DE69523462D1 - Substituierte o6-benzylguanine - Google Patents
Substituierte o6-benzylguanineInfo
- Publication number
- DE69523462D1 DE69523462D1 DE69523462T DE69523462T DE69523462D1 DE 69523462 D1 DE69523462 D1 DE 69523462D1 DE 69523462 T DE69523462 T DE 69523462T DE 69523462 T DE69523462 T DE 69523462T DE 69523462 D1 DE69523462 D1 DE 69523462D1
- Authority
- DE
- Germany
- Prior art keywords
- mammal
- substituted
- compounds
- aza
- guanine
- Prior art date
- Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
- Expired - Fee Related
Links
Classifications
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D239/00—Heterocyclic compounds containing 1,3-diazine or hydrogenated 1,3-diazine rings
- C07D239/02—Heterocyclic compounds containing 1,3-diazine or hydrogenated 1,3-diazine rings not condensed with other rings
- C07D239/24—Heterocyclic compounds containing 1,3-diazine or hydrogenated 1,3-diazine rings not condensed with other rings having three or more double bonds between ring members or between ring members and non-ring members
- C07D239/28—Heterocyclic compounds containing 1,3-diazine or hydrogenated 1,3-diazine rings not condensed with other rings having three or more double bonds between ring members or between ring members and non-ring members with hetero atoms or with carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, directly attached to ring carbon atoms
- C07D239/46—Two or more oxygen, sulphur or nitrogen atoms
- C07D239/47—One nitrogen atom and one oxygen or sulfur atom, e.g. cytosine
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P35/00—Antineoplastic agents
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P43/00—Drugs for specific purposes, not provided for in groups A61P1/00-A61P41/00
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D239/00—Heterocyclic compounds containing 1,3-diazine or hydrogenated 1,3-diazine rings
- C07D239/02—Heterocyclic compounds containing 1,3-diazine or hydrogenated 1,3-diazine rings not condensed with other rings
- C07D239/24—Heterocyclic compounds containing 1,3-diazine or hydrogenated 1,3-diazine rings not condensed with other rings having three or more double bonds between ring members or between ring members and non-ring members
- C07D239/28—Heterocyclic compounds containing 1,3-diazine or hydrogenated 1,3-diazine rings not condensed with other rings having three or more double bonds between ring members or between ring members and non-ring members with hetero atoms or with carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, directly attached to ring carbon atoms
- C07D239/46—Two or more oxygen, sulphur or nitrogen atoms
- C07D239/48—Two nitrogen atoms
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D239/00—Heterocyclic compounds containing 1,3-diazine or hydrogenated 1,3-diazine rings
- C07D239/02—Heterocyclic compounds containing 1,3-diazine or hydrogenated 1,3-diazine rings not condensed with other rings
- C07D239/24—Heterocyclic compounds containing 1,3-diazine or hydrogenated 1,3-diazine rings not condensed with other rings having three or more double bonds between ring members or between ring members and non-ring members
