PL3157552T3 - Polipeptydy syntac i ich zastosowania - Google Patents

Polipeptydy syntac i ich zastosowania

Info

Publication number
PL3157552T3
PL3157552T3 PL15809277T PL15809277T PL3157552T3 PL 3157552 T3 PL3157552 T3 PL 3157552T3 PL 15809277 T PL15809277 T PL 15809277T PL 15809277 T PL15809277 T PL 15809277T PL 3157552 T3 PL3157552 T3 PL 3157552T3
Authority
PL
Poland
Prior art keywords
syntac polypeptides
syntac
polypeptides
Prior art date
Application number
PL15809277T
Other languages
English (en)
Polish (pl)
Inventor
Ronald D. SEIDEL III
Rodolfo J. Chaparro
Brandan S. Hillerich
Scott J. Garforth
Steven C. Almo
Original Assignee
Albert Einstein College Of Medicine
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Albert Einstein College Of Medicine filed Critical Albert Einstein College Of Medicine
Publication of PL3157552T3 publication Critical patent/PL3157552T3/pl

Links

Classifications

    • CCHEMISTRY; METALLURGY
    • C07ORGANIC CHEMISTRY
    • C07KPEPTIDES
    • C07K14/00Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof
    • C07K14/435Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from animals; from humans
    • C07K14/705Receptors; Cell surface antigens; Cell surface determinants
    • C07K14/70503Immunoglobulin superfamily
    • C07K14/70539MHC-molecules, e.g. HLA-molecules
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61KPREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K48/00Medicinal preparations containing genetic material which is inserted into cells of the living body to treat genetic diseases; Gene therapy
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61PSPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P31/00Antiinfectives, i.e. antibiotics, antiseptics, chemotherapeutics
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61PSPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P31/00Antiinfectives, i.e. antibiotics, antiseptics, chemotherapeutics
    • A61P31/04Antibacterial agents
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61PSPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P31/00Antiinfectives, i.e. antibiotics, antiseptics, chemotherapeutics
    • A61P31/12Antivirals
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61PSPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P33/00Antiparasitic agents
    • A61P33/02Antiprotozoals, e.g. for leishmaniasis, trichomoniasis, toxoplasmosis
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61PSPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P35/00Antineoplastic agents
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61PSPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P37/00Drugs for immunological or allergic disorders
    • A61P37/02Immunomodulators
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61PSPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P37/00Drugs for immunological or allergic disorders
    • A61P37/02Immunomodulators
    • A61P37/04Immunostimulants
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61PSPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P37/00Drugs for immunological or allergic disorders
    • A61P37/02Immunomodulators
    • A61P37/06Immunosuppressants, e.g. drugs for graft rejection
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61PSPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P43/00Drugs for specific purposes, not provided for in groups A61P1/00-A61P41/00
    • CCHEMISTRY; METALLURGY
    • C07ORGANIC CHEMISTRY
    • C07KPEPTIDES
    • C07K2319/00Fusion polypeptide
    • CCHEMISTRY; METALLURGY
    • C07ORGANIC CHEMISTRY
    • C07KPEPTIDES
    • C07K2319/00Fusion polypeptide
    • C07K2319/30Non-immunoglobulin-derived peptide or protein having an immunoglobulin constant or Fc region, or a fragment thereof, attached thereto
    • CCHEMISTRY; METALLURGY
    • C07ORGANIC CHEMISTRY
    • C07KPEPTIDES
    • C07K2319/00Fusion polypeptide
    • C07K2319/40Fusion polypeptide containing a tag for immunodetection, or an epitope for immunisation

