PT1101770E - Novos derivados de 12,13-(piranosil)-indolo(2,3-a)pirrolo(3,4-c)carbazol e 12,13-(piranosil)-furo(3,4-c)indolo(2,3-a)carbazol processo para a sua preparacao e as composicoes farmaceuticas que os contem - Google Patents

Novos derivados de 12,13-(piranosil)-indolo(2,3-a)pirrolo(3,4-c)carbazol e 12,13-(piranosil)-furo(3,4-c)indolo(2,3-a)carbazol processo para a sua preparacao e as composicoes farmaceuticas que os contem

Info

Publication number
PT1101770E
PT1101770E PT00403107T PT00403107T PT1101770E PT 1101770 E PT1101770 E PT 1101770E PT 00403107 T PT00403107 T PT 00403107T PT 00403107 T PT00403107 T PT 00403107T PT 1101770 E PT1101770 E PT 1101770E
Authority
PT
Portugal
Prior art keywords
indolo
alkyl
carbazole
nrarb
aryl
Prior art date
Application number
PT00403107T
Other languages
English (en)
Inventor
Alain Pierre
Pascale Moreau
Bruno Pfeiffer
Ghanem Atassi
Pierre Renard
Michelle Prudhomme
Fabrice Anizon
Christelle Marminon
Original Assignee
Servier Lab
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Servier Lab filed Critical Servier Lab
Publication of PT1101770E publication Critical patent/PT1101770E/pt

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D209/00—Heterocyclic compounds containing five-membered rings, condensed with other rings, with one nitrogen atom as the only ring hetero atom
    • C07D209/56—Ring systems containing three or more rings
    • C07D209/80—[b, c]- or [b, d]-condensed
    • C07D209/82—Carbazoles; Hydrogenated carbazoles
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07H—SUGARS; DERIVATIVES THEREOF; NUCLEOSIDES; NUCLEOTIDES; NUCLEIC ACIDS
    • C07H19/00—Compounds containing a hetero ring sharing one ring hetero atom with a saccharide radical; Nucleosides; Mononucleotides; Anhydro-derivatives thereof
    • C07H19/02—Compounds containing a hetero ring sharing one ring hetero atom with a saccharide radical; Nucleosides; Mononucleotides; Anhydro-derivatives thereof sharing nitrogen
    • C07H19/04—Heterocyclic radicals containing only nitrogen atoms as ring hetero atom
    • C07H19/23—Heterocyclic radicals containing two or more heterocyclic rings condensed among themselves or condensed with a common carbocyclic ring system, not provided for in groups C07H19/14 - C07H19/22
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P35/00—Antineoplastic agents

Landscapes

  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • Health & Medical Sciences (AREA)
  • General Health & Medical Sciences (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Biotechnology (AREA)
  • Engineering & Computer Science (AREA)
  • Molecular Biology (AREA)
  • Genetics & Genomics (AREA)
  • Biochemistry (AREA)
  • Veterinary Medicine (AREA)
  • Public Health (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • General Chemical & Material Sciences (AREA)
  • Animal Behavior & Ethology (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Medicinal Chemistry (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Nitrogen Condensed Heterocyclic Rings (AREA)
  • Saccharide Compounds (AREA)
PT00403107T 1999-11-17 2000-11-09 Novos derivados de 12,13-(piranosil)-indolo(2,3-a)pirrolo(3,4-c)carbazol e 12,13-(piranosil)-furo(3,4-c)indolo(2,3-a)carbazol processo para a sua preparacao e as composicoes farmaceuticas que os contem PT1101770E (pt)

Applications Claiming Priority (1)

Application Number Priority Date Filing Date Title
FR9914433A FR2801054B1 (fr) 1999-11-17 1999-11-17 Nouveaux derives de 12,13-(pyranosyl)-indolo[2,3-a]pyrrolo [3,4-c]carbazole et 12,13-(pyranosyl)-furo[3,4-c]indolo [2,3-a]carbazole, leur procede de preparation et les compositions pharmaceutiques qui les contiennent

Publications (1)

Publication Number Publication Date
PT1101770E true PT1101770E (pt) 2003-07-31

Family

ID=9552202

Family Applications (1)

Application Number Title Priority Date Filing Date
PT00403107T PT1101770E (pt) 1999-11-17 2000-11-09 Novos derivados de 12,13-(piranosil)-indolo(2,3-a)pirrolo(3,4-c)carbazol e 12,13-(piranosil)-furo(3,4-c)indolo(2,3-a)carbazol processo para a sua preparacao e as composicoes farmaceuticas que os contem

Country Status (23)

