PT1171111E - Granulado com teor elevado de l-carnitina ou de uma alcanoil l-carnitina particularmente adequado para a producao de comprimidos por compressao directa - Google Patents
Granulado com teor elevado de l-carnitina ou de uma alcanoil l-carnitina particularmente adequado para a producao de comprimidos por compressao directaInfo
- Publication number
- PT1171111E PT1171111E PT00917258T PT00917258T PT1171111E PT 1171111 E PT1171111 E PT 1171111E PT 00917258 T PT00917258 T PT 00917258T PT 00917258 T PT00917258 T PT 00917258T PT 1171111 E PT1171111 E PT 1171111E
- Authority
- PT
- Portugal
- Prior art keywords
- carnitine
- direct compression
- tablets
- alcanoyl
- granulated
- Prior art date
Links
Classifications
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K9/00—Medicinal preparations characterised by special physical form
- A61K9/14—Particulate form, e.g. powders, Processes for size reducing of pure drugs or the resulting products, Pure drug nanoparticles
- A61K9/16—Agglomerates; Granulates; Microbeadlets ; Microspheres; Pellets; Solid products obtained by spray drying, spray freeze drying, spray congealing,(multiple) emulsion solvent evaporation or extraction
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K9/00—Medicinal preparations characterised by special physical form
- A61K9/14—Particulate form, e.g. powders, Processes for size reducing of pure drugs or the resulting products, Pure drug nanoparticles
- A61K9/16—Agglomerates; Granulates; Microbeadlets ; Microspheres; Pellets; Solid products obtained by spray drying, spray freeze drying, spray congealing,(multiple) emulsion solvent evaporation or extraction
- A61K9/1605—Excipients; Inactive ingredients
- A61K9/1629—Organic macromolecular compounds
- A61K9/1635—Organic macromolecular compounds obtained by reactions only involving carbon-to-carbon unsaturated bonds, e.g. polyvinyl pyrrolidone, poly(meth)acrylates
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K31/00—Medicinal preparations containing organic active ingredients
- A61K31/185—Acids; Anhydrides, halides or salts thereof, e.g. sulfur acids, imidic, hydrazonic or hydroximic acids
- A61K31/205—Amine addition salts of organic acids; Inner quaternary ammonium salts, e.g. betaine, carnitine
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P3/00—Drugs for disorders of the metabolism
- A61P3/02—Nutrients, e.g. vitamins, minerals
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P39/00—General protective or antinoxious agents
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P9/00—Drugs for disorders of the cardiovascular system
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P9/00—Drugs for disorders of the cardiovascular system
- A61P9/04—Inotropic agents, i.e. stimulants of cardiac contraction; Drugs for heart failure
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P9/00—Drugs for disorders of the cardiovascular system
- A61P9/06—Antiarrhythmics
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P9/00—Drugs for disorders of the cardiovascular system
- A61P9/10—Drugs for disorders of the cardiovascular system for treating ischaemic or atherosclerotic diseases, e.g. antianginal drugs, coronary vasodilators, drugs for myocardial infarction, retinopathy, cerebrovascula insufficiency, renal arteriosclerosis
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K9/00—Medicinal preparations characterised by special physical form
- A61K9/20—Pills, tablets, discs, rods
- A61K9/2004—Excipients; Inactive ingredients
- A61K9/2022—Organic macromolecular compounds
- A61K9/2027—Organic macromolecular compounds obtained by reactions only involving carbon-to-carbon unsaturated bonds, e.g. polyvinyl pyrrolidone, poly(meth)acrylates
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K9/00—Medicinal preparations characterised by special physical form
- A61K9/48—Preparations in capsules, e.g. of gelatin, of chocolate
- A61K9/4841—Filling excipients; Inactive ingredients