Landscapes

  • Health & Medical Sciences (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • General Health & Medical Sciences (AREA)
  • Medicinal Chemistry (AREA)
  • Immunology (AREA)
  • Veterinary Medicine (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Animal Behavior & Ethology (AREA)
  • Public Health (AREA)
  • General Chemical & Material Sciences (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Engineering & Computer Science (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Genetics & Genomics (AREA)
  • Molecular Biology (AREA)
  • Communicable Diseases (AREA)
  • Oncology (AREA)
  • Gastroenterology & Hepatology (AREA)
  • Biochemistry (AREA)
  • Biophysics (AREA)
  • Toxicology (AREA)
  • Cell Biology (AREA)
  • Proteomics, Peptides & Aminoacids (AREA)
  • Zoology (AREA)
  • Biotechnology (AREA)
  • Epidemiology (AREA)
  • Transplantation (AREA)
  • Virology (AREA)
  • Tropical Medicine & Parasitology (AREA)
  • Peptides Or Proteins (AREA)
  • Micro-Organisms Or Cultivation Processes Thereof (AREA)
  • Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)
  • Medicines Containing Material From Animals Or Micro-Organisms (AREA)
  • Medicines Containing Antibodies Or Antigens For Use As Internal Diagnostic Agents (AREA)
  • Preparation Of Compounds By Using Micro-Organisms (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
PL15809277T 2014-06-18 2015-06-15 Polipeptydy syntac i ich zastosowania PL3157552T3 (pl)

Applications Claiming Priority (3)

Application Number Priority Date Filing Date Title
US201462013715P 2014-06-18 2014-06-18
EP15809277.5A EP3157552B1 (en) 2014-06-18 2015-06-15 Syntac polypeptides and uses thereof
PCT/US2015/035777 WO2015195531A2 (en) 2014-06-18 2015-06-15 Syntac polypeptides and uses thereof

Publications (1)

Publication Number Publication Date
PL3157552T3 true PL3157552T3 (pl) 2020-05-18

Family

ID=54936224

Family Applications (2)

Application Number Title Priority Date Filing Date
PL15809277T PL3157552T3 (pl) 2014-06-18 2015-06-15 Polipeptydy syntac i ich zastosowania
PL18212801T PL3480213T3 (pl) 2014-06-18 2015-06-15 Polipeptydy syntac i ich zastosowania

Family Applications After (1)

Application Number Title Priority Date Filing Date
PL18212801T PL3480213T3 (pl) 2014-06-18 2015-06-15 Polipeptydy syntac i ich zastosowania

Country Status (15)

Country Link
US (5) US20170058015A1 (OSRAM)
EP (3) EP3480213B1 (OSRAM)
JP (4) JP6652932B2 (OSRAM)
KR (1) KR102252119B1 (OSRAM)
CN (3) CN106456733B (OSRAM)
AU (3) AU2015277460B2 (OSRAM)
DK (2) DK3157552T3 (OSRAM)
ES (2) ES2767259T3 (OSRAM)
HU (2) HUE047255T2 (OSRAM)
IL (3) IL248979B (OSRAM)
PL (2) PL3157552T3 (OSRAM)
PT (2) PT3480213T (OSRAM)
SG (2) SG11201609876TA (OSRAM)
TW (3) TWI795740B (OSRAM)
WO (1) WO2015195531A2 (OSRAM)