Country Link
US (1) US6569858B2 (pt)
EP (1) EP1101770B1 (pt)
JP (1) JP3602050B2 (pt)
KR (1) KR100453980B1 (pt)
CN (1) CN1152040C (pt)
AT (1) ATE237625T1 (pt)
AU (1) AU771584B2 (pt)
BR (1) BR0005426A (pt)
CA (1) CA2325779C (pt)
DE (1) DE60002142T2 (pt)
DK (1) DK1101770T3 (pt)
EA (1) EA004737B1 (pt)
ES (1) ES2197061T3 (pt)
FR (1) FR2801054B1 (pt)
HK (1) HK1036991A1 (pt)
HU (1) HUP0004574A3 (pt)
MX (1) MXPA00010899A (pt)
NO (1) NO20005796L (pt)
NZ (1) NZ508231A (pt)
PL (1) PL343879A1 (pt)
PT (1) PT1101770E (pt)
SI (1) SI1101770T1 (pt)
ZA (1) ZA200006729B (pt)

Families Citing this family (12)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US6677450B2 (en) 2000-10-06 2004-01-13 Bristol-Myers Squibb Company Topoisomerase inhibitors
US6653290B2 (en) 2000-10-06 2003-11-25 Bristol-Myers Squibb Company Tumor proliferation inhibitors
US6610727B2 (en) 2000-10-06 2003-08-26 Bristol-Myers Squibb Company Anhydro sugar derivatives of indolocarbazoles
US6855698B2 (en) 2001-03-22 2005-02-15 Bristol-Myers Squibb Company Topoisomerase I selective cytotoxic sugar derivatives of indolopyrrolocarbazoles
FR2826653B1 (fr) * 2001-06-29 2005-10-14 Servier Lab Nouveaux derives de pyrido-pyrido-pyrrolo[3,2-g]pyrrolo [3,4-e]-indole et pyrido-pyrrolo[2,3-a]pyrrolo[3,4-c] carbazole, leur procede de preparation et les compositions pharmaceutiques qui les contiennent
FR2831169B1 (fr) * 2001-10-22 2003-12-12 Servier Lab Nouveaux derives d'hydroxyalkyle indolocarbazole, leur procede de preparation et les compositions pharmaceutiques qui les contiennent
ES2326459B1 (es) * 2008-04-08 2010-05-28 Universidad De Oviedo Indolocarbazoles glicosilados, su procedimiento de obtencion y sus usos.
CN104031052B (zh) * 2014-05-20 2016-06-08 中国科学院南海海洋研究所 抗生素Indimicins A–E及其制备方法和在制备抗肿瘤药物中的应用
US10513515B2 (en) 2017-08-25 2019-12-24 Biotheryx, Inc. Ether compounds and uses thereof
EP3830093A1 (en) 2018-07-27 2021-06-09 Biotheryx, Inc. Bifunctional compounds as cdk modulators
RU2726801C1 (ru) * 2019-10-16 2020-07-15 Федеральное государственное бюджетное учреждение "Национальный медицинский исследовательский центр онкологии имени Н.Н. Блохина" Министерства здравоохранения Российской Федерации (ФГБУ "НМИЦ онкологии им. Н.Н. Блохина" Минздрава России) Средство для терапии опухолей
US11897930B2 (en) 2020-04-28 2024-02-13 Anwita Biosciences, Inc. Interleukin-2 polypeptides and fusion proteins thereof, and their pharmaceutical compositions and therapeutic applications

Family Cites Families (5)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US5015578A (en) * 1989-03-23 1991-05-14 Bristol-Myers Squibb Company BMY-41950 antitumor antibiotic
JPH05140168A (ja) * 1991-11-13 1993-06-08 Asahi Chem Ind Co Ltd インドロカルバゾール誘導体及び該化合物を有効成分とする抗腫瘍剤
NZ245203A (en) * 1991-11-29 1997-07-27 Banyu Pharma Co Ltd 5h-indolo[2,3-a]pyrrolo[3,4-c]carbazole-5,7(6h)-dione derivatives substituted in position-13 by a pentose or hexose group; corresponding indolo-furano(anhydride)intermediates
JPH07112987A (ja) * 1993-10-14 1995-05-02 Asahi Chem Ind Co Ltd スタウロスポリン糖部分変換誘導体
CO4940430A1 (es) * 1997-07-07 2000-07-24 Novartis Ag Compuestos policiclicos que contienen estaurosporina hidrogenada con propiedades farmacologicas convenientes y un efecto inhibidor sobre el crecimiento de las celulas tumorales

