PT1183255E - Complexos metalicos de poliaminoacidos biciclicos processo de preparacao e sua aplicacao em imageologia medica - Google Patents

Complexos metalicos de poliaminoacidos biciclicos processo de preparacao e sua aplicacao em imageologia medica

Info

Publication number
PT1183255E
PT1183255E PT00940473T PT00940473T PT1183255E PT 1183255 E PT1183255 E PT 1183255E PT 00940473 T PT00940473 T PT 00940473T PT 00940473 T PT00940473 T PT 00940473T PT 1183255 E PT1183255 E PT 1183255E
Authority
PT
Portugal
Prior art keywords
polyaminoacides
bicyclic
application
preparation process
metallic complexes
Prior art date
Application number
PT00940473T
Other languages
English (en)
Inventor
Marc Port
Original Assignee
Guerbet Sa
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Guerbet Sa filed Critical Guerbet Sa
Publication of PT1183255E publication Critical patent/PT1183255E/pt

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D471/00—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, at least one ring being a six-membered ring with one nitrogen atom, not provided for by groups C07D451/00 - C07D463/00
    • C07D471/02—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, at least one ring being a six-membered ring with one nitrogen atom, not provided for by groups C07D451/00 - C07D463/00 in which the condensed system contains two hetero rings
    • C07D471/08—Bridged systems

Landscapes

  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • Medicines Containing Antibodies Or Antigens For Use As Internal Diagnostic Agents (AREA)
  • Organic Low-Molecular-Weight Compounds And Preparation Thereof (AREA)
  • Polyamides (AREA)
  • Nitrogen Condensed Heterocyclic Rings (AREA)
  • Acyclic And Carbocyclic Compounds In Medicinal Compositions (AREA)
  • Macromolecular Compounds Obtained By Forming Nitrogen-Containing Linkages In General (AREA)
  • Medicinal Preparation (AREA)
PT00940473T 1999-06-09 2000-06-08 Complexos metalicos de poliaminoacidos biciclicos processo de preparacao e sua aplicacao em imageologia medica PT1183255E (pt)

Applications Claiming Priority (1)

Application Number Priority Date Filing Date Title
FR9907283A FR2794744B1 (fr) 1999-06-09 1999-06-09 Complexes metalliques de polyaminoacides bicycliques, leur procede de preparation et leur application en imagerie medicale

Publications (1)

Publication Number Publication Date
PT1183255E true PT1183255E (pt) 2003-06-30

Family

ID=9546571

Family Applications (1)

Application Number Title Priority Date Filing Date
PT00940473T PT1183255E (pt) 1999-06-09 2000-06-08 Complexos metalicos de poliaminoacidos biciclicos processo de preparacao e sua aplicacao em imageologia medica

Country Status (22)

Country Link
US (1) US6440956B1 (pt)
EP (1) EP1183255B1 (pt)
JP (1) JP4719391B2 (pt)
KR (1) KR20020008218A (pt)
CN (1) CN1196702C (pt)
AT (1) ATE233762T1 (pt)
AU (1) AU5540400A (pt)
BR (1) BR0011436A (pt)
CA (1) CA2376497C (pt)
DE (1) DE60001564T2 (pt)
DK (1) DK1183255T3 (pt)
ES (1) ES2188556T3 (pt)
FR (1) FR2794744B1 (pt)
HU (1) HU227966B1 (pt)
IL (2) IL146304A0 (pt)
MX (1) MXPA01011439A (pt)
NO (1) NO321121B1 (pt)
PL (1) PL216974B1 (pt)
PT (1) PT1183255E (pt)
RU (1) RU2232763C2 (pt)
TR (1) TR200103525T2 (pt)
WO (1) WO2000075141A1 (pt)