- A61K9/4866—Organic macromolecular compounds
Landscapes
- Health & Medical Sciences (AREA)
- Engineering & Computer Science (AREA)
- Bioinformatics & Cheminformatics (AREA)
- Pharmacology & Pharmacy (AREA)
- Veterinary Medicine (AREA)
- Public Health (AREA)
- Chemical & Material Sciences (AREA)
- General Health & Medical Sciences (AREA)
- Medicinal Chemistry (AREA)
- Animal Behavior & Ethology (AREA)
- Life Sciences & Earth Sciences (AREA)
- General Chemical & Material Sciences (AREA)
- Organic Chemistry (AREA)
- Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
- Chemical Kinetics & Catalysis (AREA)
- Cardiology (AREA)
- Epidemiology (AREA)
- Heart & Thoracic Surgery (AREA)
- Toxicology (AREA)
- Vascular Medicine (AREA)
- Urology & Nephrology (AREA)
- Nutrition Science (AREA)
- Diabetes (AREA)
- Hematology (AREA)
- Obesity (AREA)
- Hospice & Palliative Care (AREA)
- Acyclic And Carbocyclic Compounds In Medicinal Compositions (AREA)
- Medicinal Preparation (AREA)
- Organic Low-Molecular-Weight Compounds And Preparation Thereof (AREA)
- Confectionery (AREA)
- Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
Applications Claiming Priority (1)
Application Number | Priority Date | Filing Date | Title |
---|---|---|---|
IT1999RM000189A IT1305308B1 (it) | 1999-03-26 | 1999-03-26 | Granulato ad alto contenuto di l-carnitina o alcanoil-l-carnitina,particolarmente adatto alla produzione di compresse per compressione |
Publications (1)
Publication Number | Publication Date |
---|---|
PT1171111E true PT1171111E (pt) | 2003-09-30 |
Family
ID=11406608
Family Applications (1)
Application Number | Title | Priority Date | Filing Date |
---|---|---|---|
PT00917258T PT1171111E (pt) | 1999-03-26 | 2000-03-22 | Granulado com teor elevado de l-carnitina ou de uma alcanoil l-carnitina particularmente adequado para a producao de comprimidos por compressao directa |
Country Status (20)
Country | Link |
---|---|
US (1) | US6485741B2 (pt) |
EP (1) | EP1171111B1 (pt) |
JP (2) | JP4637367B2 (pt) |
KR (1) | KR100729848B1 (pt) |
CN (1) | CN1158072C (pt) |
AT (1) | ATE238784T1 (pt) |
AU (1) | AU780413B2 (pt) |
CA (1) | CA2363038C (pt) |
CZ (1) | CZ301266B6 (pt) |
DE (1) | DE60002454T2 (pt) |
DK (1) | DK1171111T3 (pt) |
ES (1) | ES2197867T3 (pt) |
HU (1) | HU228588B1 (pt) |
IL (2) | IL144957A0 (pt) |
IT (1) | IT1305308B1 (pt) |
PL (1) | PL207961B1 (pt) |
PT (1) | PT1171111E (pt) |
SK (1) | SK285565B6 (pt) |
TR (1) | TR200102802T2 (pt) |
WO (1) | WO2000057873A2 (pt) |
Families Citing this family (9)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
ES2322328T3 (es) * | 1999-09-03 | 2009-06-19 | Sigma-Tau Healthscience S.P.A. | L-carnitina ultrafina, procedimientos de preparacion, composiciones que la contienen y procedimiento de uso de la misma. |
CN1686089B (zh) * | 2005-05-08 | 2010-08-18 | 北京健健康康生物技术有限公司 | 一种可直接压片的木糖醇颗粒及其制备方法 |
CN101212956A (zh) * | 2005-07-05 | 2008-07-02 | 隆萨股份公司 | 生产干肉碱粉末或颗粒的喷雾干燥法 |
MX342962B (es) * | 2009-09-18 | 2016-06-07 | Teva Pharmaceuticals Holdings Mexico S A De C V | Composicion farmaceutica para bajar de peso y procedimiento para obtener la misma. |
EP2335495A1 (en) | 2009-12-11 | 2011-06-22 | Lonza Ltd. | Carnitine granulate and methods for its production |
CN102349881B (zh) * | 2011-10-26 | 2013-06-26 | 东北制药(沈阳)科技发展有限公司 | 一种左卡尼汀薄膜衣片及其制备方法 |
CN105695398A (zh) * | 2016-04-25 | 2016-06-22 | 广西大学 | 含o-乙酰基-l-肉碱盐酸盐的水牛卵母细胞体外成熟液及培养方法 |
JP7366612B2 (ja) * | 2019-07-09 | 2023-10-23 | 東和薬品株式会社 | レボカルニチンを含有する錠剤 |
AU2021272292A1 (en) | 2020-05-15 | 2023-02-02 | Alfasigma S.P.A. | Composition comprising methylfolate |
Family Cites Families (18)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
DE2921852A1 (de) * | 1979-05-29 | 1980-12-11 | Fresenius Chem Pharm Ind | Lipide senkendes mittel |
IT1119853B (it) * | 1979-09-21 | 1986-03-10 | Sigma Tau Ind Farmaceuti | Composizione farmaceutica comprendente l-carnitina per il trattamento delle dislipidemie ed iperlipo proteinemie |
JPS59222412A (ja) * | 1983-06-01 | 1984-12-14 | Earth Chem Corp Ltd | 心臓疾患治療薬 |
