PL372303A1 - Nowe krystaliczne postaci soli hemi-wapniowej atorwastatyny i sposoby ich wytwarzania oraz nowe sposoby wytwarzania postaci I, VIII i IX soli hemi-wapniowej atorwastatyny - Google Patents
Nowe krystaliczne postaci soli hemi-wapniowej atorwastatyny i sposoby ich wytwarzania oraz nowe sposoby wytwarzania postaci I, VIII i IX soli hemi-wapniowej atorwastatynyInfo
- Publication number
- PL372303A1 PL372303A1 PL03372303A PL37230303A PL372303A1 PL 372303 A1 PL372303 A1 PL 372303A1 PL 03372303 A PL03372303 A PL 03372303A PL 37230303 A PL37230303 A PL 37230303A PL 372303 A1 PL372303 A1 PL 372303A1
- Authority
- PL
- Poland
- Prior art keywords
- calcium
- processes
- atorvastatin hemi
- novel
- forms
- Prior art date
Links
Classifications
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D207/00—Heterocyclic compounds containing five-membered rings not condensed with other rings, with one nitrogen atom as the only ring hetero atom
- C07D207/02—Heterocyclic compounds containing five-membered rings not condensed with other rings, with one nitrogen atom as the only ring hetero atom with only hydrogen or carbon atoms directly attached to the ring nitrogen atom
- C07D207/30—Heterocyclic compounds containing five-membered rings not condensed with other rings, with one nitrogen atom as the only ring hetero atom with only hydrogen or carbon atoms directly attached to the ring nitrogen atom having two double bonds between ring members or between ring members and non-ring members
- C07D207/32—Heterocyclic compounds containing five-membered rings not condensed with other rings, with one nitrogen atom as the only ring hetero atom with only hydrogen or carbon atoms directly attached to the ring nitrogen atom having two double bonds between ring members or between ring members and non-ring members with only hydrogen atoms, hydrocarbon or substituted hydrocarbon radicals, directly attached to ring carbon atoms
- C07D207/325—Heterocyclic compounds containing five-membered rings not condensed with other rings, with one nitrogen atom as the only ring hetero atom with only hydrogen or carbon atoms directly attached to the ring nitrogen atom having two double bonds between ring members or between ring members and non-ring members with only hydrogen atoms, hydrocarbon or substituted hydrocarbon radicals, directly attached to ring carbon atoms with substituted hydrocarbon radicals directly attached to the ring nitrogen atom
- C07D207/327—Radicals substituted by carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, e.g. ester or nitrile radicals
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D405/00—Heterocyclic compounds containing both one or more hetero rings having oxygen atoms as the only ring hetero atoms, and one or more rings having nitrogen as the only ring hetero atom
- C07D405/02—Heterocyclic compounds containing both one or more hetero rings having oxygen atoms as the only ring hetero atoms, and one or more rings having nitrogen as the only ring hetero atom containing two hetero rings
- C07D405/06—Heterocyclic compounds containing both one or more hetero rings having oxygen atoms as the only ring hetero atoms, and one or more rings having nitrogen as the only ring hetero atom containing two hetero rings linked by a carbon chain containing only aliphatic carbon atoms
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K31/00—Medicinal preparations containing organic active ingredients
