PT115583B - Processo contínuo para a preparação de medicamentos anticolinérgicos - Google Patents
Processo contínuo para a preparação de medicamentos anticolinérgicos Download PDFInfo
- Publication number
- PT115583B PT115583B PT115583A PT11558319A PT115583B PT 115583 B PT115583 B PT 115583B PT 115583 A PT115583 A PT 115583A PT 11558319 A PT11558319 A PT 11558319A PT 115583 B PT115583 B PT 115583B
- Authority
- PT
- Portugal
- Prior art keywords
- bromide
- preparation
- continuous process
- anticholinergic drugs
- anticholinergic
- Prior art date
Links
- 229940079593 drug Drugs 0.000 title abstract 3
- 239000003814 drug Substances 0.000 title abstract 3
- 230000001078 anti-cholinergic effect Effects 0.000 title abstract 2
- 238000010924 continuous production Methods 0.000 title 1
- LERNTVKEWCAPOY-VOGVJGKGSA-N C[N+]1(C)[C@H]2C[C@H](C[C@@H]1[C@H]1O[C@@H]21)OC(=O)C(O)(c1cccs1)c1cccs1 Chemical compound C[N+]1(C)[C@H]2C[C@H](C[C@@H]1[C@H]1O[C@@H]21)OC(=O)C(O)(c1cccs1)c1cccs1 LERNTVKEWCAPOY-VOGVJGKGSA-N 0.000 abstract 1
- 208000006545 Chronic Obstructive Pulmonary Disease Diseases 0.000 abstract 1
- VPNYRYCIDCJBOM-UHFFFAOYSA-M Glycopyrronium bromide Chemical compound [Br-].C1[N+](C)(C)CCC1OC(=O)C(O)(C=1C=CC=CC=1)C1CCCC1 VPNYRYCIDCJBOM-UHFFFAOYSA-M 0.000 abstract 1
- 229940121948 Muscarinic receptor antagonist Drugs 0.000 abstract 1
- ASMXXROZKSBQIH-VITNCHFBSA-N aclidinium Chemical compound C([C@@H](C(CC1)CC2)OC(=O)C(O)(C=3SC=CC=3)C=3SC=CC=3)[N+]21CCCOC1=CC=CC=C1 ASMXXROZKSBQIH-VITNCHFBSA-N 0.000 abstract 1
- 229960005012 aclidinium bromide Drugs 0.000 abstract 1
- 208000006673 asthma Diseases 0.000 abstract 1
- 239000000812 cholinergic antagonist Substances 0.000 abstract 1
- 201000010099 disease Diseases 0.000 abstract 1
- 208000037265 diseases, disorders, signs and symptoms Diseases 0.000 abstract 1
- 229960002462 glycopyrronium bromide Drugs 0.000 abstract 1
- 229960001361 ipratropium bromide Drugs 0.000 abstract 1
- KEWHKYJURDBRMN-ZEODDXGYSA-M ipratropium bromide hydrate Chemical compound O.[Br-].O([C@H]1C[C@H]2CC[C@@H](C1)[N@@+]2(C)C(C)C)C(=O)C(CO)C1=CC=CC=C1 KEWHKYJURDBRMN-ZEODDXGYSA-M 0.000 abstract 1
- 238000000034 method Methods 0.000 abstract 1
- 239000003586 protic polar solvent Substances 0.000 abstract 1
- 230000000241 respiratory effect Effects 0.000 abstract 1
- 229960000257 tiotropium bromide Drugs 0.000 abstract 1
- 229960004541 umeclidinium bromide Drugs 0.000 abstract 1
- PEJHHXHHNGORMP-AVADPIKZSA-M umeclidinium bromide Chemical compound [Br-].C=1C=CC=CC=1C([C@@]12CC[N@@+](CCOCC=3C=CC=CC=3)(CC1)CC2)(O)C1=CC=CC=C1 PEJHHXHHNGORMP-AVADPIKZSA-M 0.000 abstract 1
Classifications
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D453/00—Heterocyclic compounds containing quinuclidine or iso-quinuclidine ring systems, e.g. quinine alkaloids
- C07D453/02—Heterocyclic compounds containing quinuclidine or iso-quinuclidine ring systems, e.g. quinine alkaloids containing not further condensed quinuclidine ring systems
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K31/00—Medicinal preparations containing organic active ingredients
- A61K31/33—Heterocyclic compounds
- A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
- A61K31/40—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having five-membered rings with one nitrogen as the only ring hetero atom, e.g. sulpiride, succinimide, tolmetin, buflomedil
