PT101061B - Composicoes farmaceuticas contendo anagolos da camptotecina e um composto de coordenacao de platina e seu uso na inibicao do crescimento de celulas tumorais - Google Patents

Composicoes farmaceuticas contendo anagolos da camptotecina e um composto de coordenacao de platina e seu uso na inibicao do crescimento de celulas tumorais Download PDF

Info

Publication number
PT101061B
PT101061B PT101061A PT10106192A PT101061B PT 101061 B PT101061 B PT 101061B PT 101061 A PT101061 A PT 101061A PT 10106192 A PT10106192 A PT 10106192A PT 101061 B PT101061 B PT 101061B
Authority
PT
Portugal
Prior art keywords
compound
platinum
class
platinum coordination
coordination compound
Prior art date
Application number
PT101061A
Other languages
English (en)
Portuguese (pt)
Other versions
PT101061A (pt
Inventor
Randall Keith Johnson
Original Assignee
Smithkline Beckman Corp
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Smithkline Beckman Corp filed Critical Smithkline Beckman Corp
Publication of PT101061A publication Critical patent/PT101061A/pt
Publication of PT101061B publication Critical patent/PT101061B/pt

Links

Classifications

    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/28—Compounds containing heavy metals
    • A61K31/282—Platinum compounds
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/33—Heterocyclic compounds
    • A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
    • A61K31/435—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with one nitrogen as the only ring hetero atom
    • A61K31/47—Quinolines; Isoquinolines
    • A61K31/4738—Quinolines; Isoquinolines ortho- or peri-condensed with heterocyclic ring systems
    • A61K31/4745—Quinolines; Isoquinolines ortho- or peri-condensed with heterocyclic ring systems condensed with ring systems having nitrogen as a ring hetero atom, e.g. phenantrolines
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/33—Heterocyclic compounds
    • A61K31/555—Heterocyclic compounds containing heavy metals, e.g. hemin, hematin, melarsoprol
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K33/00—Medicinal preparations containing inorganic active ingredients
    • A61K33/24—Heavy metals; Compounds thereof
    • A61K33/243—Platinum; Compounds thereof
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K45/00—Medicinal preparations containing active ingredients not provided for in groups A61K31/00 - A61K41/00
    • A61K45/06—Mixtures of active ingredients without chemical characterisation, e.g. antiphlogistics and cardiaca
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P35/00—Antineoplastic agents

Landscapes

  • Health & Medical Sciences (AREA)
  • Veterinary Medicine (AREA)
  • Chemical & Material Sciences (AREA)
  • Medicinal Chemistry (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Animal Behavior & Ethology (AREA)
  • General Health & Medical Sciences (AREA)
  • Public Health (AREA)
  • Epidemiology (AREA)
  • Inorganic Chemistry (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • General Chemical & Material Sciences (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Organic Chemistry (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Acyclic And Carbocyclic Compounds In Medicinal Compositions (AREA)
  • Seasonings (AREA)
  • Medicines Containing Material From Animals Or Micro-Organisms (AREA)
PT101061A 1991-11-15 1992-11-13 Composicoes farmaceuticas contendo anagolos da camptotecina e um composto de coordenacao de platina e seu uso na inibicao do crescimento de celulas tumorais PT101061B (pt)

Applications Claiming Priority (1)

Application Number Priority Date Filing Date Title
US79304191A 1991-11-15 1991-11-15

Publications (2)

Publication Number Publication Date
PT101061A PT101061A (pt) 1994-06-30
PT101061B true PT101061B (pt) 1999-07-30

Family

ID=25158913

Family Applications (1)

Application Number Title Priority Date Filing Date
PT101061A PT101061B (pt) 1991-11-15 1992-11-13 Composicoes farmaceuticas contendo anagolos da camptotecina e um composto de coordenacao de platina e seu uso na inibicao do crescimento de celulas tumorais

Country Status (15)

Country Link
US (1) US5633016A (fr)
EP (3) EP1393730A3 (fr)
JP (1) JPH07501079A (fr)
AT (1) ATE247471T1 (fr)
AU (1) AU671605B2 (fr)
CA (1) CA2123321C (fr)
DE (1) DE69233169T2 (fr)
DK (1) DK0612248T3 (fr)
ES (1) ES2204894T3 (fr)
HK (1) HK1012268A1 (fr)
MX (1) MX9206577A (fr)
NZ (1) NZ245112A (fr)
PT (1) PT101061B (fr)
WO (1) WO1993009782A1 (fr)
ZA (1) ZA928771B (fr)

