PT1073618E - Processo para a producao de sertralina-tetralona enantiomericamente pura ou opticamente enriquecida usando cromotografia continua - Google Patents
Processo para a producao de sertralina-tetralona enantiomericamente pura ou opticamente enriquecida usando cromotografia continuaInfo
- Publication number
- PT1073618E PT1073618E PT99920040T PT99920040T PT1073618E PT 1073618 E PT1073618 E PT 1073618E PT 99920040 T PT99920040 T PT 99920040T PT 99920040 T PT99920040 T PT 99920040T PT 1073618 E PT1073618 E PT 1073618E
- Authority
- PT
- Portugal
- Prior art keywords
- tetralone
- continuous
- production
- enantiomerically pure
- chromotography
- Prior art date
Links
Classifications
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
- C07C49/00—Ketones; Ketenes; Dimeric ketenes; Ketonic chelates
- C07C49/587—Unsaturated compounds containing a keto groups being part of a ring
- C07C49/687—Unsaturated compounds containing a keto groups being part of a ring containing halogen
- C07C49/697—Unsaturated compounds containing a keto groups being part of a ring containing halogen containing six-membered aromatic rings
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07B—GENERAL METHODS OF ORGANIC CHEMISTRY; APPARATUS THEREFOR
- C07B57/00—Separation of optically-active compounds
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
- C07C45/00—Preparation of compounds having >C = O groups bound only to carbon or hydrogen atoms; Preparation of chelates of such compounds
- C07C45/61—Preparation of compounds having >C = O groups bound only to carbon or hydrogen atoms; Preparation of chelates of such compounds by reactions not involving the formation of >C = O groups
- C07C45/67—Preparation of compounds having >C = O groups bound only to carbon or hydrogen atoms; Preparation of chelates of such compounds by reactions not involving the formation of >C = O groups by isomerisation; by change of size of the carbon skeleton
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
- C07C45/00—Preparation of compounds having >C = O groups bound only to carbon or hydrogen atoms; Preparation of chelates of such compounds
- C07C45/78—Separation; Purification; Stabilisation; Use of additives
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
- C07C45/00—Preparation of compounds having >C = O groups bound only to carbon or hydrogen atoms; Preparation of chelates of such compounds
- C07C45/78—Separation; Purification; Stabilisation; Use of additives
- C07C45/79—Separation; Purification; Stabilisation; Use of additives by solid-liquid treatment; by chemisorption
Landscapes
- Chemical & Material Sciences (AREA)
- Organic Chemistry (AREA)
- Chemical Kinetics & Catalysis (AREA)
- Organic Low-Molecular-Weight Compounds And Preparation Thereof (AREA)
Applications Claiming Priority (1)
Application Number | Priority Date | Filing Date | Title |
---|---|---|---|
US8385198P | 1998-05-01 | 1998-05-01 |
Publications (1)
Publication Number | Publication Date |
---|---|
PT1073618E true PT1073618E (pt) | 2004-03-31 |
Family
ID=22181106
Family Applications (1)
Application Number | Title | Priority Date | Filing Date |
---|---|---|---|
PT99920040T PT1073618E (pt) | 1998-05-01 | 1999-04-27 | Processo para a producao de sertralina-tetralona enantiomericamente pura ou opticamente enriquecida usando cromotografia continua |
Country Status (9)
Country | Link |
---|---|
US (1) | US6444854B1 (pt) |
EP (1) | EP1073618B1 (pt) |
AT (1) | ATE255555T1 (pt) |
CA (1) | CA2342201C (pt) |
DE (1) | DE69913332T2 (pt) |
DK (1) | DK1073618T3 (pt) |
ES (1) | ES2211080T3 (pt) |
PT (1) | PT1073618E (pt) |
WO (1) | WO1999057089A1 (pt) |
Families Citing this family (24)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
US6410794B1 (en) | 1994-12-16 | 2002-06-25 | Uop Llc | Process for preparation of pharmaceutically desired chiral tetralone from tetralones |
US6458955B1 (en) | 1994-12-16 | 2002-10-01 | Uop Llc | Process for preparation of pharmaceutically desired enantiomers |
US6455736B1 (en) | 1994-12-16 | 2002-09-24 | Uop Llc | Process for preparation of pharmaceutically desired sertraline and sertraline analogs |
FR2810978B1 (fr) * | 2000-06-29 | 2004-05-28 | Chiralsep Sarl | Procede de dedoublement de l'intermediaire tetralone de la sertraline |
US6740757B2 (en) | 2001-08-29 | 2004-05-25 | Pfizer Inc | Enantiomers of 6-[(4-chloro-phenyl)-hydroxy-(3-methyl-3h-imidazol-4-yl)-methyl]-4-[3-(3-hydroxy-3-methyl-but-1-ynyl)-phenyl]-1-methyl-1h-quinolin-2-one and salts thereof, useful in the treatment of cancer |
