PT102160B - Processo para a preparacao de 4-(des-dimetilamino)-tetraciclinas - Google Patents

Processo para a preparacao de 4-(des-dimetilamino)-tetraciclinas Download PDF

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Publication number
PT102160B
PT102160B PT102160A PT10216098A PT102160B PT 102160 B PT102160 B PT 102160B PT 102160 A PT102160 A PT 102160A PT 10216098 A PT10216098 A PT 10216098A PT 102160 B PT102160 B PT 102160B
Authority
PT
Portugal
Prior art keywords
process according
tetracyclines
dimethylamino
tetracycline
solution
Prior art date
Application number
PT102160A
Other languages
English (en)
Portuguese (pt)
Other versions
PT102160A (pt
Inventor
Pedro Paulo De Lacerda Santos
William Heggie
Jose Manuel Camoes Galindro
Luis Daniel Dos Anjos Carvalho
Original Assignee
Hovione Sociedade Quimica S A
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Hovione Sociedade Quimica S A filed Critical Hovione Sociedade Quimica S A
Priority to PT102160A priority Critical patent/PT102160B/pt
Priority to HU9900761A priority patent/HUP9900761A3/hu
Priority to AU22444/99A priority patent/AU746608B2/en
Priority to IL12924499A priority patent/IL129244A/xx
Priority to NZ334940A priority patent/NZ334940A/xx
Priority to ZA9902484A priority patent/ZA992484B/xx
Priority to AT99302600T priority patent/ATE213788T1/de
Priority to DE69900927T priority patent/DE69900927T2/de
Priority to EP99302600A priority patent/EP0962552B1/en
Priority to ES99302600T priority patent/ES2173706T3/es
Priority to KR1019990012481A priority patent/KR19990087905A/ko
Priority to IN555DE1999 priority patent/IN192877B/en
Priority to JP11105105A priority patent/JP2000034264A/ja
Priority to CNB991051548A priority patent/CN1192016C/zh
Priority to NO19992072A priority patent/NO325059B1/no
Priority to CA002272598A priority patent/CA2272598C/en
Priority to US09/317,396 priority patent/US6143161A/en
Publication of PT102160A publication Critical patent/PT102160A/pt
Publication of PT102160B publication Critical patent/PT102160B/pt

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
    • C07C209/00—Preparation of compounds containing amino groups bound to a carbon skeleton
    • C07C209/24—Preparation of compounds containing amino groups bound to a carbon skeleton by reductive alkylation of ammonia, amines or compounds having groups reducible to amino groups, with carbonyl compounds
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
    • C07C231/00—Preparation of carboxylic acid amides
    • C07C231/12—Preparation of carboxylic acid amides by reactions not involving the formation of carboxamide groups
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P43/00—Drugs for specific purposes, not provided for in groups A61P1/00-A61P41/00
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
    • C07C2603/00—Systems containing at least three condensed rings
    • C07C2603/02—Ortho- or ortho- and peri-condensed systems
    • C07C2603/40—Ortho- or ortho- and peri-condensed systems containing four condensed rings
    • C07C2603/42—Ortho- or ortho- and peri-condensed systems containing four condensed rings containing only six-membered rings
    • C07C2603/44—Naphthacenes; Hydrogenated naphthacenes
    • C07C2603/46—1,4,4a,5,5a,6,11,12a- Octahydronaphthacenes, e.g. tetracyclines

Landscapes

  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Health & Medical Sciences (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Animal Behavior & Ethology (AREA)
  • General Chemical & Material Sciences (AREA)
  • Medicinal Chemistry (AREA)
  • Engineering & Computer Science (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • General Health & Medical Sciences (AREA)
  • Public Health (AREA)
  • Veterinary Medicine (AREA)
  • Organic Low-Molecular-Weight Compounds And Preparation Thereof (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Electrolytic Production Of Non-Metals, Compounds, Apparatuses Therefor (AREA)
PT102160A 1998-05-26 1998-05-26 Processo para a preparacao de 4-(des-dimetilamino)-tetraciclinas PT102160B (pt)