- C07D239/28—Heterocyclic compounds containing 1,3-diazine or hydrogenated 1,3-diazine rings not condensed with other rings having three or more double bonds between ring members or between ring members and non-ring members with hetero atoms or with carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, directly attached to ring carbon atoms
- C07D239/46—Two or more oxygen, sulphur or nitrogen atoms
- C07D239/50—Three nitrogen atoms
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D251/00—Heterocyclic compounds containing 1,3,5-triazine rings
- C07D251/02—Heterocyclic compounds containing 1,3,5-triazine rings not condensed with other rings
- C07D251/12—Heterocyclic compounds containing 1,3,5-triazine rings not condensed with other rings having three double bonds between ring members or between ring members and non-ring members
- C07D251/26—Heterocyclic compounds containing 1,3,5-triazine rings not condensed with other rings having three double bonds between ring members or between ring members and non-ring members with only hetero atoms directly attached to ring carbon atoms
- C07D251/40—Nitrogen atoms
- C07D251/48—Two nitrogen atoms
- C07D251/52—Two nitrogen atoms with an oxygen or sulfur atom attached to the third ring carbon atom
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D473/00—Heterocyclic compounds containing purine ring systems
- C07D473/02—Heterocyclic compounds containing purine ring systems with oxygen, sulphur, or nitrogen atoms directly attached in positions 2 and 6
- C07D473/04—Heterocyclic compounds containing purine ring systems with oxygen, sulphur, or nitrogen atoms directly attached in positions 2 and 6 two oxygen atoms
- C07D473/06—Heterocyclic compounds containing purine ring systems with oxygen, sulphur, or nitrogen atoms directly attached in positions 2 and 6 two oxygen atoms with radicals containing only hydrogen and carbon atoms, attached in position 1 or 3
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D473/00—Heterocyclic compounds containing purine ring systems
- C07D473/02—Heterocyclic compounds containing purine ring systems with oxygen, sulphur, or nitrogen atoms directly attached in positions 2 and 6
- C07D473/18—Heterocyclic compounds containing purine ring systems with oxygen, sulphur, or nitrogen atoms directly attached in positions 2 and 6 one oxygen and one nitrogen atom, e.g. guanine
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D473/00—Heterocyclic compounds containing purine ring systems
- C07D473/40—Heterocyclic compounds containing purine ring systems with halogen atoms or perhalogeno-alkyl radicals directly attached in position 2 or 6
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D487/00—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, not provided for by groups C07D451/00 - C07D477/00
- C07D487/02—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, not provided for by groups C07D451/00 - C07D477/00 in which the condensed system contains two hetero rings
- C07D487/04—Ortho-condensed systems
Applications Claiming Priority (2)
Application Number | Priority Date | Filing Date | Title |
---|---|---|---|
US08/283,953 US5525606A (en) | 1994-08-01 | 1994-08-01 | Substituted 06-benzylguanines and 6(4)-benzyloxypyrimidines |
PCT/US1995/009702 WO1996004281A1 (en) | 1994-08-01 | 1995-07-31 | Substituted o6-benzylguanines and 6(4)-benzyloxypyrimidines |
Publications (2)
Publication Number | Publication Date |
---|---|