- A61K31/33—Heterocyclic compounds
- A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
- A61K31/40—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having five-membered rings with one nitrogen as the only ring hetero atom, e.g. sulpiride, succinimide, tolmetin, buflomedil
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P3/00—Drugs for disorders of the metabolism
- A61P3/06—Antihyperlipidemics
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P43/00—Drugs for specific purposes, not provided for in groups A61P1/00-A61P41/00
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D207/00—Heterocyclic compounds containing five-membered rings not condensed with other rings, with one nitrogen atom as the only ring hetero atom
- C07D207/02—Heterocyclic compounds containing five-membered rings not condensed with other rings, with one nitrogen atom as the only ring hetero atom with only hydrogen or carbon atoms directly attached to the ring nitrogen atom
- C07D207/30—Heterocyclic compounds containing five-membered rings not condensed with other rings, with one nitrogen atom as the only ring hetero atom with only hydrogen or carbon atoms directly attached to the ring nitrogen atom having two double bonds between ring members or between ring members and non-ring members
- C07D207/34—Heterocyclic compounds containing five-membered rings not condensed with other rings, with one nitrogen atom as the only ring hetero atom with only hydrogen or carbon atoms directly attached to the ring nitrogen atom having two double bonds between ring members or between ring members and non-ring members with hetero atoms or with carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, e.g. ester or nitrile radicals, directly attached to ring carbon atoms
Landscapes
- Chemical & Material Sciences (AREA)
- Organic Chemistry (AREA)
- Health & Medical Sciences (AREA)
- Life Sciences & Earth Sciences (AREA)
- Veterinary Medicine (AREA)
- Public Health (AREA)
- General Health & Medical Sciences (AREA)
- Medicinal Chemistry (AREA)
- Animal Behavior & Ethology (AREA)
- Pharmacology & Pharmacy (AREA)
- Chemical Kinetics & Catalysis (AREA)
- Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
- General Chemical & Material Sciences (AREA)
- Bioinformatics & Cheminformatics (AREA)
- Engineering & Computer Science (AREA)
- Diabetes (AREA)
- Hematology (AREA)
- Obesity (AREA)
- Epidemiology (AREA)
- Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
- Pyrrole Compounds (AREA)
Applications Claiming Priority (2)
Application Number | Priority Date | Filing Date | Title |
---|---|---|---|
US35718102P | 2002-02-15 | 2002-02-15 | |
US42532502P | 2002-11-12 | 2002-11-12 |
Publications (1)
Publication Number | Publication Date |
---|---|
PL372303A1 true PL372303A1 (pl) | 2005-07-11 |
Family
ID=27760457
Family Applications (1)
Application Number | Title | Priority Date | Filing Date |
---|---|---|---|
PL03372303A PL372303A1 (pl) | 2002-02-15 | 2003-02-19 | Nowe krystaliczne postaci soli hemi-wapniowej atorwastatyny i sposoby ich wytwarzania oraz nowe sposoby wytwarzania postaci I, VIII i IX soli hemi-wapniowej atorwastatyny |
Country Status (14)
Country | Link |
---|---|
EP (1) | EP1480950A4 (pl) |
JP (2) | JP2005519076A (pl) |
KR (1) | KR100724515B1 (pl) |
CN (1) | CN100406436C (pl) |
AU (1) | AU2003217653A1 (pl) |
CA (1) | CA2475864A1 (pl) |
DE (1) | DE03713610T1 (pl) |
ES (1) | ES2241507T1 (pl) |
HR (1) | HRP20040768A2 (pl) |
IS (1) | IS7402A (pl) |
