PL368313A1 - Nowy sposób hamowania wzrostu wirusów i/lub zwalczania wirusów oraz nowy pirazynowy analog nukleotydu lub pirazynowy analog nukleozydu - Google Patents

Nowy sposób hamowania wzrostu wirusów i/lub zwalczania wirusów oraz nowy pirazynowy analog nukleotydu lub pirazynowy analog nukleozydu

Info

Publication number
PL368313A1
PL368313A1 PL02368313A PL36831302A PL368313A1 PL 368313 A1 PL368313 A1 PL 368313A1 PL 02368313 A PL02368313 A PL 02368313A PL 36831302 A PL36831302 A PL 36831302A PL 368313 A1 PL368313 A1 PL 368313A1
Authority
PL
Poland
Prior art keywords
pyradine
novel
nucleotide
nucleoside analogue
proliferation inhibition
Prior art date
Application number
PL02368313A
Other languages
English (en)
Other versions
PL209765B1 (pl
Inventor
Yousuke Furuta
Hiroyuki Egawa
Kazumi Takahashi
Yasuhiro Tsutsui
Sayuri Uehara
Makoto Murakami
Original Assignee
Toyama Chemical Co, Ltd.
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Toyama Chemical Co, Ltd. filed Critical Toyama Chemical Co, Ltd.
Publication of PL368313A1 publication Critical patent/PL368313A1/pl
Publication of PL209765B1 publication Critical patent/PL209765B1/pl

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07H—SUGARS; DERIVATIVES THEREOF; NUCLEOSIDES; NUCLEOTIDES; NUCLEIC ACIDS
    • C07H19/00—Compounds containing a hetero ring sharing one ring hetero atom with a saccharide radical; Nucleosides; Mononucleotides; Anhydro-derivatives thereof
    • C07H19/02—Compounds containing a hetero ring sharing one ring hetero atom with a saccharide radical; Nucleosides; Mononucleotides; Anhydro-derivatives thereof sharing nitrogen
    • C07H19/04—Heterocyclic radicals containing only nitrogen atoms as ring hetero atom
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07H—SUGARS; DERIVATIVES THEREOF; NUCLEOSIDES; NUCLEOTIDES; NUCLEIC ACIDS
    • C07H19/00—Compounds containing a hetero ring sharing one ring hetero atom with a saccharide radical; Nucleosides; Mononucleotides; Anhydro-derivatives thereof
    • C07H19/02—Compounds containing a hetero ring sharing one ring hetero atom with a saccharide radical; Nucleosides; Mononucleotides; Anhydro-derivatives thereof sharing nitrogen
    • C07H19/04—Heterocyclic radicals containing only nitrogen atoms as ring hetero atom
    • C07H19/06—Pyrimidine radicals
    • C07H19/10—Pyrimidine radicals with the saccharide radical esterified by phosphoric or polyphosphoric acids
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/70—Carbohydrates; Sugars; Derivatives thereof
    • A61K31/7042—Compounds having saccharide radicals and heterocyclic rings
    • A61K31/7052—Compounds having saccharide radicals and heterocyclic rings having nitrogen as a ring hetero atom, e.g. nucleosides, nucleotides
    • A61K31/706—Compounds having saccharide radicals and heterocyclic rings having nitrogen as a ring hetero atom, e.g. nucleosides, nucleotides containing six-membered rings with nitrogen as a ring hetero atom
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P31/00—Antiinfectives, i.e. antibiotics, antiseptics, chemotherapeutics
    • A61P31/12—Antivirals
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P43/00—Drugs for specific purposes, not provided for in groups A61P1/00-A61P41/00
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07H—SUGARS; DERIVATIVES THEREOF; NUCLEOSIDES; NUCLEOTIDES; NUCLEIC ACIDS
    • C07H19/00—Compounds containing a hetero ring sharing one ring hetero atom with a saccharide radical; Nucleosides; Mononucleotides; Anhydro-derivatives thereof
    • C07H19/02—Compounds containing a hetero ring sharing one ring hetero atom with a saccharide radical; Nucleosides; Mononucleotides; Anhydro-derivatives thereof sharing nitrogen
    • C07H19/04—Heterocyclic radicals containing only nitrogen atoms as ring hetero atom
    • C07H19/16—Purine radicals
    • C07H19/20—Purine radicals with the saccharide radical esterified by phosphoric or polyphosphoric acids
    • Y—GENERAL TAGGING OF NEW TECHNOLOGICAL DEVELOPMENTS; GENERAL TAGGING OF CROSS-SECTIONAL TECHNOLOGIES SPANNING OVER SEVERAL SECTIONS OF THE IPC; TECHNICAL SUBJECTS COVERED BY FORMER USPC CROSS-REFERENCE ART COLLECTIONS [XRACs] AND DIGESTS
    • Y02—TECHNOLOGIES OR APPLICATIONS FOR MITIGATION OR ADAPTATION AGAINST CLIMATE CHANGE
    • Y02A—TECHNOLOGIES FOR ADAPTATION TO CLIMATE CHANGE
    • Y02A50/00—TECHNOLOGIES FOR ADAPTATION TO CLIMATE CHANGE in human health protection, e.g. against extreme weather
    • Y02A50/30—Against vector-borne diseases, e.g. mosquito-borne, fly-borne, tick-borne or waterborne diseases whose impact is exacerbated by climate change

