PL356423A1 - Nowa krystaliczna postać kwasu N-[4-[2-(2-amino-4,7-dihydro-4-okso-3H-pirolo[2,3-d]-pirymidyn-5-ylo)-etylo]-benzoilo]-L-glutaminowego i proces jej przygotowania - Google Patents

Nowa krystaliczna postać kwasu N-[4-[2-(2-amino-4,7-dihydro-4-okso-3H-pirolo[2,3-d]-pirymidyn-5-ylo)-etylo]-benzoilo]-L-glutaminowego i proces jej przygotowania

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Publication number
PL356423A1
PL356423A1 PL01356423A PL35642301A PL356423A1 PL 356423 A1 PL356423 A1 PL 356423A1 PL 01356423 A PL01356423 A PL 01356423A PL 35642301 A PL35642301 A PL 35642301A PL 356423 A1 PL356423 A1 PL 356423A1
Authority
PL
Poland
Prior art keywords
pyrrolo
pyrimidin
dihydro
benzoyl
oxo
Prior art date
Application number
PL01356423A
Other languages
English (en)
Other versions
PL208061B1 (pl
Inventor
Erik Christopher Chelius
Susan Marie Reutzel-Edens
Den Berghe Snorek Sharon Van
Original Assignee
Eli Lilly And Company
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Family has litigation
First worldwide family litigation filed litigation Critical https://patents.darts-ip.com/?family=22679017&utm_source=google_patent&utm_medium=platform_link&utm_campaign=public_patent_search&patent=PL356423(A1) "Global patent litigation dataset” by Darts-ip is licensed under a Creative Commons Attribution 4.0 International License.
Application filed by Eli Lilly And Company filed Critical Eli Lilly And Company
Publication of PL356423A1 publication Critical patent/PL356423A1/pl
Publication of PL208061B1 publication Critical patent/PL208061B1/pl

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D487/00—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, not provided for by groups C07D451/00 - C07D477/00
    • C07D487/02—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, not provided for by groups C07D451/00 - C07D477/00 in which the condensed system contains two hetero rings
    • C07D487/04—Ortho-condensed systems
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/33—Heterocyclic compounds
    • A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
    • A61K31/495—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with two or more nitrogen atoms as the only ring heteroatoms, e.g. piperazine or tetrazines
    • A61K31/505—Pyrimidines; Hydrogenated pyrimidines, e.g. trimethoprim
    • A61K31/519—Pyrimidines; Hydrogenated pyrimidines, e.g. trimethoprim ortho- or peri-condensed with heterocyclic rings
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P35/00—Antineoplastic agents

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  • Chemical & Material Sciences (AREA)
  • Health & Medical Sciences (AREA)
  • Organic Chemistry (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • General Health & Medical Sciences (AREA)
  • Veterinary Medicine (AREA)
  • Public Health (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Medicinal Chemistry (AREA)
  • Animal Behavior & Ethology (AREA)
  • Epidemiology (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • General Chemical & Material Sciences (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Nitrogen Condensed Heterocyclic Rings (AREA)
  • Medicinal Preparation (AREA)
PL356423A 2000-02-25 2001-02-12 Postać krystaliczna heptahydratu soli disodowej kwasu N-[4-[2-(2-amino-4,7-dihydro-4-okso-3H-pirolo [2,3-d]-pirymidyn-5-ylo) etylo] benzoilo]-L-glutaminowego i jej zastosowanie PL208061B1 (pl)

Applications Claiming Priority (2)

Application Number Priority Date Filing Date Title
US18496400P 2000-02-25 2000-02-25
PCT/US2001/001229 WO2001062760A2 (en) 2000-02-25 2001-02-12 A NOVEL CRYSTALLINE FORM OF N-[4-[2-(2-AMINO-4,7-DIHYDRO-4-OXO-3H-PYRROLO[2,3-d]PYRIMIDIN-5-YL)ETHYL]BENZOYL]-L-GLUTAMIC ACID AND PROCESS THEREFOR

Publications (2)

Publication Number Publication Date
PL356423A1 true PL356423A1 (pl) 2004-06-28
PL208061B1 PL208061B1 (pl) 2011-03-31

