PL331465A1 - Novel compounds and agents for treating diseases associated with triptase activity - Google Patents
Novel compounds and agents for treating diseases associated with triptase activityInfo
- Publication number
- PL331465A1 PL331465A1 PL97331465A PL33146597A PL331465A1 PL 331465 A1 PL331465 A1 PL 331465A1 PL 97331465 A PL97331465 A PL 97331465A PL 33146597 A PL33146597 A PL 33146597A PL 331465 A1 PL331465 A1 PL 331465A1
- Authority
- PL
- Poland
- Prior art keywords
- triptase
- agents
- activity
- novel compounds
- diseases associated
- Prior art date
Links
Classifications
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D295/00—Heterocyclic compounds containing polymethylene-imine rings with at least five ring members, 3-azabicyclo [3.2.2] nonane, piperazine, morpholine or thiomorpholine rings, having only hydrogen atoms directly attached to the ring carbon atoms
- C07D295/16—Heterocyclic compounds containing polymethylene-imine rings with at least five ring members, 3-azabicyclo [3.2.2] nonane, piperazine, morpholine or thiomorpholine rings, having only hydrogen atoms directly attached to the ring carbon atoms acylated on ring nitrogen atoms
- C07D295/20—Heterocyclic compounds containing polymethylene-imine rings with at least five ring members, 3-azabicyclo [3.2.2] nonane, piperazine, morpholine or thiomorpholine rings, having only hydrogen atoms directly attached to the ring carbon atoms acylated on ring nitrogen atoms by radicals derived from carbonic acid, or sulfur or nitrogen analogues thereof
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D295/00—Heterocyclic compounds containing polymethylene-imine rings with at least five ring members, 3-azabicyclo [3.2.2] nonane, piperazine, morpholine or thiomorpholine rings, having only hydrogen atoms directly attached to the ring carbon atoms
- C07D295/16—Heterocyclic compounds containing polymethylene-imine rings with at least five ring members, 3-azabicyclo [3.2.2] nonane, piperazine, morpholine or thiomorpholine rings, having only hydrogen atoms directly attached to the ring carbon atoms acylated on ring nitrogen atoms
- C07D295/20—Heterocyclic compounds containing polymethylene-imine rings with at least five ring members, 3-azabicyclo [3.2.2] nonane, piperazine, morpholine or thiomorpholine rings, having only hydrogen atoms directly attached to the ring carbon atoms acylated on ring nitrogen atoms by radicals derived from carbonic acid, or sulfur or nitrogen analogues thereof
- C07D295/215—Radicals derived from nitrogen analogues of carbonic acid
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P11/00—Drugs for disorders of the respiratory system
- A61P11/06—Antiasthmatics
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P29/00—Non-central analgesic, antipyretic or antiinflammatory agents, e.g. antirheumatic agents; Non-steroidal antiinflammatory drugs [NSAID]
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P43/00—Drugs for specific purposes, not provided for in groups A61P1/00-A61P41/00
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D211/00—Heterocyclic compounds containing hydrogenated pyridine rings, not condensed with other rings
- C07D211/04—Heterocyclic compounds containing hydrogenated pyridine rings, not condensed with other rings with only hydrogen or carbon atoms directly attached to the ring nitrogen atom
- C07D211/06—Heterocyclic compounds containing hydrogenated pyridine rings, not condensed with other rings with only hydrogen or carbon atoms directly attached to the ring nitrogen atom having no double bonds between ring members or between ring members and non-ring members