Landscapes

  • Chemical & Material Sciences (AREA)
  • Health & Medical Sciences (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Organic Chemistry (AREA)
  • General Health & Medical Sciences (AREA)
  • Molecular Biology (AREA)
  • Engineering & Computer Science (AREA)
  • Biochemistry (AREA)
  • Biotechnology (AREA)
  • Genetics & Genomics (AREA)
  • Veterinary Medicine (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Public Health (AREA)
  • Medicinal Chemistry (AREA)
  • Animal Behavior & Ethology (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • General Chemical & Material Sciences (AREA)
  • Epidemiology (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Virology (AREA)
  • Communicable Diseases (AREA)
  • Oncology (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Saccharide Compounds (AREA)
PL368313A 2001-08-14 2002-08-13 Pirazynowy analog nukleotydu i jego zastosowanie PL209765B1 (pl)

Applications Claiming Priority (1)

Application Number Priority Date Filing Date Title
JP2001245896 2001-08-14

Publications (2)

Publication Number Publication Date
PL368313A1 true PL368313A1 (pl) 2005-03-21
PL209765B1 PL209765B1 (pl) 2011-10-31

Family

ID=19075560

Family Applications (1)

Application Number Title Priority Date Filing Date
PL368313A PL209765B1 (pl) 2001-08-14 2002-08-13 Pirazynowy analog nukleotydu i jego zastosowanie

Country Status (12)

Country Link
US (1) US20040235761A1 (pl)
EP (1) EP1417967A4 (pl)
JP (1) JP4370164B2 (pl)
KR (1) KR100894167B1 (pl)
CN (1) CN100434079C (pl)
BR (1) BR0211900A (pl)
CA (1) CA2456292A1 (pl)
MX (1) MXPA04001361A (pl)
PL (1) PL209765B1 (pl)
RU (1) RU2292894C2 (pl)
WO (1) WO2003015798A1 (pl)
ZA (1) ZA200400925B (pl)