Family

ID=22679017

Family Applications (1)

Application Number Title Priority Date Filing Date
PL356423A PL208061B1 (pl) 2000-02-25 2001-02-12 Postać krystaliczna heptahydratu soli disodowej kwasu N-[4-[2-(2-amino-4,7-dihydro-4-okso-3H-pirolo [2,3-d]-pirymidyn-5-ylo) etylo] benzoilo]-L-glutaminowego i jej zastosowanie

Country Status (35)

Country Link
US (1) US7138521B2 (pl)
EP (1) EP1259513B1 (pl)
JP (1) JP4846158B2 (pl)
KR (1) KR100744917B1 (pl)
CN (1) CN1183135C (pl)
AR (1) AR029471A1 (pl)
AT (1) ATE249462T1 (pl)
AU (1) AU777047B2 (pl)
BR (1) BR0108604A (pl)
CA (1) CA2400155C (pl)
CO (1) CO5261585A1 (pl)
CZ (1) CZ303772B6 (pl)
DE (1) DE60100750T2 (pl)
DK (1) DK1259513T3 (pl)
DZ (1) DZ3283A1 (pl)
EA (1) EA004684B1 (pl)
EG (1) EG24073A (pl)
ES (1) ES2206403T3 (pl)
HR (1) HRP20020701B1 (pl)
HU (1) HU229704B1 (pl)
IL (2) IL150480A0 (pl)
MX (1) MXPA02008242A (pl)
MY (1) MY124784A (pl)
NO (1) NO323422B1 (pl)
NZ (1) NZ519796A (pl)
PE (1) PE20011082A1 (pl)
PL (1) PL208061B1 (pl)
PT (1) PT1259513E (pl)
SI (1) SI1259513T1 (pl)
SK (1) SK287375B6 (pl)
SV (1) SV2002000321A (pl)
TW (1) TWI237024B (pl)
UA (1) UA72791C2 (pl)
WO (1) WO2001062760A2 (pl)
ZA (1) ZA200205265B (pl)