Families Citing this family (56)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
JP2016500255A (ja) 2012-12-11 2016-01-12 アルバート アインシュタイン カレッジ オブ メディシン オブ イエシバ ユニバーシティ ハイスループットなレセプター:リガンド同定の方法
US20190062400A1 (en) * 2016-03-02 2019-02-28 Cue Biopharma, Inc. T-cell modulatory multimeric polypeptides and methods of use thereof
JP7372036B2 (ja) * 2016-03-03 2023-10-31 キュー バイオファーマ, インコーポレイテッド T細胞調節多量体ポリペプチド及びその使用方法
AU2017268348A1 (en) * 2016-05-18 2018-10-25 Cue Biopharma, Inc. T-cell modulatory multimeric polypeptides and methods of use thereof
CA3022331A1 (en) * 2016-05-18 2017-11-23 Albert Einstein College Of Medicine, Inc. Variant pd-l1 polypeptides, t-cell modulatory multimeric polypeptides, and methods of use thereof
JP2019528689A (ja) * 2016-08-11 2019-10-17 ザ カウンシル オブ ザ クイーンズランド インスティテュート オブ メディカル リサーチ 免疫調節化合物
IL303806B2 (en) * 2016-12-22 2024-05-01 Cue Biopharma Inc Multimeric polypeptides modulate T cells and methods for their use
WO2018129474A1 (en) 2017-01-09 2018-07-12 Cue Biopharma, Inc. T-cell modulatory multimeric polypeptides and methods of use thereof
WO2018170168A1 (en) * 2017-03-15 2018-09-20 Cue Biopharma, Inc. Methods for modulating an immune response
WO2018187190A1 (en) * 2017-04-06 2018-10-11 Albert Einstein College Of Medicine, Inc. Precision activation of hiv-specific ctls to eliminate reactived latent t cells
GB2588249B (en) * 2017-06-12 2023-01-04 Sinai Health Sys Allograft tolerance without the need for systemic immune suppression
CN107266581B (zh) * 2017-06-13 2021-07-09 四川大学 藏猪il-12重组质粒增强pcv2疫苗免疫佐剂的制备方法及应用
UY37757A (es) * 2017-08-10 2018-11-30 Grifols Diagnostic Solutions Inc Composiciones, procedimientos y/o kits que comprenden un dominio extracelular de cd38 humano recombinante
KR20200064085A (ko) * 2017-09-07 2020-06-05 큐 바이오파마, 인크. 접합 부위를 갖는 t-세포 조절 다량체 폴리펩타이드 및 이의 사용 방법
TW201925235A (zh) * 2017-09-07 2019-07-01 美商信號生物製藥公司 具有化學結合位點之抗原呈現多肽及其使用方法
EA202090471A1 (ru) * 2017-09-07 2020-06-10 Кью Биофарма, Инк. Модулирующие т-клетки мультимерные полипептиды и способы их применения
KR20200064083A (ko) * 2017-09-07 2020-06-05 큐 바이오파마, 인크. 항원-제시 폴리펩티드 및 이의 사용 방법
JP6967578B2 (ja) * 2017-11-30 2021-11-17 グリフォルス ダイアグノステック ソリューションズ インコーポレーテッド 免疫チェックポイント阻害剤pd−1及びpd−l1に対する抗体治療をモニタリングするためのイムノアッセイ及び操作されたタンパク質
CN111886241A (zh) 2018-01-09 2020-11-03 库尔生物制药有限公司 多聚体t细胞调节多肽及其使用方法
LT3772927T (lt) 2018-03-24 2025-02-10 Regeneron Pharmaceuticals, Inc. Genetiškai modifikuotos pelės arba žiurkės, skirtos gaminti terapinius antikūnus prieš peptidų- mhc kompleksus, jų gamybos būdai ir panaudojimas
US20220047710A1 (en) * 2018-09-12 2022-02-17 Washington University Single chain constructs
US20220016181A1 (en) * 2018-12-13 2022-01-20 Sinai Health System Immunomodulatory cells and uses thereof
WO2020132368A1 (en) * 2018-12-19 2020-06-25 Cue Biopharma, Inc. T-cell modulatory multimeric polypeptides with conjugation sites and methods of use thereof
TWI856047B (zh) * 2018-12-19 2024-09-21 美商信號生物製藥公司 多聚體t細胞調節多肽及其使用方法
WO2020132138A1 (en) * 2018-12-19 2020-06-25 Cue Biopharma, Inc. Multimeric t-cell modulatory polypeptides and methods of use thereof
WO2020181062A1 (en) * 2019-03-06 2020-09-10 Cue Biopharma, Inc. T-cell modulatory multimeric polypeptides and methods of use thereof
JP7691927B2 (ja) * 2019-03-06 2025-06-12 キュー バイオファーマ, インコーポレイテッド T細胞調節抗原提示ポリペプチド及びその使用方法
MX2021014476A (es) * 2019-05-29 2022-02-11 Cue Biopharma Inc Polipeptidos multimericos moduladores de linfocitos t y metodos de uso de estos.