Families Citing this family (33)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US8518373B2 (en) 2001-08-03 2013-08-27 Bracco Imaging Spa Ionic and non-ionic radiographic contrast agents for use in combined X-ray and nuclear magnetic resonance diagnostics
ITMI20011706A1 (it) 2001-08-03 2003-02-03 Bracco Imaging Spa Agenti di contrasto radiografici ionici e non ionici, utilizzabili per l'indagine diagnostica combinata tramite raggi-x e risonanza magnetic
FR2836916B1 (fr) * 2002-03-05 2004-06-11 Guerbet Sa Oligomeres de chelates de gadolinium, leur application comme produits de contraste en imagerie par resonance magnetique et leurs intermediaires de synthese
DE10307759B3 (de) * 2003-02-19 2004-11-18 Schering Ag Trimere makrocyclisch substituierte Benzolderivate, deren Herstellung und Verwendung als Kontrastmittel sowie diese enthaltende pharmazeutische Mittel
JP2004307356A (ja) * 2003-04-02 2004-11-04 Hamamatsu Kagaku Gijutsu Kenkyu Shinkokai 新規なデンドリマーおよび造影剤
FR2856689A1 (fr) * 2003-06-25 2004-12-31 Guerbet Sa Composes specifiques a forte relaxivite
FR2857967B1 (fr) * 2003-07-25 2015-04-24 Centre Nat Rech Scient Complexes de lanthanide, leur preparation et leurs utilisations
FR2867473B1 (fr) 2004-03-12 2006-06-23 Guerbet Sa Compose de porphyrines et utilisation a haut champ en irm
ATE430146T1 (de) 2004-07-02 2009-05-15 Bracco Imaging Spa Kontrastmittel mit hoher relaxivität zur verwendung in der magnetresonanzbilddarstellung (mri), enthaltend eine chelatbildende gruppe mit polyhydroxylierten substituenten
FR2875410B1 (fr) * 2004-09-23 2012-11-16 Guerbet Sa Composes de diagnostique pour le ciblage de recpteur a chimiokines
CN100355806C (zh) * 2005-03-04 2007-12-19 华东师范大学 端氨基嵌段聚氧乙烯改性的钆配合物及其合成方法
FR2883562B1 (fr) * 2005-03-24 2009-02-27 Guerbet Sa Chelates lipophiles et leur utilisation en imagerie
US8926945B2 (en) * 2005-10-07 2015-01-06 Guerbet Compounds comprising a biological target recognizing part, coupled to a signal part capable of complexing gallium
FR2891830B1 (fr) 2005-10-07 2011-06-24 Guerbet Sa Composes a chaines aminoalcools courtes et complexes metalliques pour l'imagerie medicale
US8986650B2 (en) 2005-10-07 2015-03-24 Guerbet Complex folate-NOTA-Ga68
FR2914304B1 (fr) * 2007-03-28 2012-11-16 Guerbet Sa Composes pour le diagnostic de maladies liees a l'expression de vcam.
FR2914303A1 (fr) * 2007-03-28 2008-10-03 Guerbet Sa Composes pour le diagnostic de l'apoptose.
DE102007058220A1 (de) 2007-12-03 2009-06-04 Bayer Schering Pharma Aktiengesellschaft Dimere macrocyclisch substituierte Benzolderivate
FR2942227B1 (fr) 2009-02-13 2011-04-15 Guerbet Sa Utilisation de tampons pour la complexation de radionucleides
CN102612511A (zh) * 2009-09-28 2012-07-25 肯塔基大学研究基金会 用于从污染的环境中去除元素的含巯基化合物及其使用方法
ES2626582T5 (es) 2013-04-26 2022-10-07 Guerbet Sa Formulación de producto de contraste y su procedimiento de preparación asociado
GB201610738D0 (en) * 2016-06-20 2016-08-03 Ge Healthcare As Chelate compounds
JP7034160B2 (ja) 2016-11-28 2022-03-11 バイエル・ファルマ・アクティエンゲゼルシャフト 磁気共鳴画像法に使用するための高緩和度ガドリニウムキレート化合物
HUE050402T2 (hu) * 2016-12-21 2020-12-28 Ge Healthcare As MRl képalkotó szerként alkalmazható tetraazabiciklo-makrociklus alapú mangán-kelát vegyületek
JP7332600B2 (ja) * 2017-12-20 2023-08-23 ゼネラル・エレクトリック・カンパニイ アニオン性キレート化合物
FI3770160T3 (fi) * 2018-08-06 2023-03-16 Bracco Imaging Spa Gadoliniumpitoisia pcta-pohjaisia varjoaineita
PE20211471A1 (es) 2018-11-23 2021-08-05 Bayer Ag Formulacion de medios de contraste y proceso para prepararlos
US11370804B2 (en) 2019-01-17 2022-06-28 Guerbet Complex of gadolinium and a chelating ligand derived from a diastereoisomerically enriched PCTA and preparation and purification process
FR3091873B1 (fr) 2019-01-17 2020-12-25 Guerbet Sa Complexe de gadolinium et d’un ligand chelateur derive de pcta diastereoisomeriquement enrichi et procede de preparation et de purification
US11426470B2 (en) 2019-01-17 2022-08-30 Guerbet Complex of gadolinium and a chelating ligand derived of a diastereoisomerically enriched PCTA and synthesis method
FR3091872B1 (fr) * 2019-01-17 2020-12-25 Guerbet Sa Complexe de gadolinium et d’un ligand chelateur derive de pcta diastereoisomeriquement enrichi et procede de synthese
WO2022013440A1 (fr) * 2020-07-16 2022-01-20 Guerbet Procede de synthese de diesters d'acide 2-bromoglutarique
CN115722276B (zh) * 2022-11-15 2024-06-18 江苏美亚科泽过滤技术有限公司 一种粒状多效吸附剂组合物及其制备方法