Families Citing this family (39)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
CN100364993C (zh) * 2003-05-30 2008-01-30 江苏恒瑞医药股份有限公司 培美曲噻盐及其制备方法
CN100364994C (zh) * 2004-11-25 2008-01-30 重庆医药工业研究院有限责任公司 培美曲塞二钠的一种新晶型及其制备方法
WO2007056244A2 (en) * 2005-11-04 2007-05-18 Merck & Co., Inc. Methods of using saha and erlotinib for treating cancer
WO2007056135A1 (en) * 2005-11-04 2007-05-18 Merck & Co., Inc. Method of treating cancers with saha and pemetrexed
JP2008543973A (ja) 2006-08-14 2008-12-04 シコール インコーポレイティド ペメトレキセドの中間体の調製方法
EP1934226A2 (en) 2006-08-14 2008-06-25 Sicor, Inc. Highly pure pemetrexed diacid and processes for the preparation thereof
WO2008021411A2 (en) * 2006-08-14 2008-02-21 Sicor Inc. Processes for the preparation of lyophilized pharmaceutically acceptable salts of pemetrexed diacid
EP2270013A1 (en) * 2006-08-14 2011-01-05 Sicor, Inc. Crystalline form of pemetrexed diacid and process for the preparation thereof
JP2010509221A (ja) * 2006-11-03 2010-03-25 ユニバーシテイ・オブ・メリーランド，ボルテイモア 多発性骨髄腫を治療するためにｓａｈａおよびボルテゾミブを使用する方法
WO2008124485A2 (en) * 2007-04-03 2008-10-16 Dr. Reddy's Laboratories Ltd. Solid forms of pemetrexed
CN101417998B (zh) * 2007-10-24 2012-10-24 重庆医药工业研究院有限责任公司 一种培美曲塞盐的纯化方法
EP2072518A1 (en) 2007-12-23 2009-06-24 Sun Pharma Advanced Research Company Limited Stable Amorphous Form of Pemextred Disodium
EP2334685A4 (en) * 2008-09-08 2011-10-26 Reddys Lab Ltd Dr AMORPHOUS PEMETREXED DISODIUM
WO2010030598A2 (en) * 2008-09-11 2010-03-18 Dr. Reddy's Laboratories Limited Pharmaceutical formulations comprising pemetrexed
CN101684121B (zh) 2008-09-22 2013-04-03 重庆医药工业研究院有限责任公司 培美曲塞二酸的新晶型及其制备方法
CN102050825B (zh) * 2009-11-05 2014-12-17 上海创诺制药有限公司 制备培美曲塞二钠2.5水结晶的方法
EP2504341A1 (en) 2009-11-24 2012-10-03 Azad Pharmaceutical Ingredients AG A new crystalline form of pemetrexed disodium
CN102372719B (zh) * 2010-08-26 2013-10-30 齐鲁制药有限公司 培美曲塞二甲酯对甲苯磺酸盐晶型及其制备方法
KR101069128B1 (ko) * 2011-03-10 2011-09-30 건일제약 주식회사 페메트렉시드 또는 그의 염을 포함하는 항산화제-비함유 주사용 용액 형태의 약학적 제제의 제조방법
US9051322B2 (en) 2011-03-23 2015-06-09 Scinopharm Taiwan, Ltd. Process for the production of a pemetrexed salt
WO2012134392A1 (en) * 2011-03-25 2012-10-04 Scinopharm Taiwan Ltd Process for the production of a pemetrexed salt
ITRM20120398A1 (it) 2012-08-08 2014-02-09 Berlin Chemie Ag Procedimento di sintesi pemetrexed e suo sale di lisina.
CN102911176B (zh) * 2012-10-10 2015-07-22 德州德药制药有限公司 一种培美曲塞二钠的制备方法
WO2014060959A1 (en) * 2012-10-17 2014-04-24 Shilpa Medicare Limited Crystalline pemetrexed dipotassium process
WO2014122460A2 (en) 2013-02-06 2014-08-14 Cipla House Pemetrexed complexes and pharmaceutical compositions containing pemetrexed complexes
EP3308770A1 (en) 2013-04-12 2018-04-18 Actavis Group PTC EHF Pemetrexed formulation
KR101485243B1 (ko) 2013-05-08 2015-01-21 씨제이헬스케어 주식회사 안정화된 페메트렉시드 제제
JP6094388B2 (ja) * 2013-06-07 2017-03-15 ニプロ株式会社 ペメトレキセドを含む注射用組成物
WO2014198338A1 (en) 2013-06-14 2014-12-18 Synthon B.V. Stable pemetrexed arginine salt and compositions comprising it
US9688682B2 (en) 2013-07-16 2017-06-27 Dr. Reddy's Laboratories Limited Crystalline forms of pemetrexed tromethamine salts
JP6313317B2 (ja) 2013-10-03 2018-04-18 富士フイルム株式会社 注射液製剤及びその製造方法
NZ630292A (en) * 2013-11-25 2015-02-27 Shilpa Medicare Ltd Process for crystalline pemetrexed dipotassium salt
NZ630299A (en) 2014-06-30 2014-11-28 Shilpa Medicare Ltd Pemetrexed dipotassium formulations
CA2962383C (en) * 2014-10-30 2019-10-08 Scinopharm Taiwan, Ltd. Crystalline forms of pemetrexed diacid and manufacturing processes therefor
CN105566328B (zh) * 2014-11-06 2018-04-24 博瑞生物医药（苏州）股份有限公司 培美曲塞二酸多晶型的制备方法
PL3804686T3 (pl) * 2017-10-10 2023-12-11 Sun Pharmaceutical Industries Ltd Dożylna infuzyjna postać dawkowania dla pemetreksedu
CA3090483A1 (en) 2018-02-07 2019-08-15 L.E.A.F. Holdings Group Llc Gamma polyglutamated pemetrexed and uses thereof
WO2019157138A1 (en) 2018-02-07 2019-08-15 L.E.A.F. Holdings Group Llc Alpha polyglutamated pemetrexed and uses thereof
WO2025244944A1 (en) * 2024-05-20 2025-11-27 Opna Bio SA Crystal forms of an agent