Families Citing this family (59)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US5552154A (en) 1989-11-06 1996-09-03 The Stehlin Foundation For Cancer Research Method for treating cancer with water-insoluble s-camptothecin of the closed lactone ring form and derivatives thereof
ATE247471T1 (de) * 1991-11-15 2003-09-15 Smithkline Beecham Corp Cisplatin und topotecan enthaltende zusammensetzung als antitumor.
WO1994015604A1 (fr) * 1993-01-15 1994-07-21 The Stehlin Foundation For Cancer Research Traitement transdermique du cancer au moyen de s-camptothecine insoluble dans l'eau de la forme fermee du cycle de lactone
EP0715854B1 (fr) 1994-11-11 2003-09-10 Debiopharm S.A. Compositions carcinostatiques contenant du cis-oxaliplatine et un ou plusieurs autres carcinostatiques
WO1997001344A2 (fr) * 1995-06-27 1997-01-16 Henry M. Jackson Foundation For The Advancement Of Military Medicine Procede de ralentissement dynamique de la cinetique du cycle cellulaire, destine a potentialiser les lesions cellulaires
US6274576B1 (en) 1995-06-27 2001-08-14 The Henry Jackson Foundation For The Advancement Of Military Medicine Method of dynamic retardation of cell cycle kinetics to potentiate cell damage
GB9804013D0 (en) 1998-02-25 1998-04-22 Sanofi Sa Formulations
US6858598B1 (en) 1998-12-23 2005-02-22 G. D. Searle & Co. Method of using a matrix metalloproteinase inhibitor and one or more antineoplastic agents as a combination therapy in the treatment of neoplasia
US6833373B1 (en) 1998-12-23 2004-12-21 G.D. Searle & Co. Method of using an integrin antagonist and one or more antineoplastic agents as a combination therapy in the treatment of neoplasia
US7105492B2 (en) * 1999-03-09 2006-09-12 Sigma-Tau Industrie Farmaceutiche Riunite S.P.A. Camptothecin derivatives having antitumor activity
ES2175919T3 (es) * 1999-03-09 2002-11-16 Sigma Tau Ind Farmaceuti Derivados del camptothecin con actividad antitumoral.
EP1165144A2 (fr) * 1999-03-15 2002-01-02 Introgen Therapeutics, Inc. Cellules dendritiques transduites avec un gene du soi de type sauvage suscitant des reponses immunitaires antitumorales puissantes
EP1754488A1 (fr) 1999-05-24 2007-02-21 Introgen Therapeutics, Inc. Methodes et compositions de thérapie génique non-virale pour le traitement des maladies hyperprolifératives
WO2001024763A2 (fr) 1999-10-01 2001-04-12 Immunogen, Inc. Compositions et methodes de traitement du cancer utilisant des immunoconjugues et des agents chimiotherapeutiques
US6420378B1 (en) * 1999-10-15 2002-07-16 Supergen, Inc. Inhibition of abnormal cell proliferation with camptothecin and combinations including the same
WO2001066144A2 (fr) * 2000-03-08 2001-09-13 Rhode Island Hospital, A Lifespan Partner Therapie d'association de medicaments
US6545010B2 (en) * 2000-03-17 2003-04-08 Aventis Pharma S.A. Composition comprising camptothecin or a camptothecin derivative and a platin derivative for the treatment of cancer
GB0011903D0 (en) * 2000-05-18 2000-07-05 Astrazeneca Ab Combination chemotherapy
US10293056B1 (en) 2000-05-24 2019-05-21 Board Of Regents, The University Of Texas System Methods and compositions for non-viral gene therapy for treatment of hyperproliferative diseases
DE10032256C2 (de) * 2000-07-03 2003-06-05 Infineon Technologies Ag Chip-ID-Register-Anordnung
AU2002220257A1 (en) * 2000-12-07 2002-06-18 Board Of Regents, The University Of Texas System Methods of treatment involving human mda-7
US6476068B1 (en) 2001-12-06 2002-11-05 Pharmacia Italia, S.P.A. Platinum derivative pharmaceutical formulations
WO2003075952A1 (fr) * 2002-03-05 2003-09-18 Board Of Regents, The University Of Texas System Procedes d'amelioration de l'induction de la reponse immunitaire impliquant mda-7
EP2269618A1 (fr) 2002-08-12 2011-01-05 Jennerex Biotherapeutics ULC Virus de vaccinia oncolytique pour usage en combinaison aven une chémiothérapie pour le traitement du cancer
WO2004078124A2 (fr) * 2003-03-03 2004-09-16 Board Of Regents, The University Of Texas System Procedes et compositions impliquant mda-7
US8034790B2 (en) * 2003-12-01 2011-10-11 Introgen Therapeutics Use of MDA-7 to inhibit pathogenic infectious organisms
US20070281041A1 (en) * 2004-03-02 2007-12-06 Introgen Therapeutics, Inc. Compositions and Methods Involving MDA-7 for the Treatment of Cancer
EP1863516A2 (fr) * 2005-02-08 2007-12-12 Board of Regents, The University of Texas System Compositions et methodes faisant intervenir la proteine mda-7 pour le traitement du cancer
EP1888105A2 (fr) * 2005-05-12 2008-02-20 Introgen Therapeutics, Inc. Vaccins p53 permettant de traiter les cancers
US20100190180A1 (en) * 2005-07-06 2010-07-29 Heidi Kay Materials and Methods for Screening, Diagnosis and Prognosis of Conditions Associated With Stat Protein Expression
US8980246B2 (en) 2005-09-07 2015-03-17 Sillajen Biotherapeutics, Inc. Oncolytic vaccinia virus cancer therapy
KR20090004839A (ko) * 2005-09-07 2009-01-12 제네렉스, 인코포레이티드 Ｇｍ-ｃｓｆ를 발현하는 폭스바이러스를 사용한 전이성및/또는 전신 파종성 암의 전신 치료법
WO2007092944A2 (fr) * 2006-02-08 2007-08-16 Introgen Therapeutics, Inc. Compositions et procedes impliquant une therapie de gene et une modulation de proteasome
WO2008021549A2 (fr) * 2006-08-18 2008-02-21 Sidney Kimmel Cancer Center Procédés et compositions pour la suppression de tumeurs modulées par la topoisomérase i
US8178564B2 (en) * 2006-11-06 2012-05-15 Poniard Pharmaceuticals, Inc. Use of picoplatin to treat colorectal cancer
US8173686B2 (en) 2006-11-06 2012-05-08 Poniard Pharmaceuticals, Inc. Use of picoplatin to treat colorectal cancer
US8168661B2 (en) * 2006-11-06 2012-05-01 Poniard Pharmaceuticals, Inc. Use of picoplatin to treat colorectal cancer
US8168662B1 (en) 2006-11-06 2012-05-01 Poniard Pharmaceuticals, Inc. Use of picoplatin to treat colorectal cancer
US20110033528A1 (en) * 2009-08-05 2011-02-10 Poniard Pharmaceuticals, Inc. Stabilized picoplatin oral dosage form
KR20080084528A (ko) 2007-03-15 2008-09-19 제네렉스 바이오테라퓨틱스 인크. 종양살상형 백시니아 바이러스 암 치료
US20100260832A1 (en) * 2007-06-27 2010-10-14 Poniard Pharmaceuticals, Inc. Combination therapy for ovarian cancer
TW200916094A (en) * 2007-06-27 2009-04-16 Poniard Pharmaceuticals Inc Stabilized picoplatin dosage form
CN101809024A (zh) * 2007-07-16 2010-08-18 铂雅制药公司 吡铂的口服制剂
JP2011511071A (ja) * 2008-02-08 2011-04-07 ポニアード ファーマシューティカルズ， インコーポレイテッド 肺癌を治療するためのピコプラチンおよびアムルビシン
BR112012005774B8 (pt) 2009-09-14 2023-02-14 Jennerex Inc uso de um inibidor de quinase antiangiogênico no tratamento de câncer
WO2011160063A2 (fr) 2010-06-18 2011-12-22 Myriad Genetics, Inc. Procédés et matériaux pour évaluer la perte d'hétérozygotie
DK2609216T3 (en) 2010-08-24 2016-09-12 Dana Farber Cancer Inst Inc Methods to predict anti-cancer response
CN103429258B (zh) 2011-01-04 2016-03-09 新罗杰公司 通过施用溶瘤痘苗病毒生成针对肿瘤抗原的抗体和生成肿瘤特异性补体依赖性细胞毒性
EP2721181B1 (fr) 2011-06-17 2019-12-18 Myriad Genetics, Inc. Méthodes et matériaux permettant de déterminer un déséquilibre allélique
WO2013094581A1 (fr) * 2011-12-21 2013-06-27 株式会社ヤクルト本社 Nouveau dérivé de camptothécine
AU2012358244A1 (en) 2011-12-21 2014-06-12 Myriad Genetics, Inc. Methods and materials for assessing loss of heterozygosity
NZ628813A (en) 2012-02-23 2015-10-30 Univ Denmark Tech Dtu Methods for predicting anti-cancer response
CA3190075A1 (fr) 2012-06-07 2013-12-12 Institut Curie Methodes de detection de l'inactivation de la voie de recombinaison homologue (brca1/2) dans les tumeurs humaines
US10308986B2 (en) 2013-03-14 2019-06-04 Children's Medical Center Corporation Cancer diagnosis, treatment selection and treatment
AU2014248007B2 (en) 2013-04-05 2020-03-26 Myriad Genetics, Inc. Methods and materials for assessing homologous recombination deficiency
US9821008B2 (en) * 2013-11-25 2017-11-21 The University Of Toledo Inhibitors of ERCC1-XPF and methods of using the same
US11149316B2 (en) 2013-12-09 2021-10-19 Institut Curie Methods for detecting inactivation of the homologous recombination pathway (BRCA1/2) in human tumors
DK3180447T3 (da) 2014-08-15 2020-06-15 Myriad Genetics Inc Fremgangsmåder og materialer til analyse af homolog rekombinationsdeficiens
EP4141127A1 (fr) 2021-08-30 2023-03-01 Zentrum Familiärer Brust- und Eierstockkrebs Universitätsklinik Köln Procédé d'évaluation de déficience de recombinaison homologue dans des cellules du cancer de l'ovaire