Family Cites Families (6)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
DE4001655A1 (de) * 1990-01-18 1991-07-25 Schering Ag 6-ring enthaltende makrocyclische tetraaza-verbindungen, verfahren zu ihrer herstellung und diese enthaltende pharmazeutische mittel
DE3825040A1 (de) * 1988-07-20 1990-01-25 Schering Ag, 13353 Berlin 5- oder 6-ring- enthaltende makrocyclische polyaza-verbindungen, verfahren zu ihrer herstellung und diese enthaltende pharmazeutische mittel
FR2644785B1 (fr) * 1989-03-24 1991-07-05 Guerbet Sa Nouveaux ligands macrocycliques azotes, procede de preparation, complexes metalliques formes par ces ligands et composition de diagnostic les contenant
US5554748A (en) * 1989-04-07 1996-09-10 Nycomed Salutar, Inc. Adducts of macrocyclic chelants
HUT67602A (en) * 1991-12-10 1995-04-28 Dow Chemical Co Process for producing bicyclo-polyaza-macrocyclo-carboxylic acid complexes, their conjugates and contrast materials containing them
FR2736051B3 (fr) * 1995-06-29 1997-09-26 Guerbet Sa Complexes metalliques de polyaminoacides, leur procede de preparation et leur utilisation en imagerie diagnostique

Also Published As

Publication number Publication date
HUP0201468A3 (en) 2010-01-28
FR2794744B1 (fr) 2001-09-21
HU227966B1 (en) 2012-07-30
HUP0201468A2 (en) 2002-08-28
ATE233762T1 (de) 2003-03-15
CN1354751A (zh) 2002-06-19
AU5540400A (en) 2000-12-28
CN1196702C (zh) 2005-04-13
RU2232763C2 (ru) 2004-07-20
US6440956B1 (en) 2002-08-27
FR2794744A1 (fr) 2000-12-15
EP1183255A1 (fr) 2002-03-06
CA2376497A1 (fr) 2000-12-14
IL146304A (en) 2006-04-10
BR0011436A (pt) 2002-03-05
DE60001564T2 (de) 2003-12-11
MXPA01011439A (es) 2002-06-04
NO321121B1 (no) 2006-03-20
EP1183255B1 (fr) 2003-03-05
KR20020008218A (ko) 2002-01-29
WO2000075141A1 (fr) 2000-12-14
PL352483A1 (en) 2003-08-25
PL216974B1 (pl) 2014-05-30
IL146304A0 (en) 2002-07-25
NO20015991L (no) 2002-02-06
TR200103525T2 (tr) 2002-05-21
DE60001564D1 (de) 2003-04-10
DK1183255T3 (da) 2003-06-02
JP4719391B2 (ja) 2011-07-06
NO20015991D0 (no) 2001-12-07
ES2188556T3 (es) 2003-07-01
JP2003501430A (ja) 2003-01-14
CA2376497C (fr) 2009-10-20

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