PL3759113T3 - Pochodne 10-(di(fenylo)metylo)-4-hydroksy-8,9,9a,10-tetrahydro-7h- pirolo[1’,2’:4,5]pirazyno[1,2-b]pirydazyno-3,5-dionowe i związki pokrewne jako inhibitory replikacji ortomyksowirusów do leczenia grypy - Google Patents
Pochodne 10-(di(fenylo)metylo)-4-hydroksy-8,9,9a,10-tetrahydro-7h- pirolo[1’,2’:4,5]pirazyno[1,2-b]pirydazyno-3,5-dionowe i związki pokrewne jako inhibitory replikacji ortomyksowirusów do leczenia grypyInfo
- Publication number
- PL3759113T3 PL3759113T3 PL19713572.6T PL19713572T PL3759113T3 PL 3759113 T3 PL3759113 T3 PL 3759113T3 PL 19713572 T PL19713572 T PL 19713572T PL 3759113 T3 PL3759113 T3 PL 3759113T3
- Authority
- PL
- Poland
- Prior art keywords
- pyrrollo
- pyrazino
- pyridazine
- influenza
- tetrahydro
- Prior art date
Links
- YXKFWFPIHMMZAG-UHFFFAOYSA-N 1h-pyridazine-4,6-dione Chemical class O=C1CC(=O)C=NN1 YXKFWFPIHMMZAG-UHFFFAOYSA-N 0.000 title 1
- 150000001875 compounds Chemical class 0.000 title 1
- 206010022000 influenza Diseases 0.000 title 1
- 239000003112 inhibitor Substances 0.000 title 1
- 230000010076 replication Effects 0.000 title 1
Classifications
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K31/00—Medicinal preparations containing organic active ingredients
- A61K31/33—Heterocyclic compounds
- A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
- A61K31/495—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with two or more nitrogen atoms as the only ring heteroatoms, e.g. piperazine or tetrazines
- A61K31/50—Pyridazines; Hydrogenated pyridazines
- A61K31/5025—Pyridazines; Hydrogenated pyridazines ortho- or peri-condensed with heterocyclic ring systems
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D487/00—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, not provided for by groups C07D451/00 - C07D477/00
- C07D487/12—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, not provided for by groups C07D451/00 - C07D477/00 in which the condensed system contains three hetero rings
- C07D487/14—Ortho-condensed systems
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P31/00—Antiinfectives, i.e. antibiotics, antiseptics, chemotherapeutics
- A61P31/12—Antivirals
- A61P31/14—Antivirals for RNA viruses
- A61P31/16—Antivirals for RNA viruses for influenza or rhinoviruses
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D498/00—Heterocyclic compounds containing in the condensed system at least one hetero ring having nitrogen and oxygen atoms as the only ring hetero atoms
- C07D498/12—Heterocyclic compounds containing in the condensed system at least one hetero ring having nitrogen and oxygen atoms as the only ring hetero atoms in which the condensed system contains three hetero rings
- C07D498/14—Ortho-condensed systems
Landscapes
- Chemical & Material Sciences (AREA)
- Organic Chemistry (AREA)
- Health & Medical Sciences (AREA)
- Life Sciences & Earth Sciences (AREA)
- Virology (AREA)
- Veterinary Medicine (AREA)
- Public Health (AREA)
- General Health & Medical Sciences (AREA)
- Animal Behavior & Ethology (AREA)
- Pharmacology & Pharmacy (AREA)
- Medicinal Chemistry (AREA)
- Oncology (AREA)
- Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
- General Chemical & Material Sciences (AREA)
- Chemical Kinetics & Catalysis (AREA)
- Communicable Diseases (AREA)
- Molecular Biology (AREA)
- Pulmonology (AREA)
- Epidemiology (AREA)
- Nitrogen Condensed Heterocyclic Rings (AREA)
- Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
- Nitrogen And Oxygen Or Sulfur-Condensed Heterocyclic Ring Systems (AREA)
- Medicinal Preparation (AREA)
- Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)
