PL3581650T3 - Zmutowany polipeptyd czynnika ix, jego zastosowania i sposób jego wytwarzania - Google Patents
Zmutowany polipeptyd czynnika ix, jego zastosowania i sposób jego wytwarzaniaInfo
- Publication number
- PL3581650T3 PL3581650T3 PL19174517.3T PL19174517T PL3581650T3 PL 3581650 T3 PL3581650 T3 PL 3581650T3 PL 19174517 T PL19174517 T PL 19174517T PL 3581650 T3 PL3581650 T3 PL 3581650T3
- Authority
- PL
- Poland
- Prior art keywords
- polypeptide
- production
- mutated factor
- mutated
- factor
- Prior art date
Links
Classifications
-
- C—CHEMISTRY; METALLURGY
- C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
- C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
- C12N9/00—Enzymes; Proenzymes; Compositions thereof; Processes for preparing, activating, inhibiting, separating or purifying enzymes
- C12N9/14—Hydrolases (3)
- C12N9/48—Hydrolases (3) acting on peptide bonds (3.4)
- C12N9/50—Proteinases, e.g. Endopeptidases (3.4.21-3.4.25)
- C12N9/64—Proteinases, e.g. Endopeptidases (3.4.21-3.4.25) derived from animal tissue
- C12N9/6421—Proteinases, e.g. Endopeptidases (3.4.21-3.4.25) derived from animal tissue from mammals
- C12N9/6424—Serine endopeptidases (3.4.21)
- C12N9/644—Coagulation factor IXa (3.4.21.22)
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K38/00—Medicinal preparations containing peptides
- A61K38/16—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof
- A61K38/43—Enzymes; Proenzymes; Derivatives thereof
- A61K38/46—Hydrolases (3)
- A61K38/48—Hydrolases (3) acting on peptide bonds (3.4)
- A61K38/482—Serine endopeptidases (3.4.21)
- A61K38/4846—Factor VII (3.4.21.21); Factor IX (3.4.21.22); Factor Xa (3.4.21.6); Factor XI (3.4.21.27); Factor XII (3.4.21.38)
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P7/00—Drugs for disorders of the blood or the extracellular fluid
- A61P7/04—Antihaemorrhagics; Procoagulants; Haemostatic agents; Antifibrinolytic agents
-
- C—CHEMISTRY; METALLURGY
- C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
- C12Y—ENZYMES
- C12Y304/00—Hydrolases acting on peptide bonds, i.e. peptidases (3.4)
- C12Y304/21—Serine endopeptidases (3.4.21)
- C12Y304/21022—Coagulation factor IXa (3.4.21.22)
Landscapes
- Health & Medical Sciences (AREA)
- Life Sciences & Earth Sciences (AREA)
- Chemical & Material Sciences (AREA)
- Engineering & Computer Science (AREA)
- Bioinformatics & Cheminformatics (AREA)
- Organic Chemistry (AREA)
- General Health & Medical Sciences (AREA)
- Zoology (AREA)
- Wood Science & Technology (AREA)
- Genetics & Genomics (AREA)
- Medicinal Chemistry (AREA)
- Biomedical Technology (AREA)
- Biochemistry (AREA)
- General Engineering & Computer Science (AREA)
- Veterinary Medicine (AREA)
- Animal Behavior & Ethology (AREA)
- Pharmacology & Pharmacy (AREA)
- Public Health (AREA)
- Molecular Biology (AREA)
- Microbiology (AREA)
- Biotechnology (AREA)
- Immunology (AREA)
- Gastroenterology & Hepatology (AREA)
- Proteomics, Peptides & Aminoacids (AREA)
- Epidemiology (AREA)
- Diabetes (AREA)
- Hematology (AREA)
- Chemical Kinetics & Catalysis (AREA)
- General Chemical & Material Sciences (AREA)
- Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
- Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)
- Peptides Or Proteins (AREA)