Priority Applications (17)

Application Number Priority Date Filing Date Title
PT102160A PT102160B (pt) 1998-05-26 1998-05-26 Processo para a preparacao de 4-(des-dimetilamino)-tetraciclinas
HU9900761A HUP9900761A3 (en) 1998-05-26 1999-03-25 A process for the preparation of 4-(desdimethyl-amino)-tetracyclines
AU22444/99A AU746608B2 (en) 1998-05-26 1999-03-26 A process for the preparation of 4-(des-dimethylamino)- tetracyclines
IL12924499A IL129244A (en) 1998-05-26 1999-03-30 Electrochemical process for the preparation of 4-(desdimethylamino)-tetracyclines
NZ334940A NZ334940A (en) 1998-05-26 1999-03-30 process of producing 4-(des-dimethylamino)-tetracycline
ZA9902484A ZA992484B (en) 1998-05-26 1999-03-31 A process for the preparation of 4-(Des-dimethylamino)-tetracyclines.
AT99302600T ATE213788T1 (de) 1998-05-26 1999-04-01 Verfahren zur herstellung von 4-(des- dimethylamino)-tetracyclinen
DE69900927T DE69900927T2 (de) 1998-05-26 1999-04-01 Verfahren zur Herstellung von 4-(des-dimethylamino)-Tetracyclinen
EP99302600A EP0962552B1 (en) 1998-05-26 1999-04-01 A process for the preparation of 4-(des-dimethylamino)-tetracyclines
ES99302600T ES2173706T3 (es) 1998-05-26 1999-04-01 Procedimiento para la preparacion de 4 - (des-dimetilanino) - tetraciclinas.
KR1019990012481A KR19990087905A (ko) 1998-05-26 1999-04-09 4-(데스-디메틸아미노)-테트라사이클린의제조방법
IN555DE1999 IN192877B (enFirst) 1998-05-26 1999-04-09
JP11105105A JP2000034264A (ja) 1998-05-26 1999-04-13 ４―（デス―ジメチルアミノ）―テトラサイクリンの製造方法
CNB991051548A CN1192016C (zh) 1998-05-26 1999-04-21 4－(脱二甲氨基)四环素的制备方法
NO19992072A NO325059B1 (no) 1998-05-26 1999-04-29 Fremgangsmate ved fremstilling av 4-(des-dimetylamino)-tetracykliner
CA002272598A CA2272598C (en) 1998-05-26 1999-05-21 A process for the preparation of 4-(des-dimethylamino)-tetracyclines
US09/317,396 US6143161A (en) 1998-05-26 1999-05-24 Process for the preparation of 4-(des-dimethylamino)-tetracyclines

Applications Claiming Priority (1)

Application Number Priority Date Filing Date Title
PT102160A PT102160B (pt) 1998-05-26 1998-05-26 Processo para a preparacao de 4-(des-dimetilamino)-tetraciclinas

Publications (2)

Publication Number Publication Date
PT102160A PT102160A (pt) 1999-11-30
PT102160B true PT102160B (pt) 2001-04-30

Family

ID=20085765

Family Applications (1)

Application Number Title Priority Date Filing Date
PT102160A PT102160B (pt) 1998-05-26 1998-05-26 Processo para a preparacao de 4-(des-dimetilamino)-tetraciclinas

Country Status (17)

Country Link
US (1) US6143161A (enFirst)
EP (1) EP0962552B1 (enFirst)
JP (1) JP2000034264A (enFirst)
KR (1) KR19990087905A (enFirst)
CN (1) CN1192016C (enFirst)
AT (1) ATE213788T1 (enFirst)
AU (1) AU746608B2 (enFirst)
CA (1) CA2272598C (enFirst)
DE (1) DE69900927T2 (enFirst)
ES (1) ES2173706T3 (enFirst)
HU (1) HUP9900761A3 (enFirst)
IL (1) IL129244A (enFirst)
IN (1) IN192877B (enFirst)
NO (1) NO325059B1 (enFirst)
NZ (1) NZ334940A (enFirst)
PT (1) PT102160B (enFirst)
ZA (1) ZA992484B (enFirst)