MX (1) | MXPA04007939A (pl) |
NO (1) | NO20043842L (pl) |
PL (1) | PL372303A1 (pl) |
WO (1) | WO2003070702A1 (pl) |
Families Citing this family (20)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
US7411075B1 (en) | 2000-11-16 | 2008-08-12 | Teva Pharmaceutical Industries Ltd. | Polymorphic form of atorvastatin calcium |
US7501450B2 (en) | 2000-11-30 | 2009-03-10 | Teva Pharaceutical Industries Ltd. | Crystal forms of atorvastatin hemi-calcium and processes for their preparation as well as novel processes for preparing other forms |
IL156055A0 (en) | 2000-11-30 | 2003-12-23 | Teva Pharma | Novel crystal forms of atorvastatin hemi calcium and processes for their preparation as well as novel processes for preparing other forms |
KR20090045420A (ko) | 2002-02-19 | 2009-05-07 | 테바 파마슈티컬 인더스트리즈 리미티드 | 아토르바스타틴 헤미-칼슘 용매화합물의 탈용매화 |
WO2004050618A2 (en) * | 2002-11-28 | 2004-06-17 | Teva Pharmaceutical Industries Ltd. | Crystalline form f of atorvastatin hemi-calcium salt |
US7655692B2 (en) | 2003-06-12 | 2010-02-02 | Pfizer Inc. | Process for forming amorphous atorvastatin |
US20050271717A1 (en) | 2003-06-12 | 2005-12-08 | Alfred Berchielli | Pharmaceutical compositions of atorvastatin |
EP1771412A2 (en) * | 2004-07-20 | 2007-04-11 | Warner-Lambert Company LLC | Crystalline forms of [r-(r*)]-2-(4-fluorophenyl)-bet a,gamma-dihydroxy-5-(1-methylethyl)-3-phenyl-4-[(phenylamino)carbonyl]-1h-pyrrole-1-hept anoic acid calcium salt (2:1) |
DE202005020766U1 (de) * | 2004-07-22 | 2006-10-05 | Teva Pharmaceutical Industries Ltd. | Neue Kristallformen von Atorvastatin-Hemi-Calcium |
WO2006048894A1 (en) * | 2004-11-05 | 2006-05-11 | Morepen Laboratories Limited | Novel crystalline forms of atorvastatin calcium and processes for preparing them. |
CZ2007772A3 (cs) * | 2005-04-08 | 2008-02-27 | EGIS GYOGYSZERGYÁR Nyilvánosan Müködö Részvénytársaság | Nová krystalická polymorfní forma hemivápenaté soli atorvastatinu |
US8084488B2 (en) | 2005-11-21 | 2011-12-27 | Pfizer Inc. | Forms of [R-(R*,R*)]-2-(4-fluorophenyl)-β,δ-dihydroxy-5-(1-methylethyl)-3-phenyl-4-[(phenylamino)carbonyl]-1H-pyrrole-1-heptanoic acid magnesium |
BRPI0610344A2 (pt) | 2005-12-13 | 2016-11-29 | Teva Pharma | forma cristalizada do atorvastatin hemi-calcium, processo para sua preparação, produto famacêutico derivado e seu uso medicinal |
US20070265456A1 (en) * | 2006-05-09 | 2007-11-15 | Judith Aronhime | Novel crystal forms of atorvastatin hemi-calcium and processes for their preparation as well as novel processes for preparing other forms |
RU2421445C1 (ru) | 2007-03-02 | 2011-06-20 | Донг-А Фарм. Ко., Лтд. | Новые кристаллические формы производных пирролилгептановой кислоты |
KR20120011249A (ko) | 2010-07-28 | 2012-02-07 | 주식회사 경보제약 | 아토바스타틴 헤미칼슘염의 신규한 결정형, 이의 수화물, 및 그의 제조방법 |
KR101324862B1 (ko) * | 2011-07-12 | 2013-11-01 | (주)에이에스텍 | 클로피도그렐 황산수소염의 구형 입자, 이를 포함하는 약학적 조성물 및 이의 제조방법 |
TWI665190B (zh) | 2013-11-15 | 2019-07-11 | 阿克比治療有限公司 | {[5-(3-氯苯基)-3-羥基吡啶-2-羰基]胺基}乙酸之固體型式,其組合物及用途 |
CN105055357A (zh) * | 2015-09-25 | 2015-11-18 | 青岛华之草医药科技有限公司 | 一种治疗高胆固醇血症的药物阿托伐他汀钙组合物片剂 |
KR101723783B1 (ko) * | 2017-02-24 | 2017-04-07 | 주식회사 경보제약 | 아토바스타틴 헤미칼슘염의 신규한 결정형, 이의 수화물, 및 그의 제조방법 |
Family Cites Families (15)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
HRP960313B1 (en) * | 1995-07-17 | 2002-08-31 | Warner Lambert Co | Form iii crystalline (r- (r*, r*)-2- (4-fluorophenyl) -beta-delta-hydroxy-5-(1-methylethyl) -3-phenyl-4- ((phenylamino) carbonyl -1h-pyrrole-1-heptanoic acid calcium salt (2:1) |
