PL347885A1 - Azepinoindole derivatives, the production and use thereof - Google Patents
Azepinoindole derivatives, the production and use thereofInfo
- Publication number
- PL347885A1 PL347885A1 PL00347885A PL34788500A PL347885A1 PL 347885 A1 PL347885 A1 PL 347885A1 PL 00347885 A PL00347885 A PL 00347885A PL 34788500 A PL34788500 A PL 34788500A PL 347885 A1 PL347885 A1 PL 347885A1
- Authority
- PL
- Poland
- Prior art keywords
- production
- azepinoindole derivatives
- azepinoindole
- derivatives
- Prior art date
Links
Classifications
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D487/00—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, not provided for by groups C07D451/00 - C07D477/00
- C07D487/02—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, not provided for by groups C07D451/00 - C07D477/00 in which the condensed system contains two hetero rings
- C07D487/06—Peri-condensed systems
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P11/00—Drugs for disorders of the respiratory system
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P13/00—Drugs for disorders of the urinary system
- A61P13/12—Drugs for disorders of the urinary system of the kidneys
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P19/00—Drugs for skeletal disorders
- A61P19/02—Drugs for skeletal disorders for joint disorders, e.g. arthritis, arthrosis
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P25/00—Drugs for disorders of the nervous system
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P25/00—Drugs for disorders of the nervous system
- A61P25/08—Antiepileptics; Anticonvulsants
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P25/00—Drugs for disorders of the nervous system
- A61P25/08—Antiepileptics; Anticonvulsants
- A61P25/10—Antiepileptics; Anticonvulsants for petit-mal
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P25/00—Drugs for disorders of the nervous system
- A61P25/14—Drugs for disorders of the nervous system for treating abnormal movements, e.g. chorea, dyskinesia
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P25/00—Drugs for disorders of the nervous system
- A61P25/14—Drugs for disorders of the nervous system for treating abnormal movements, e.g. chorea, dyskinesia
- A61P25/16—Anti-Parkinson drugs
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P25/00—Drugs for disorders of the nervous system
- A61P25/28—Drugs for disorders of the nervous system for treating neurodegenerative disorders of the central nervous system, e.g. nootropic agents, cognition enhancers, drugs for treating Alzheimer's disease or other forms of dementia
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P29/00—Non-central analgesic, antipyretic or antiinflammatory agents, e.g. antirheumatic agents; Non-steroidal antiinflammatory drugs [NSAID]
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P3/00—Drugs for disorders of the metabolism
- A61P3/08—Drugs for disorders of the metabolism for glucose homeostasis
- A61P3/10—Drugs for disorders of the metabolism for glucose homeostasis for hyperglycaemia, e.g. antidiabetics
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P35/00—Antineoplastic agents