Families Citing this family (5)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
BRPI0510113B1 (pt) 2004-05-21 2022-09-27 President And Fellows Of Harvard College Compostos de tetraciclinas e análogos das mesmas
CA2648668C (en) * 2006-04-07 2015-06-23 The President And Fellows Of Harvard College Synthesis of tetracyclines and analogues thereof
EP2076133B1 (en) * 2006-10-11 2012-12-12 President and Fellows of Harvard College Synthesis of enone intermediate
EP2424834B1 (en) 2009-04-30 2018-07-11 President and Fellows of Harvard College Synthesis of tetracyclines and intermediates thereof
PT108978B (pt) 2015-11-24 2020-03-09 Hovione Farm S A Sais de tetraciclinas

Family Cites Families (9)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
GB1349043A (en) * 1971-04-05 1974-03-27 Pliva Pharm & Chem Works Process for the preparation of 6-demethyl-6-deoxy-6-methylene tetracyclines
US5308839A (en) * 1989-12-04 1994-05-03 The Research Foundation Of State University Of New York Composition comprising non-steroidal anti-inflammatory agent tenidap and effectively non-antibacterial tetracycline
JP3016587B2 (ja) * 1989-12-04 2000-03-06 ザ・リサーチ・ファンデーション・オブ・ステート・ユニバーシティ・オブ・ニューヨーク 非ステロイド抗炎症剤及びテトラサイクリンの配合
US5223248A (en) * 1991-02-11 1993-06-29 The Research Foundation Of State University Of New York Non-antibacterial tetracycline compositions possessing antiplaque properties
CA2094874C (en) * 1992-04-27 2003-02-11 Thomas F. Mcnamara Non-antibacterial tetracycline compositons possessing antiplaque properties
JPH069523A (ja) * 1992-06-18 1994-01-18 Kuraray Co Ltd ４−デジメチルアミノテトラサイクリンの精製法
DE69304292T2 (de) * 1992-11-17 1997-01-02 Univ New York Tetracycline inclusive nicht antimicrobiel wirksame, chemisch modifizierte Tetracycline hemmende exzessive Kollagenquervernetzung bei Diabetes
US5552297A (en) * 1993-12-21 1996-09-03 Abbott Laboratories Lead detection method and reggents utilizing aminolevulinic acid dehydratase and tertiary phosphines
US5789395A (en) * 1996-08-30 1998-08-04 The Research Foundation Of State University Of New York Method of using tetracycline compounds for inhibition of endogenous nitric oxide production

Also Published As

Publication number Publication date
US6143161A (en) 2000-11-07
EP0962552B1 (en) 2002-02-27
IN192877B (enFirst) 2004-05-29
KR19990087905A (ko) 1999-12-27
CN1192016C (zh) 2005-03-09
DE69900927T2 (de) 2002-08-29
HUP9900761A2 (hu) 1999-12-28
ZA992484B (en) 1999-10-05
EP0962552A1 (en) 1999-12-08
AU746608B2 (en) 2002-05-02
NO992072L (no) 1999-11-29
HU9900761D0 (en) 1999-05-28
IL129244A0 (en) 2000-02-17
NO325059B1 (no) 2008-01-21
IL129244A (en) 2003-01-12
DE69900927D1 (de) 2002-04-04
CA2272598A1 (en) 1999-11-26
NZ334940A (en) 2000-05-26
NO992072D0 (no) 1999-04-29
CA2272598C (en) 2008-01-22
CN1236775A (zh) 1999-12-01
PT102160A (pt) 1999-11-30
ES2173706T3 (es) 2002-10-16
HUP9900761A3 (en) 2000-06-28
JP2000034264A (ja) 2000-02-02
ATE213788T1 (de) 2002-03-15
AU2244499A (en) 1999-12-02

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BB1A Laying open of patent application

Effective date: 19980727

FG3A Patent granted, date of granting

Effective date: 20010123

MA3A Withdrawal of patent

Effective date: 20120614