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K31/00—Medicinal preparations containing organic active ingredients
- A61K31/33—Heterocyclic compounds
- A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
- A61K31/435—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with one nitrogen as the only ring hetero atom
- A61K31/439—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with one nitrogen as the only ring hetero atom the ring forming part of a bridged ring system, e.g. quinuclidine
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K31/00—Medicinal preparations containing organic active ingredients
- A61K31/33—Heterocyclic compounds
- A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
- A61K31/435—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with one nitrogen as the only ring hetero atom
- A61K31/46—8-Azabicyclo [3.2.1] octane; Derivatives thereof, e.g. atropine, cocaine
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K9/00—Medicinal preparations characterised by special physical form
- A61K9/0012—Galenical forms characterised by the site of application
- A61K9/007—Pulmonary tract; Aromatherapy
- A61K9/0073—Sprays or powders for inhalation; Aerolised or nebulised preparations generated by other means than thermal energy
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P11/00—Drugs for disorders of the respiratory system
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P11/00—Drugs for disorders of the respiratory system
- A61P11/06—Antiasthmatics
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D451/00—Heterocyclic compounds containing 8-azabicyclo [3.2.1] octane, 9-azabicyclo [3.3.1] nonane, or 3-oxa-9-azatricyclo [3.3.1.0<2,4>] nonane ring systems, e.g. tropane or granatane alkaloids, scopolamine; Cyclic acetals thereof
- C07D451/02—Heterocyclic compounds containing 8-azabicyclo [3.2.1] octane, 9-azabicyclo [3.3.1] nonane, or 3-oxa-9-azatricyclo [3.3.1.0<2,4>] nonane ring systems, e.g. tropane or granatane alkaloids, scopolamine; Cyclic acetals thereof containing not further condensed 8-azabicyclo [3.2.1] octane or 3-oxa-9-azatricyclo [3.3.1.0<2,4>] nonane ring systems, e.g. tropane; Cyclic acetals thereof
- C07D451/04—Heterocyclic compounds containing 8-azabicyclo [3.2.1] octane, 9-azabicyclo [3.3.1] nonane, or 3-oxa-9-azatricyclo [3.3.1.0<2,4>] nonane ring systems, e.g. tropane or granatane alkaloids, scopolamine; Cyclic acetals thereof containing not further condensed 8-azabicyclo [3.2.1] octane or 3-oxa-9-azatricyclo [3.3.1.0<2,4>] nonane ring systems, e.g. tropane; Cyclic acetals thereof with hetero atoms directly attached in position 3 of the 8-azabicyclo [3.2.1] octane or in position 7 of the 3-oxa-9-azatricyclo [3.3.1.0<2,4>] nonane ring system
- C07D451/06—Oxygen atoms
- C07D451/10—Oxygen atoms acylated by aliphatic or araliphatic carboxylic acids, e.g. atropine, scopolamine
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D471/00—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, at least one ring being a six-membered ring with one nitrogen atom, not provided for by groups C07D451/00 - C07D463/00
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07B—GENERAL METHODS OF ORGANIC CHEMISTRY; APPARATUS THEREFOR
