PL3461890T3 - Całkowita fermentacja oligosacharydów - Google Patents

Całkowita fermentacja oligosacharydów

Info

Publication number
PL3461890T3
PL3461890T3 PL18204608.6T PL18204608T PL3461890T3 PL 3461890 T3 PL3461890 T3 PL 3461890T3 PL 18204608 T PL18204608 T PL 18204608T PL 3461890 T3 PL3461890 T3 PL 3461890T3
Authority
PL
Poland
Prior art keywords
oligosaccharides
total fermentation
fermentation
total
Prior art date
Application number
PL18204608.6T
Other languages
English (en)
Inventor
Stefan Jennewein
Original Assignee
Chr. Hansen HMO GmbH
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Chr. Hansen HMO GmbH filed Critical Chr. Hansen HMO GmbH
Publication of PL3461890T3 publication Critical patent/PL3461890T3/pl

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
    • C12N15/00—Mutation or genetic engineering; DNA or RNA concerning genetic engineering, vectors, e.g. plasmids, or their isolation, preparation or purification; Use of hosts therefor
    • C12N15/09—Recombinant DNA-technology
    • C12N15/63—Introduction of foreign genetic material using vectors; Vectors; Use of hosts therefor; Regulation of expression
    • C12N15/70—Vectors or expression systems specially adapted for E. coli
    • C—CHEMISTRY; METALLURGY
    • C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
    • C12N9/00—Enzymes; Proenzymes; Compositions thereof; Processes for preparing, activating, inhibiting, separating or purifying enzymes
    • C12N9/10—Transferases (2.)
    • C12N9/1048—Glycosyltransferases (2.4)
    • C12N9/1051—Hexosyltransferases (2.4.1)
    • C—CHEMISTRY; METALLURGY
    • C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12P—FERMENTATION OR ENZYME-USING PROCESSES TO SYNTHESISE A DESIRED CHEMICAL COMPOUND OR COMPOSITION OR TO SEPARATE OPTICAL ISOMERS FROM A RACEMIC MIXTURE
    • C12P19/00—Preparation of compounds containing saccharide radicals
    • C12P19/04—Polysaccharides, i.e. compounds containing more than five saccharide radicals attached to each other by glycosidic bonds
    • C—CHEMISTRY; METALLURGY
    • C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12P—FERMENTATION OR ENZYME-USING PROCESSES TO SYNTHESISE A DESIRED CHEMICAL COMPOUND OR COMPOSITION OR TO SEPARATE OPTICAL ISOMERS FROM A RACEMIC MIXTURE
    • C12P19/00—Preparation of compounds containing saccharide radicals
    • C12P19/18—Preparation of compounds containing saccharide radicals produced by the action of a glycosyl transferase, e.g. alpha-, beta- or gamma-cyclodextrins

Landscapes

  • Chemical & Material Sciences (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Organic Chemistry (AREA)
  • Engineering & Computer Science (AREA)
  • Health & Medical Sciences (AREA)
  • Genetics & Genomics (AREA)
  • Wood Science & Technology (AREA)
  • Zoology (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Biotechnology (AREA)
  • General Engineering & Computer Science (AREA)
  • Microbiology (AREA)
  • Biochemistry (AREA)
  • General Health & Medical Sciences (AREA)
  • Biomedical Technology (AREA)
  • General Chemical & Material Sciences (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Molecular Biology (AREA)
  • Medicinal Chemistry (AREA)
  • Physics & Mathematics (AREA)
  • Biophysics (AREA)
  • Plant Pathology (AREA)
  • Micro-Organisms Or Cultivation Processes Thereof (AREA)
  • Preparation Of Compounds By Using Micro-Organisms (AREA)
PL18204608.6T 2014-03-31 2014-03-31 Całkowita fermentacja oligosacharydów PL3461890T3 (pl)

Applications Claiming Priority (2)

Application Number Priority Date Filing Date Title
EP14162869.3A EP2927316B1 (en) 2014-03-31 2014-03-31 Total fermentation of oligosaccharides
EP18204608.6A EP3461890B1 (en) 2014-03-31 2014-03-31 Total fermentation of oligosaccharides

Publications (1)

