PT100426A - Derivados 4-aril-3-heteroarilureidoquinolina uteis como agentes anti-hipercolesterolemicos e antiateroscleroticos - Google Patents
Derivados 4-aril-3-heteroarilureidoquinolina uteis como agentes anti-hipercolesterolemicos e antiateroscleroticos Download PDFInfo
- Publication number
- PT100426A PT100426A PT100426A PT10042692A PT100426A PT 100426 A PT100426 A PT 100426A PT 100426 A PT100426 A PT 100426A PT 10042692 A PT10042692 A PT 10042692A PT 100426 A PT100426 A PT 100426A
- Authority
- PT
- Portugal
- Prior art keywords
- chlorophenyl
- ureido
- bis
- methylthio
- quinoline
- Prior art date
Links
Classifications
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D215/00—Heterocyclic compounds containing quinoline or hydrogenated quinoline ring systems
- C07D215/02—Heterocyclic compounds containing quinoline or hydrogenated quinoline ring systems having no bond between the ring nitrogen atom and a non-ring member or having only hydrogen atoms or carbon atoms directly attached to the ring nitrogen atom
- C07D215/16—Heterocyclic compounds containing quinoline or hydrogenated quinoline ring systems having no bond between the ring nitrogen atom and a non-ring member or having only hydrogen atoms or carbon atoms directly attached to the ring nitrogen atom with hetero atoms or with carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, e.g. ester or nitrile radicals, directly attached to ring carbon atoms
- C07D215/38—Nitrogen atoms
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P3/00—Drugs for disorders of the metabolism
- A61P3/06—Antihyperlipidemics
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P43/00—Drugs for specific purposes, not provided for in groups A61P1/00-A61P41/00
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P9/00—Drugs for disorders of the cardiovascular system
- A61P9/10—Drugs for disorders of the cardiovascular system for treating ischaemic or atherosclerotic diseases, e.g. antianginal drugs, coronary vasodilators, drugs for myocardial infarction, retinopathy, cerebrovascula insufficiency, renal arteriosclerosis
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D215/00—Heterocyclic compounds containing quinoline or hydrogenated quinoline ring systems
- C07D215/02—Heterocyclic compounds containing quinoline or hydrogenated quinoline ring systems having no bond between the ring nitrogen atom and a non-ring member or having only hydrogen atoms or carbon atoms directly attached to the ring nitrogen atom
- C07D215/16—Heterocyclic compounds containing quinoline or hydrogenated quinoline ring systems having no bond between the ring nitrogen atom and a non-ring member or having only hydrogen atoms or carbon atoms directly attached to the ring nitrogen atom with hetero atoms or with carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, e.g. ester or nitrile radicals, directly attached to ring carbon atoms
- C07D215/36—Sulfur atoms
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D401/00—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom
- C07D401/02—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom containing two hetero rings
- C07D401/12—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom containing two hetero rings linked by a chain containing hetero atoms as chain links
Landscapes
- Organic Chemistry (AREA)
- Chemical & Material Sciences (AREA)
- Health & Medical Sciences (AREA)
- Bioinformatics & Cheminformatics (AREA)
- Engineering & Computer Science (AREA)
- General Health & Medical Sciences (AREA)
- Medicinal Chemistry (AREA)
- Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
- General Chemical & Material Sciences (AREA)
- Pharmacology & Pharmacy (AREA)
- Life Sciences & Earth Sciences (AREA)
- Animal Behavior & Ethology (AREA)
- Chemical Kinetics & Catalysis (AREA)
- Public Health (AREA)
- Veterinary Medicine (AREA)
- Vascular Medicine (AREA)
- Urology & Nephrology (AREA)
- Cardiology (AREA)
- Heart & Thoracic Surgery (AREA)
- Diabetes (AREA)