DE69523462D1 true DE69523462D1 (de) | 2001-11-29 |
DE69523462T2 DE69523462T2 (de) | 2002-07-11 |
Family
ID=23088285
Family Applications (2)
Application Number | Title | Priority Date | Filing Date |
---|---|---|---|
DE69533900T Expired - Fee Related DE69533900T2 (de) | 1994-08-01 | 1995-07-31 | Substituierte 6(4)-Benzyloxypyrimidine |
DE69523462T Expired - Fee Related DE69523462T2 (de) | 1994-08-01 | 1995-07-31 | Substituierte o6-benzylguanine |
Family Applications Before (1)
Application Number | Title | Priority Date | Filing Date |
---|---|---|---|
DE69533900T Expired - Fee Related DE69533900T2 (de) | 1994-08-01 | 1995-07-31 | Substituierte 6(4)-Benzyloxypyrimidine |
Country Status (10)
Country | Link |
---|---|
US (8) | US5525606A (de) |
EP (3) | EP1142893B1 (de) |
JP (2) | JP3981407B2 (de) |
AT (2) | ATE286054T1 (de) |
CA (2) | CA2632452A1 (de) |
DE (2) | DE69533900T2 (de) |
DK (2) | DK1142893T3 (de) |
ES (2) | ES2167451T3 (de) |
PT (2) | PT1142893E (de) |
WO (1) | WO1996004281A1 (de) |
Families Citing this family (55)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
US6043228A (en) * | 1993-06-08 | 2000-03-28 | Cancer Research Campaign Technology Limited | O6 -substituted guanine derivatives, a process for their preparation and their use in treating tumor cells |
US5929046A (en) * | 1994-06-08 | 1999-07-27 | Cancer Research Campaign Technology Limited | Pyrimidine and purine derivatives and their use in treating tumour cells |
US5525606A (en) | 1994-08-01 | 1996-06-11 | The United States Of America As Represented By The Department Of Health And Human Services | Substituted 06-benzylguanines and 6(4)-benzyloxypyrimidines |
US6794390B2 (en) * | 1996-08-02 | 2004-09-21 | Cv Therapeutics, Inc. | Purine inhibitors of cyclin dependent kinase 2 & ikappabalpha |
DE19653646A1 (de) * | 1996-12-20 | 1998-06-25 | Hoechst Ag | Substituierte Purinderivate, Verfahren zu deren Herstellung, sie enthaltende Mittel und deren Verwendung |
EP1017394B1 (de) * | 1997-07-12 | 2005-12-07 | Cancer Research Technology Limited | Cyclin-abhängige-kinase inhibierende purinderivate |
US6060458A (en) * | 1998-02-13 | 2000-05-09 | The United States Of America As Represented By The Department Of Health And Human Services | Oligodeoxyribonucleotides comprising O6 -benzylguanine and their use |
US6677345B1 (en) * | 1998-03-28 | 2004-01-13 | Cancer Research Campaign Technology Limited | Cyclin dependent kinase inhibitors |
GB9806739D0 (en) * | 1998-03-28 | 1998-05-27 | Univ Newcastle Ventures Ltd | Cyclin dependent kinase inhibitors |
US6303607B1 (en) * | 1998-09-10 | 2001-10-16 | Cv Therapeutics, Inc. | Method for administering a sustained release ranolanolazine formulation |
KR100368515B1 (ko) * | 1999-02-03 | 2003-01-24 | 주식회사 엘지생명과학 | 싸이클린 의존 키나아제 저해제 및 그의 제조 방법 |
US8791081B2 (en) * | 1999-08-13 | 2014-07-29 | Case Western Reserve University | MGMT inhibitor combination for the treatment of neoplastic disorders |
US6693099B2 (en) | 2000-10-17 | 2004-02-17 | The Procter & Gamble Company | Substituted piperazine compounds optionally containing a quinolyl moiety for treating multidrug resistance |
US6376514B1 (en) | 2000-10-17 | 2002-04-23 | The Procter & Gamble Co. | Substituted six-membered heterocyclic compounds useful for treating multidrug resistance and compositions and methods thereof |