- C07B2200/00—Indexing scheme relating to specific properties of organic compounds
- C07B2200/13—Crystalline forms, e.g. polymorphs
Landscapes
- Health & Medical Sciences (AREA)
- Chemical & Material Sciences (AREA)
- Organic Chemistry (AREA)
- Veterinary Medicine (AREA)
- Public Health (AREA)
- Medicinal Chemistry (AREA)
- Pharmacology & Pharmacy (AREA)
- Life Sciences & Earth Sciences (AREA)
- Animal Behavior & Ethology (AREA)
- General Health & Medical Sciences (AREA)
- Epidemiology (AREA)
- Pulmonology (AREA)
- Bioinformatics & Cheminformatics (AREA)
- Engineering & Computer Science (AREA)
- Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
- General Chemical & Material Sciences (AREA)
- Chemical Kinetics & Catalysis (AREA)
- Emergency Medicine (AREA)
- Otolaryngology (AREA)
- Nitrogen Condensed Heterocyclic Rings (AREA)
- Medicinal Preparation (AREA)
- Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)
- Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
Priority Applications (11)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| PT115583A PT115583B (pt) | 2019-06-17 | 2019-06-17 | Processo contínuo para a preparação de medicamentos anticolinérgicos |
| CA3141271A CA3141271A1 (en) | 2019-06-17 | 2020-06-16 | Continuous process for the preparation of anticholinergic drugs |
| JP2021574905A JP2022549545A (ja) | 2019-06-17 | 2020-06-16 | 抗コリン薬の調製のための連続プロセス |
| KR1020227000471A KR20220024433A (ko) | 2019-06-17 | 2020-06-16 | 항콜린 약물의 연속 제조방법 |
| EP20734291.6A EP3982923B1 (en) | 2019-06-17 | 2020-06-16 | Continuous process for the preparation of anticholinergic drugs |
| CN202080049646.2A CN114206863A (zh) | 2019-06-17 | 2020-06-16 | 制备抗胆碱药的连续方法 |
| AU2020296972A AU2020296972B2 (en) | 2019-06-17 | 2020-06-16 | Continuous process for the preparation of anticholinergic drugs |
| US17/617,725 US20220251078A1 (en) | 2019-06-17 | 2020-06-16 | Continuous Process for the Preparation of Anticholinergic Drugs |
| PCT/GB2020/051448 WO2020254791A1 (en) | 2019-06-17 | 2020-06-16 | Continuous process for the preparation of anticholinergic drugs |
| IL288972A IL288972A (en) | 2019-06-17 | 2021-12-13 | A continuous process for the preparation of anticholinergic drugs |
| JP2025025794A JP2025081547A (ja) | 2019-06-17 | 2025-02-20 | 抗コリン薬の調製のための連続方法 |
Applications Claiming Priority (1)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| PT115583A PT115583B (pt) | 2019-06-17 | 2019-06-17 | Processo contínuo para a preparação de medicamentos anticolinérgicos |
Publications (2)
| Publication Number | Publication Date |
|---|---|
| PT115583A PT115583A (pt) | 2021-06-03 |
| PT115583B true PT115583B (pt) | 2022-05-02 |
Family
ID=71120199
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| PT115583A PT115583B (pt) | 2019-06-17 | 2019-06-17 | Processo contínuo para a preparação de medicamentos anticolinérgicos |
Country Status (10)
| Country | Link |
|---|---|
| US (1) | US20220251078A1 (https=) |
| EP (1) | EP3982923B1 (https=) |
| JP (2) | JP2022549545A (https=) |
| KR (1) | KR20220024433A (https=) |
| CN (1) | CN114206863A (https=) |
| AU (1) | AU2020296972B2 (https=) |
| CA (1) | CA3141271A1 (https=) |
| IL (1) | IL288972A (https=) |
| PT (1) | PT115583B (https=) |
| WO (1) | WO2020254791A1 (https=) |