WO2020257191A1 (en) * 2019-06-19 2020-12-24 Cue Biopharma, Inc. Multimeric t-cell modulatory polypeptides and methods of use thereof
AU2020348373A1 (en) * 2019-09-20 2022-02-24 Cue Biopharma, Inc. T-cell modulatory polypeptides and methods of use thereof
EP4048689A4 (en) * 2019-10-23 2023-11-01 Cue Biopharma, Inc. T-CELL MODULATING CHIMERIC MOLECULES AND METHOD OF USE THEREOF
TW202136317A (zh) 2019-12-20 2021-10-01 美商再生元醫藥公司 新穎之il2促效劑及其使用方法(二)
WO2021168122A1 (en) * 2020-02-18 2021-08-26 Institute For Systems Biology Single chain trimer mhc class ii nucleic acids and proteins and methods of use
EP4106790A4 (en) * 2020-02-21 2024-02-21 3T Biosciences, Inc. YEAST DISPLAY LIBRARIES, RELATED COMPOSITIONS AND RELATED METHODS OF USE
WO2021178975A1 (en) * 2020-03-06 2021-09-10 Albert Einstein College Of Medicine A method to generate chimeric antigen receptor (car) t-cells (car-t cells) from pathogen-specific cytotoxic lymphocytes to enable the subsequent in vivo modulation of their functional activity
IL296209A (en) 2020-05-12 2022-11-01 Cue Biopharma Inc Multimeric t-cell modulatory polypeptides and methods of using them
CN115605494A (zh) * 2020-05-12 2023-01-13 株式会社Lg化学(Kr) 多聚体t细胞调节多肽及其使用方法
JP2023541366A (ja) 2020-09-09 2023-10-02 キュー バイオファーマ, インコーポレイテッド 1型真性糖尿病(t1d)を治療するためのmhcクラスii t細胞調節多量体ポリペプチド及びその使用方法
WO2022056015A1 (en) * 2020-09-09 2022-03-17 Cue Biopharma, Inc. Mhc class ii t-cell modulatory multimeric polypeptides and methods of use thereof
CN112779224A (zh) * 2021-01-27 2021-05-11 河南省华隆生物技术有限公司 一种表达细胞因子组合物的nk滋养层细胞及其制备方法和应用
CN112852744A (zh) * 2021-01-27 2021-05-28 河南省华隆生物技术有限公司 一种nk滋养层细胞及其制备方法和应用
CN112725273A (zh) * 2021-01-27 2021-04-30 河南省华隆生物技术有限公司 一种nk细胞及其制备方法和应用
CN112725284A (zh) * 2021-01-27 2021-04-30 河南省华隆生物技术有限公司 一种nk滋养层细胞及其应用
EP4308142A4 (en) * 2021-03-19 2025-04-16 Cue Biopharma, Inc. T-CELL MODULATORY POLYPEPTIDES AND METHODS OF USE THEREOF
US20240190941A1 (en) * 2021-04-07 2024-06-13 Repertoire Immune Medicines, Inc. Peptide-mhc-immunoglobulin multimers and methods of use thereof
US20240239869A1 (en) * 2021-05-07 2024-07-18 Institute For Systems Biology Single chain trimer mhc class i nucleic acids and proteins and methods of use
AU2022331241A1 (en) 2021-08-16 2024-03-28 Regeneron Pharmaceuticals, Inc. Novel il27 receptor agonists and methods of use thereof
US20240376464A1 (en) * 2021-08-20 2024-11-14 3T Biosciences, Inc. PEPTIDE-HLA-B*35 Libraries, Associated Compositions, and Associated Methods of Use
US20250059254A1 (en) * 2022-01-03 2025-02-20 Aarhus Universitet Proteinaceous compound for generating specific cytotoxic t-cell effect
US20250271443A1 (en) * 2022-04-21 2025-08-28 Institute For Systems Biology Soluble single-chain dimers from cleavable single chain trimers
EP4536836A1 (en) 2022-06-07 2025-04-16 Regeneron Pharmaceuticals, Inc. Pseudotyped viral particles for targeting tcr-expressing cells
CA3258639A1 (en) 2022-06-07 2023-12-14 Regeneron Pharmaceuticals, Inc. Multispecific molecules to modulate T lymphocyte activity, and their uses
WO2024059740A1 (en) * 2022-09-14 2024-03-21 Synthego Corporation Genetically modified polynucleotides and cells expressing modified mhc proteins and uses thereof
CN120936364A (zh) 2023-01-27 2025-11-11 瑞泽恩制药公司 修饰的弹状病毒糖蛋白及其用途
WO2024182540A2 (en) 2023-02-28 2024-09-06 Regeneron Pharmaceuticals, Inc. T cell activators and methods of use thereof
WO2025081106A2 (en) * 2023-10-12 2025-04-17 Vanderbilt University Nanobody vaccine compositions