WO2002036578A2 (en) | 2000-10-31 | 2002-05-10 | Lynn Bonham | Triazine derivatives as lpaat-b inhibitors and uses thereof |
GB0101686D0 (en) * | 2001-01-23 | 2001-03-07 | Cancer Res Campaign Tech | Cyclin dependent kinase inhibitors |
BR0207302A (pt) * | 2001-02-08 | 2004-02-10 | Memory Pharm Corp | Trifluorometilpurinas como inibidores da fosfodiesterase 4 |
US20030129186A1 (en) | 2001-07-25 | 2003-07-10 | Biomarin Pharmaceutical Inc. | Compositions and methods for modulating blood-brain barrier transport |
US7241890B2 (en) * | 2001-10-30 | 2007-07-10 | Conforma Therapeutics Corporation | Purine analogs having HSP90-inhibiting activity |
US20070129334A1 (en) * | 2001-10-30 | 2007-06-07 | Conforma Therapeutics Corporation | Orally Active Purine-Based Inhibitors of Heat Shock Protein 90 |
JP2005538134A (ja) * | 2002-08-08 | 2005-12-15 | メモリー・ファーマシューティカルズ・コーポレイション | ホスホジエステラーゼ4阻害剤 |
US7335654B2 (en) * | 2002-08-08 | 2008-02-26 | Memory Pharmaceuticals Corporation | Phosphodiesterase 4 inhibitors |
GB0219746D0 (en) * | 2002-08-23 | 2002-10-02 | Inst Of Ex Botany Ascr | Azapurine derivatives |
DE10307928A1 (de) * | 2003-02-25 | 2004-09-16 | Faustus Forschungs Cie. Translational Cancer Research Gmbh | Verwendung von 1-(2-Chlorethyl)-1-nitroso-3-(2-hydroxyethyl)-urea zur Behandlung von Pankreaskarzinomen, Weichteilsarkomen, Hodentumoren, Lymphomen, Thymomen, Wilms Tumoren, Nierenkarzinomen, Melanomen, Lungentumoren, intracerebralen Metastasen, Tumoren im Kopf- und Halsbereich, und Mamma-Karzinomen |
US7129244B2 (en) * | 2003-09-18 | 2006-10-31 | Conforma Therapeutics Corporation | Triazolopyrimidines and related analogs as HSP90-inhibitors |
AU2004313931A1 (en) * | 2004-01-06 | 2005-07-28 | Government Of The United States Of America, Represented By The Secretary, Department Of Health And Human Services | 2-amino-O4-substituted pteridines and their use as inactivators of O6-alkylguanine-DNA alkyltransferase |
DE602005015570D1 (de) * | 2004-05-12 | 2009-09-03 | Bayer Cropscience Ag | Regulation des pflanzenwachstums |
US7825096B2 (en) * | 2004-09-08 | 2010-11-02 | The United States Of America As Represented By The Department Of Health And Human Services | O6-alkylguanine-DNA alkyltransferase inactivators and beta-glucuronidase cleavable prodrugs |
CA2579660A1 (en) * | 2004-09-08 | 2006-03-16 | Government Of The United States Of America, As Represented By The Secretary, Department Of Health And Human Services (The) | Beta-glucuronidase cleavable prodrugs of o6-alkylguanine-dna alkyltransferase inactivators |
CN100386115C (zh) * | 2004-10-14 | 2008-05-07 | 孔庆忠 | 一种抗癌药物组合物 |
GB0502573D0 (en) * | 2005-02-08 | 2005-03-16 | Topotarget As | Therapeutic compounds |
BRPI0609509A2 (pt) | 2005-03-30 | 2010-04-13 | Conforma Therapeutics Corp | composto ou um polimorfo, solvato, tautÈmero, enanciÈmero, pró-droga ou sal farmaceuticamente aceitável do mesmo, composição farmacêutica, e, uso do composto, polimorfo, solvato, tautÈmero, enanciÈmero, pró-droga ou sal farmaceuticamente aceitável |
US8178314B2 (en) * | 2005-04-27 | 2012-05-15 | Covalys Biosciences Ag | Pyrimidines reacting with O6-alkylguanine-DNA alkyltransferase fusion protein and method for detecting protein |
CN101287411B (zh) | 2005-04-28 | 2013-03-06 | 普罗秋斯生物医学公司 | 药物信息系统及其用途 |