DE69616808T2 (de) * | 1995-07-17 | 2002-05-29 | Warner Lambert Co | Kristallines (r-(r*,r*))-2-(4-fluorphenyl)-beta,delta-dihydroxy-5-(1-methylethyl)-3-phenyl-4-((phenylamino)carbonyl)-1h-pyrrol-1-heptancarbonsäure hemi calcium salz (atorvastatin) |
US6087511A (en) | 1996-07-16 | 2000-07-11 | Warner-Lambert Company | Process for the production of amorphous [R-(R*,R*)]-2-(4-fluorophenyl)-β,δ-dihydroxy-5-(1-methylethyl )-3-phenyl-4-[(phenylamino)carbonyl]-1H-pyrrole-1-heptanoic acid) calcium salt (2:1) |
IL149681A0 (en) * | 1999-11-17 | 2002-11-10 | Teva Pharma | Polymorphic form of atorvstatin calcium |
HUP0203708A3 (en) * | 1999-12-17 | 2003-11-28 | Warner Lambert Res & Dev Ie | A factory scale process for producing crystalline atorvastatin trihydrate hemi calcium salt |
CA2391357C (en) * | 1999-12-17 | 2009-01-06 | Warner Lambert Research And Development Ireland Limited | A process for producing crystalline atorvastatin calcium |
MXPA03003900A (es) * | 2000-11-03 | 2005-02-17 | Teva Pharma | Forma vii de hemicalcio de atorvastatina. |
IL156055A0 (en) * | 2000-11-30 | 2003-12-23 | Teva Pharma | Novel crystal forms of atorvastatin hemi calcium and processes for their preparation as well as novel processes for preparing other forms |
CA2622477A1 (en) * | 2000-12-27 | 2002-07-04 | Teva Pharmaceutical Industries Ltd. | Crystalline forms of atorvastatin |
WO2002057229A1 (en) * | 2001-01-19 | 2002-07-25 | Biocon India Limited | FORM V CRYSTALLINE [R-(R*,R*)]-2-(4-FLUOROPHENYL)-ß,$G(D)-DIHYDROXY-5-(1-METHYLETHYL)-3-PHENYL-4-[(PHENYLAMINO)CARBONYL]-1H-PYRROLE-1- HEPTANOIC ACID HEMI CALCIUM SALT. (ATORVASTATIN) |
PL367943A1 (pl) * | 2001-06-29 | 2005-03-07 | Warner-Lambert Company Llc | Krystaliczne formy soli wapniowej kwasu [R-(R, R)]-2-(4-fluorofenylo)-Beta, Delta-dihydroksy-5-(1-metyloetylo)-3-fenylo-4-[(fenyloamino) karbonylo]-1H pirolo-1-heptanowego (2:1) (atorvastatyny) |
CA2454500C (en) * | 2001-07-30 | 2009-11-10 | Dr. Reddy's Laboratories Ltd. | Crystalline forms vi and vii of atorvastatin calcium |
UA77990C2 (en) * | 2001-12-12 | 2007-02-15 | Crystalline calcium salt of (2:1) [r-(r*,r*)]-2-(4-fluorophenyl)-?,?-dihydroxy-5-(1-methylethyl)-3-phenyl-4-[(phenylamino)carbonyl]-1h-pyrroleheptanic acid | |
JP2006503024A (ja) * | 2002-09-03 | 2006-01-26 | モレペン、ラボラトリーズ、リミテッド | Vi型アトルバスタチンカルシウムまたはその水和物 |
WO2004050618A2 (en) * | 2002-11-28 | 2004-06-17 | Teva Pharmaceutical Industries Ltd. | Crystalline form f of atorvastatin hemi-calcium salt |
-
2003
- 2003-02-19 DE DE03713610T patent/DE03713610T1/de active Pending
- 2003-02-19 EP EP03713610A patent/EP1480950A4/en not_active Withdrawn
- 2003-02-19 WO PCT/US2003/005384 patent/WO2003070702A1/en active Application Filing
- 2003-02-19 CN CNB038082071A patent/CN100406436C/zh not_active Expired - Fee Related
- 2003-02-19 CA CA002475864A patent/CA2475864A1/en not_active Abandoned
- 2003-02-19 MX MXPA04007939A patent/MXPA04007939A/es unknown
- 2003-02-19 PL PL03372303A patent/PL372303A1/pl not_active Application Discontinuation
- 2003-02-19 JP JP2003569609A patent/JP2005519076A/ja not_active Withdrawn
- 2003-02-19 AU AU2003217653A patent/AU2003217653A1/en not_active Abandoned
- 2003-02-19 ES ES03713610T patent/ES2241507T1/es active Pending
- 2003-02-19 KR KR1020047012591A patent/KR100724515B1/ko not_active IP Right Cessation
-
2004
- 2004-08-13 IS IS7402A patent/IS7402A/is unknown
- 2004-08-25 HR HR20040768A patent/HRP20040768A2/hr not_active Application Discontinuation