Publication Number Publication Date
PL3461890T3 true PL3461890T3 (pl) 2026-01-12

Family

ID=50389365

Family Applications (2)

Application Number Title Priority Date Filing Date
PL18204608.6T PL3461890T3 (pl) 2014-03-31 2014-03-31 Całkowita fermentacja oligosacharydów
PL14162869T PL2927316T3 (pl) 2014-03-31 2014-03-31 Całkowita fermentacja oligosacharydów

Family Applications After (1)

Application Number Title Priority Date Filing Date
PL14162869T PL2927316T3 (pl) 2014-03-31 2014-03-31 Całkowita fermentacja oligosacharydów

Country Status (7)

Country Link
EP (2) EP3461890B1 (pl)
JP (1) JP6360908B2 (pl)
KR (1) KR102012070B1 (pl)
DK (1) DK2927316T3 (pl)
ES (2) ES2715010T3 (pl)
PL (2) PL3461890T3 (pl)
WO (1) WO2015150328A1 (pl)

Families Citing this family (69)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
EP2675899A4 (en) 2011-02-16 2014-09-10 Glycosyn LLC BIOSYNTHESIS OF HUMAN MILK OLIGOSACCHARIDES IN MANIPULATED BACTERIA
DK2896628T3 (en) 2014-01-20 2019-01-14 Jennewein Biotechnologie Gmbh Process for Effective Purification of Neutral Milk Oligosaccharides (HMOs) from Microbial Fermentation
US11046984B2 (en) * 2014-05-15 2021-06-29 Glycosyn LLC Alpha (1,2) fucosyltransferase syngenes for use in the production of fucosylated oligosaccharides
US11926858B2 (en) 2014-06-27 2024-03-12 Glycom A/S Oligosaccharide production
EP3161143B8 (en) 2014-06-27 2024-11-27 Glycom A/S Oligosaccharide production
EP3141610A1 (en) 2015-09-12 2017-03-15 Jennewein Biotechnologie GmbH Production of human milk oligosaccharides in microbial hosts with engineered import / export
US10829508B2 (en) 2015-12-18 2020-11-10 Glycom A/S Fermentative production of oligosaccharides
DE202017007248U1 (de) 2016-04-19 2020-04-23 Glycom A/S Abtrennung von Oligosacchariden aus der Fermentationsbrühe
KR101731263B1 (ko) 2016-04-25 2017-05-02 서울대학교 산학협력단 코리네박테리움 글루타미쿰을 이용한 2'-푸코실락토오스의 생산방법
ES2856749T3 (es) 2016-10-29 2021-09-28 Chr Hansen Hmo Gmbh Proceso para la producción de oligosacáridos fucosilados
CN108611344A (zh) * 2016-12-10 2018-10-02 中国科学院大连化学物理研究所 AtAGM2与AtAGM3编码基因及酶的制备与应用
JP2020503066A (ja) 2016-12-27 2020-01-30 インバイオス エン．フェー． シアル酸付加化合物のｉｎ ｖｉｖｏ合成
ES2928859T3 (es) * 2017-03-17 2022-11-23 Chr Hansen Hmo Gmbh Un método para inhibir la isomerización de un sacárido reductor tras el tratamiento térmico
KR102050522B1 (ko) * 2017-04-21 2020-01-08 서울대학교산학협력단 코리네박테리움 글루타미쿰을 이용한 3'-푸코실락토오스의 생산방법
WO2019003136A1 (en) 2017-06-30 2019-01-03 Glycom A/S SYNTHESIS OF OLIGOSACCHARIDES
US11597938B2 (en) 2017-06-30 2023-03-07 Zimitech, Inc. Engineered microorganisms for enhanced use of oligosaccharides
EP3425052A1 (en) * 2017-07-07 2019-01-09 Jennewein Biotechnologie GmbH Fucosyltransferases and their use in producing fucosylated oligosaccharides
US11505567B2 (en) 2017-07-12 2022-11-22 Glycom A/S Amorphous mixture comprising a neutral mono- or oligosaccharide and an acidic non-carbohydrate component
CN111133112B (zh) * 2017-07-26 2024-09-10 科汉森母乳低聚糖股份有限公司 唾液酸转移酶及其在生产唾液酸化低聚糖中的用途
EP3450443A1 (en) 2017-08-29 2019-03-06 Jennewein Biotechnologie GmbH Process for purifying sialylated oligosaccharides
EP3494807A1 (en) 2017-12-11 2019-06-12 Jennewein Biotechnologie GmbH Spray-dried sialyllactose
PL3494805T3 (pl) 2017-12-08 2025-10-06 Chr. Hansen HMO GmbH Suszone rozpyłowo tetrasacharydy
PL3494804T3 (pl) 2017-12-08 2025-10-06 Chr. Hansen HMO GmbH Suszona rozpyłowo 3-fukozylolaktoza
PL3494806T3 (pl) 2017-12-08 2025-10-06 Chr. Hansen HMO GmbH Suszona rozpyłowo lakto-n-fukopentaoza
CN111447844A (zh) 2017-12-08 2020-07-24 詹尼温生物技术有限责任公司 喷雾干燥的四糖
DK3524067T3 (da) 2018-02-08 2025-05-19 Chr Hansen Hmo Gmbh Spraytørret blanding af modermælksoligosaccharider
CN108410787A (zh) * 2018-03-13 2018-08-17 光明乳业股份有限公司 一种合成乳酰-n-新四糖的重组枯草芽孢杆菌及其构建方法与应用
WO2019209245A1 (en) * 2018-04-23 2019-10-31 Dupont Nutrition Biosciences Aps Increasing activity of 2' fucosyllactose transporters endogenous to microbial cells
EP3784791A1 (en) * 2018-04-23 2021-03-03 DuPont Nutrition Biosciences ApS Increasing export of 2' fucosyllactose from microbial cells through the expression of a heterologous nucleic acid
EP3569713A1 (en) * 2018-05-16 2019-11-20 Jennewein Biotechnologie GmbH Use of glycosidases in the production of oligosaccharides
CN109554385B (zh) * 2018-07-24 2022-04-12 石家庄葛兰德生物科技有限公司 一种基因工程菌制备2-岩藻糖基乳糖的方法
EP3620510B1 (en) 2018-09-06 2023-11-01 Chr. Hansen HMO GmbH Fermentative production of oligosaccharides by total fermentation utilizing a mixed feedstock