JP2009504803A (ja) | 2005-08-22 | 2009-02-05 | ザ リージェンツ オブ ザ ユニバーシティ オブ カリフォルニア | Tlrアゴニスト |
EP1937258A2 (de) * | 2005-09-23 | 2008-07-02 | Conforma Therapeutics Corporation | Antitumorale verfahren mit multi-arzneiresistenz-unabhägnigen synthetischen hsp90-hemmern |
CA2653941C (en) * | 2006-05-31 | 2013-01-08 | The Regents Of The University Of California | Substituted amino purine derivatives and uses thereof |
MX2009002893A (es) | 2006-09-18 | 2009-07-10 | Raptor Pharmaceutical Inc | Tratamiento de trastornos hepaticos mediante la administracion de conjugados de la proteina asociada al receptor (rap). |
JP5425642B2 (ja) | 2007-02-07 | 2014-02-26 | ザ リージェンツ オブ ザ ユニバーシティ オブ カリフォルニア | 合成tlrアゴニストの結合体およびそのための使用 |
WO2008137207A2 (en) * | 2007-05-02 | 2008-11-13 | Government Of The United States Of America, Represented By The Secretary, Department Of Health And Human Services | Inactivators of o6-alkylguanine-dna alkyltransferase |
US8542442B2 (en) | 2007-05-07 | 2013-09-24 | Centre Suisse d'Electronique et de Microtechnique SA—Recherche et Developpement | Isotropic zero-order diffractive filter |
AU2009210655B2 (en) * | 2008-02-07 | 2013-08-15 | Telormedix Sa | Treatment of bladder diseases with a TLR7 activator |
WO2010088924A1 (en) | 2009-02-06 | 2010-08-12 | Telormedix Sa | Pharmaceutical compositions comprising imidazoquinolin(amines) and derivatives thereof suitable for local administration |
SG173617A1 (en) * | 2009-02-11 | 2011-09-29 | Univ California | Toll-like receptor modulators and treatment of diseases |
CA2752373C (en) | 2009-02-20 | 2017-10-10 | To-Bbb Holding B.V. | Glutathione-based drug delivery system |
KR20180114970A (ko) | 2009-05-06 | 2018-10-19 | 라보라토리 스킨 케어, 인크. | 활성제-칼슘 포스페이트 입자 복합체를 포함하는 피부 전달 조성물 및 이들을 이용하는 방법 |
EP2470535A4 (de) * | 2009-08-24 | 2014-01-01 | Univ Duke | Zusammensetzungen, verfahren und kits zur bestimmung einer alkyltransferase |
CN101850504B (zh) * | 2010-05-06 | 2011-11-16 | 陕西理工学院 | 一种用两个步进电机控制主轴运动的振动制孔装置 |
US20120077778A1 (en) | 2010-09-29 | 2012-03-29 | Andrea Bourdelais | Ladder-Frame Polyether Conjugates |
GB201106814D0 (en) * | 2011-04-21 | 2011-06-01 | Astex Therapeutics Ltd | New compounds |
KR20150144817A (ko) | 2011-06-10 | 2015-12-28 | 메르크 파텐트 게엠베하 | Btk 억제 활성을 갖는 피리미딘 및 피리딘 화합물의 조성물 및 제조방법 |
US20130236504A1 (en) * | 2012-03-06 | 2013-09-12 | Medical University Of South Carolina | Delivery System for Enhancing Drug Efficacy |
US9775835B2 (en) | 2012-08-06 | 2017-10-03 | Sirga Advanced Biopharma, Inc. | Small molecule inhibitors of viral protein interactions with human t-RNA |
US20170247343A1 (en) * | 2014-09-11 | 2017-08-31 | Bristol-Myers Squibb Company | Thioether triazolopyridine and triazolopyrimidine inhibitors of myeloperoxidase |
US11697851B2 (en) | 2016-05-24 | 2023-07-11 | The Regents Of The University Of California | Early ovarian cancer detection diagnostic test based on mRNA isoforms |
Family Cites Families (31)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
US4199574A (en) * | 1974-09-02 | 1980-04-22 | Burroughs Wellcome Co. | Methods and compositions for treating viral infections and guanine acyclic nucleosides |
US4235871A (en) | 1978-02-24 | 1980-11-25 | Papahadjopoulos Demetrios P | Method of encapsulating biologically active materials in lipid vesicles |