Family Cites Families (14)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| US6908928B2 (en) | 2000-10-12 | 2005-06-21 | Bi Pharma Kg. | Crystalline tiotropium bromide monohydrate, processes for the preparation thereof, and pharmaceutical compositions |
| UY28871A1 (es) | 2004-04-27 | 2005-11-30 | Glaxo Group Ltd | Antagonistas del receptor de acetilcolina muscarinico |
| JP2008540367A (ja) * | 2005-05-02 | 2008-11-20 | ベーリンガー インゲルハイム インターナショナル ゲゼルシャフト ミット ベシュレンクテル ハフツング | 新規結晶性臭化チオトロピウム |
| WO2006117299A2 (en) | 2005-05-02 | 2006-11-09 | Boehringer Ingelheim International Gmbh | Novel crystalline forms of tiotropium bromide |
| RU2453547C2 (ru) | 2005-12-19 | 2012-06-20 | Сикор Инк. | Новые формы тиотропия бромида и способы их получения |
| US8163913B2 (en) | 2005-12-19 | 2012-04-24 | Sicor Inc. | Forms of tiotropium bromide and processes for preparation thereof |
| JP5333342B2 (ja) | 2009-06-29 | 2013-11-06 | 株式会社デンソー | 半導体装置 |
| SMT201700269T1 (it) * | 2011-12-22 | 2017-07-18 | Cerbios Pharma Sa | Procedimento in continuo per l'alchilazione di ammine terziarie cicliche |
| PT106142B (pt) | 2012-02-10 | 2014-07-18 | Hovione Farmaci Ncia S A | Processo para a preparação de brometo de tiotrópio |
| BR112015003101B1 (pt) * | 2012-08-15 | 2022-06-14 | Glaxo Group Limited | Processo para a preparação de um composto |
| CZ27764U1 (cs) | 2014-08-22 | 2015-02-02 | Zentiva, K.S. | uMethanolový solvát umeclidinium bromidu |
| PT108370B (pt) * | 2015-03-30 | 2018-10-25 | Hovione Farm S A | Processo de preparação de brometo de aclidínio |
| EP3248970A1 (en) | 2016-05-27 | 2017-11-29 | Zentiva K.S. | Forms of umeclidinium bromide |
| PT109740B (pt) | 2016-11-14 | 2020-07-30 | Hovione Farmaciencia Sa | Processo para a preparação de brometo de umeclidínio |
-
2019
- 2019-06-17 PT PT115583A patent/PT115583B/pt active IP Right Grant
-
2020
- 2020-06-16 AU AU2020296972A patent/AU2020296972B2/en active Active
- 2020-06-16 WO PCT/GB2020/051448 patent/WO2020254791A1/en not_active Ceased
- 2020-06-16 KR KR1020227000471A patent/KR20220024433A/ko active Pending
- 2020-06-16 JP JP2021574905A patent/JP2022549545A/ja active Pending
- 2020-06-16 US US17/617,725 patent/US20220251078A1/en active Pending
- 2020-06-16 CA CA3141271A patent/CA3141271A1/en active Pending
- 2020-06-16 CN CN202080049646.2A patent/CN114206863A/zh active Pending
- 2020-06-16 EP EP20734291.6A patent/EP3982923B1/en active Active
-
2021
- 2021-12-13 IL IL288972A patent/IL288972A/en unknown
-
2025
- 2025-02-20 JP JP2025025794A patent/JP2025081547A/ja active Pending
Also Published As
| Publication number | Publication date |
|---|---|
| PT115583A (pt) | 2021-06-03 |
| IL288972A (en) | 2022-02-01 |
| EP3982923B1 (en) | 2024-05-15 |
| EP3982923A1 (en) | 2022-04-20 |
| JP2025081547A (ja) | 2025-05-27 |
| WO2020254791A1 (en) | 2020-12-24 |
| CA3141271A1 (en) | 2020-12-24 |
| EP3982923C0 (en) | 2024-05-15 |
| KR20220024433A (ko) | 2022-03-03 |
| AU2020296972A1 (en) | 2022-01-20 |
| JP2022549545A (ja) | 2022-11-28 |
| AU2020296972B2 (en) | 2025-04-24 |
| CN114206863A (zh) | 2022-03-18 |
| US20220251078A1 (en) | 2022-08-11 |
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Legal Events
| Date | Code | Title | Description |
|---|---|---|---|
| BB1A | Laying open of patent application |
Effective date: 20210531 |
|
| FG3A | Patent granted, date of granting |
Effective date: 20220427 |