2011-09-20 | Байоарктик Ньюросайенс Аб | Улучшенные селективные в отношении протофибрилл антитела и их применение |
| US8784810B2 (en) * | 2006-04-18 | 2014-07-22 | Janssen Alzheimer Immunotherapy | Treatment of amyloidogenic diseases |
| US20090123488A1 (en) * | 2006-08-14 | 2009-05-14 | Thymon, Llc | Compositions and methods for the treatment and prophylaxis of Alzheimer's disease |
| WO2008021295A2 (en) * | 2006-08-14 | 2008-02-21 | Thymon, L.L.C. | Compositions and methods for the treatment and prophylaxis of multiple strains and subtypes of hiv-1 |
| WO2008070284A2 (en) | 2006-10-16 | 2008-06-12 | Johnnie B. Byrd, Sr. Alzheimer's Center And Research Institute | Amyloid beta peptides and methods of uses thereof |
| US8455626B2 (en) | 2006-11-30 | 2013-06-04 | Abbott Laboratories | Aβ conformer selective anti-aβ globulomer monoclonal antibodies |
| TW200902063A (en) | 2007-02-15 | 2009-01-16 | Univ Kumamoto | Therapeutic agent comprising antibody capable of specifically binding to human hmgb-1 as active ingredient |
| EP2123298A4 (en) * | 2007-02-15 | 2011-09-28 | Univ Fukuoka | AGENT FOR SUPPRESSING REJECTION IN AN ORGAN TRANSPLANT COMPRISING ANTI-HMGB-1 ANTIBODY |
| JP5241518B2 (ja) * | 2007-02-15 | 2013-07-17 | 国立大学法人九州大学 | 抗hmgb−1抗体を含む間質性肺疾患治療剤 |
| US20100311767A1 (en) * | 2007-02-27 | 2010-12-09 | Abbott Gmbh & Co. Kg | Method for the treatment of amyloidoses |
| WO2008106657A2 (en) * | 2007-03-01 | 2008-09-04 | Intezyne Technologies, Inc. | Encapsulated amyloid-beta peptides |
| US8003097B2 (en) * | 2007-04-18 | 2011-08-23 | Janssen Alzheimer Immunotherapy | Treatment of cerebral amyloid angiopathy |
| CN101970000A (zh) * | 2007-04-18 | 2011-02-09 | 杨森阿尔茨海默氏症免疫治疗公司 | 脑淀粉样血管病的预防和治疗 |
| DK2182983T3 (da) | 2007-07-27 | 2014-07-14 | Janssen Alzheimer Immunotherap | Behandling af amyloidogene sygdomme med humaniserede anti-abeta antistoffer |
| JO3076B1 (ar) * | 2007-10-17 | 2017-03-15 | Janssen Alzheimer Immunotherap | نظم العلاج المناعي المعتمد على حالة apoe |
| KR101581733B1 (ko) | 2007-11-16 | 2015-12-31 | 더 락커펠러 유니버시티 | 원섬유 형태의 베타아밀로이드 단백질에 대해 특이적인 항체 |
| AU2009266552B2 (en) * | 2008-07-01 | 2014-01-23 | De Staat Der Nederlanden, Vert. Door De Minister Van Vws | Vaccine against amyloid folding intermediate |
| US9067981B1 (en) | 2008-10-30 | 2015-06-30 | Janssen Sciences Ireland Uc | Hybrid amyloid-beta antibodies |
| TWI508976B (zh) * | 2009-04-21 | 2015-11-21 | Univ Rockefeller | 對β-類澱粉蛋白之基原纖維形式具專一性之抗體 |
| US8409584B2 (en) | 2009-05-05 | 2013-04-02 | New York University | Immunotherapy targeting of the shared abnormal conformational state of amyloidogenic peptides/proteins |
| US8748386B2 (en) | 2009-06-10 | 2014-06-10 | New York University | Immunological targeting of pathological Tau proteins |
| CN101920008B (zh) * | 2009-06-15 | 2013-07-31 | 浙江仙琚制药股份有限公司 | 包含Aβ40多肽和铝佐剂的制剂以及纯化Aβ40多肽的方法 |
| CN104744591B (zh) | 2010-04-15 | 2022-09-27 | Abbvie德国有限责任两合公司 | β淀粉样蛋白结合蛋白 |
| EP3533803B1 (en) | 2010-08-14 | 2021-10-27 | AbbVie Inc. | Anti-amyloid-beta antibodies |
| US9926353B2 (en) | 2011-07-19 | 2018-03-27 | New York University | Immunotherapeutic modulation of amyloidogenic disease using non-fibrillogenic, non-amyloidogenic polymerized proteins and peptides |