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P9/00—Drugs for disorders of the cardiovascular system
- A61P9/10—Drugs for disorders of the cardiovascular system for treating ischaemic or atherosclerotic diseases, e.g. antianginal drugs, coronary vasodilators, drugs for myocardial infarction, retinopathy, cerebrovascula insufficiency, renal arteriosclerosis
Landscapes
- Health & Medical Sciences (AREA)
- Chemical & Material Sciences (AREA)
- Organic Chemistry (AREA)
- Engineering & Computer Science (AREA)
- Bioinformatics & Cheminformatics (AREA)
- Veterinary Medicine (AREA)
- Animal Behavior & Ethology (AREA)
- Public Health (AREA)
- Chemical Kinetics & Catalysis (AREA)
- General Chemical & Material Sciences (AREA)
- Medicinal Chemistry (AREA)
- Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
- General Health & Medical Sciences (AREA)
- Pharmacology & Pharmacy (AREA)
- Life Sciences & Earth Sciences (AREA)
- Neurosurgery (AREA)
- Biomedical Technology (AREA)
- Neurology (AREA)
- Diabetes (AREA)
- Pain & Pain Management (AREA)
- Urology & Nephrology (AREA)
- Rheumatology (AREA)
- Psychology (AREA)
- Hospice & Palliative Care (AREA)
- Obesity (AREA)
- Heart & Thoracic Surgery (AREA)
- Vascular Medicine (AREA)
- Emergency Medicine (AREA)
- Endocrinology (AREA)
- Hematology (AREA)
- Psychiatry (AREA)
- Cardiology (AREA)
- Pulmonology (AREA)
- Immunology (AREA)
- Orthopedic Medicine & Surgery (AREA)
- Physical Education & Sports Medicine (AREA)
- Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
- Nitrogen Condensed Heterocyclic Rings (AREA)
Applications Claiming Priority (2)
Application Number | Priority Date | Filing Date | Title |
---|---|---|---|
DE19946289A DE19946289A1 (de) | 1999-09-28 | 1999-09-28 | Benzodiazepin-Derivate, deren Herstellung und Anwendung |
DE10039610A DE10039610A1 (de) | 2000-08-09 | 2000-08-09 | Azepinoindol-Derivate, deren Herstellung und Anwendung |
Publications (1)
Publication Number | Publication Date |
---|---|
PL347885A1 true PL347885A1 (en) | 2002-04-22 |
Family
ID=26006691
Family Applications (1)
Application Number | Title | Priority Date | Filing Date |
---|---|---|---|
PL00347885A PL347885A1 (en) | 1999-09-28 | 2000-09-15 | Azepinoindole derivatives, the production and use thereof |
Country Status (17)
Country | Link |
---|---|
EP (1) | EP1183259A2 (hu) |
JP (1) | JP2003510328A (hu) |
KR (1) | KR20010087401A (hu) |
CN (1) | CN1374961A (hu) |
AU (1) | AU1271201A (hu) |
BG (1) | BG105650A (hu) |
BR (1) | BR0007174A (hu) |
CA (1) | CA2352194A1 (hu) |
CZ (1) | CZ20012373A3 (hu) |
HK (1) | HK1048999A1 (hu) |
HU (1) | HUP0104917A3 (hu) |
IL (1) | IL143349A0 (hu) |
NO (1) | NO20012567L (hu) |
PL (1) | PL347885A1 (hu) |
SK (1) | SK8842001A3 (hu) |
TR (1) | TR200101499T1 (hu) |
WO (1) | WO2001023390A2 (hu) |
Families Citing this family (40)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
SI20691B (sl) | 1999-01-11 | 2008-10-31 | Agouron Pharma | Triciklični inhibitorji poli(ADP-riboza) polimeraz |
US7151102B2 (en) | 2000-10-30 | 2006-12-19 | Kudos Pharmaceuticals Limited | Phthalazinone derivatives |
WO2002044183A2 (en) * | 2000-12-01 | 2002-06-06 | Guilford Pharmaceuticals Inc. | Benzoazepine and benzodiazepine derivatives and their use as parp inhibitors |
