CY1125885T1 - Τροποποιημενο πολυπεπτιδιο παραγοντα ix, οι χρησεις του και μια μεθοδος για την παραγωγη του - Google Patents

Τροποποιημενο πολυπεπτιδιο παραγοντα ix, οι χρησεις του και μια μεθοδος για την παραγωγη του

Info

Publication number
CY1125885T1
CY1125885T1 CY20231100138T CY231100138T CY1125885T1 CY 1125885 T1 CY1125885 T1 CY 1125885T1 CY 20231100138 T CY20231100138 T CY 20231100138T CY 231100138 T CY231100138 T CY 231100138T CY 1125885 T1 CY1125885 T1 CY 1125885T1
Authority
CY
Cyprus
Prior art keywords
polypeptide
fix polypeptide
modified fix
production
modified factor
Prior art date
Application number
CY20231100138T
Other languages
English (en)
Inventor
Paolo Simioni
Original Assignee
Uniqure Biopharma B.V.
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Family has litigation
First worldwide family litigation filed litigation Critical https://patents.darts-ip.com/?family=41397565&utm_source=google_patent&utm_medium=platform_link&utm_campaign=public_patent_search&patent=CY1125885(T1) "Global patent litigation dataset” by Darts-ip is licensed under a Creative Commons Attribution 4.0 International License.
Priority claimed from ITBO2008A000564A external-priority patent/IT1394177B1/it
Priority claimed from ITBO2009A000275A external-priority patent/IT1395980B1/it
Application filed by Uniqure Biopharma B.V. filed Critical Uniqure Biopharma B.V.
Publication of CY1125885T1 publication Critical patent/CY1125885T1/el

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
    • C12N9/00—Enzymes; Proenzymes; Compositions thereof; Processes for preparing, activating, inhibiting, separating or purifying enzymes
    • C12N9/14—Hydrolases (3)
    • C12N9/48—Hydrolases (3) acting on peptide bonds (3.4)
    • C12N9/50—Proteinases, e.g. Endopeptidases (3.4.21-3.4.25)
    • C12N9/64—Proteinases, e.g. Endopeptidases (3.4.21-3.4.25) derived from animal tissue
    • C12N9/6421—Proteinases, e.g. Endopeptidases (3.4.21-3.4.25) derived from animal tissue from mammals
    • C12N9/6424—Serine endopeptidases (3.4.21)
    • C12N9/644—Coagulation factor IXa (3.4.21.22)
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K38/00—Medicinal preparations containing peptides
    • A61K38/16—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof
    • A61K38/43—Enzymes; Proenzymes; Derivatives thereof
    • A61K38/46—Hydrolases (3)
    • A61K38/48—Hydrolases (3) acting on peptide bonds (3.4)
    • A61K38/482—Serine endopeptidases (3.4.21)
    • A61K38/4846—Factor VII (3.4.21.21); Factor IX (3.4.21.22); Factor Xa (3.4.21.6); Factor XI (3.4.21.27); Factor XII (3.4.21.38)
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P7/00—Drugs for disorders of the blood or the extracellular fluid
    • A61P7/04—Antihaemorrhagics; Procoagulants; Haemostatic agents; Antifibrinolytic agents
    • C—CHEMISTRY; METALLURGY
    • C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12Y—ENZYMES
    • C12Y304/00—Hydrolases acting on peptide bonds, i.e. peptidases (3.4)
    • C12Y304/21—Serine endopeptidases (3.4.21)
    • C12Y304/21022—Coagulation factor IXa (3.4.21.22)

Landscapes

  • Health & Medical Sciences (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Chemical & Material Sciences (AREA)
  • Engineering & Computer Science (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Organic Chemistry (AREA)
  • General Health & Medical Sciences (AREA)
  • Genetics & Genomics (AREA)
  • Wood Science & Technology (AREA)
  • Zoology (AREA)
  • Medicinal Chemistry (AREA)
  • Biomedical Technology (AREA)
  • General Engineering & Computer Science (AREA)
  • Biochemistry (AREA)
  • Veterinary Medicine (AREA)
  • Public Health (AREA)
  • Animal Behavior & Ethology (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Biotechnology (AREA)
  • Microbiology (AREA)
  • Molecular Biology (AREA)
  • Immunology (AREA)
  • Gastroenterology & Hepatology (AREA)
  • Proteomics, Peptides & Aminoacids (AREA)
  • Epidemiology (AREA)
  • Hematology (AREA)
  • Diabetes (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • General Chemical & Material Sciences (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)
  • Peptides Or Proteins (AREA)
  • Preparation Of Compounds By Using Micro-Organisms (AREA)
  • Micro-Organisms Or Cultivation Processes Thereof (AREA)

Abstract

Στο παρόν κείμενο περιλαμβάνονται ένα τροποποιημένο πολυπεπτίδιο FIX (παράγοντας IX) που περιλαμβάνει λευκίνη, κυστεΐνη, ασπαρτικό οξύ, γλουταμικό οξύ, ιστιδίνη, λυσίνη, ασπαραγίνη, γλουταμίνη ή τυροσίνη στη θέση 338 · φαρμακευτικά σκευάσματα που περιέχουν το εν λόγω τροποποιημένο πολυπεπτίδιο FIX · μια νουκλεοτιδική αλληλουχία που κωδικοποιεί το τροποποιημένο πολυπεπτίδιο FIX · και μια μέθοδο για την παραγωγή του τροποποιημένου πολυπεπτιδίου FIX.
CY20231100138T 2008-09-15 2023-03-14 Τροποποιημενο πολυπεπτιδιο παραγοντα ix, οι χρησεις του και μια μεθοδος για την παραγωγη του CY1125885T1 (el)