- Micro-Organisms Or Cultivation Processes Thereof (AREA)
- Preparation Of Compounds By Using Micro-Organisms (AREA)
Applications Claiming Priority (2)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| ITBO2008A000564A IT1394177B1 (it) | 2008-09-15 | 2008-09-15 | Polipeptide fattore ix modificato, sue utilizzazioni e metodo per la sua produzione |
| ITBO2009A000275A IT1395980B1 (it) | 2009-05-06 | 2009-05-06 | Polipeptide fattore ix modificato, sue utilizzazioni e metodo per la sua produzione |
Publications (1)
| Publication Number | Publication Date |
|---|---|
| PL3581650T3 true PL3581650T3 (pl) | 2023-05-22 |
Family
ID=41397565
Family Applications (3)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| PL19174517.3T PL3581650T3 (pl) | 2008-09-15 | 2009-09-15 | Zmutowany polipeptyd czynnika ix, jego zastosowania i sposób jego wytwarzania |
| PL09748260T PL2337849T3 (pl) | 2008-09-15 | 2009-09-15 | Zmutowany polipeptyd czynnika ix, jego zastosowania i sposób jego otrzymywania |
| PL21200005.3T PL4032979T3 (pl) | 2008-09-15 | 2009-09-15 | Mutant polipeptydu czynnika ix, jego zastosowania i sposób jego otrzymywania |
Family Applications After (2)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| PL09748260T PL2337849T3 (pl) | 2008-09-15 | 2009-09-15 | Zmutowany polipeptyd czynnika ix, jego zastosowania i sposób jego otrzymywania |
| PL21200005.3T PL4032979T3 (pl) | 2008-09-15 | 2009-09-15 | Mutant polipeptydu czynnika ix, jego zastosowania i sposób jego otrzymywania |
Country Status (20)
| Country | Link |
|---|---|
| US (13) | US9249405B2 (de) |
| EP (5) | EP4219547A3 (de) |
| CA (1) | CA2737094C (de) |
| CY (3) | CY1125885T1 (de) |
| DK (2) | DK3581650T3 (de) |
| ES (3) | ES2687038T3 (de) |
| FI (5) | FI3581650T3 (de) |
| FR (4) | FR23C1028I1 (de) |
| HK (1) | HK1244507A1 (de) |
| HR (2) | HRP20230259T1 (de) |
| HU (6) | HUE061345T2 (de) |
| LT (5) | LT3581650T (de) |
| LU (1) | LUC00311I2 (de) |
| NO (2) | NO2023029I1 (de) |
| PL (3) | PL3581650T3 (de) |
| PT (1) | PT3581650T (de) |
| SI (1) | SI3581650T1 (de) |
| SM (2) | SMT202300084T1 (de) |
| TR (1) | TR201813067T4 (de) |
| WO (1) | WO2010029178A1 (de) |
Families Citing this family (26)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| EP4219547A3 (de) | 2008-09-15 | 2023-10-18 | uniQure biopharma B.V. | Faktor-ix-polypeptidmutante, deren verwendungen und verfahren zu deren herstellung |
| TWI595004B (zh) | 2010-11-03 | 2017-08-11 | 介控生化科技公司 | 經修飾之第九因子多胜肽及其用途 |
| MX365612B (es) | 2012-07-25 | 2019-06-07 | Catalyst Biosciences Inc | Polipeptidos de factor x modificados y usos de los mismos. |
| SI3889173T1 (sl) | 2013-02-15 | 2023-11-30 | Bioverativ Therapeutics Inc. | Optimiran gen dejavnika VIII |
| EP3160478A4 (de) | 2014-06-30 | 2018-05-16 | Bioverativ Therapeutics Inc. | Optimiertes faktor-ix-gen |
| GB201420139D0 (en) | 2014-11-12 | 2014-12-24 | Ucl Business Plc | Factor IX gene therapy |
| WO2016210170A1 (en) * | 2015-06-23 | 2016-12-29 | The Children's Hospital Of Philadelphia | Modified factor ix, and compositions, methods and uses for gene transfer to cells, organs and tissues |
| WO2017136358A1 (en) | 2016-02-01 | 2017-08-10 | Bioverativ Therapeutics Inc. | Optimized factor viii genes |
| PE20190401A1 (es) | 2016-07-26 | 2019-03-13 | Biomarin Pharm Inc | Novedosas proteinas de la capside del virus adenoasociado |