US7026311B2 (en) * | 2002-01-10 | 2006-04-11 | Abbott Gmbh & Co., Kg | Dibenzodiazepine derivatives, their preparation and use |
US7196085B2 (en) | 2002-04-30 | 2007-03-27 | Kudos Pharmaceuticals Limited | Phthalazinone derivatives |
DE50310378D1 (de) | 2002-07-26 | 2008-10-02 | Basf Plant Science Gmbh | Neue selektionsverfahren |
US7449464B2 (en) | 2003-03-12 | 2008-11-11 | Kudos Pharmaceuticals Limited | Phthalazinone derivatives |
GB0305681D0 (en) | 2003-03-12 | 2003-04-16 | Kudos Pharm Ltd | Phthalazinone derivatives |
WO2005028467A1 (en) | 2003-09-15 | 2005-03-31 | Anadys Pharmaceuticals, Inc. | Antibacterial 3,5-diaminopiperidine-substitute aromatic and heteroaromatic compounds |
CN102107008B (zh) | 2003-12-01 | 2013-04-03 | 库多斯药物有限公司 | 用于治疗癌症的dna损伤修复抑制剂 |
US8013006B2 (en) | 2004-07-14 | 2011-09-06 | Ptc Therapeutics, Inc. | Methods for treating hepatitis C |
US7772271B2 (en) | 2004-07-14 | 2010-08-10 | Ptc Therapeutics, Inc. | Methods for treating hepatitis C |
US7781478B2 (en) | 2004-07-14 | 2010-08-24 | Ptc Therapeutics, Inc. | Methods for treating hepatitis C |
US7868037B2 (en) | 2004-07-14 | 2011-01-11 | Ptc Therapeutics, Inc. | Methods for treating hepatitis C |
MX2007000762A (es) | 2004-07-22 | 2007-04-02 | Ptc Therapeutics Inc | Tienopiridinas para tratamientode hepatitis c. |
EP2166100B1 (en) | 2005-03-08 | 2012-07-18 | BASF Plant Science GmbH | Expression enhancing intron sequences |
US7662824B2 (en) | 2005-03-18 | 2010-02-16 | Janssen Pharmaceutica Nv | Acylhydrazones as kinase modulators |
GB0521373D0 (en) | 2005-10-20 | 2005-11-30 | Kudos Pharm Ltd | Pthalazinone derivatives |
UY30639A1 (es) | 2006-10-17 | 2008-05-31 | Kudos Pharm Ltd | Derivados sustituidos de 2h-ftalazin-1-ona, sus formas cristalinas, proceso de preparacion y aplicaciones |
AU2008299721A1 (en) | 2007-09-14 | 2009-03-19 | Astrazeneca Ab | Phthalazinone derivatives |
UY31603A1 (es) | 2008-01-23 | 2009-08-31 | Derivados de ftalazinona | |
GB0804755D0 (en) * | 2008-03-14 | 2008-04-16 | Angeletti P Ist Richerche Bio | Therapeutic compounds |
HUE030800T2 (hu) | 2008-10-07 | 2017-05-29 | Astrazeneca Uk Ltd | 514 számú gyógyszerkészítmény |
WO2011058367A2 (en) | 2009-11-13 | 2011-05-19 | Astrazeneca Ab | Diagnostic test for predicting responsiveness to treatment with poly(adp-ribose) polymerase (parp) inhibitor |
CN102686726B (zh) | 2009-11-27 | 2015-12-16 | 巴斯夫植物科学有限公司 | 嵌合内切核酸酶及其用途 |
BR112012012444A2 (pt) | 2009-11-27 | 2015-09-22 | Basf Plant Science Co Gmbh | "endonuclease quimérica, polinucleotídeo isolado, cassete de expressão, vetor, organismo não humano, método para fornecer uma endonuclease quimérica, método para recombinação homóloga de polinucleotídeos, método para mutação alvejada de polinucleotídeosa e método para recombinação homóloga ou mutação alvejada" |
AU2010325549B2 (en) | 2009-11-27 | 2017-04-20 | Basf Plant Science Company Gmbh | Optimized endonucleases and uses thereof |
AU2011261375B2 (en) | 2010-06-04 | 2016-09-22 | Albany Molecular Research, Inc. | Glycine transporter-1 inhibitors, methods of making them, and uses thereof |
CN108138177B9 (zh) | 2015-07-23 | 2021-08-13 | 法国居里学院 | Dbait分子与PARP抑制剂的组合用于治疗癌症的用途 |