IL64501A (en) * | 1980-12-22 | 1985-07-31 | Astra Laekemedel Ab | 9-substituted 4-hydroxybutyl guanine derivatives,their preparation and antiviral use |
US5260291A (en) | 1981-08-24 | 1993-11-09 | Cancer Research Campaign Technology Limited | Tetrazine derivatives |
US5731304A (en) * | 1982-08-23 | 1998-03-24 | Cancer Research Campaign Technology | Potentiation of temozolomide in human tumour cells |
US4501728A (en) | 1983-01-06 | 1985-02-26 | Technology Unlimited, Inc. | Masking of liposomes from RES recognition |
DE3485225D1 (de) * | 1983-08-18 | 1991-12-05 | Beecham Group Plc | Antivirale guanin-derivate. |
US5019369A (en) | 1984-10-22 | 1991-05-28 | Vestar, Inc. | Method of targeting tumors in humans |
US4801710A (en) * | 1984-10-26 | 1989-01-31 | Merck & Co., Inc. | Regioselective synthesis of 9-substituted purine acyclonucleoside derivatives |
EP0184473A1 (de) * | 1984-10-26 | 1986-06-11 | Merck & Co. Inc. | Regiospezifische Synthese von 9-substituierten Purinazyklonukleosidverbindungen |
US4751221A (en) * | 1985-10-18 | 1988-06-14 | Sloan-Kettering Institute For Cancer Research | 2-fluoro-arabinofuranosyl purine nucleosides |
US4837028A (en) | 1986-12-24 | 1989-06-06 | Liposome Technology, Inc. | Liposomes with enhanced circulation time |
US4965270A (en) * | 1987-05-30 | 1990-10-23 | Beecham Group P.L.C. | Purine derivatives |
US5723609A (en) * | 1988-03-30 | 1998-03-03 | E. R. Squibb & Sons, Inc. | Bis (hydroxymethyl) cyclobutyl purines |
US5352669A (en) * | 1990-03-13 | 1994-10-04 | The Of The United States Of America As Represented By The Department Of Health And Human Services | O6 -benzylated guanine, guanosine and 2'-deoxyguanosine compounds possessing O6 -alkylguanine-DNA alkyltransferase depleting activity |
US5091430A (en) * | 1990-03-13 | 1992-02-25 | The United States Of America As Represented By The Secretary Of The Department Of Health And Human Services | O6 -substituted guanine compounds and methods for depleting O6 -alkylguanine-DNA alkyltransferase levels |
US5691307A (en) * | 1990-03-13 | 1997-11-25 | The United States Of America As Represented By The Department Of Health And Human Services | O6 -substituted guanine compositions and methods for depleting O6 |
US5364904A (en) * | 1990-06-29 | 1994-11-15 | Unilever Patent Holdings B.V. | Emulsion polymerization |
FR2676058B1 (fr) | 1991-04-30 | 1994-02-25 | Hoechst Lab | Prodrogues glycosylees, leur procede de preparation et leur utilisation dans le traitement des cancers. |
NZ244306A (en) * | 1991-09-30 | 1995-07-26 | Boehringer Ingelheim Int | Composition for introducing nucleic acid complexes into eucaryotic cells, complex containing nucleic acid and endosomolytic agent, peptide with endosomolytic domain and nucleic acid binding domain and preparation |
DE4236237A1 (de) | 1992-10-27 | 1994-04-28 | Behringwerke Ag | Prodrugs, ihre Herstellung und Verwendung als Arzneimittel |
DE4311651A1 (de) * | 1993-04-08 | 1994-10-13 | Boehringer Ingelheim Int | Virus für den Transport von Fremd-DNA in höhere eukaryotische Zellen |
CN1048493C (zh) | 1993-06-08 | 2000-01-19 | 癌症研究运动技术有限公司 | O6取代的鸟嘌呤衍生物,及其制备方法和用途 |
US6043228A (en) | 1993-06-08 | 2000-03-28 | Cancer Research Campaign Technology Limited | O6 -substituted guanine derivatives, a process for their preparation and their use in treating tumor cells |