US12123041B2 (en) 2018-09-21 2024-10-22 Universiteit Gent Method for the production of amino sugar-containing products
BR112021010116A2 (pt) * 2018-12-04 2021-08-31 Glycom A/S Síntese do oligossacarídeo fucosilado lnfp-v
EP3702468A1 (en) * 2019-03-01 2020-09-02 Jennewein Biotechnologie GmbH Fermentative production of carbohydrates by microbial cells utilizing a mixed feedstock
CA3151145A1 (en) 2019-09-24 2021-04-01 David N. Cook Compositions and methods for treatment of inflammatory and immune diseases
CN110804577B (zh) * 2019-11-28 2021-05-28 江南大学 一种高效生产2’-岩藻糖基乳糖的重组菌的构建方法及其应用
CN110885364B (zh) * 2019-12-26 2021-02-02 江南大学 一种促进N-乙酰氨基葡萄糖生产的RamA转录因子突变体及其应用
US12428657B2 (en) * 2020-01-23 2025-09-30 Glycom A/S HMO production
JP2023511524A (ja) * 2020-01-23 2023-03-20 グリコム・アクティーゼルスカブ Ｈｍｏ産生
US12351806B2 (en) 2020-01-23 2025-07-08 Glycom A/S HMO production
US20230109937A1 (en) * 2020-01-23 2023-04-13 Glycom A/S New major facilitator superfamily (mfs) protein (fred) in hmo production
WO2021160830A1 (en) 2020-02-14 2021-08-19 Inbiose N.V. Glycominimized bacterial host cells
WO2021160827A2 (en) 2020-02-14 2021-08-19 Inbiose N.V. Production of glycosylated product in host cells
EP4179102A1 (en) 2020-07-13 2023-05-17 Glycom A/S Oligosaccharide production
CN116096912A (zh) * 2020-08-10 2023-05-09 因比奥斯公司 借由细胞生产中性未岩藻糖化寡糖的混合物
US20230313252A1 (en) * 2020-08-10 2023-10-05 Inbiose N.V. Cellular production of sialylated di and/or oligosaccharides
US20240139222A1 (en) 2020-08-14 2024-05-02 Prolacta Bioscience, Inc. Human milk oligosaccharide compositions for use with bacteriotherapies
JP2024502629A (ja) 2021-01-12 2024-01-22 プロラクタ バイオサイエンス，インコーポレイテッド シンバイオティック治療レジメン
JP2024505126A (ja) * 2021-01-22 2024-02-05 グリコム・アクティーゼルスカブ シアル酸付加ｈｍｏの産生における新規の主要ファシリテータースーパーファミリー（ｍｆｓ）タンパク質（ｆｒｅｄ）
EP4043571A1 (en) * 2021-02-11 2022-08-17 GALAB Laboratories GmbH Genetically modified corynebacterium for the production of fucosyllactose
EP4043572A1 (en) * 2021-02-11 2022-08-17 GALAB Laboratories GmbH Glycosyltransferase deficient corynebacterium for the production of fucosyllactose
DK181497B1 (en) * 2021-05-17 2024-03-12 Dsm Ip Assets Bv ENHANCING FORMATION OF THE HMOS LNT AND/OR LNnT BY MODIFYING LACTOSE IMPORT IN THE CELL
DK181242B1 (en) 2021-05-17 2023-05-30 Dsm Ip Assets Bv GENETICALLY ENGINEERED CELLS COMPRISING A RECOMBINANT NUCLEIC ACID SEQUNCE ENCODING AN α-1,2-FUCOSYLTRANSFERASE CAPABLE OF PRODUCING LNFP-I, NUCLEIC ACID SEQUENCES ENCODING SAME AND METHODS FOR USE OF SAME
CN113684164B (zh) 2021-08-06 2023-08-25 江南大学 一种高产乳酰-n-新四糖的微生物的构建方法及应用
KR102477273B1 (ko) * 2021-11-24 2022-12-16 (주)에이피테크놀로지 효소 처리를 통한 2'-푸코실락토오스의 생산성 증대 방법
EP4555077A1 (en) 2022-07-15 2025-05-21 DSM IP Assets B.V. New fucosyltransferases for in vivo synthesis of complex fucosylated human milk oligosaccharides
CN115058369B (zh) * 2022-07-20 2024-02-20 威海迪普森生物科技有限公司 一种胞外多糖来源岩藻寡糖发酵型合生元的制备方法
EP4577061A1 (en) 2022-08-25 2025-07-02 DSM IP Assets B.V. Hybrid method for producing complex hmos
WO2024046993A1 (en) 2022-08-29 2024-03-07 Chr. Hansen A/S Process for the production of a purified human milk oligosaccharide derived from a microbial fermentation process
CN120265786A (zh) 2022-11-25 2025-07-04 帝斯曼知识产权资产管理有限公司 用于生产寡糖的双菌株系统
DK202201117A1 (en) * 2022-12-09 2024-08-08 Dsm Ip Assets Bv Genetically modified udp-n-acetylgalactosamine producing cells
WO2024130119A2 (en) 2022-12-16 2024-06-20 Prolacta Bioscience, Inc. Synbiotic compositions for short chain fatty acid production
DK202201202A1 (en) 2022-12-22 2024-08-21 Dsm Ip Assets Bv New fucosyltransferases for in vivo synthesis of complex fucosylated human milk oligosaccharides mixtures comprising lndfh-iii
EP4669756A1 (en) 2023-02-24 2025-12-31 DSM IP Assets B.V. SPECIFIC PRODUCT CARRIER FOR THE IN VIVO SYNTHESIS OF HUMAN MILK OLIGOSACCHARIDES
DK181822B1 (en) 2023-06-07 2025-01-30 Dsm Ip Assets Bv Genetically engineered strains with reduced byproduct formation and methods and uses of same
WO2025012169A1 (en) * 2023-07-07 2025-01-16 Inbiose N.V. A simple method for animal free lactose synthesis
DK182227B1 (en) 2023-10-17 2025-12-18 Dsm Ip Assets Bv Genetically engineered cells comprising new fucosyltransferases for in vivo synthesis of complex fucosylated human milk oligosaccharides mixtures comprising lnfp-vi, methods using the same, and uses of new fucosyltransferases thereof.
WO2025190861A1 (en) 2024-03-11 2025-09-18 Dsm Ip Assets B.V. Fucosyltransferase mutants with low dfl formation