| CN116355883A (zh) * | 2016-10-14 | 2023-06-30 | 四川至善唯新生物科技有限公司 | 一种高活性凝血因子ix突变体、重组蛋白与融合蛋白的制备与应用 |
| CN110945127B (zh) | 2017-05-22 | 2024-07-12 | 武田药品工业株式会社 | 用于血友病b的基因疗法的编码具有增加的表达的重组fix的病毒载体 |
| PT3652326T (pt) | 2017-07-10 | 2024-12-26 | Uniqure Ip Bv | Meios e métodos para terapia génica de aav em humanos |
| US11491212B1 (en) | 2017-09-27 | 2022-11-08 | Catalyst Biosciences, Inc. | Subcutaneous administration of modified factor IX polypeptides and treatment of hemophilia B |
| BR112020022722A8 (pt) | 2018-05-09 | 2022-01-18 | Biomarin Pharm Inc | Genoma e seu uso, vetor, partícula, molécula de ácido nucleico isolada, ácido nucleico, composição, tratamento, método |
| TW202005978A (zh) | 2018-05-14 | 2020-02-01 | 美商拜奧馬林製藥公司 | 新穎肝靶向腺相關病毒載體 |
| US20200069819A1 (en) | 2018-05-14 | 2020-03-05 | Biomarin Pharmaceutical Inc. | Stable expression of aav vectors in juvenile subjects |
| SG11202101560QA (en) * | 2018-08-20 | 2021-03-30 | Ucl Business Ltd | Factor ix encoding nucleotides |
| GB201813528D0 (en) | 2018-08-20 | 2018-10-03 | Ucl Business Plc | Factor IX encoding nucleotides |
| US10842885B2 (en) | 2018-08-20 | 2020-11-24 | Ucl Business Ltd | Factor IX encoding nucleotides |
| UY38389A (es) * | 2018-09-27 | 2020-04-30 | Sigilon Therapeutics Inc | Dispositivos implantables para terapia celular y métodos relacionados |
| JP7578590B2 (ja) | 2018-10-18 | 2024-11-06 | インテリア セラピューティクス,インコーポレーテッド | 第ix因子を発現するための組成物及び方法 |
| JP7803014B2 (ja) | 2019-09-30 | 2026-01-21 | バイオベラティブ セラピューティクス インコーポレイテッド | レンチウイルスベクター製剤 |
| WO2021154414A2 (en) | 2020-01-29 | 2021-08-05 | Catalyst Biosciences, Inc. | Gene therapy for hemophilia b with a chimeric aav capsid vector encoding modified factor ix polypeptides |
| US12173307B2 (en) | 2020-06-24 | 2024-12-24 | Bioverativ Therapeutics Inc. | Methods for the purification of viral vectors |
| EP4362971A1 (de) * | 2021-07-01 | 2024-05-08 | CSL Behring Lengnau AG | Subkutane verabreichung von faktor ix mit erhöhter sicherheit |
| WO2025022005A1 (en) * | 2023-07-26 | 2025-01-30 | Le Quellec Sandra | Intranasal administration of factor ix polypeptides |
Family Cites Families (74)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| DE3380848D1 (en) | 1982-08-04 | 1989-12-21 | Nat Res Dev | Molecular cloning of the gene for human anti-haemophilic factor ix |
| US5171569A (en) | 1985-03-15 | 1992-12-15 | National Research Development Corporation | Factor IX preparations uncontaminated by plasma components or pox virus |
| US4994371A (en) | 1987-08-28 | 1991-02-19 | Davie Earl W | DNA preparation of Christmas factor and use of DNA sequences |
| US5583107A (en) | 1990-09-04 | 1996-12-10 | Cor Therapeutics, Inc. | Agents affecting thrombosis and hemostasis |
| US5223408A (en) | 1991-07-11 | 1993-06-29 | Genentech, Inc. | Method for making variant secreted proteins with altered properties |
| GB9408717D0 (en) | 1994-05-03 | 1994-06-22 | Biotech & Biolog Scien Res | DNA sequences |
| US6227618B1 (en) | 1996-02-23 | 2001-05-08 | Schukra Usa, Inc. | Cable attachment for a lumbar support |
| WO1997047737A1 (de) | 1996-06-11 | 1997-12-18 | Boehringer Mannheim Gmbh | Rekombinante blutgerinnungsproteasen |