Family Cites Families (9)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US4342776A (en) 1979-11-05 1982-08-03 Merck & Co., Inc. 4-Substituted-3-hydroxy-3-pyrroline-2,5-dione inhibitors of glycolic acid oxidase
US4399276A (en) 1981-01-09 1983-08-16 Kabushiki Kaisha Yakult Honsha 7-Substituted camptothecin derivatives
US4473692A (en) 1981-09-04 1984-09-25 Kabushiki Kaisha Yakult Honsha Camptothecin derivatives and process for preparing same
JPS5839685A (ja) 1981-09-04 1983-03-08 Yakult Honsha Co Ltd 新規なカンプトテシン誘導体及びその製造法
JPS58154582A (ja) 1982-03-10 1983-09-14 Yakult Honsha Co Ltd 新規なカンプトテシン誘導体およびその製造法
JPS6019790A (ja) 1983-07-14 1985-01-31 Yakult Honsha Co Ltd 新規なカンプトテシン誘導体
US5004758A (en) 1987-12-01 1991-04-02 Smithkline Beecham Corporation Water soluble camptothecin analogs useful for inhibiting the growth of animal tumor cells
ES2165346T3 (es) 1989-09-15 2002-03-16 Res Triangle Inst Analogos de 10,11-metilendioxi-20(rs)-camptotecina y 10,11-metilendioxi-20(s)-camptotecina.
ATE247471T1 (de) * 1991-11-15 2003-09-15 Smithkline Beecham Corp Cisplatin und topotecan enthaltende zusammensetzung als antitumor.