US6683220B2 (en) * | 2001-10-31 | 2004-01-27 | Pfizer, Inc. | Process for the preparation of optically pure or enriched racemic tetralone |
US20060128955A1 (en) * | 2003-05-09 | 2006-06-15 | Vela Pharmaceuticals, Inc. | Method of isolating (R)-tofisopam |
BRPI0413595B8 (pt) * | 2003-08-18 | 2021-05-25 | H Lundbeck As | sal de malonato, composição farmacêutica, uso de um sal de malonato, e, método de fabricação de um composto |
GB0325055D0 (en) * | 2003-10-27 | 2003-12-03 | Smithkline Beecham Corp | New process |
US20060086667A1 (en) * | 2004-09-13 | 2006-04-27 | Cephalon, Inc., U.S. Corporation | Methods for the separation of enantiomeric sulfinylacetamides |
TWI453198B (zh) | 2005-02-16 | 2014-09-21 | Lundbeck & Co As H | 製造反式-1-((1r,3s)-6-氯基-3-苯基茚滿-1-基) -3 , 3 -二甲基六氫吡與其鹽類之方法及製造4-((1r , 3s)-6 -氯基-3-苯基茚滿-1-基 )-1,2,2-三甲基六氫吡與其鹽類之方法 |
JP2008530039A (ja) * | 2005-02-16 | 2008-08-07 | ハー・ルンドベック・アクチエゼルスカベット | トランス−1−((1r,3s)−6−クロロ−3−フェニルインダン−1−イル)−3,3−ジメチルピペラジンの酒石酸塩およびリンゴ酸塩 |
TWI376373B (en) * | 2005-02-16 | 2012-11-11 | Lundbeck & Co As H | Crystalline base of a pharmaceutical compound |
FR2898283B1 (fr) | 2006-03-08 | 2011-07-15 | Novasep | Procede et dispositif de separation de fractions d'un melange. |
WO2008088830A2 (en) * | 2007-01-16 | 2008-07-24 | Evolved Nanomaterial Sciences, Inc. | Chiral separating agents with active support |
US7776740B2 (en) * | 2008-01-22 | 2010-08-17 | Tokyo Electron Limited | Method for integrating selective low-temperature ruthenium deposition into copper metallization of a semiconductor device |
JP2011519873A (ja) * | 2008-05-07 | 2011-07-14 | ハー・ルンドベック・アクチエゼルスカベット | 認知欠損を治療する方法 |
KR20110081176A (ko) * | 2008-10-03 | 2011-07-13 | 하. 룬드벡 아크티에셀스카브 | 경구용 제형물 |
CN104122342A (zh) * | 2014-07-04 | 2014-10-29 | 惠州市莱佛士制药技术有限公司 | 一种盐酸舍曲林中间体(±)-Tetralone及其手性色谱拆分方法 |
US9127136B1 (en) * | 2014-07-18 | 2015-09-08 | Sabic Global Technologies B.V. | Purification of monomer from recycle polyesters |
CN104826619A (zh) * | 2015-05-08 | 2015-08-12 | 广州研创生物技术发展有限公司 | 键合3,5-二甲基苯氨基甲酰化β-环糊精手性固定相在手性分析和/或分离盐酸舍曲林中间体(±)-Tetralone的应用 |
CN106268657A (zh) * | 2015-05-14 | 2017-01-04 | 株式会社大赛璐 | 光学异构体用分离剂 |
EP3566769B1 (fr) | 2018-05-07 | 2023-07-26 | Yf1 | Methode et dispositif de simulation d'une installation industrielle pour l'exploitation d'un procede chimique ou biochimique |
EP3786733B1 (fr) | 2019-08-29 | 2023-04-12 | Yf1 | Système et procédé pour la simulation d'un procédé chimique ou biochimique |
Family Cites Families (5)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
JP3010816B2 (ja) * | 1991-08-22 | 2000-02-21 | ダイセル化学工業株式会社 | 光学分割における光学異性体と溶媒との回収方法、溶媒の循環使用方法、および光学異性体の再利用方法 |
DE69327134T2 (de) * | 1992-06-30 | 2000-07-06 | Daicel Chem | Trennsystem mit simuliertem Fliessbett |
US5466880A (en) * | 1992-09-15 | 1995-11-14 | Pfizer Inc. | Process for preparing ketone enantiomer |
US5288916A (en) | 1993-03-25 | 1994-02-22 | Bend Research, Inc. | Enantiomeric resolution of 4-(3,4-dichlorophenyl)-3,4-dihydro-1(2H)-naphthalenone |
US5630943A (en) * | 1995-11-30 | 1997-05-20 | Merck Patent Gesellschaft Mit Beschrankter Haftung | Discontinuous countercurrent chromatographic process and apparatus |
-
1999
- 1999-04-27 PT PT99920040T patent/PT1073618E/pt unknown
- 1999-04-27 DE DE69913332T patent/DE69913332T2/de not_active Expired - Fee Related
- 1999-04-27 DK DK99920040T patent/DK1073618T3/da active
- 1999-04-27 EP EP99920040A patent/EP1073618B1/en not_active Expired - Lifetime
- 1999-04-27 US US09/700,435 patent/US6444854B1/en not_active Expired - Fee Related
- 1999-04-27 AT AT99920040T patent/ATE255555T1/de not_active IP Right Cessation
- 1999-04-27 ES ES99920040T patent/ES2211080T3/es not_active Expired - Lifetime
- 1999-04-27 CA CA002342201A patent/CA2342201C/en not_active Expired - Fee Related
- 1999-04-27 WO PCT/US1999/009037 patent/WO1999057089A1/en active IP Right Grant
Also Published As
Publication number | Publication date |
---|---|
DE69913332D1 (de) | 2004-01-15 |
EP1073618B1 (en) | 2003-12-03 |
DE69913332T2 (de) | 2004-05-27 |
DK1073618T3 (da) | 2004-03-15 |
EP1073618A1 (en) | 2001-02-07 |
CA2342201A1 (en) | 1999-11-11 |
CA2342201C (en) | 2005-08-09 |
US6444854B1 (en) | 2002-09-03 |
ES2211080T3 (es) | 2004-07-01 |
WO1999057089A1 (en) | 1999-11-11 |
ATE255555T1 (de) | 2003-12-15 |
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