EP0150688B1 (en) * | 1983-12-28 | 1987-04-22 | Sigma-Tau Industrie Farmaceutiche Riunite S.p.A. | Salts of l-carnitine and alkanoyl l-carnitines and process for preparing same |
IT1181682B (it) * | 1985-06-11 | 1987-09-30 | Sigma Tau Ind Farmaceuti | Impiego di alcanoil l-carnitine per il trattamento terapeutico del parkinsonismo idiopatico o indotto |
IT1190370B (it) * | 1985-06-19 | 1988-02-16 | Zambon Spa | Composizione farmaceutica solida per uso orale |
JPH03120211A (ja) * | 1989-10-04 | 1991-05-22 | Earth Chem Corp Ltd | 粒状カルニチン製剤 |
US5073376A (en) * | 1989-12-22 | 1991-12-17 | Lonza Ltd. | Preparations containing l-carnitine |
JPH0656659A (ja) * | 1992-06-10 | 1994-03-01 | Natl Sci Council | 直接打錠できる薬学組成物及びその錠剤の製造法 |
EP0681839A3 (en) * | 1994-05-12 | 1997-11-12 | Hirohiko Kuratsune | A pharmaceutical preparation comprising an acylcarnitine |
JPH0812569A (ja) * | 1994-06-24 | 1996-01-16 | Takeda Chem Ind Ltd | 塩化カルニチン吸着固形物 |
IL116674A (en) * | 1995-01-09 | 2003-05-29 | Mendell Co Inc Edward | Microcrystalline cellulose-based excipient having improved compressibility, pharmaceutical compositions containing the same and methods for the preparation of said excipient and of solid dosage form thereof |
IT1277953B1 (it) * | 1995-12-21 | 1997-11-12 | Sigma Tau Ind Farmaceuti | Composizione farmaceutica contenente l-carnitina o una alcanoil l- carnitina e un acido poliinsaturo della serie 3-omega utile per |
US5837292A (en) * | 1996-07-03 | 1998-11-17 | Yamanouchi Europe B.V. | Granulate for the preparation of fast-disintegrating and fast-dissolving compositions containing a high amount of drug |
DE19629753A1 (de) * | 1996-07-23 | 1998-01-29 | Basf Ag | Verfahren zur Herstellung von festen Arzneiformen |
IT1291126B1 (it) * | 1997-04-01 | 1998-12-29 | Sigma Tau Ind Farmaceuti | Composizioni solide atte alla somministrazione orale comprendenti sali non igroscopici della l-carnitina e delle alcanoil l-carnitine |
IT1291133B1 (it) * | 1997-04-07 | 1998-12-29 | Sigma Tau Ind Farmaceuti | Composizioni solide atte alla somministrazione orale comprendenti l-carnitina e alcanoil l-carnitine magnesio tartrato |
IT1290600B1 (it) * | 1997-04-30 | 1998-12-10 | Sigma Tau Ind Farmaceuti | Composizioni solide atte alla somministrazione orale comprendenti l-carnitina e alcanoil l-carnitine magnesio fumarato |
-
1999
- 1999-03-26 IT IT1999RM000189A patent/IT1305308B1/it active
-
2000
- 2000-03-22 IL IL14495700A patent/IL144957A0/xx active IP Right Grant
- 2000-03-22 TR TR2001/02802T patent/TR200102802T2/xx unknown
- 2000-03-22 DE DE60002454T patent/DE60002454T2/de not_active Expired - Lifetime
- 2000-03-22 ES ES00917258T patent/ES2197867T3/es not_active Expired - Lifetime
- 2000-03-22 CA CA002363038A patent/CA2363038C/en not_active Expired - Lifetime
- 2000-03-22 JP JP2000607624A patent/JP4637367B2/ja not_active Expired - Lifetime
- 2000-03-22 WO PCT/IT2000/000097 patent/WO2000057873A2/en active IP Right Grant
- 2000-03-22 AU AU38344/00A patent/AU780413B2/en not_active Expired
- 2000-03-22 CZ CZ20013078A patent/CZ301266B6/cs not_active IP Right Cessation
- 2000-03-22 AT AT00917258T patent/ATE238784T1/de active
- 2000-03-22 KR KR1020017011856A patent/KR100729848B1/ko active IP Right Grant
- 2000-03-22 CN CNB008055742A patent/CN1158072C/zh not_active Expired - Lifetime
- 2000-03-22 PL PL350908A patent/PL207961B1/pl unknown
- 2000-03-22 DK DK00917258T patent/DK1171111T3/da active
- 2000-03-22 HU HU0200465A patent/HU228588B1/hu unknown
- 2000-03-22 SK SK1159-2001A patent/SK285565B6/sk not_active IP Right Cessation
- 2000-03-22 EP EP00917258A patent/EP1171111B1/en not_active Expired - Lifetime
- 2000-03-22 PT PT00917258T patent/PT1171111E/pt unknown
- 2000-07-24 JP JP2000221826A patent/JP2001097353A/ja not_active Withdrawn
-
2001
- 2001-08-16 IL IL144957A patent/IL144957A/en not_active IP Right Cessation
- 2001-09-26 US US09/962,605 patent/US6485741B2/en not_active Expired - Lifetime
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