EP0647450A1 (de) | 1993-09-09 | 1995-04-12 | BEHRINGWERKE Aktiengesellschaft | Verbesserte Prodrogen für Enzym-vermittelten-Aktivierungen |
DE69425356T2 (de) | 1993-09-22 | 2002-04-18 | Hoechst Ag | Pro-Prodrugs, ihre Herstellung und Anwendung |
US5929046A (en) | 1994-06-08 | 1999-07-27 | Cancer Research Campaign Technology Limited | Pyrimidine and purine derivatives and their use in treating tumour cells |
US5525606A (en) * | 1994-08-01 | 1996-06-11 | The United States Of America As Represented By The Department Of Health And Human Services | Substituted 06-benzylguanines and 6(4)-benzyloxypyrimidines |
ES2257756T3 (es) | 1996-03-12 | 2006-08-01 | Sanofi-Aventis Deutschland Gmbh | Nuevos profarmacos para la terapia de tumores y enfermedades inflamatorias. |
US5965126A (en) | 1996-03-25 | 1999-10-12 | The Penn State Research Foundation | use of mutant alkyltransferases for gene therapy to protect from toxicity of therapeutic alkylating agents |
WO1999025386A1 (en) | 1997-11-13 | 1999-05-27 | Case Western Reserve University | delta-O6-METHYLGUANINE-DNA METHYLTRANSFERASE GENE TRANSFER FOR O6-BENZYLGUANINE AND (N,N'-BIS(2-CHLOROETHYL)-N-NITROSOUREA) RESISTANCE |
-
1994
- 1994-08-01 US US08/283,953 patent/US5525606A/en not_active Expired - Lifetime
-
1995
- 1995-07-31 EP EP01108585A patent/EP1142893B1/de not_active Expired - Lifetime
- 1995-07-31 CA CA002632452A patent/CA2632452A1/en not_active Abandoned
- 1995-07-31 DE DE69533900T patent/DE69533900T2/de not_active Expired - Fee Related
- 1995-07-31 AT AT01108585T patent/ATE286054T1/de not_active IP Right Cessation
- 1995-07-31 AT AT95928237T patent/ATE207490T1/de not_active IP Right Cessation
- 1995-07-31 US US08/849,223 patent/US5958932A/en not_active Expired - Fee Related
- 1995-07-31 EP EP04030121A patent/EP1518854A1/de not_active Withdrawn
- 1995-07-31 ES ES95928237T patent/ES2167451T3/es not_active Expired - Lifetime
- 1995-07-31 ES ES01108585T patent/ES2233513T3/es not_active Expired - Lifetime
- 1995-07-31 DK DK01108585T patent/DK1142893T3/da active
- 1995-07-31 WO PCT/US1995/009702 patent/WO1996004281A1/en active IP Right Grant
- 1995-07-31 PT PT01108585T patent/PT1142893E/pt unknown
- 1995-07-31 DK DK95928237T patent/DK0775142T3/da active
- 1995-07-31 DE DE69523462T patent/DE69523462T2/de not_active Expired - Fee Related
- 1995-07-31 CA CA002195856A patent/CA2195856C/en not_active Expired - Fee Related
- 1995-07-31 EP EP95928237A patent/EP0775142B1/de not_active Expired - Lifetime
- 1995-07-31 JP JP50669496A patent/JP3981407B2/ja not_active Expired - Lifetime
- 1995-07-31 PT PT95928237T patent/PT775142E/pt unknown
-
1996
- 1996-06-11 US US08/661,923 patent/US5753668A/en not_active Expired - Lifetime
-
1997
- 1997-09-11 US US08/927,846 patent/US5916894A/en not_active Expired - Fee Related
-
1999
- 1999-05-25 US US09/318,238 patent/US6172070B1/en not_active Expired - Fee Related
- 1999-06-15 US US09/333,047 patent/US6333331B1/en not_active Expired - Fee Related
-
2000
- 2000-06-09 US US09/590,187 patent/US6303604B1/en not_active Expired - Fee Related
-
2001
- 2001-08-14 US US09/928,410 patent/US6436945B2/en not_active Expired - Fee Related
-
2006
- 2006-10-04 JP JP2006273447A patent/JP2007077157A/ja active Pending
Also Published As
Publication number | Publication date |
---|---|
AU3207995A (en) | 1996-03-04 |
EP1142893A1 (de) | 2001-10-10 |
