PT1142893E - 6 (4) - benziloxipirimidinas substituidas - Google Patents

6 (4) - benziloxipirimidinas substituidas

Info

Publication number
PT1142893E
PT1142893E PT01108585T PT01108585T PT1142893E PT 1142893 E PT1142893 E PT 1142893E PT 01108585 T PT01108585 T PT 01108585T PT 01108585 T PT01108585 T PT 01108585T PT 1142893 E PT1142893 E PT 1142893E
Authority
PT
Portugal
Prior art keywords
mammal
compounds
aza
guanine
chem
Prior art date
Application number
PT01108585T
Other languages
English (en)
Portuguese (pt)
Original Assignee
Penn State Res Foundation Inc
Arch Dev Corp
Us Health
Etary Dept Of Health And Human
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Penn State Res Foundation Inc, Arch Dev Corp, Us Health, Etary Dept Of Health And Human filed Critical Penn State Res Foundation Inc
Publication of PT1142893E publication Critical patent/PT1142893E/pt

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D239/00—Heterocyclic compounds containing 1,3-diazine or hydrogenated 1,3-diazine rings
    • C07D239/02—Heterocyclic compounds containing 1,3-diazine or hydrogenated 1,3-diazine rings not condensed with other rings
    • C07D239/24—Heterocyclic compounds containing 1,3-diazine or hydrogenated 1,3-diazine rings not condensed with other rings having three or more double bonds between ring members or between ring members and non-ring members
    • C07D239/28—Heterocyclic compounds containing 1,3-diazine or hydrogenated 1,3-diazine rings not condensed with other rings having three or more double bonds between ring members or between ring members and non-ring members with hetero atoms or with carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, directly attached to ring carbon atoms
    • C07D239/46—Two or more oxygen, sulphur or nitrogen atoms
    • C07D239/47—One nitrogen atom and one oxygen or sulfur atom, e.g. cytosine
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P35/00—Antineoplastic agents
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P43/00—Drugs for specific purposes, not provided for in groups A61P1/00-A61P41/00
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D239/00—Heterocyclic compounds containing 1,3-diazine or hydrogenated 1,3-diazine rings
    • C07D239/02—Heterocyclic compounds containing 1,3-diazine or hydrogenated 1,3-diazine rings not condensed with other rings
    • C07D239/24—Heterocyclic compounds containing 1,3-diazine or hydrogenated 1,3-diazine rings not condensed with other rings having three or more double bonds between ring members or between ring members and non-ring members
    • C07D239/28—Heterocyclic compounds containing 1,3-diazine or hydrogenated 1,3-diazine rings not condensed with other rings having three or more double bonds between ring members or between ring members and non-ring members with hetero atoms or with carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, directly attached to ring carbon atoms
    • C07D239/46—Two or more oxygen, sulphur or nitrogen atoms
    • C07D239/48—Two nitrogen atoms
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D239/00—Heterocyclic compounds containing 1,3-diazine or hydrogenated 1,3-diazine rings
    • C07D239/02—Heterocyclic compounds containing 1,3-diazine or hydrogenated 1,3-diazine rings not condensed with other rings
    • C07D239/24—Heterocyclic compounds containing 1,3-diazine or hydrogenated 1,3-diazine rings not condensed with other rings having three or more double bonds between ring members or between ring members and non-ring members
    • C07D239/28—Heterocyclic compounds containing 1,3-diazine or hydrogenated 1,3-diazine rings not condensed with other rings having three or more double bonds between ring members or between ring members and non-ring members with hetero atoms or with carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, directly attached to ring carbon atoms
    • C07D239/46—Two or more oxygen, sulphur or nitrogen atoms
    • C07D239/50—Three nitrogen atoms
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D251/00—Heterocyclic compounds containing 1,3,5-triazine rings
    • C07D251/02—Heterocyclic compounds containing 1,3,5-triazine rings not condensed with other rings
    • C07D251/12—Heterocyclic compounds containing 1,3,5-triazine rings not condensed with other rings having three double bonds between ring members or between ring members and non-ring members
    • C07D251/26—Heterocyclic compounds containing 1,3,5-triazine rings not condensed with other rings having three double bonds between ring members or between ring members and non-ring members with only hetero atoms directly attached to ring carbon atoms
    • C07D251/40—Nitrogen atoms
    • C07D251/48—Two nitrogen atoms
    • C07D251/52—Two nitrogen atoms with an oxygen or sulfur atom attached to the third ring carbon atom
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D473/00—Heterocyclic compounds containing purine ring systems
    • C07D473/02—Heterocyclic compounds containing purine ring systems with oxygen, sulphur, or nitrogen atoms directly attached in positions 2 and 6
    • C07D473/04—Heterocyclic compounds containing purine ring systems with oxygen, sulphur, or nitrogen atoms directly attached in positions 2 and 6 two oxygen atoms
    • C07D473/06—Heterocyclic compounds containing purine ring systems with oxygen, sulphur, or nitrogen atoms directly attached in positions 2 and 6 two oxygen atoms with radicals containing only hydrogen and carbon atoms, attached in position 1 or 3
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D473/00—Heterocyclic compounds containing purine ring systems
    • C07D473/02—Heterocyclic compounds containing purine ring systems with oxygen, sulphur, or nitrogen atoms directly attached in positions 2 and 6
    • C07D473/18—Heterocyclic compounds containing purine ring systems with oxygen, sulphur, or nitrogen atoms directly attached in positions 2 and 6 one oxygen and one nitrogen atom, e.g. guanine
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D473/00—Heterocyclic compounds containing purine ring systems
    • C07D473/40—Heterocyclic compounds containing purine ring systems with halogen atoms or perhalogeno-alkyl radicals directly attached in position 2 or 6
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D487/00—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, not provided for by groups C07D451/00 - C07D477/00
    • C07D487/02—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, not provided for by groups C07D451/00 - C07D477/00 in which the condensed system contains two hetero rings
    • C07D487/04—Ortho-condensed systems