| US8906382B2 (en) | 2011-07-19 | 2014-12-09 | New York University | Method for treating amyloid disease |
| RS61717B1 (sr) | 2014-07-10 | 2021-05-31 | Bioarctic Ab | Poboljšana antitela koja vezuju a-beta protofibril |
| WO2018038973A1 (en) * | 2016-08-20 | 2018-03-01 | The Arizona Board Of Regents On Behalf Of The University Of Arizona | Neuroprotective beta amyloid core peptides and peptidomimetic derivatives |
| CN119136838A (zh) | 2022-02-28 | 2024-12-13 | 特瑞德姆生物科技有限责任两合公司 | 由至少一种β-葡聚糖或甘露聚糖组成或包含至少一种β-葡聚糖或甘露聚糖的偶联物 |
| MX2024010450A (es) | 2022-02-28 | 2024-09-18 | Tridem Bioscience Gmbh & Co Kg | Conjugado que consiste de o que comprende al menos un beta-glucano o un manano. |
Family Cites Families (7)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| EP0760676B1 (en) | 1994-05-25 | 2001-07-11 | McMICHAEL, John | Materials and methods for treatment of plaquing diseases |
| US5688651A (en) * | 1994-12-16 | 1997-11-18 | Ramot University Authority For Applied Research And Development Ltd. | Prevention of protein aggregation |
| US5948763A (en) * | 1995-06-07 | 1999-09-07 | New York University | Peptides and pharmaceutical compositions thereof for treatment of disorders or diseases associated with abnormal protein folding into amyloid or amyloid-like deposits |
| TWI239847B (en) * | 1997-12-02 | 2005-09-21 | Elan Pharm Inc | N-terminal fragment of Abeta peptide and an adjuvant for preventing and treating amyloidogenic disease |
| US6787523B1 (en) * | 1997-12-02 | 2004-09-07 | Neuralab Limited | Prevention and treatment of amyloidogenic disease |
| US7964192B1 (en) * | 1997-12-02 | 2011-06-21 | Janssen Alzheimer Immunotherapy | Prevention and treatment of amyloidgenic disease |
| AU742970C (en) * | 1997-12-03 | 2003-03-20 | Janssen Alzheimer Immunotherapy | Method of suppressing beta-amyloid-related changes in Alzheimer's disease |
-
2001
- 2001-05-22 AT AT01941526T patent/ATE286072T1/de not_active IP Right Cessation
- 2001-05-22 WO PCT/US2001/016322 patent/WO2001090182A2/en not_active Ceased
- 2001-05-22 IL IL15262501A patent/IL152625A0/xx unknown
- 2001-05-22 CN CNB018100058A patent/CN1249085C/zh not_active Expired - Fee Related
- 2001-05-22 DE DE60108111T patent/DE60108111T2/de not_active Expired - Lifetime
- 2001-05-22 ES ES01941526T patent/ES2238049T3/es not_active Expired - Lifetime
- 2001-05-22 CA CA002408925A patent/CA2408925A1/en not_active Abandoned
- 2001-05-22 AU AU2001274873A patent/AU2001274873B2/en not_active Ceased
- 2001-05-22 JP JP2001586993A patent/JP2003534351A/ja not_active Withdrawn
- 2001-05-22 US US09/861,847 patent/US6713450B2/en not_active Expired - Lifetime
- 2001-05-22 AU AU7487301A patent/AU7487301A/xx active Pending
- 2001-05-22 EP EP01941526A patent/EP1284998B1/en not_active Expired - Lifetime
- 2001-05-22 NZ NZ521939A patent/NZ521939A/en unknown
- 2001-05-22 PT PT01941526T patent/PT1284998E/pt unknown
-
2002
- 2002-10-04 ZA ZA200207992A patent/ZA200207992B/xx unknown
- 2002-11-03 IL IL152625A patent/IL152625A/en not_active IP Right Cessation
-
2003
- 2003-09-19 US US10/666,423 patent/US7427655B2/en not_active Expired - Fee Related
-
2008
- 2008-09-19 US US12/234,456 patent/US7700107B2/en not_active Expired - Fee Related
Also Published As
| Publication number | Publication date |