Also Published As

Publication number Publication date
ZA928771B (en) 1993-09-08
EP1393729A3 (fr) 2004-03-17
NZ245112A (en) 1995-07-26
CA2123321A1 (fr) 1993-05-27
EP1393730A3 (fr) 2004-03-17
JPH07501079A (ja) 1995-02-02
AU671605B2 (en) 1996-09-05
MX9206577A (es) 1993-05-01
ES2204894T3 (es) 2004-05-01
CA2123321C (fr) 2003-09-30
HK1012268A1 (en) 1999-07-30
EP0612248A1 (fr) 1994-08-31
DE69233169D1 (de) 2003-09-25
ATE247471T1 (de) 2003-09-15
EP0612248B1 (fr) 2003-08-20
PT101061A (pt) 1994-06-30
DE69233169T2 (de) 2004-05-27
AU3137993A (en) 1993-06-15
EP0612248A4 (en) 1996-05-08
WO1993009782A1 (fr) 1993-05-27
EP1393729A2 (fr) 2004-03-03
EP1393730A2 (fr) 2004-03-03
US5633016A (en) 1997-05-27
DK0612248T3 (da) 2003-12-08

Similar Documents

Publication Publication Date Title
PT101061B (pt) Composicoes farmaceuticas contendo anagolos da camptotecina e um composto de coordenacao de platina e seu uso na inibicao do crescimento de celulas tumorais
ES2267841T3 (es) Uso de una derivado de alfa-halogeno-acriloil distamicina para la preparacion de un medicamento para el tratamiento del cancer.
US5674872A (en) Treatment of ovarian cancer
AU664172B2 (en) Treatment of esophageal cancer
EP0661977A4 (fr) Traitement du cancer colo-rectal.
US5756512A (en) Treatment of non-small cell lung carcinoma
US20020115677A1 (en) Combination comprising camptothecin and a stilbene derivative for the treatment of cancer
EP1707568B1 (fr) Composition pharmaceutique utilisée dans le traitement du cancer de l'ovaire
EP1267873A2 (fr) Composition comprenant de la camptothecine ou un derive de la camptothecine et un agent alkylant, destinee au traitement du cancer
JPH0517353A (ja) 制癌作用増強剤
KR20110104932A (ko) Ａｖｅ８０６２ 및 도세탁셀이 조합된 항종양 조합물

Legal Events

Date Code Title Description
BB1A Laying open of patent application

Effective date: 19931122

FG3A Patent granted, date of granting

Effective date: 19990420

MM4A Annulment/lapse due to non-payment of fees, searched and examined patent

Free format text: LAPSE DUE TO NON-PAYMENT OF FEES

Effective date: 20121022