- Hematology (AREA)
- Obesity (AREA)
- Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
- Plural Heterocyclic Compounds (AREA)
- Quinoline Compounds (AREA)
- Nitrogen Condensed Heterocyclic Rings (AREA)
- Pyridine Compounds (AREA)
Applications Claiming Priority (1)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| US69232391A | 1991-04-26 | 1991-04-26 |
Publications (1)
| Publication Number | Publication Date |
|---|---|
| PT100426A true PT100426A (pt) | 1993-08-31 |
Family
ID=24780107
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| PT100426A PT100426A (pt) | 1991-04-26 | 1992-04-24 | Derivados 4-aril-3-heteroarilureidoquinolina uteis como agentes anti-hipercolesterolemicos e antiateroscleroticos |
Country Status (20)
| Country | Link |
|---|---|
| EP (1) | EP0590094A1 (OSRAM) |
| JP (1) | JPH0776215B2 (OSRAM) |
| CN (1) | CN1066068A (OSRAM) |
| AU (1) | AU1879792A (OSRAM) |
| BR (1) | BR9205939A (OSRAM) |
| CA (1) | CA2108014A1 (OSRAM) |
| CZ (1) | CZ395592A3 (OSRAM) |
| DE (1) | DE9290049U1 (OSRAM) |
| FI (1) | FI934710A7 (OSRAM) |
| HU (1) | HUT65748A (OSRAM) |
| IE (1) | IE921330A1 (OSRAM) |
| IL (1) | IL101627A0 (OSRAM) |
| MX (1) | MX9201916A (OSRAM) |
| NO (1) | NO933837L (OSRAM) |
| NZ (1) | NZ242493A (OSRAM) |
| PT (1) | PT100426A (OSRAM) |
| TW (1) | TW197436B (OSRAM) |
| WO (1) | WO1992019614A1 (OSRAM) |
| YU (1) | YU44592A (OSRAM) |
| ZA (1) | ZA922976B (OSRAM) |
Families Citing this family (10)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| ES2125325T3 (es) * | 1992-01-23 | 1999-03-01 | Pfizer | Derivados de 4-fenil-3-(heteroarilureido)-1,2-dihidro-2-oxoquinolina como agentes antihipercolesterolemicos y antiateroscleroticos. |
| US5565472A (en) * | 1992-12-21 | 1996-10-15 | Pfizer Inc. | 4-aryl-3-(heteroarylureido)-1,2-dihydro-2-oxo-quinoline derivatives as antihypercholesterolemic and antiatherosclerotic agents |
| NZ264063A (en) * | 1993-08-13 | 1995-11-27 | Nihon Nohyaku Co Ltd | N-(2-phenylpyrid-3-yl)- and n-(4-phenylpyrimidin-5-yl)-n'-phenylurea derivatives and pharmaceutical compositions |
| US5843957A (en) * | 1995-05-19 | 1998-12-01 | Sumitomo Pharmaceuticals Company, Ltd. | Naphthyridine derivatives |
| AU699091B2 (en) * | 1995-05-31 | 1998-11-19 | Dainippon Sumitomo Pharma Co., Ltd. | Novel naphthyridine derivatives |
| EP0947515A4 (en) * | 1996-11-26 | 2002-10-23 | Sumitomo Pharma | NEW NAPHTHYRIDINE DERIVATIVES |
| CA2321237A1 (en) | 1998-02-25 | 1999-09-02 | Masami Muraoka | Pyridone derivatives and process for producing the same |
| US6452008B2 (en) | 1998-02-25 | 2002-09-17 | Sumitomo Pharmaceuticals Company, Limited | Pyridone derivatives and process for preparing the same |
| SV2005001973A (es) | 2003-12-12 | 2005-11-04 | Wyeth Corp | Quinolinas utiles en el tratamiento de enfermedades cardiovasculares ref. wyth0090-504 (am101500) |
| CN103601677B (zh) * | 2013-11-19 | 2015-11-18 | 清华大学 | 制备2-烷硫基喹啉衍生物的方法 |
Family Cites Families (3)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| IE892088L (en) * | 1988-07-12 | 1990-01-12 | William Henry Deryk Morris | Quinoline derivatives, their production and use |
| WO1991004027A1 (en) * | 1989-09-15 | 1991-04-04 | Pfizer Inc. | New n-aryl and n-heteroarylamide and urea derivatives as inhibitors of acyl coenzyme a: cholesterol acyl transferase (acat) |
| TW205037B (OSRAM) * | 1989-10-06 | 1993-05-01 | Takeda Pharm Industry Co Ltd |
-
1992
- 1992-03-16 WO PCT/US1992/001801 patent/WO1992019614A1/en not_active Application Discontinuation
- 1992-03-16 EP EP92923349A patent/EP0590094A1/en not_active Withdrawn
- 1992-03-16 BR BR9205939A patent/BR9205939A/pt not_active Application Discontinuation
- 1992-03-16 JP JP4510186A patent/JPH0776215B2/ja not_active Expired - Lifetime
- 1992-03-16 AU AU18797/92A patent/AU1879792A/en not_active Abandoned
- 1992-03-16 FI FI934710A patent/FI934710A7/fi unknown
- 1992-03-16 HU HU9303025A patent/HUT65748A/hu active IP Right Revival
- 1992-03-16 CZ CS923955A patent/CZ395592A3/cs unknown