Family Cites Families (7)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
NO169490C (no) * 1988-03-24 1992-07-01 Takeda Chemical Industries Ltd Analogifremgangsmaate for fremstilling av terapeutisk aktive pyrrolopyrimidinderivater
KR0162654B1 (ko) 1989-12-11 1998-11-16 알렌 제이. 시니스갤리 N-(피롤로[2,3-d]피리미딘-3-일아크릴)-글루타민산 유도체
US5416211A (en) 1992-09-25 1995-05-16 Eli Lilly And Company Process for preparing 5-substituted pyrrolo-[2,3-d]pyrimidines
WO1998008382A1 (en) * 1996-08-30 1998-03-05 Eli Lilly And Company Nonclassical pyrrolo[2,3-d]pyrimidine antifolates
ZA987550B (en) * 1997-09-26 2000-02-21 Lilly Co Eli Processes and intermediates useful to make antifolates.
CA2304656A1 (en) * 1997-09-26 1999-04-08 Eli Lilly And Company Processes and intermediates useful to make antifolates
EP1212325A2 (en) * 1999-08-23 2002-06-12 Eli Lilly And Company A novel crystalline form of disodium n-[4-[2-(2-amino-4,7-dihydro-4-oxo-3h-pyrrolo[2,3-d]-pyrimidin-5-yl)ethyl]benzoyl]-l-glutamic acid salt and processes therefor

Also Published As

Publication number Publication date
SI1259513T1 (en) 2003-12-31
US7138521B2 (en) 2006-11-21
HUP0204232A3 (en) 2006-01-30
IL150480A (en) 2007-12-03
CN1406238A (zh) 2003-03-26
AR029471A1 (es) 2003-07-02
EA200200905A1 (ru) 2003-02-27
MY124784A (en) 2006-07-31
KR100744917B1 (ko) 2007-08-01
HRP20020701A2 (en) 2003-12-31
SV2002000321A (es) 2002-07-16
EG24073A (en) 2008-05-11
WO2001062760A3 (en) 2001-12-06
SK11862002A3 (sk) 2003-01-09
HUP0204232A2 (hu) 2003-04-28
ES2206403T3 (es) 2004-05-16
JP4846158B2 (ja) 2011-12-28
DE60100750D1 (de) 2003-10-16
EP1259513B1 (en) 2003-09-10
CA2400155C (en) 2009-09-15
US20030216416A1 (en) 2003-11-20
PL208061B1 (pl) 2011-03-31
NO20023974D0 (no) 2002-08-21
EA004684B1 (ru) 2004-06-24
NO20023974L (no) 2002-08-21
HRP20020701B1 (en) 2011-02-28
HK1051856A1 (en) 2003-08-22
PE20011082A1 (es) 2001-10-22
JP2003530321A (ja) 2003-10-14
AU3445101A (en) 2001-09-03
NO323422B1 (no) 2007-04-30
DK1259513T3 (da) 2004-01-12
CO5261585A1 (es) 2003-03-31
NZ519796A (en) 2003-01-31
EP1259513A2 (en) 2002-11-27
CZ303772B6 (cs) 2013-05-02
PT1259513E (pt) 2004-02-27
UA72791C2 (uk) 2005-04-15
WO2001062760A2 (en) 2001-08-30
IL150480A0 (en) 2002-12-01
SK287375B6 (sk) 2010-08-09
CN1183135C (zh) 2005-01-05
CZ20022875A3 (cs) 2003-02-12
BR0108604A (pt) 2002-11-19
ATE249462T1 (de) 2003-09-15
CA2400155A1 (en) 2001-08-30
HU229704B1 (en) 2014-05-28
DZ3283A1 (fr) 2001-08-30
ZA200205265B (en) 2003-11-11
MXPA02008242A (es) 2002-11-29
DE60100750T2 (de) 2004-07-29
TWI237024B (en) 2005-08-01
KR20020075449A (ko) 2002-10-04
AU777047B2 (en) 2004-09-30

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