- C07D211/08—Heterocyclic compounds containing hydrogenated pyridine rings, not condensed with other rings with only hydrogen or carbon atoms directly attached to the ring nitrogen atom having no double bonds between ring members or between ring members and non-ring members with hydrocarbon or substituted hydrocarbon radicals directly attached to ring carbon atoms
- C07D211/18—Heterocyclic compounds containing hydrogenated pyridine rings, not condensed with other rings with only hydrogen or carbon atoms directly attached to the ring nitrogen atom having no double bonds between ring members or between ring members and non-ring members with hydrocarbon or substituted hydrocarbon radicals directly attached to ring carbon atoms with substituted hydrocarbon radicals attached to ring carbon atoms
- C07D211/26—Heterocyclic compounds containing hydrogenated pyridine rings, not condensed with other rings with only hydrogen or carbon atoms directly attached to the ring nitrogen atom having no double bonds between ring members or between ring members and non-ring members with hydrocarbon or substituted hydrocarbon radicals directly attached to ring carbon atoms with substituted hydrocarbon radicals attached to ring carbon atoms with hydrocarbon radicals, substituted by nitrogen atoms
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D233/00—Heterocyclic compounds containing 1,3-diazole or hydrogenated 1,3-diazole rings, not condensed with other rings
- C07D233/04—Heterocyclic compounds containing 1,3-diazole or hydrogenated 1,3-diazole rings, not condensed with other rings having one double bond between ring members or between a ring member and a non-ring member
- C07D233/06—Heterocyclic compounds containing 1,3-diazole or hydrogenated 1,3-diazole rings, not condensed with other rings having one double bond between ring members or between a ring member and a non-ring member with only hydrogen atoms or radicals containing only hydrogen and carbon atoms, directly attached to ring carbon atoms
- C07D233/08—Heterocyclic compounds containing 1,3-diazole or hydrogenated 1,3-diazole rings, not condensed with other rings having one double bond between ring members or between a ring member and a non-ring member with only hydrogen atoms or radicals containing only hydrogen and carbon atoms, directly attached to ring carbon atoms with alkyl radicals, containing more than four carbon atoms, directly attached to ring carbon atoms
- C07D233/12—Heterocyclic compounds containing 1,3-diazole or hydrogenated 1,3-diazole rings, not condensed with other rings having one double bond between ring members or between a ring member and a non-ring member with only hydrogen atoms or radicals containing only hydrogen and carbon atoms, directly attached to ring carbon atoms with alkyl radicals, containing more than four carbon atoms, directly attached to ring carbon atoms with substituted hydrocarbon radicals attached to ring nitrogen atoms
- C07D233/14—Radicals substituted by oxygen atoms
Landscapes
- Chemical & Material Sciences (AREA)
- Organic Chemistry (AREA)
- Health & Medical Sciences (AREA)
- Life Sciences & Earth Sciences (AREA)
- Public Health (AREA)
- General Chemical & Material Sciences (AREA)
- Medicinal Chemistry (AREA)
- Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
- Chemical Kinetics & Catalysis (AREA)
- Pharmacology & Pharmacy (AREA)
- Veterinary Medicine (AREA)
- Animal Behavior & Ethology (AREA)
- General Health & Medical Sciences (AREA)
- Bioinformatics & Cheminformatics (AREA)
- Engineering & Computer Science (AREA)
- Pulmonology (AREA)
- Pain & Pain Management (AREA)
- Rheumatology (AREA)
- Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
- Plural Heterocyclic Compounds (AREA)