- 1992-03-16 CA CA002108014A patent/CA2108014A1/en not_active Abandoned
- 1992-03-16 DE DE9290049U patent/DE9290049U1/de not_active Expired - Lifetime
- 1992-03-17 TW TW081102005A patent/TW197436B/zh active
- 1992-03-24 ZA ZA922976A patent/ZA922976B/xx unknown
- 1992-04-16 IL IL101627A patent/IL101627A0/xx unknown
- 1992-04-24 MX MX9201916A patent/MX9201916A/es not_active IP Right Cessation
- 1992-04-24 IE IE133092A patent/IE921330A1/en not_active Application Discontinuation
- 1992-04-24 YU YU44592A patent/YU44592A/sh unknown
- 1992-04-24 PT PT100426A patent/PT100426A/pt not_active Application Discontinuation
- 1992-04-24 NZ NZ242493A patent/NZ242493A/en unknown
- 1992-04-25 CN CN92103010A patent/CN1066068A/zh active Pending
-
1993
- 1993-10-25 NO NO933837A patent/NO933837L/no unknown
Also Published As
| Publication number | Publication date |
|---|---|
| DE9290049U1 (de) | 1994-01-05 |
| EP0590094A1 (en) | 1994-04-06 |
| TW197436B (OSRAM) | 1993-01-01 |
| NZ242493A (en) | 1994-08-26 |
| HUT65748A (en) | 1994-07-28 |
| MX9201916A (es) | 1992-11-01 |
| CA2108014A1 (en) | 1992-10-27 |
| NO933837L (no) | 1993-10-25 |
| CZ395592A3 (en) | 1994-02-16 |
| JPH06501025A (ja) | 1994-01-27 |
| BR9205939A (pt) | 1994-09-27 |
| IL101627A0 (en) | 1992-12-30 |
| YU44592A (sh) | 1994-12-28 |
| FI934710L (fi) | 1993-10-25 |
| ZA922976B (en) | 1993-10-25 |
| AU1879792A (en) | 1992-12-21 |
| FI934710A0 (fi) | 1993-10-25 |
| HU9303025D0 (en) | 1994-01-28 |
| WO1992019614A1 (en) | 1992-11-12 |
| JPH0776215B2 (ja) | 1995-08-16 |
| CN1066068A (zh) | 1992-11-11 |
| FI934710A7 (fi) | 1993-10-25 |
| IE921330A1 (en) | 1992-11-04 |
Similar Documents
| Publication | Publication Date | Title |
|---|---|---|
| US5596001A (en) | 4-aryl-3-(heteroarylureido)quinoline derivatves | |
| US5885996A (en) | Antiproliferative quinazolines | |
| RU2529468C2 (ru) | Производные 1, 2-дигидроциклобутендиона в качестве ингибиторов фосфорибозилтрансферазы никотинамида | |
| JPH03120243A (ja) | アシル補酵素ａ：コレステロールアシルトランスフエラーゼ（ａｃａｔ）阻害剤としての新規ｎ―アリール及びｎ―ヘテロアリールアミド及び尿素誘導体 | |
| EP0642498A1 (en) | NEW $i(N)-ARYL AND $i(N)-HETEROARYLUREA DERIVATIVES AS INHIBITORS OF ACYL COENZYME A:CHOLESTEROL ACYL TRANSFERASE (ACAT) | |
| JP5717730B2 (ja) | 酵素ニコチンアミドホスホリボシルトランスフェラーゼの阻害剤としてのピリジニル誘導体 | |
| CA2361402C (en) | Bis-sulfonamides | |
| EP0781766A1 (en) | Heterocyclic derivative and medicine | |
| US5063227A (en) | Quinazoline-substituted pyridazinone derivatives having cardiotonic activity | |
| EP0088593A2 (en) | 1,2,4-Triazine and pyrazine derivatives | |
| US5565472A (en) | 4-aryl-3-(heteroarylureido)-1,2-dihydro-2-oxo-quinoline derivatives as antihypercholesterolemic and antiatherosclerotic agents | |
| EP2888248B1 (en) | Substituted 4-pyridones and their use as inhibitors of neutrophil elastase activity | |
| PT100426A (pt) | Derivados 4-aril-3-heteroarilureidoquinolina uteis como agentes anti-hipercolesterolemicos e antiateroscleroticos | |
| CA2128093C (en) | 4-aryl-3-(heteroarylureido)-1,2-dihydro-2-oxoquinoline derivatives as antihypercholesterolemic and antiatherosclerotic agents | |
| EP0144730B1 (en) | 2-anilino-1,6-dihydro-6-oxo-5-pyrimidinecarboxylic acid derivatives, processes for the preparation thereof, and antiallergic agent containing the same | |
| JPWO2004014873A1 (ja) | ４−置換キナゾリン−８−カルボン酸アミド誘導体とその薬理上許容される付加塩 | |
| JP2790926B2 (ja) | スルホンアミド誘導体 | |
| Jatczak et al. | Straightforward entry to pyrido [2, 3-d] pyrimidine-2, 4 (1H, 3H)-diones and their ADME properties | |
| US4840953A (en) | 9-(Substituted thio)-4H-pyrido[1,2,-A]pyrimidin-4-one derivatives | |
| Warner Jr et al. | Synthesis of 6-(N-alkyl-N-arylamino) pyrimidines as potential antimetabolites | |
| WO2004082613A2 (en) | 2,4-diamino-5-[5’-substituted-benzyl] pyrimidines and 2,4-diamino-6-[5’-substituted-benzyl] quinazolines | |
| JPH0259571A (ja) | ピリドン誘導体又はその塩類 |
Legal Events
| Date | Code | Title | Description |
|---|---|---|---|
| BB1A | Laying open of patent application |
Effective date: 19930331 |
|
| FC3A | Refusal |
Effective date: 19990607 |