| US6315995B1 (en) | 1996-09-27 | 2001-11-13 | The Trustees Of Columbia University In The City Of New York | Methods for treating an ischemic disorder and improving stroke outcome |
| ES2340008T3 (es) | 1997-02-14 | 2010-05-27 | American Red Cross | Expresion de factor ix humano activo en tejido mamario de animales transgenicos. |
| WO1999003496A1 (en) * | 1997-07-21 | 1999-01-28 | The University Of North Carolina At Chapel Hill | Factor ix antihemophilic factor with increased clotting activity |
| US6200560B1 (en) | 1998-10-20 | 2001-03-13 | Avigen, Inc. | Adeno-associated virus vectors for expression of factor VIII by target cells |
| US6759050B1 (en) | 1998-12-03 | 2004-07-06 | Avigen, Inc. | Excipients for use in adeno-associated virus pharmaceutical formulations, and pharmaceutical formulations made therewith |
| US6610906B1 (en) | 1999-06-09 | 2003-08-26 | The Regents Of The University Of Michigan | Nucleotide sequences for gene regulation and methods of use thereof |
| US7109170B2 (en) | 1999-06-16 | 2006-09-19 | Saint Louis University | Region of factor IXa protease domain that interacts with factor VIIIa and methods therefor |
| WO2001070763A1 (en) | 2000-03-22 | 2001-09-27 | The Children's Hospital Of Philadelphia | Modified blood clotting factors and methods of use |
| AU2001269961A1 (en) | 2000-07-06 | 2002-01-21 | Guilford Pharmaceuticals | Improved polymers and polymerization processes |
| AU2002226028A1 (en) | 2000-11-14 | 2002-05-27 | Board Of Regents, Unversity Of Texas Systems | Mutant human factor ix with an increased resistance to inhibition by heparin |
| US20040133930A1 (en) | 2002-03-11 | 2004-07-08 | Cooper Julian D. | Production of high levels of transgenic factor ix without gene rescue, and its therapeutic uses |
| WO2002096454A1 (en) | 2001-05-31 | 2002-12-05 | D. Collen Research Foundation Vzw | Recombinant molecules with reduced immunogenicity, methods and intermediates for obtaining them and their use in pharmaceutical compositions and diagnostic tools |
| KR20040039328A (ko) | 2001-09-04 | 2004-05-10 | 메르크 파텐트 게엠베하 | 변형된 펙터 ⅸ |
| US7179617B2 (en) * | 2001-10-10 | 2007-02-20 | Neose Technologies, Inc. | Factor IX: remolding and glycoconjugation of Factor IX |
| US20040009151A1 (en) | 2002-04-04 | 2004-01-15 | Kay Mark A. | Methods for delivering recombinant adeno-associated virus virions to the liver of a mammal |
| AU2003221733A1 (en) | 2002-04-17 | 2003-11-03 | University Of Florida Research Foundation, Inc. | Improved raav vectors |
| CA2501295A1 (en) | 2002-10-02 | 2004-04-15 | Jack Nguyen | Methods of generating and screening for proteases with altered specificity |
| DE602004030327D1 (de) | 2003-05-21 | 2011-01-13 | Genzyme Corp | Verfahren zur herstellung von präparationen rekombinanter aav-virionen, die weitgehend frei von leeren capsiden sind |
| US20060040856A1 (en) | 2003-12-03 | 2006-02-23 | Neose Technologies, Inc. | Glycopegylated factor IX |
| GB0329681D0 (en) | 2003-12-23 | 2004-01-28 | Delta Biotechnology Ltd | Gene expression technique |
| ATE469216T1 (de) | 2004-08-17 | 2010-06-15 | Csl Behring Gmbh | Modifizierte vitamin-k-abhängige polypeptide |
| EP1627771B1 (de) | 2004-08-19 | 2008-10-15 | Gerd Bär | Hubladebühne mit querverschiebbarem Verbindungsrohr |
| WO2006031226A1 (en) | 2004-09-13 | 2006-03-23 | Saint Louis University | Region of factor ixa protease domain that interacts with factor viiia and methods therefor |