Also Published As

Publication number Publication date
FR2801054B1 (fr) 2003-06-13
JP2001139578A (ja) 2001-05-22
FR2801054A1 (fr) 2001-05-18
DE60002142D1 (de) 2003-05-22
BR0005426A (pt) 2001-07-03
HUP0004574A3 (en) 2001-12-28
DE60002142T2 (de) 2004-03-18
US6569858B2 (en) 2003-05-27
US20020055510A1 (en) 2002-05-09
DK1101770T3 (da) 2003-08-04
KR20010051775A (ko) 2001-06-25
EA004737B1 (ru) 2004-08-26
MXPA00010899A (es) 2002-05-23
ATE237625T1 (de) 2003-05-15
NZ508231A (en) 2001-09-28
AU7168100A (en) 2002-01-03
KR100453980B1 (ko) 2004-10-20
CN1303859A (zh) 2001-07-18
AU771584B2 (en) 2004-03-25
SI1101770T1 (en) 2003-08-31
CN1152040C (zh) 2004-06-02
NO20005796D0 (no) 2000-11-16
EP1101770B1 (fr) 2003-04-16
HU0004574D0 (pt) 2001-02-28
NO20005796L (no) 2001-05-18
JP3602050B2 (ja) 2004-12-15
CA2325779A1 (fr) 2001-05-17
EA200001078A1 (ru) 2001-06-25
ZA200006729B (en) 2001-06-05
HK1036991A1 (en) 2002-01-25
EP1101770A1 (fr) 2001-05-23
HUP0004574A2 (hu) 2001-10-28
ES2197061T3 (es) 2004-01-01
PL343879A1 (en) 2001-05-21
CA2325779C (fr) 2006-07-11

Similar Documents

Publication Publication Date Title
PT1101770E (pt) Novos derivados de 12,13-(piranosil)-indolo(2,3-a)pirrolo(3,4-c)carbazol e 12,13-(piranosil)-furo(3,4-c)indolo(2,3-a)carbazol processo para a sua preparacao e as composicoes farmaceuticas que os contem
EA200000391A1 (ru) Производные тиенопиримидина и тиенопиридина, полезные в качестве противораковых агентов
FR2619111B1 (fr) Derives de (piperidinyl-4)methyl-2 tetrahydro-1,2,3,4 9h-pyrido (3,4-b) indole, leur preparation et leur application en therapeutique
PE20021085A1 (es) PIRROLO (2.1-a) DIHIDROISOQUINOLINAS
PT81004B (pt) Processo para a preparacao de oxindoles trigiclicos uteis como agentes anti-inflamatorios
SE9300758L (sv) Förfarande för framställning av kavulansyrasalter
AR246270A1 (es) Un procedimiento para producir derivados de tieno-¡2,3-d¿azepina.
KR950702563A (ko) 테트라시클릭 화합물, 이것의 제조방법 및 중간체와, 항암제로서의 이들의 사용방법(tetracyclic compounds process and intermediates for their preparation and their use as antitumour agents)
ES2162856T3 (es) Derivados de ergolina serotoninergicos.
CO4700463A1 (es) Compuestos sustituidos de dihidroimidazo [2,1-b] tiazol y dihidro-5h-tiazol(3,2-a)pirimidina, procedimientos para su preparacion
KR920004390A (ko) 피롤로벤조이미다졸, 이미다조벤족사지논 및 이미다조퀴놀론, 이들의 제조방법, 이들의 용도 및 이 화합물들을 함유하는 제제
DE69332929D1 (de) ANTIALLERGISCHE IMIDAZO[1,2-a]THIENO[2,3-d]AZEPINDERIVATE
BG101671A (en) Diclavunic salt with diaminoether and method for its preparation
KR950032205A (ko) 5,6-디 히드로-4H-티에노 [3,4-c] 피롤유도체, 그것의 제조방법 및 치료에의 이용
NZ223333A (en) 3-phenyl-7h-thiazole (3,2-b (1,2, triazin-7-one derivatives and pharmaceutical compositions
ZA987076B (en) Bis-pyrido[4,3-b]carbazole compounds a process for their preparation and pharmaceutical compositions containing them
ES2040629A1 (es) Procedimiento de obtencion de derivados triciclicos de la benzotiazepina farmacologicamente activos.
MX9101659A (es) Derivados de ergolina, proceso para su produccion y composicion farmaceutica que los contiene.
TNSN86037A1 (fr) Nouveaux derives de la pyrrolo (1,2-a) azepinone, leur preparation et les compositions pharmaceutiques qui les contiennent
ATE113046T1 (de) Triazolo(4,5-c>pyridinderivate mit krampflindernder wirkung.
WO2000034286A3 (en) Process for the preparation of pyrimidinone derivatives
RU2000100997A (ru) Производные 3-замещенного пиридо (3',4':4,5)тиено (2,3-d) пиримидина