Applications Claiming Priority (5)

Application Number Priority Date Filing Date Title
ITBO2008A000564A IT1394177B1 (it) 2008-09-15 2008-09-15 Polipeptide fattore ix modificato, sue utilizzazioni e metodo per la sua produzione
ITBO2009A000275A IT1395980B1 (it) 2009-05-06 2009-05-06 Polipeptide fattore ix modificato, sue utilizzazioni e metodo per la sua produzione
EP09748260.8A EP2337849B1 (en) 2008-09-15 2009-09-15 Factor ix polypeptide mutant, its uses and a method for its production
EP17175191.0A EP3252157A1 (en) 2008-09-15 2009-09-15 Factor ix polypeptide mutant, its uses and a method for its production
PCT/EP2009/061935 WO2010029178A1 (en) 2008-09-15 2009-09-15 Factor ix polypeptide mutant, its uses and a method for its production

Publications (1)

Publication Number Publication Date
CY1125885T1 true CY1125885T1 (el) 2024-02-16

Family

ID=41397565

Family Applications (2)

Application Number Title Priority Date Filing Date
CY20231100138T CY1125885T1 (el) 2008-09-15 2023-03-14 Τροποποιημενο πολυπεπτιδιο παραγοντα ix, οι χρησεις του και μια μεθοδος για την παραγωγη του
CY2023016C CY2023016I2 (el) 2008-09-15 2023-07-27 Τροποποιημενο πολυπεπτιδιο παραγοντα ix, οι χρησεις του και μια μεθοδος για την παραγωγη του

Family Applications After (1)

Application Number Title Priority Date Filing Date
CY2023016C CY2023016I2 (el) 2008-09-15 2023-07-27 Τροποποιημενο πολυπεπτιδιο παραγοντα ix, οι χρησεις του και μια μεθοδος για την παραγωγη του

Country Status (18)

Country Link
US (11) US9249405B2 (el)
EP (5) EP4032979B1 (el)
CA (1) CA2737094C (el)
CY (2) CY1125885T1 (el)
DK (2) DK3581650T3 (el)
ES (2) ES2940323T3 (el)
FI (2) FI3581650T3 (el)
FR (1) FR23C1028I1 (el)
HK (1) HK1244507A1 (el)
HR (2) HRP20230259T1 (el)
HU (2) HUE061345T2 (el)
LT (2) LT3581650T (el)
NO (1) NO2023029I1 (el)
PL (3) PL4032979T3 (el)
PT (1) PT3581650T (el)
SI (1) SI3581650T1 (el)
TR (1) TR201813067T4 (el)
WO (1) WO2010029178A1 (el)

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Publication number Publication date
US20210238573A1 (en) 2021-08-05
EP3581650A2 (en) 2019-12-18
FIC20230026I1 (fi) 2023-07-25
HRP20181442T1 (hr) 2018-12-14
US20220002702A1 (en) 2022-01-06
FR23C1028I1 (fr) 2023-10-06
ES2940323T3 (es) 2023-05-05
PT3581650T (pt) 2023-03-08
US20160122740A1 (en) 2016-05-05
NO2023029I1 (no) 2023-07-31
PL2337849T3 (pl) 2018-11-30
ES2687038T3 (es) 2018-10-23
US9982248B2 (en) 2018-05-29
CA2737094F (en) 2010-03-18
US20200231958A1 (en) 2020-07-23
HUE061345T2 (hu) 2023-06-28
EP4219547A2 (en) 2023-08-02
EP4032979A1 (en) 2022-07-27
EP3581650A3 (en) 2020-03-25
HRP20230259T1 (hr) 2023-04-28
EP3581650B1 (en) 2022-12-28
CA2737094C (en) 2018-02-20
LT3581650T (lt) 2023-05-10
US20110244550A1 (en) 2011-10-06
SI3581650T1 (sl) 2023-06-30
DK3581650T3 (da) 2023-03-13
TR201813067T4 (tr) 2018-09-21
EP4219547A3 (en) 2023-10-18
HUS2300024I1 (hu) 2023-08-28
US10465180B2 (en) 2019-11-05
US20170355973A1 (en) 2017-12-14
US20180258413A1 (en) 2018-09-13
CY2023016I1 (el) 2024-02-16
EP2337849A1 (en) 2011-06-29
US20220090042A1 (en) 2022-03-24
US20200199564A1 (en) 2020-06-25
CA2737094A1 (en) 2010-03-18
US20200190498A1 (en) 2020-06-18
CY2023016I2 (el) 2024-02-16
US9249405B2 (en) 2016-02-02
EP4032979B1 (en) 2024-05-01
PL3581650T3 (pl) 2023-05-22
DK2337849T3 (en) 2018-10-01
US20210214704A1 (en) 2021-07-15
PL4032979T3 (pl) 2024-09-30
HK1244507A1 (zh) 2018-08-10
LTPA2023521I1 (el) 2023-08-25
EP2337849B1 (en) 2018-06-13
FI3581650T3 (fi) 2023-03-23
EP4032979C0 (en) 2024-05-01
WO2010029178A1 (en) 2010-03-18
EP3252157A1 (en) 2017-12-06

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