Family Cites Families (10)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US6699705B2 (en) * 1999-02-01 2004-03-02 National Research Council Of Canada Campylobacter glycosyltransferases for biosynthesis of gangliosides and ganglioside mimics
FR2796082B1 (fr) * 1999-07-07 2003-06-27 Centre Nat Rech Scient Procede de production d'oligosaccharides
WO2006034225A2 (en) 2004-09-17 2006-03-30 Neose Technologies, Inc. Production of oligosaccharides by microorganisms
KR101083136B1 (ko) * 2009-02-13 2011-11-11 씨제이제일제당 (주) Ｌ-아미노산 생산용 미생물 및 이를 이용하여 ｌ-아미노산을 생산하는 방법
SG176651A1 (en) * 2009-06-08 2012-01-30 Jennewein Biotechnologie Gmbh Hmo synthesis
JP5998130B2 (ja) * 2010-07-12 2016-09-28 ユニヴェルシテイト ヘントＵｎｉｖｅｒｓｉｔｅｉｔ Ｇｅｎｔ 付加価値バイオ生成物の生成のための代謝操作された生物
EP2439264B1 (en) 2010-10-11 2015-06-03 Jennewein Biotechnologie GmbH Novel fucosyltransferases and their applications
EP2479263B1 (en) 2011-01-20 2013-11-27 Jennewein Biotechnologie GmbH Novel Fucosyltransferases and their applications
EP2675899A4 (en) * 2011-02-16 2014-09-10 Glycosyn LLC BIOSYNTHESIS OF HUMAN MILK OLIGOSACCHARIDES IN MANIPULATED BACTERIA
WO2013182206A1 (en) * 2012-06-08 2013-12-12 Glycom A/S Method for producing oligosaccharides and oligosaccharide glycosides by fermentation