Landscapes

  • Organic Chemistry (AREA)
  • Chemical & Material Sciences (AREA)
  • Health & Medical Sciences (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • General Health & Medical Sciences (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • General Chemical & Material Sciences (AREA)
  • Medicinal Chemistry (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Veterinary Medicine (AREA)
  • Animal Behavior & Ethology (AREA)
  • Public Health (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Engineering & Computer Science (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Nitrogen Condensed Heterocyclic Rings (AREA)
  • Hydrogenated Pyridines (AREA)
  • Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)
  • Acyclic And Carbocyclic Compounds In Medicinal Compositions (AREA)
PT01108585T 1994-08-01 1995-07-31 6 (4) - benziloxipirimidinas substituidas PT1142893E (pt)

Applications Claiming Priority (1)

Application Number Priority Date Filing Date Title
US08/283,953 US5525606A (en) 1994-08-01 1994-08-01 Substituted 06-benzylguanines and 6(4)-benzyloxypyrimidines

Publications (1)

Publication Number Publication Date
PT1142893E true PT1142893E (pt) 2005-04-29

Family

ID=23088285

Family Applications (2)

Application Number Title Priority Date Filing Date
PT01108585T PT1142893E (pt) 1994-08-01 1995-07-31 6 (4) - benziloxipirimidinas substituidas
PT95928237T PT775142E (pt) 1994-08-01 1995-07-31 O6-benzilguaninas substituidas

Family Applications After (1)

Application Number Title Priority Date Filing Date
PT95928237T PT775142E (pt) 1994-08-01 1995-07-31 O6-benzilguaninas substituidas

Country Status (10)

Country Link
US (8) US5525606A (enExample)
EP (3) EP0775142B1 (enExample)
JP (2) JP3981407B2 (enExample)
AT (2) ATE286054T1 (enExample)
CA (2) CA2632452A1 (enExample)
DE (2) DE69523462T2 (enExample)
DK (2) DK0775142T3 (enExample)
ES (2) ES2167451T3 (enExample)
PT (2) PT1142893E (enExample)
WO (1) WO1996004281A1 (enExample)

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Also Published As

Publication number Publication date
US5916894A (en) 1999-06-29
EP1518854A1 (en) 2005-03-30
ATE207490T1 (de) 2001-11-15
ES2233513T3 (es) 2005-06-16
EP0775142B1 (en) 2001-10-24
DK1142893T3 (da) 2005-03-29
PT775142E (pt) 2002-04-29
AU3207995A (en) 1996-03-04
DE69523462T2 (de) 2002-07-11
US20020013299A1 (en) 2002-01-31
JPH10508288A (ja) 1998-08-18
US6303604B1 (en) 2001-10-16
EP1142893A1 (en) 2001-10-10
DE69523462D1 (de) 2001-11-29
US6436945B2 (en) 2002-08-20
JP2007077157A (ja) 2007-03-29
CA2195856C (en) 2008-09-30
DE69533900T2 (de) 2005-12-29
DE69533900D1 (de) 2005-02-03
EP0775142A1 (en) 1997-05-28
JP3981407B2 (ja) 2007-09-26
AU702711B2 (en) 1999-03-04
CA2632452A1 (en) 1996-02-15
US6172070B1 (en) 2001-01-09
US5753668A (en) 1998-05-19
US6333331B1 (en) 2001-12-25
CA2195856A1 (en) 1996-02-15
ES2167451T3 (es) 2002-05-16
EP1142893B1 (en) 2004-12-29
ATE286054T1 (de) 2005-01-15
US5525606A (en) 1996-06-11
DK0775142T3 (da) 2002-02-18
US5958932A (en) 1999-09-28
WO1996004281A1 (en) 1996-02-15

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