Applications Claiming Priority (2)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| US201862636378P | 2018-02-28 | 2018-02-28 | |
| PCT/IB2019/051549 WO2019166950A1 (en) | 2018-02-28 | 2019-02-26 | 10-(di(phenyl)methyl)-4-hydroxy-8,9,9a,10-tetrahydro-7h-pyrrolo[1 ',2':4,5]pyrazino[1,2-b]pyridazine-3,5-dione derivatives and related compounds as inhibitors of the orthomyxovirus replication for treating influenza |
Publications (1)
| Publication Number | Publication Date |
|---|---|
| PL3759113T3 true PL3759113T3 (pl) | 2025-01-20 |
Family
ID=65911219
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| PL19713572.6T PL3759113T3 (pl) | 2018-02-28 | 2019-02-26 | Pochodne 10-(di(fenylo)metylo)-4-hydroksy-8,9,9a,10-tetrahydro-7h- pirolo[1’,2’:4,5]pirazyno[1,2-b]pirydazyno-3,5-dionowe i związki pokrewne jako inhibitory replikacji ortomyksowirusów do leczenia grypy |
Country Status (31)
| Country | Link |
|---|---|
| US (3) | US11629149B2 (pl) |
| EP (2) | EP4467198A3 (pl) |
| JP (3) | JP7065989B2 (pl) |
| KR (3) | KR102521320B1 (pl) |
| CN (2) | CN111801333B (pl) |
| AU (1) | AU2019227250B2 (pl) |
| BR (1) | BR112020017121A2 (pl) |
| CA (1) | CA3092544A1 (pl) |
| CL (1) | CL2020002202A1 (pl) |
| CR (2) | CR20240350A (pl) |
| DK (1) | DK3759113T3 (pl) |
| EA (1) | EA202091696A1 (pl) |
| ES (1) | ES2993277T3 (pl) |
| FI (1) | FI3759113T3 (pl) |
| HR (1) | HRP20241522T1 (pl) |
| HU (1) | HUE069183T2 (pl) |
| IL (2) | IL305957A (pl) |
| LT (1) | LT3759113T (pl) |
| MX (2) | MX2020008959A (pl) |
| MY (1) | MY203207A (pl) |
| NZ (1) | NZ767072A (pl) |
| PE (1) | PE20210403A1 (pl) |
| PH (1) | PH12020500660A1 (pl) |
| PL (1) | PL3759113T3 (pl) |
| PT (1) | PT3759113T (pl) |
| SA (1) | SA520420046B1 (pl) |
| SG (1) | SG11202007718SA (pl) |
| SI (1) | SI3759113T1 (pl) |
| UA (1) | UA126253C2 (pl) |
| WO (1) | WO2019166950A1 (pl) |
| ZA (1) | ZA202005507B (pl) |
Families Citing this family (3)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| JP6918819B2 (ja) | 2016-03-08 | 2021-08-11 | ノバルティス アーゲー | オルトミクソウイルス感染の処置に有用な三環式化合物 |
| JOP20170169A1 (ar) | 2016-08-29 | 2019-01-30 | Novartis Ag | مركبات بيريدازين ثلاثية الحلقة مندمجة تفيد في علاج العدوى بفيروس أورثوميكسو |
| NZ767072A (en) * | 2018-02-28 | 2024-03-22 | Novartis Ag | 10-(di(phenyl)methyl)-4-hydroxy-8,9,9a,10-tetrahydro-7h-pyrrolo[1 ‘,2’:4,5]pyrazino[1,2-b]pyridazine-3,5-dione derivatives and related compounds as inhibitors of the orthomyxovirus replication for treating influenza |
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| US2225112A (en) | 1938-07-09 | 1940-12-17 | Wright Aeronautical Corp | Air cleaner |
| GB8501542D0 (en) | 1985-01-22 | 1985-02-20 | Erba Farmitalia | 4 5 6 7-tetrahydro-imidazo(4 5-clpyridine derivatives |
| AUPM354694A0 (en) | 1994-01-27 | 1994-02-17 | Biota Scientific Management Pty Ltd | Chemical compounds |
| CN101513402B (zh) | 2001-08-10 | 2012-03-21 | 盐野义制药株式会社 | 抗病毒药 |
| WO2004078163A2 (en) | 2003-02-28 | 2004-09-16 | Transform Pharmaceuticals, Inc. | Pharmaceutical co-crystal compositions of drugs such as carbamazepine, celecoxib, olanzapine, itraconazole, topiramate, modafinil, 5-fluorouracil, hydrochlorothiazide, acetaminophen, aspirin, flurbiprofen, phenytoin and ibuprofen |
| TW200510425A (en) | 2003-08-13 | 2005-03-16 | Japan Tobacco Inc | Nitrogen-containing fused ring compound and use thereof as HIV integrase inhibitor |
| TW200526635A (en) | 2003-12-22 | 2005-08-16 | Shionogi & Co | Hydroxypyrimidinone derivative having HIV integrase inhibitory activity |
| US20070161639A1 (en) | 2004-03-09 | 2007-07-12 | Philip Jones | Hiv integrase inhibitors |