DE69523462T2 (de) | 2002-07-11 |
EP1142893B1 (de) | 2004-12-29 |
US5958932A (en) | 1999-09-28 |
EP0775142B1 (de) | 2001-10-24 |
ATE207490T1 (de) | 2001-11-15 |
JP3981407B2 (ja) | 2007-09-26 |
CA2195856C (en) | 2008-09-30 |
DE69533900T2 (de) | 2005-12-29 |
DK1142893T3 (da) | 2005-03-29 |
ES2167451T3 (es) | 2002-05-16 |
ES2233513T3 (es) | 2005-06-16 |
CA2632452A1 (en) | 1996-02-15 |
US6436945B2 (en) | 2002-08-20 |
PT775142E (pt) | 2002-04-29 |
WO1996004281A1 (en) | 1996-02-15 |
US6333331B1 (en) | 2001-12-25 |
EP0775142A1 (de) | 1997-05-28 |
CA2195856A1 (en) | 1996-02-15 |
US5525606A (en) | 1996-06-11 |
EP1518854A1 (de) | 2005-03-30 |
US5916894A (en) | 1999-06-29 |
US20020013299A1 (en) | 2002-01-31 |
JP2007077157A (ja) | 2007-03-29 |
AU702711B2 (en) | 1999-03-04 |
PT1142893E (pt) | 2005-04-29 |
DK0775142T3 (da) | 2002-02-18 |
US6303604B1 (en) | 2001-10-16 |
JPH10508288A (ja) | 1998-08-18 |
ATE286054T1 (de) | 2005-01-15 |
US5753668A (en) | 1998-05-19 |
DE69533900D1 (de) | 2005-02-03 |
US6172070B1 (en) | 2001-01-09 |
Similar Documents
Publication | Publication Date | Title |
---|---|---|
ATE207490T1 (de) | Substituierte o6-benzylguanine | |
FI930753A (fi) | Nya fosfolipidderivat av nukleosider, deras framstaellning och deras anvaendning saosom antivirala laekemedel | |
SG54203A1 (en) | Novel 7- (substituted)-8-(substituted)-9- [(substituted glycyl]-6-demethyl-6-deoxytetracyclines | |
DK0582788T3 (da) | 7-(Substituerede)-9-[(substitueret glycyl)-amido]-demethyl-6-deoxytetracycliner | |
EA200000592A1 (ru) | Азаполициклические соединения, конденсированные с арилом | |
DE69331319T2 (de) | Biotin-DOTA Konjugate und deren Verwendung in "Pretargeting" Verfahren | |
HUT49600A (en) | Process for producing substituted flavonoid deriatives and salts, thereof, as well as pharmaceutical compositions comprising such compounds | |
IL94484A0 (en) | Diarylstyrylquinoline diacids and pharmaceutical compositions containing them | |
ES2072881T3 (es) | Procedimiento de preparacion de glicoconjugados de fosforamida mostaza e isofosforamida mostaza. | |
NO890567D0 (no) | Anthracyklin-derivater. | |
EA200100516A1 (ru) | Производные 3,3-биарилпиперидина и 2,2-биарилморфолина | |
DE3028340C2 (de) | ||
ES2102772T3 (es) | Compuesto citotoxico y antiviral. | |
EP0050286A3 (en) | Novel pharmaceutical guanidine derivatives | |
BR0000901A (pt) | Derivados 4-fenil-4-heteroarilpiperidina | |
IT1262565B (it) | Disaccaridi di antracicline, loro processi di preparazione e composizioni farmaceutiche che li contengono. | |
DE69308009T2 (de) | Derivate des 5,6,7,9-Tetrahydro-1,2,3-trimethoxy-9-oxo-benzo(alpha)heptalens | |
EP0381533A3 (de) | Cyclische Monophosphate von Purin- und Pyrimidin-Acyclonucleosiden | |
KR970702869A (ko) | 항종양성 인돌로피롤로카르바졸 유도체(antitumor indolopyprolocarbazole derivative) | |
HUT47897A (en) | Process for producing salicilates and pharmaceutical compositions containing them | |
AR042571A1 (es) | L-arabino disacaridos de antraciclinas, sus procesos de preparacion y composiciones farmaceuticas que los contienen y su uso para la preparacion de composisiones farmaceuticas | |
TH52867B (th) | โปรดรักของโลบูคาเวียร์และวิธี การใช้ |
Legal Events
Date | Code | Title | Description |
---|---|---|---|
8364 | No opposition during term of opposition | ||
8339 | Ceased/non-payment of the annual fee |