- Heterocyclic Carbon Compounds Containing A Hetero Ring Having Nitrogen And Oxygen As The Only Ring Hetero Atoms (AREA)
- Acyclic And Carbocyclic Compounds In Medicinal Compositions (AREA)
Applications Claiming Priority (2)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| US2313996P | 1996-07-30 | 1996-07-30 | |
| US89577297A | 1997-07-17 | 1997-07-17 |
Publications (1)
| Publication Number | Publication Date |
|---|---|
| PL331465A1 true PL331465A1 (en) | 1999-07-19 |
Family
ID=26696778
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| PL97331465A PL331465A1 (en) | 1996-07-30 | 1997-07-30 | Novel compounds and agents for treating diseases associated with triptase activity |
Country Status (17)
| Country | Link |
|---|---|
| EP (1) | EP0934293A1 (sk) |
| JP (1) | JP2001509787A (sk) |
| KR (1) | KR20000029679A (sk) |
| CN (1) | CN1073103C (sk) |
| AU (1) | AU733621B2 (sk) |
| CA (1) | CA2262542A1 (sk) |
| CZ (1) | CZ29799A3 (sk) |
| EE (1) | EE9900036A (sk) |
| FI (1) | FI990171A (sk) |
| HU (1) | HUP0003267A3 (sk) |
| LV (1) | LV12291B (sk) |
| NO (1) | NO990433L (sk) |
| NZ (1) | NZ333713A (sk) |
| PL (1) | PL331465A1 (sk) |
| SI (1) | SI9720047A (sk) |
| SK (1) | SK8599A3 (sk) |
| WO (1) | WO1998004537A1 (sk) |
Families Citing this family (25)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| US6221914B1 (en) | 1997-11-10 | 2001-04-24 | Array Biopharma Inc. | Sulfonamide bridging compounds that inhibit tryptase activity |
| AU2723099A (en) * | 1998-02-06 | 1999-08-23 | Byk Gulden Lomberg Chemische Fabrik Gmbh | Tryptase inhibitors |
| PT1060175E (pt) * | 1998-02-06 | 2005-03-31 | Max Planck Ges Ford Wissenscha | Inibidores de triptase |
| IL141654A0 (en) * | 1998-09-04 | 2002-03-10 | Byk Gulden Lomberg Chem Fab | Pyranose derivatives and pharmaceutical compositions containing the same |
| KR20020016942A (ko) | 1999-08-10 | 2002-03-06 | 빅 굴덴 롬베르크 케미쉐 파브릭 게엠베하 | 디아조신-디온 유도체 및 이것의 트립타제 억제제로서 용도 |
| EP1216236A1 (en) * | 1999-09-14 | 2002-06-26 | Byk Gulden Lomberg Chemische Fabrik GmbH | Tryptase inhibitors |
| WO2001036386A1 (fr) * | 1999-11-17 | 2001-05-25 | Sumitomo Pharmaceuticals Co., Ltd. | Traitement du diabete contenant un derive de dipiperazine |
| DE19955476A1 (de) * | 1999-11-18 | 2001-05-23 | Boehringer Ingelheim Pharma | Bis-basische Verbindungen als Tryptase-Inhibitoren, Verfahren zu deren Herstellung sowie deren Verwendung als Arzneimittel |
| US6815557B2 (en) | 1999-12-20 | 2004-11-09 | Altana Pharma Ag | Tryptase inhibitors |
| AU783217B2 (en) * | 1999-12-20 | 2005-10-06 | Altana Pharma Ag | Tryptase inhibitors |
| PT1358182E (pt) * | 2001-01-31 | 2004-12-31 | Altana Pharma Ag | Derivados de diazocinas e sua utilizacao como inibidores de triptase |
| AU2002253035B8 (en) | 2001-02-21 | 2008-02-21 | Altana Pharma Ag | Tryptase inhibitors |
| DE60220504T2 (de) | 2001-02-21 | 2008-02-14 | Nycomed Gmbh | Tryptasehemmer |
| WO2002074732A2 (en) * | 2001-03-15 | 2002-09-26 | Altana Pharma Ag | Tryptase-inhibitors |
| US20040087792A1 (en) * | 2001-03-15 | 2004-05-06 | Thomas Martin | Tryptase-inhibitors |
| ES2296956T5 (es) | 2001-06-11 | 2011-07-12 | Xenoport, Inc. | Profármacos de análogos de gaba, composiciones y sus usos. |
| US6818787B2 (en) | 2001-06-11 | 2004-11-16 | Xenoport, Inc. | Prodrugs of GABA analogs, compositions and uses thereof |
| US7186855B2 (en) | 2001-06-11 | 2007-03-06 | Xenoport, Inc. | Prodrugs of GABA analogs, compositions and uses thereof |
| US8048917B2 (en) | 2005-04-06 | 2011-11-01 | Xenoport, Inc. | Prodrugs of GABA analogs, compositions and uses thereof |
| DE60216920T2 (de) | 2001-06-19 | 2007-11-15 | Nycomed Gmbh | Tryptase-inhibitoren |
| BRPI0517227B8 (pt) | 2004-11-04 | 2021-05-25 | Xenoport Inc | comprimido oral de liberação prolongada do ácido 1-{[alfa-isobutanoiloxietoxi)carbonil]amino metil}-1-cicloexano acético, e, uso do comprimido |