Families Citing this family (47)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US8481712B2 (en) 2001-01-22 2013-07-09 Merck Sharp & Dohme Corp. Nucleoside derivatives as inhibitors of RNA-dependent RNA viral polymerase
SI1355916T1 (sl) 2001-01-22 2007-04-30 Merck & Co Inc Nukleozidni derivati kot inhibitorji RNA-odvisne RNA virusne polimeraze
US7105499B2 (en) 2001-01-22 2006-09-12 Merck & Co., Inc. Nucleoside derivatives as inhibitors of RNA-dependent RNA viral polymerase
SE0302486D0 (sv) * 2003-09-18 2003-09-18 Astrazeneca Ab Novel compounds
JP2008514639A (ja) * 2004-09-24 2008-05-08 イデニクス（ケイマン）リミテツド フラビウイルス、ペスチウイルス及びヘパシウイルスの感染症を治療するための方法及び組成物
TW200808763A (en) * 2006-05-08 2008-02-16 Astrazeneca Ab Novel compounds I
TW200808771A (en) * 2006-05-08 2008-02-16 Astrazeneca Ab Novel compounds II
JP2008174524A (ja) * 2007-01-22 2008-07-31 Nippon Shinyaku Co Ltd リボ核酸化合物の製造方法
WO2008099874A1 (ja) 2007-02-16 2008-08-21 Toyama Chemical Co., Ltd. ピラジン誘導体を含有する医薬組成物およびピラジン誘導体を組み合わせて使用する方法
AU2008251555B2 (en) * 2007-05-10 2012-08-30 Biocryst Pharmaceuticals, Inc. Tetrahydrofuro [3 4-D] dioxolane compounds for use in the treatment of viral infections and cancer
CA2703996A1 (en) * 2007-11-06 2009-05-14 Astrazeneca Ab Some 2-pyrazinone derivatives and their use as inhibitors of neutrophile elastase
TW201036957A (en) * 2009-02-20 2010-10-16 Astrazeneca Ab Novel salt 628
TWI583692B (zh) * 2009-05-20 2017-05-21 基利法瑪席特有限責任公司 核苷磷醯胺
DK2442809T3 (en) 2009-06-17 2016-12-19 Vertex Pharma Inhibitors of the replication of influenza virus
RU2012116877A (ru) * 2009-10-02 2013-11-10 Астразенека Аб Соединения 2-пиридона, применяемые в качестве ингибиторов нейтрофильной эластазы
WO2011076923A1 (en) * 2009-12-23 2011-06-30 Institut National De La Sante Et De La Recherche Medicale Inhibitor for inosine monophosphate (imp) dehydrogenase and/or viral rna polymerase for treatment of hepatitis e
AU2011343642A1 (en) 2010-12-16 2013-05-02 Vertex Pharmaceuticals Incorporated Inhibitors of influenza viruses replication
CN103492382A (zh) 2010-12-16 2014-01-01 沃泰克斯药物股份有限公司 流感病毒复制的抑制剂
KR20130128435A (ko) 2010-12-16 2013-11-26 버텍스 파마슈티칼스 인코포레이티드 인플루엔자 바이러스 복제의 억제제
EP2696681B1 (en) 2011-04-13 2018-10-03 Merck Sharp & Dohme Corp. 2'-substituted nucleoside derivatives and methods of use thereof for the treatment of viral diseases
US9156872B2 (en) 2011-04-13 2015-10-13 Merck Sharp & Dohme Corp. 2′-azido substituted nucleoside derivatives and methods of use thereof for the treatment of viral diseases
JP2014511875A (ja) 2011-04-13 2014-05-19 メルク・シャープ・アンド・ドーム・コーポレーション ２’−シアノ置換ヌクレオシド誘導体およびウイルス疾患の治療のためのその使用方法
US9416154B2 (en) 2011-07-13 2016-08-16 Merck Sharp & Dohme Corp. 5′-substituted nucleoside derivatives and methods of use thereof for the treatment of viral diseases
WO2013009737A1 (en) 2011-07-13 2013-01-17 Merck Sharp & Dohme Corp. 5'-substituted nucleoside analogs and methods of use thereof for the treatment of viral diseases
UA118010C2 (uk) 2011-08-01 2018-11-12 Вертекс Фармасьютікалз Інкорпорейтед Інгібітори реплікації вірусів грипу
SG10201610936RA (en) 2011-12-22 2017-02-27 Alios Biopharma Inc Substituted nucleosides, nucleotides and analogs thereof
USRE48171E1 (en) 2012-03-21 2020-08-25 Janssen Biopharma, Inc. Substituted nucleosides, nucleotides and analogs thereof
US9441007B2 (en) 2012-03-21 2016-09-13 Alios Biopharma, Inc. Substituted nucleosides, nucleotides and analogs thereof
WO2013184985A1 (en) 2012-06-08 2013-12-12 Vertex Pharmaceuticals Incorporated Inhibitors of influenza viruses replication
CN102775358B (zh) * 2012-08-22 2015-05-27 山东齐都药业有限公司 6-氟-3-羟基-2-吡嗪酰胺的制备方法
CN103833812A (zh) * 2012-11-23 2014-06-04 中国人民解放军军事医学科学院毒物药物研究所 吡嗪衍生物及其医药用途
EP3068776B1 (en) 2013-11-13 2019-05-29 Vertex Pharmaceuticals Incorporated Inhibitors of influenza viruses replication
RS57541B1 (sr) 2013-11-13 2018-10-31 Vertex Pharma Postupci za pripremu inhibitora replikacije virusa gripa
MA40773A (fr) 2014-10-02 2017-08-08 Vertex Pharma Variants du virus influenza a
MA40772A (fr) 2014-10-02 2017-08-08 Vertex Pharma Variants du virus de la grippe a
CN105732748B (zh) * 2014-12-12 2019-01-01 浙江医药股份有限公司新昌制药厂 一种核苷酸类似物及其制备方法、以及含有核苷酸类似物的药物组合物及其应用
JP6704416B2 (ja) 2015-05-13 2020-06-03 バーテックス ファーマシューティカルズ インコーポレイテッドＶｅｒｔｅｘ Ｐｈａｒｍａｃｅｕｔｉｃａｌｓ Ｉｎｃｏｒｐｏｒａｔｅｄ インフルエンザウイルスの複製の阻害剤を調製する方法
CA3059362A1 (en) 2017-04-12 2018-10-18 Vertex Pharmaceuticals Incorporated Combination therapies for treating influenza virus infection
ES2901875T3 (es) 2017-04-24 2022-03-24 Cocrystal Pharma Inc Derivados de la pirrolopirimidina útiles como inhibidores de la replicación del virus de la influenza
WO2020023813A1 (en) 2018-07-27 2020-01-30 Cocrystal Pharma, Inc. Pyrrolo[2,3-b]pyridin derivatives as inhibitors of influenza virus replication
EP3849978B1 (en) 2018-09-10 2022-11-02 Cocrystal Pharma, Inc. Pyridopyrazine and pyridotriazine inhibitors of influenza virus replication
US12565488B2 (en) 2018-11-26 2026-03-03 Cocrystal Pharma, Inc. Inhibitors of influenza virus replication
TW202114678A (zh) 2019-06-20 2021-04-16 美商健生醫藥公司 氮雜吲哚化合物之調配物
CN113444132A (zh) * 2020-03-25 2021-09-28 药康众拓(江苏)医药科技有限公司 吡嗪甲酰胺核苷酸类似物或药学上可接受的盐、异构体、代谢产物、前药及制备方法和用途
CN111995649A (zh) * 2020-04-09 2020-11-27 瀚海新拓(杭州)生物医药有限公司 一种蝶啶酮核苷酸类似物及其药物组合物、制备方法和医药用途
US20230312684A1 (en) 2020-07-31 2023-10-05 Pinetree Therapeutics, Inc. Neuropilin and angiotensin converting enzyme 2 fusion peptides for treating viral infections
CN112661801B (zh) * 2020-12-18 2025-01-17 成都阿奇生物医药科技有限公司 一种核苷类似物及其氘代物及其制备方法和用途