Also Published As

Publication number Publication date
ES3053098T3 (en) 2026-01-19
KR20170003546A (ko) 2017-01-09
WO2015150328A1 (en) 2015-10-08
PL2927316T3 (pl) 2019-05-31
EP3461890C0 (en) 2025-09-24
KR102012070B1 (ko) 2019-08-19
JP2017509346A (ja) 2017-04-06
ES2715010T3 (es) 2019-05-31
EP2927316A1 (en) 2015-10-07
EP3461890A1 (en) 2019-04-03
JP6360908B2 (ja) 2018-07-18
EP3461890B1 (en) 2025-09-24
EP2927316B1 (en) 2018-11-07
DK2927316T3 (en) 2019-03-04

Similar Documents

Publication Publication Date Title
PL3461890T3 (pl) Całkowita fermentacja oligosacharydów
IL252114A0 (en) A bioreactor using macroalgae
GB2535388B (en) System of living
EP3140722A4 (en) Characterizing states of subject
GB201507834D0 (en) Culture medium
GB201421094D0 (en) Culture medium
EP3092008A4 (en) Skin probiotic
HUE055536T2 (hu) Átvezetés
EP3124591A4 (en) Culture vessel
PT3136841T (pt) Sistemas de fermentação
PL2940242T3 (pl) Złącze przepustowe blokujące ciśnienie
GB201408039D0 (en) Culture dish
EP3235357C0 (en) EXECUTION
PL3209764T3 (pl) Układ bioreaktora
EP3218468A4 (en) Petri dish
SG11201610514SA (en) Bioreactor and uses thereof
SG11201702844VA (en) Photobioreactor
ZA201802390B (en) Improved fermenter
GB201514420D0 (en) Bioreactor
GB201520827D0 (en) Bioreactor
IL249130A0 (en) Preparation of piperidine-4-carbthioamide
ZA201404072B (en) Transducer
GB201413535D0 (en) Culture
GB201404718D0 (en) Modified enzymes
GB201518810D0 (en) Bioreactor