| TWI432188B (zh) | 2008-12-19 | 2014-04-01 | Merz Pharma Gmbh & Co Kgaa | 供治療發炎性皮膚疾病之１－胺基－烷基環己烷衍生物類 |
| KR101335118B1 (ko) | 2008-12-19 | 2013-12-05 | 메르츠 파마 게엠베하 운트 코. 카가아 | 비만 세포 매개 질환의 치료를 위한 １-아미노-알킬시클로헥산 유도체 |
| FR3038605B1 (fr) | 2015-07-06 | 2018-08-24 | Universite Amiens Picardie Jules Verne | Diamines primaires vicinales associees a des motifs chelateurs de metaux et/ou de radicaux libres, actives contre les stress carbonyle et oxydant et leur utilisation |
| JP7373191B2 (ja) * | 2017-05-12 | 2023-11-02 | 国立研究開発法人理化学研究所 | クラスａ ｇｐｃｒ結合性化合物改変体 |
Family Cites Families (7)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| US4845242A (en) * | 1987-04-28 | 1989-07-04 | Georgia Tech Research Corporation | Isocoumarins with basic substituents as serine proteases inhibitors, anticoagulants and anti-inflammatory agents |
| US5525623A (en) * | 1993-03-12 | 1996-06-11 | Arris Pharmaceutical Corporation | Compositions and methods for the treatment of immunomediated inflammatory disorders |
| KR100309616B1 (ko) * | 1993-03-12 | 2002-02-28 | 추후제출 | 면역중재된염증질환의치료를위한조성물및방법 |
| WO1995032945A1 (en) * | 1994-06-01 | 1995-12-07 | Arris Pharmaceutical Corporation | Compositions and methods for treating mast-cell mediated conditions |
| HUT77770A (hu) * | 1994-09-23 | 1998-08-28 | Axys Pharmaceuticals, Inc. | Készítmény és eljárás hízósejtek által közvetített gyulladásos állapotok kezelésére |
| PL322409A1 (en) * | 1995-03-24 | 1998-01-19 | Arris Pharm Corp | Reversible protease inhibitors |
| TW438591B (en) * | 1995-06-07 | 2001-06-07 | Arris Pharm Corp | Reversible cysteine protease inhibitors |
-
1997
- 1997-07-30 NZ NZ333713A patent/NZ333713A/xx unknown
- 1997-07-30 CN CN97196877A patent/CN1073103C/zh not_active Expired - Fee Related
- 1997-07-30 WO PCT/US1997/013422 patent/WO1998004537A1/en not_active Application Discontinuation
- 1997-07-30 HU HU0003267A patent/HUP0003267A3/hu unknown
- 1997-07-30 SK SK85-99A patent/SK8599A3/sk unknown
- 1997-07-30 EP EP97937066A patent/EP0934293A1/en not_active Withdrawn
- 1997-07-30 AU AU39670/97A patent/AU733621B2/en not_active Ceased
- 1997-07-30 CA CA002262542A patent/CA2262542A1/en not_active Abandoned
- 1997-07-30 PL PL97331465A patent/PL331465A1/xx unknown
- 1997-07-30 EE EEP199900036A patent/EE9900036A/xx unknown
- 1997-07-30 CZ CZ99297A patent/CZ29799A3/cs unknown
- 1997-07-30 JP JP50913698A patent/JP2001509787A/ja active Pending
- 1997-07-30 KR KR1019997000757A patent/KR20000029679A/ko not_active Application Discontinuation
- 1997-07-30 SI SI9720047A patent/SI9720047A/sl unknown
-
1999
- 1999-01-29 FI FI990171A patent/FI990171A/fi unknown
- 1999-01-29 NO NO990433A patent/NO990433L/no not_active Application Discontinuation
- 1999-02-18 LV LVP-99-27A patent/LV12291B/en unknown
Also Published As
| Publication number | Publication date |
|---|---|
| NO990433L (no) | 1999-03-25 |
| CZ29799A3 (cs) | 1999-06-16 |
| LV12291A (lv) | 1999-06-20 |
| HUP0003267A3 (en) | 2002-02-28 |
| AU3967097A (en) | 1998-02-20 |
| KR20000029679A (ko) | 2000-05-25 |
| AU733621B2 (en) | 2001-05-17 |
| HUP0003267A2 (hu) | 2001-06-28 |
| FI990171A (fi) | 1999-03-23 |
| NO990433D0 (no) | 1999-01-29 |
| LV12291B (en) | 2000-04-20 |
| JP2001509787A (ja) | 2001-07-24 |
| EP0934293A1 (en) | 1999-08-11 |
| CN1226892A (zh) | 1999-08-25 |
| CA2262542A1 (en) | 1998-02-05 |
| WO1998004537A1 (en) | 1998-02-05 |
| FI990171A0 (fi) | 1999-01-29 |
| SI9720047A (sl) | 1999-08-31 |
| CN1073103C (zh) | 2001-10-17 |
| EE9900036A (et) | 1999-08-16 |
| SK8599A3 (en) | 2000-03-13 |
| NZ333713A (en) | 2000-12-22 |
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