GB201519573D0 (en) | 2015-11-05 | 2015-12-23 | King S College London | Combination |
WO2018162439A1 (en) | 2017-03-08 | 2018-09-13 | Onxeo | New predictive biomarker for the sensitivity to a treatment of cancer with a dbait molecule |
AU2018260094A1 (en) | 2017-04-28 | 2019-11-07 | Akribes Biomedical Gmbh | A PARP inhibitor in combination with a glucocorticoid and/or ascorbic acid and/or a protein growth factor for the treatment of impaired wound healing |
WO2018218025A1 (en) * | 2017-05-24 | 2018-11-29 | The Trustees Of The University Of Pennsylvania | Radiolabeled and fluorescent parp inhibitors for imaging and radiotherapy |
US20200407720A1 (en) | 2018-03-13 | 2020-12-31 | Onxeo | A dbait molecule against acquired resistance in the treatment of cancer |
WO2020113094A1 (en) | 2018-11-30 | 2020-06-04 | Nuvation Bio Inc. | Pyrrole and pyrazole compounds and methods of use thereof |
BR112021015149A2 (pt) * | 2019-02-02 | 2021-09-28 | Chia Tai Tianqing Pharmaceutical Group Co., Ltd | Análogo de indolo heptamil oxima como inibidor de parp |
WO2021018298A1 (zh) * | 2019-08-01 | 2021-02-04 | 南京明德新药研发有限公司 | 作为parp抑制剂吲哚并七元酰肟化合物 |
GB201913030D0 (en) | 2019-09-10 | 2019-10-23 | Francis Crick Institute Ltd | Treatment of hr deficient cancer |
WO2021148581A1 (en) | 2020-01-22 | 2021-07-29 | Onxeo | Novel dbait molecule and its use |
US20230331739A1 (en) * | 2020-07-31 | 2023-10-19 | Chia Tai Tianqing Pharmaceutical Group Co., Ltd. | Indolo heptamyl oxime analog crystal as parp inhibitor and method for preparing same |
Family Cites Families (3)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
WO1999011644A1 (en) * | 1997-09-03 | 1999-03-11 | Guilford Pharmaceuticals Inc. | Di-n-heterocyclic compounds, methods, and compositions for inhibiting parp activity |
SI20691B (sl) * | 1999-01-11 | 2008-10-31 | Agouron Pharma | Triciklični inhibitorji poli(ADP-riboza) polimeraz |
ECSP003637A (es) * | 1999-08-31 | 2002-03-25 | Agouron Pharma | Inhibidores triciclicos de poli (adp-ribosa) polimerasas |
-
2000
- 2000-09-15 KR KR1020017006614A patent/KR20010087401A/ko not_active Application Discontinuation
- 2000-09-15 EP EP00974379A patent/EP1183259A2/de not_active Withdrawn
- 2000-09-15 BR BR0007174-9A patent/BR0007174A/pt not_active IP Right Cessation
- 2000-09-15 JP JP2001526542A patent/JP2003510328A/ja active Pending
- 2000-09-15 PL PL00347885A patent/PL347885A1/xx not_active Application Discontinuation
- 2000-09-15 TR TR2001/01499T patent/TR200101499T1/xx unknown
- 2000-09-15 SK SK884-2001A patent/SK8842001A3/sk unknown
- 2000-09-15 IL IL14334900A patent/IL143349A0/xx unknown
- 2000-09-15 CN CN00802408A patent/CN1374961A/zh active Pending
- 2000-09-15 CA CA002352194A patent/CA2352194A1/en not_active Abandoned
- 2000-09-15 WO PCT/EP2000/009024 patent/WO2001023390A2/de not_active Application Discontinuation
- 2000-09-15 HU HU0104917A patent/HUP0104917A3/hu unknown
- 2000-09-15 AU AU12712/01A patent/AU1271201A/en not_active Abandoned
- 2000-09-15 CZ CZ20012373A patent/CZ20012373A3/cs unknown
-
2001
- 2001-05-25 NO NO20012567A patent/NO20012567L/no not_active Application Discontinuation
- 2001-06-26 BG BG105650A patent/BG105650A/xx unknown
-
2003
- 2003-02-18 HK HK03101179.8A patent/HK1048999A1/zh unknown