Family Cites Families (21)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US3094530A (en) * 1961-02-01 1963-06-18 Humphrey I X Mager 5-azidocarbonyl pyrazinamide
US3336289A (en) * 1965-09-20 1967-08-15 Upjohn Co 9-beta-d-ribofuranosyl-7-deazapurine 5'-phosphate esters
US3824229A (en) * 1972-07-20 1974-07-16 Int Chem & Nuclear Corp 3-oxo-1,2,4-triazine nucleosides
US4766125A (en) * 1981-06-23 1988-08-23 Janssen Pharmaceutica N.V. N-aryl-piperazinealkanamides useful for protecting hearts from myocardial injury caused by ischaemia, anoxia or hypoxia
US4512991A (en) * 1982-12-27 1985-04-23 Merck & Co., Inc. 3-Acyl-2-amino-5-halo-6-(substituted)pyrazine antimicrobial compounds
US5744600A (en) * 1988-11-14 1998-04-28 Institute Of Organic Chemistry And Biochemistry Of The Academy Of Sciences Of The Czech Republic Phosphonomethoxy carbocyclic nucleosides and nucleotides
US5192764A (en) * 1991-05-30 1993-03-09 Research Foundation Of State Of N.Y. Pyrazinone n-oxide nucleosides and analogs thereof
FR2688003B1 (fr) * 1992-02-28 1995-06-30 Univ Limoges Derives de nucleosides, leur preparation et leurs applications biologiques.
US6677310B1 (en) * 1999-04-21 2004-01-13 Nabi Ring-expanded nucleosides and nucleotides
US5525711A (en) * 1994-05-18 1996-06-11 The United States Of America As Represented By The Secretary Of The Department Of Health And Human Services Pteridine nucleotide analogs as fluorescent DNA probes
GB9505025D0 (en) * 1995-03-13 1995-05-03 Medical Res Council Chemical compounds
US6248878B1 (en) * 1996-12-24 2001-06-19 Ribozyme Pharmaceuticals, Inc. Nucleoside analogs
AU9016998A (en) * 1997-08-08 1999-03-01 Newbiotics, Inc. Methods and compositions for overcoming resistance to biologic and chemotherapy
AU753155B2 (en) * 1998-01-23 2002-10-10 Kiadis Pharma Intellectual Property B.V. Enzyme catalyzed therapeutic agents
US6274725B1 (en) * 1998-06-02 2001-08-14 Isis Pharmaceuticals, Inc. Activators for oligonucleotide synthesis
US6160118A (en) * 1998-07-01 2000-12-12 Merck & Co., Inc. Process for the synthesis of substituted piperazinones via Mitsunobu reaction
HU227475B1 (en) * 1998-08-20 2011-07-28 Toyama Chemical Co Ltd Nitrogenous heterocyclic carboxamide derivatives or salts thereof and antiviral agents containing them
KR100589935B1 (ko) * 2000-02-16 2006-06-15 토야마 케미칼 컴퍼니 리미티드 신규한 피라진 유도체 또는 그 염, 및 이를 함유하는 의약 조성물
US6875751B2 (en) * 2000-06-15 2005-04-05 Idenix Pharmaceuticals, Inc. 3′-prodrugs of 2′-deoxy-β-L-nucleosides
WO2002024650A2 (en) * 2000-09-19 2002-03-28 Centre National De La Recherche Scientifique (Cnrs) Pyridinone and pyridinethione derivatives having hiv inhibiting properties
RU2297414C2 (ru) * 2001-02-14 2007-04-20 Тояма Кемикал Ко., Лтд. Производные пиразина или их соли, фармацевтическая композиция, содержащая данные соединения, и промежуточные соединения для их получения