|---|---|
| CN1444598A (zh) | 2003-09-24 |
| US20020077288A1 (en) | 2002-06-20 |
| US20040043935A1 (en) | 2004-03-04 |
| EP1284998B1 (en) | 2004-12-29 |
| WO2001090182A3 (en) | 2002-05-23 |
| US6713450B2 (en) | 2004-03-30 |
| US20090081204A1 (en) | 2009-03-26 |
| AU2001274873B2 (en) | 2006-10-05 |
| ATE286072T1 (de) | 2005-01-15 |
| IL152625A (en) | 2009-12-24 |
| ZA200207992B (en) | 2003-07-02 |
| DE60108111D1 (de) | 2005-02-03 |
| WO2001090182A2 (en) | 2001-11-29 |
| CA2408925A1 (en) | 2001-11-29 |
| ES2238049T3 (es) | 2005-08-16 |
| US7700107B2 (en) | 2010-04-20 |
| AU7487301A (en) | 2001-12-03 |
| CN1249085C (zh) | 2006-04-05 |
| JP2003534351A (ja) | 2003-11-18 |
| US7427655B2 (en) | 2008-09-23 |
| DE60108111T2 (de) | 2005-12-08 |
| NZ521939A (en) | 2004-04-30 |
| EP1284998A2 (en) | 2003-02-26 |
| IL152625A0 (en) | 2003-06-24 |
Similar Documents
| Publication | Publication Date | Title |
|---|---|---|
| PT1284998E (pt) | Eptideos imunogenicos sinteticos mas nao-amiloidogenicos homologos a beta-amiloides, destinados a induzir uma reaccao imunitaria contra os beta-amiloides e os depositos amiloides | |
| AR125327A2 (es) | Composiciones de neisseria meningitidis y métodos de las mismas | |
| PT1187629E (pt) | Composicao adjuvante que compreende saponina e um oligonucleotido imunoestimulador | |
| TW200730189A (en) | Novel composition | |
| DE122010000042I1 (de) | Solubilisierung von capsulären Polysacchariden | |
| ATE426412T1 (de) | Adjuvante influenza-vakzine | |
| WO2004030608A3 (en) | Nanoemulsion vaccines | |
| MY125202A (en) | Vaccine | |
| UY27843A1 (es) | Composicion de vacuna | |
| NO20015074D0 (no) | Nye sammensetninger | |
| PT1104306E (pt) | Composicoes de cpg e adjuvantes de saponina e seus metodos | |
| BR0012424A (pt) | Peptìdeos meningocócicos antigênicos | |
| PT1154790E (pt) | Reforco da actividade bactericida de antigenios contra a neisseria com oligonucleotidos contendo motivos cg | |
| BRPI0410341B8 (pt) | conjugados de polissacarídeo-proteína derivatizados de meningococos multivalentes e vacina | |
| BRPI0314373B8 (pt) | produto imunogênico estável para a indução de anticorpos contra uma ou várias proteínas antigênicas em um indivíduo, composições farmacêutica, imunogênica e de vacina e processo de preparação de um produto imunogênico | |
| DE60011560D1 (de) | Salmonella Impfstoff, der keinen Antikörper gegen Flagellin oder gegen Flagella induziert | |
| UA107177C2 (uk) | Імуногенна композиція цвс2 та спосіб приготування такої композиції | |
| BRPI0414073A (pt) | método para induzir uma resposta imune contra infecção por rotavìrus a partir de um sorotipo de rotavìrus, e, uso de uma cepa de rotavìrus atenuado de um sorotipo | |
| AU6761301A (en) | Adjuvant composition comprising fha protein or fragment of fha protein in free form | |
| DE60024977D1 (de) | Klonierung und expression von haemophilus somnus transferrin-bindenden proteinen | |
| DK1401492T3 (da) | LTB4 som vaccineadjuvans | |
| UA38352A (uk) | Засіб для лікувальних ванн | |
| ITRM20000507A0 (it) | Metodi per la ricostruzione di sequenze da frammenti. | |
| HK1075842A (en) | Nanoemulsion vaccines | |
| ECSP003412A (es) | Derivados de 3- amino -3-arilpropan - 1 - ol, su preparacion y su uso |