- 2004-09-14 NO NO20043842A patent/NO20043842L/no not_active Application Discontinuation
-
2009
- 2009-06-08 JP JP2009137400A patent/JP2009235083A/ja active Pending
Also Published As
Publication number | Publication date |
---|---|
KR100724515B1 (ko) | 2007-06-04 |
NO20043842L (no) | 2004-09-14 |
CN100406436C (zh) | 2008-07-30 |
HRP20040768A2 (en) | 2005-06-30 |
IS7402A (is) | 2004-08-13 |
EP1480950A1 (en) | 2004-12-01 |
DE03713610T1 (de) | 2005-10-20 |
CA2475864A1 (en) | 2003-08-28 |
WO2003070702A1 (en) | 2003-08-28 |
AU2003217653A1 (en) | 2003-09-09 |
KR20040081202A (ko) | 2004-09-20 |
JP2009235083A (ja) | 2009-10-15 |
JP2005519076A (ja) | 2005-06-30 |
CN1646490A (zh) | 2005-07-27 |
EP1480950A4 (en) | 2005-05-18 |
MXPA04007939A (es) | 2004-11-26 |
ES2241507T1 (es) | 2005-11-01 |
Similar Documents
Publication | Publication Date | Title |
---|---|---|
EP1480950A4 (en) | NOVEL HEMI-CALCIUM CRYSTALLINE FORMS OF ATORVASTATIN AND METHODS FOR THEIR PREPARATION, AS WELL AS NEW METHODS FOR THE PREPARATION OF FORORVASTATIN HEMI-CALCIUM FORMS I, VIII AND IX | |
HUP0600538A2 (en) | Novel crystal forms of atorvastatin hemi-calcium and processes for their preparation as well as novel processes for preparing other forms | |
PL377555A1 (pl) | Nowe krystaliczne postaci soli hemi-wapniowej atorwastatyny i sposoby ich wytwarzania oraz nowe sposoby wytwarzania innych postaci | |
HRP20150163T1 (en) | Process for the preparation of n-substituted 2-cyanopyrrolidines | |
HK1084114A1 (en) | Compounds for synthesizing intermediate useful in the preparation of atorvastatin | |
WO2003070725A3 (en) | Process for preparing indolinone derivatives | |
AU2003245572A1 (en) | Preparation of chiral amino-nitriles | |
AU2003230457A1 (en) | Compression of containers | |
IL180708A0 (en) | Novel crystal forms of atorvastatin hemi-calcium and processes for their preparation | |
IL173012A0 (en) | Process and intermediate compounds useful in the preparation of statins, particularly atorvastatin | |
AU2003297594A1 (en) | Crystalline form f of atorvastatin hemi-calcium salt | |
HK1081950A1 (en) | 1-Oxa-dibenzoazolenes as inhibitors of thmour necrosis factor production and intermediates for the preparation thereof | |
EP1547993A4 (en) | PROCESS FOR PREPARING SPIROFLUORENOLS | |
AU2002367890A1 (en) | Process for the preparation of 4-methyl-thiazole-5-carbaldehyde intermediate | |
AU2003216848A1 (en) | Deracemisation of amines | |
AU2003217438A1 (en) | Novel crystalline forms of levetiracetam | |
AU2002358357A1 (en) | Improvements relating to frequency synthesis | |
PL1685104T3 (pl) | Sposoby wytwarzania N-podstawionych ftalimidów | |
AU2003302645A1 (en) | Synthesis of pyrrolidine compound and salt thereof | |
AU2003262704A1 (en) | Synthesis of gatifloxacin | |
EP1486485A4 (en) | NEW 5-HYDROXYCARBAMIMIDOYL-2-HYDROXYBENZENESULFONAMIDE DERIVATIVE CRYSTALS | |
AU2003235129A1 (en) | Process for preparation of 2-aminoketones | |
AU2003296482A1 (en) | Tetracyclines as anti-fungal agents for treatment of ringworm | |
LT2004018A (en) | Novel crystal forms of atorvastatin hemi-calcium and processes for their preparation as well as novel processes for preparing other forms | |
AU2002249557A1 (en) | COMBUSTION PROCESS FOR THE PREPARATION OF LiCoVO4 |
Legal Events
Date | Code | Title | Description |
---|---|---|---|
REFS | Decisions on refusal to grant patents (taken after the publication of the particulars of the applications) |