| FR2901795A1 (fr) | 2006-05-30 | 2007-12-07 | Fourtillan Snc | Derives de pyrimidino[1',6'-1,2]pyrido[3,4-b]indoles et leur utilisation en therapeutique |
| EA019520B1 (ru) | 2008-10-31 | 2014-04-30 | Сионоги Энд Ко., Лтд. | Цефалоспорины, содержащие катехольную группу |
| EP2412708A4 (en) | 2009-03-26 | 2014-07-23 | Shionogi & Co | SUBSTITUTED 3-HYDROXY-4-PYRIDONE DERIVATIVE |
| TWI518084B (zh) | 2009-03-26 | 2016-01-21 | 鹽野義製藥股份有限公司 | 哌喃酮與吡啶酮衍生物之製造方法 |
| PT2444400T (pt) | 2009-06-15 | 2018-06-06 | Shionogi & Co | Derivado de carbamoilpiridona policíclico substituído |
| KR20120120252A (ko) | 2009-12-23 | 2012-11-01 | 엘란 파마슈티칼스, 인크. | 폴로-유사 키나제의 억제제로서의 프테리디논 |
| TW201201813A (en) | 2010-03-31 | 2012-01-16 | Arqule Inc | Substituted benzo-pyrido-triazolo-diazepine compounds |
| US20120195857A1 (en) | 2010-08-12 | 2012-08-02 | Bristol-Myers Squibb Company | Hepatitis C Virus Inhibitors |
| MX2013003139A (es) | 2010-09-24 | 2013-06-18 | Shionogi & Co | Profarmaco de derivado de carbamoilpiridona policiclica substituida. |
| US9328075B2 (en) | 2011-05-05 | 2016-05-03 | St. Jude Children's Research Hospital | Pyrimidinone compounds and methods for treating influenza |
| EP2774928B1 (en) | 2011-10-12 | 2017-08-30 | Shionogi & Co., Ltd. | Polycyclic pyridone derivative having integrase-inhibiting activity |
| CA2885973C (en) | 2012-09-20 | 2017-09-05 | Celltrion, Inc. | Dolastatin-10 derivative, method of producing the same and anticancer drug composition containing the same |
| MX2015008293A (es) | 2013-01-08 | 2016-06-02 | Savira Pharmaceuticals Gmbh | Derivados de pirimidona y su uso en el tratamiento, mejora o prevencion de una enfermedad viral. |
| MX2016002199A (es) | 2013-08-21 | 2016-07-13 | Alios Biopharma Inc | Compuestos antivirales. |
| WO2015038665A1 (en) | 2013-09-11 | 2015-03-19 | University Of Southern California | A composition of stem cells having highly expressed fas ligand |
| EP3778603A1 (en) * | 2013-09-12 | 2021-02-17 | Janssen BioPharma, Inc. | 7,8-dihydro-3h-pyrazino[1,2-b]pyridazine-3,5(6h)-dione compounds and uses thereof |
| CA2922943A1 (en) | 2013-09-12 | 2015-03-19 | Alios Biopharma, Inc. | Pyridazinone compounds and uses thereof |
| CN107074880A (zh) | 2014-07-07 | 2017-08-18 | 萨维拉制药有限公司 | 二氢吡啶并吡嗪‑1,8‑二酮和它们在治疗、改善或预防病毒疾病中的用途 |
| HK1246780A1 (zh) | 2015-03-11 | 2018-09-14 | Janssen Biopharma, Inc. | 氮杂-吡啶酮化合物及其用途 |
| JP6918819B2 (ja) | 2016-03-08 | 2021-08-11 | ノバルティス アーゲー | オルトミクソウイルス感染の処置に有用な三環式化合物 |
| US10183945B2 (en) | 2016-03-10 | 2019-01-22 | Alios Biopharma, Inc. | Method of preparing AZA-pyridone compounds |
| WO2018005860A1 (en) | 2016-07-01 | 2018-01-04 | G1 Therapeutics, Inc. | Pyrimidine-based antiproliferative agents |
| WO2018005863A1 (en) | 2016-07-01 | 2018-01-04 | G1 Therapeutics, Inc. | Pyrimidine-based compounds for the treatment of cancer |
| CR20190123A (es) * | 2016-08-10 | 2019-04-30 | Shionogi & Co | Composiciones farmacéuticas que contienen derivados de piridona policíclicos sustituídos y profármacos de los mismos |
| JOP20170169A1 (ar) | 2016-08-29 | 2019-01-30 | Novartis Ag | مركبات بيريدازين ثلاثية الحلقة مندمجة تفيد في علاج العدوى بفيروس أورثوميكسو |
| JP2019059697A (ja) | 2017-09-28 | 2019-04-18 | 塩野義製薬株式会社 | 置換された多環性ピリダジン誘導体およびそのプロドラッグ |
| CN110041327B (zh) * | 2018-01-17 | 2022-01-21 | 江西彩石医药科技有限公司 | 吡啶酮衍生物、其组合物及作为抗流感病毒药物的应用 |
| AU2019210414B2 (en) | 2018-01-17 | 2021-04-01 | Jiangxi Caishi Pharmaceutical Technology Co., Ltd. | Pyridone derivative, composition thereof and application thereof as anti-influenza drug |
| AR114270A1 (es) | 2018-02-28 | 2020-08-12 | Japan Tobacco Inc | Compuestos de 4-metildihidropirimidinona y su uso farmacéutico |