Also Published As

Publication number Publication date
US20040235761A1 (en) 2004-11-25
PL209765B1 (pl) 2011-10-31
CN1551777A (zh) 2004-12-01
EP1417967A1 (en) 2004-05-12
JP4370164B2 (ja) 2009-11-25
MXPA04001361A (es) 2004-05-27
CA2456292A1 (en) 2003-02-27
BR0211900A (pt) 2004-08-24
ZA200400925B (en) 2005-04-26
KR100894167B1 (ko) 2009-04-22
KR20040030099A (ko) 2004-04-08
RU2004107499A (ru) 2005-04-20
JPWO2003015798A1 (ja) 2004-12-02
WO2003015798A1 (fr) 2003-02-27
EP1417967A4 (en) 2007-03-28
CN100434079C (zh) 2008-11-19
RU2292894C2 (ru) 2007-02-10

Similar Documents

Publication Publication Date Title
PT1505963E (pt) Inibidores do vírus da hepatite c
SI3587433T1 (sl) Modificirani nukleotidi
AU2003211953A1 (en) Nucleoside analogues and oligonucleotide derivative comprising nucleotide analogue thereof
IL222761A0 (en) Viral polymerase inhibitors
EP1497304A4 (en) DOUBLE MARKED NUCLEOTIDE
EP1684787A4 (en) INHIBITORS OF HEPATITIS C VIRUS
AU2003241621A8 (en) Oligonucleotides having modified nucleoside units
GB0128526D0 (en) Nucleotide analogues
EP1534161A4 (en) TARGET WARPING BASED ON HORN SKIN TOPOGRAPHY
AU2003273670A1 (en) Protective ceramic coating
EP1417967A4 (en) NEW VIRUS PROTECTION INHIBITION, VIRCIDIDIC PROCEDURE AND NEW PYRADIN NUCLEOTIDE / PYRADIN NUCLEOSIDE ANALOGON
AU2002365081A8 (en) Anti-icing coatings and methods
AU2003290710A8 (en) Muc1 interference rna compositions and methods derived therefrom
EP1544294B8 (en) Nucleosides or nucleotides having novel unnatural bases and use thereof
IL157013A0 (en) Ultrafine-grain-copper-base sputter targets
AU2003256919A8 (en) Virus induced gene silencing in plants
GB0229834D0 (en) Target and method
GB2395849B (en) Improved analogue selector
GB0230082D0 (en) Oven
ID30477A (id) Analog nukleosida antivirus
EP1541580A4 (en) SULFOTRANSFERASE INHIBITORS
AU2002327087A1 (en) Novel virus proliferation inhibition/virucidal method and novel pyradine nucleotide/pyradine nucleoside analogue
EP1651791A4 (en) THERMAL SPRAY COATINGS OF PROTECTED CERAMICS
HUP0500513A3 (en) Intermediates for preparing glycogen phosphorylase inhibitors
EP1613722A4 (en) OLIGONUCLEOTIDES INHIBITORS BASED ON RNA