| EP1804839B1 (de) | 2004-09-22 | 2012-03-14 | St. Jude Children's Research Hospital | Verbesserte expression von faktor-ix in gentherapie-vektoren |
| US7998930B2 (en) | 2004-11-04 | 2011-08-16 | Hanall Biopharma Co., Ltd. | Modified growth hormones |
| EP1828390B1 (de) | 2004-12-15 | 2012-06-13 | The University Of North Carolina At Chapel Hill | Chimäre vektoren |
| EP2433642B1 (de) | 2005-10-21 | 2016-12-07 | Catalyst Biosciences, Inc. | Modifizierte Proteasen zur Hemmung der Komplementaktivierung |
| WO2007059473A2 (en) | 2005-11-12 | 2007-05-24 | Introgen Therapeutics, Inc. | Methods for the production and purification of adenoviral vectors |
| EP1791039A1 (de) | 2005-11-25 | 2007-05-30 | The Swatch Group Research and Development Ltd. | Spiralfeder aus athermisches Glas für ein Uhrwerk und Herstellungsverfahren dafür |
| EP1969127B8 (de) | 2005-12-21 | 2017-12-13 | Aptevo BioTherapeutics LLC | Verfahren zur herstellung biologisch wirksamer vitamin-k-abhängiger proteine mit rekombinanten verfahren |
| US7867484B2 (en) | 2006-01-27 | 2011-01-11 | University Of North Carolina At Chapel Hill | Heparin and heparan sulfate binding chimeric vectors |
| US7375084B2 (en) | 2006-03-07 | 2008-05-20 | Baxter International Inc. | Highly phosphorylated and sulfated recombinant factor IX |
| US20080038224A1 (en) | 2006-03-28 | 2008-02-14 | Thierry Guyon | Modified interferon-beta (IFN-beta) polypeptides |
| US7588772B2 (en) | 2006-03-30 | 2009-09-15 | Board Of Trustees Of The Leland Stamford Junior University | AAV capsid library and AAV capsid proteins |
| CN101460055A (zh) | 2006-04-07 | 2009-06-17 | 得克萨斯大学体系董事会 | 和腺伴随病毒-噬菌体颗粒相关的方法和组合物 |
| KR20090013816A (ko) | 2006-05-24 | 2009-02-05 | 노보 노르디스크 헬스 케어 악티엔게젤샤프트 | 연장된 생체내 반감기를 갖는 인자 ⅸ 유사체 |
| US20070280906A1 (en) | 2006-06-03 | 2007-12-06 | Ognjen Petras | Method to generate mirrored adenoassociated viral vectors |
| EP2423305A1 (de) | 2006-06-19 | 2012-02-29 | Catalyst Biosciences, Inc. | Modifizierte Gerinnungsfaktor-IX-Polypeptide und deren Verwendung bei der Behandlung |
| EP2848253A1 (de) | 2006-06-19 | 2015-03-18 | Asklepios Biopharmaceutical, Inc. | Modifizierte Faktor-VIII- und Faktor-IX-Gene und Vektoren für Gentherapie |
| US7700734B2 (en) | 2007-01-09 | 2010-04-20 | Shu-Wha Lin | Recombinant human factor IX and use thereof |
| WO2008092643A2 (en) | 2007-02-01 | 2008-08-07 | Baxter International Inc. | Improved fix-mutant proteins for hemophilia b treatment |
| WO2008119815A1 (en) | 2007-04-02 | 2008-10-09 | Novo Nordisk A/S | Subcutaneous administration of coagulation factor ix |
| WO2008127654A2 (en) | 2007-04-11 | 2008-10-23 | The University Of North Carolina At Chapel Hill | Methods and compositions for intra-articular coagulation proteins |
| US20080260820A1 (en) | 2007-04-19 | 2008-10-23 | Gilles Borrelly | Oral dosage formulations of protease-resistant polypeptides |
| BRPI0705943A2 (pt) | 2007-04-19 | 2008-12-09 | Nautilus Biotech | formulaÇÕes de dosagem oral de polipeptÍdeos resistentes À protease e usos das mesmas para tratamento |
| US20090030072A1 (en) | 2007-07-03 | 2009-01-29 | Sucampo Ag | Pharmaceutical combination of opioid and prostaglandin compound |