| NZ767072A (en) | 2018-02-28 | 2024-03-22 | Novartis Ag | 10-(di(phenyl)methyl)-4-hydroxy-8,9,9a,10-tetrahydro-7h-pyrrolo[1 ‘,2’:4,5]pyrazino[1,2-b]pyridazine-3,5-dione derivatives and related compounds as inhibitors of the orthomyxovirus replication for treating influenza |
| AU2019228916A1 (en) | 2018-02-28 | 2020-07-02 | Japan Tobacco Inc. | Saturated ring-condensed dihydropyrimidinone or dihydrotriazinone compound, and pharmaceutical use thereof |
| CA3091950A1 (en) | 2018-02-28 | 2019-09-06 | F. Hoffmann-La Roche Ag | 7-substituted sulfonimidoylpurinone compounds and derivatives for the treatment and prophylaxis of liver cancer |
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2019
- 2019-02-26 NZ NZ767072A patent/NZ767072A/en unknown
- 2019-02-26 EP EP24195375.1A patent/EP4467198A3/en active Pending
- 2019-02-26 CN CN201980015931.XA patent/CN111801333B/zh active Active
- 2019-02-26 KR KR1020207027420A patent/KR102521320B1/ko active Active
- 2019-02-26 PL PL19713572.6T patent/PL3759113T3/pl unknown
- 2019-02-26 SG SG11202007718SA patent/SG11202007718SA/en unknown
- 2019-02-26 KR KR1020237006152A patent/KR20230031990A/ko not_active Ceased
- 2019-02-26 KR KR1020247015694A patent/KR20240073143A/ko active Pending
- 2019-02-26 US US16/975,784 patent/US11629149B2/en active Active
- 2019-02-26 EA EA202091696A patent/EA202091696A1/ru unknown
- 2019-02-26 AU AU2019227250A patent/AU2019227250B2/en active Active
- 2019-02-26 LT LTEPPCT/IB2019/051549T patent/LT3759113T/lt unknown
- 2019-02-26 CR CR20240350A patent/CR20240350A/es unknown
- 2019-02-26 HU HUE19713572A patent/HUE069183T2/hu unknown
- 2019-02-26 PT PT197135726T patent/PT3759113T/pt unknown
- 2019-02-26 CN CN202410938055.0A patent/CN118878544A/zh active Pending
- 2019-02-26 SI SI201930859T patent/SI3759113T1/sl unknown
- 2019-02-26 FI FIEP19713572.6T patent/FI3759113T3/fi active
- 2019-02-26 PE PE2020001286A patent/PE20210403A1/es unknown
- 2019-02-26 HR HRP20241522TT patent/HRP20241522T1/hr unknown
- 2019-02-26 ES ES19713572T patent/ES2993277T3/es active Active
- 2019-02-26 MY MYPI2020004423A patent/MY203207A/en unknown
- 2019-02-26 CR CR20200372A patent/CR20200372A/es unknown
- 2019-02-26 EP EP19713572.6A patent/EP3759113B1/en active Active
- 2019-02-26 BR BR112020017121-2A patent/BR112020017121A2/pt unknown
- 2019-02-26 MX MX2020008959A patent/MX2020008959A/es unknown
- 2019-02-26 IL IL305957A patent/IL305957A/en unknown
- 2019-02-26 JP JP2020544932A patent/JP7065989B2/ja active Active
- 2019-02-26 CA CA3092544A patent/CA3092544A1/en active Pending
- 2019-02-26 DK DK19713572.6T patent/DK3759113T3/da active
- 2019-02-26 WO PCT/IB2019/051549 patent/WO2019166950A1/en not_active Ceased
- 2019-02-26 UA UAA202005624A patent/UA126253C2/uk unknown
- 2019-02-26 IL IL276901A patent/IL276901B2/en unknown
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2020
- 2020-08-26 SA SA520420046A patent/SA520420046B1/ar unknown
- 2020-08-26 CL CL2020002202A patent/CL2020002202A1/es unknown
- 2020-08-27 MX MX2023000084A patent/MX2023000084A/es unknown
- 2020-08-27 PH PH12020500660A patent/PH12020500660A1/en unknown
- 2020-09-03 ZA ZA2020/05507A patent/ZA202005507B/en unknown
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2022
- 2022-02-04 JP JP2022016352A patent/JP2022048391A/ja not_active Withdrawn
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2023
- 2023-02-27 US US18/114,336 patent/US12071441B2/en active Active
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2024
- 2024-02-05 JP JP2024016007A patent/JP2024033009A/ja active Pending
- 2024-07-03 US US18/764,058 patent/US20250034156A1/en active Pending
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