Also Published As
Publication number | Publication date |
---|---|
BG105650A (en) | 2002-02-28 |
CN1374961A (zh) | 2002-10-16 |
NO20012567L (no) | 2001-06-25 |
BR0007174A (pt) | 2001-09-04 |
CA2352194A1 (en) | 2001-04-05 |
TR200101499T1 (tr) | 2002-09-23 |
WO2001023390A2 (de) | 2001-04-05 |
AU1271201A (en) | 2001-04-30 |
IL143349A0 (en) | 2002-04-21 |
NO20012567D0 (no) | 2001-05-25 |
JP2003510328A (ja) | 2003-03-18 |
CZ20012373A3 (cs) | 2002-05-15 |
HUP0104917A2 (hu) | 2002-04-29 |
SK8842001A3 (en) | 2002-01-07 |
HK1048999A1 (zh) | 2003-04-25 |
EP1183259A2 (de) | 2002-03-06 |
WO2001023390A3 (de) | 2001-12-27 |
KR20010087401A (ko) | 2001-09-15 |
HUP0104917A3 (en) | 2002-12-28 |
Similar Documents
Publication | Publication Date | Title |
---|---|---|
IL143349A0 (en) | Azepinoindole derivatives, the production and use thereof | |
ZA200104196B (en) | Azepinoindole derivatives, the production and use thereof. | |
IL148545A0 (en) | Substituted 2-thio-3,5-dicyano-4-aryl-6-aminopyridines and the use thereof | |
HK1047743A1 (en) | New use and novel n-azabicyclo-amide derivatives. | |
IL142917A0 (en) | Substituted 2-phenylbenzimidazoles, the production thereof and their use | |
IL138702A0 (en) | Substituted indolinones, the production thereof and their use as medicaments | |
IL149400A0 (en) | Indeno-, naphtho-, and benzocyclohepta-dihydrothiazole derivatives, the production thereof and their use as anorectic medicaments | |
SI1268522T1 (sl) | Novi antagonisti lhrh, njihova priprava in uporaba kot zdravila | |
HK1044946A1 (zh) | 依泊昔酮衍生物、其製備方法及藥物用途 | |
ZA200001746B (en) | 3-amino-3-arylpropan-1-ol derivatives, and their preparation and use. | |
EP1210084A4 (en) | PYRIDOMORPHINANS, THIENOMORPHINANS AND THEIR USE | |
FI104003B1 (fi) | Stabiloitu täyteaine, sen valmistus ja käyttö | |
AU2011501A (en) | Benzimidazoles, production thereof and the use thereof as antithrombotic | |
AU7563800A (en) | Marsh-mallow and the marsh-mallow production technique | |
HU0001397D0 (en) | 3-amino-3-arylpropan-1-ol derivatives, production and use thereof | |
HUP0103358A3 (en) | N-substituted azabicycloheptane derivatives, production and use thereof | |
IL157793A0 (en) | Caloporoside derivatives, methods for the production thereof and their use | |
HUP0203455A3 (en) | 2-arylquinoline derivatives, preparation and therautic use thereof | |
GB2350361B (en) | 3,4,5-tricyanophenyl derivatives | |
HRP20020971A2 (en) | 4,5-dihydro-thiazo-2-ylamine derivatives and their use as no-inhibitors | |
SI1127052T1 (en) | Substituted 2-phenylbenzimidazoles, the production thereof and their use | |
SI1230230T1 (en) | Indeno-dihydrothiazole derivatives, the production thereof and their use as anorectic medicaments | |
SI1372670T1 (en) | Caloporoside derivatives, methods for the production thereof and their use | |
HUP0103099A3 (en) | N-substituted azabicycloheptane derivatives, production and use thereof | |
SI1104419T1 (en) | N-substituted azabicycloheptane derivatives, production and use thereof |
Legal Events
Date | Code | Title | Description |
---|---|---|---|
REFS | Decisions on refusal to grant patents (taken after the publication of the particulars of the applications) |