| AU2008311973B2 (en) | 2007-10-15 | 2013-10-03 | Cangene Corporation | Human Factor IX variants with an extended half life |
| CA2721683A1 (en) * | 2008-04-16 | 2009-11-12 | Bayer Healthcare Llc | Modified factor ix polypeptides and uses thereof |
| JP2011517950A (ja) | 2008-04-16 | 2011-06-23 | バイエル・ヘルスケア・エルエルシー | 第ix因子の部位特異的修飾 |
| CN102105582A (zh) | 2008-04-21 | 2011-06-22 | 诺沃-诺迪斯克有限公司 | 高糖基化人凝血因子ix |
| EP2149603A1 (de) | 2008-07-28 | 2010-02-03 | DRK-Blutspendedienst Baden-Württemberg-Hessen gGmbH | Faktor-IX-Varianten mit Gerinnungsaktivität in Abwesenheit ihres Cofaktors und ihre Verwendung zur Behandlung von Blutungsstörungen |
| EP4219547A3 (de) | 2008-09-15 | 2023-10-18 | uniQure biopharma B.V. | Faktor-ix-polypeptidmutante, deren verwendungen und verfahren zu deren herstellung |
| CN102596231B (zh) | 2009-06-25 | 2016-01-20 | 北卡罗来纳-查佩尔山大学 | 嵌合因子ⅶ分子 |
| EP2461821A4 (de) | 2009-07-31 | 2013-07-03 | Bayer Healthcare Llc | Modifizierte faktor-ix-polypeptide und verwendungen davon |
| TWI595004B (zh) | 2010-11-03 | 2017-08-11 | 介控生化科技公司 | 經修飾之第九因子多胜肽及其用途 |
| EP3513802B1 (de) | 2012-10-26 | 2023-11-29 | Vrije Universiteit Brussel | Vektor für gegen die leber gerichtete gentherapie von hämophilie, verfahren und verwendung davon |
| EP2881463A1 (de) | 2013-12-09 | 2015-06-10 | DRK-Blutspendedienst Baden-Württemberg-Hessen gGmbH | Faktor-IX-Varianten mit Gerinnungsaktivität in Abwesenheit ihres Cofaktors und/oder mit erhöhter F.IX-Gerinnungsaktivität und ihre Verwendung zur Behandlung von Blutungsstörungen |
| EP3160478A4 (de) | 2014-06-30 | 2018-05-16 | Bioverativ Therapeutics Inc. | Optimiertes faktor-ix-gen |
| EP3270944B1 (de) | 2015-03-17 | 2019-10-23 | Vrije Universiteit Brussel | Leberspezifische optimierte expressionssysteme für fviii und fix |
| CN115074366A (zh) | 2015-04-16 | 2022-09-20 | 埃默里大学 | 用于肝脏中蛋白质表达的重组启动子和载体及其用途 |
| WO2016210170A1 (en) | 2015-06-23 | 2016-12-29 | The Children's Hospital Of Philadelphia | Modified factor ix, and compositions, methods and uses for gene transfer to cells, organs and tissues |
| BR112018002150A2 (pt) | 2015-08-03 | 2018-09-18 | Bioverativ Therapeutics Inc | proteínas de fusão do fator ix e métodos de fabricação e uso das mesmas |
| EP3442597A1 (de) | 2016-04-15 | 2019-02-20 | The Trustees Of The University Of Pennsylvania | Gentherapie zur behandlung von hämophilie b |
| KR102450833B1 (ko) | 2016-04-15 | 2022-10-05 | 더 트러스티스 오브 더 유니버시티 오브 펜실베니아 | 혈우병 a 치료용 유전자 요법 |
| PT3652326T (pt) | 2017-07-10 | 2024-12-26 | Uniqure Ip Bv | Meios e métodos para terapia génica de aav em humanos |
| US20210228738A1 (en) | 2017-07-17 | 2021-07-29 | INSERM (Institut National de la Santé et de la Recherche Médicale) | Compositions and methods for increasing or enhancing transduction of gene therapy vectors and for removing or reducing immunoglobulins |
-
2009
- 2009-09-15 EP EP22214327.3A patent/EP4219547A3/de active Pending
- 2009-09-15 US US13/063,898 patent/US9249405B2/en not_active Ceased
- 2009-09-15 WO PCT/EP2009/061935 patent/WO2010029178A1/en not_active Ceased
- 2009-09-15 EP EP21200005.3A patent/EP4032979B1/de active Active
- 2009-09-15 HU HUE19174517A patent/HUE061345T2/hu unknown
- 2009-09-15 PL PL19174517.3T patent/PL3581650T3/pl unknown
- 2009-09-15 HR HRP20230259TT patent/HRP20230259T1/hr unknown
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