Family Cites Families (29)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US4235871A (en) 1978-02-24 1980-11-25 Papahadjopoulos Demetrios P Method of encapsulating biologically active materials in lipid vesicles
US4501728A (en) 1983-01-06 1985-02-26 Technology Unlimited, Inc. Masking of liposomes from RES recognition
US4837028A (en) 1986-12-24 1989-06-06 Liposome Technology, Inc. Liposomes with enhanced circulation time
US5585362A (en) 1989-08-22 1996-12-17 The Regents Of The University Of Michigan Adenovirus vectors for gene therapy
DK0648271T3 (da) 1991-08-20 2003-07-21 Us Gov Health & Human Serv Adenovirusmedieret overførsel af gener til mave-/tarmkanal
US5252479A (en) 1991-11-08 1993-10-12 Research Corporation Technologies, Inc. Safe vector for gene therapy
FR2688514A1 (fr) 1992-03-16 1993-09-17 Centre Nat Rech Scient Adenovirus recombinants defectifs exprimant des cytokines et medicaments antitumoraux les contenant.
CA2145641C (en) 1992-12-03 2008-05-27 Richard J. Gregory Pseudo-adenovirus vectors
JP3532566B2 (ja) 1993-06-24 2004-05-31 エル. グラハム,フランク 遺伝子治療のためのアデノウイルスベクター
CN1263864C (zh) 1993-10-25 2006-07-12 坎吉公司 重组腺病毒载体及其使用方法
US5869270A (en) * 1996-01-31 1999-02-09 Sunol Molecular Corporation Single chain MHC complexes and uses thereof
US6211342B1 (en) * 1996-07-18 2001-04-03 Children's Hospital Medical Center Multivalent MHC complex peptide fusion protein complex for stimulating specific T cell function
US20050003431A1 (en) * 1996-08-16 2005-01-06 Wucherpfennig Kai W. Monovalent, multivalent, and multimeric MHC binding domain fusion proteins and conjugates, and uses therefor
US7078387B1 (en) 1998-12-28 2006-07-18 Arch Development Corp. Efficient and stable in vivo gene transfer to cardiomyocytes using recombinant adeno-associated virus vectors
US6287860B1 (en) 2000-01-20 2001-09-11 Isis Pharmaceuticals, Inc. Antisense inhibition of MEKK2 expression
ES2747357T3 (es) * 2001-03-14 2020-03-10 Dako Denmark As Construcciones de moléculas MHC y sus usos para el diagnóstico y terapia
DE102004014983A1 (de) * 2004-03-26 2005-10-20 Univ Stuttgart Rekombinante Polypeptide der Mitglieder der TNF Ligandenfamilie und deren Verwendung
US7670595B2 (en) * 2004-06-28 2010-03-02 Merck Patent Gmbh Fc-interferon-beta fusion proteins
US7855279B2 (en) 2005-09-27 2010-12-21 Amunix Operating, Inc. Unstructured recombinant polymers and uses thereof
SI2402754T2 (sl) 2006-03-06 2023-09-29 Amunix Operating Inc. Nestrukturirani rekombinantni polimeri in njihove uporabe
US8518697B2 (en) * 2006-04-04 2013-08-27 Washington University Single chain trimers and uses therefor
EP2155782A2 (en) * 2007-03-26 2010-02-24 Dako Denmark A/S Mhc peptide complexes and uses thereof in infectious diseases
WO2009023270A2 (en) 2007-08-15 2009-02-19 Amunix, Inc. Compositions and methods for modifying properties of biologically active polypeptides
WO2010037395A2 (en) * 2008-10-01 2010-04-08 Dako Denmark A/S Mhc multimers in cancer vaccines and immune monitoring
EP3178835B1 (en) 2009-02-03 2019-04-10 Amunix Pharmaceuticals, Inc. Extended recombinant polypeptides and compositions comprising same
US8956619B2 (en) * 2011-10-25 2015-02-17 University Of Maryland, Baltimore County Soluble CD80 as a therapeutic to reverse immune supression in cancer patients
HK1211949A1 (en) 2012-11-30 2016-06-03 罗切格利卡特公司 Removal of cancer cells by circulating virus-specific cytotoxic t-cells using cancer cell targeted mhc class i comprising multi-function proteins
KR20200064085A (ko) * 2017-09-07 2020-06-05 큐 바이오파마, 인크. 접합 부위를 갖는 t-세포 조절 다량체 폴리펩타이드 및 이의 사용 방법
CN111886241A (zh) * 2018-01-09 2020-11-03 库尔生物制药有限公司 多聚体t细胞调节多肽及其使用方法

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CN113248623A (zh) 2021-08-13
CA2947489A1 (en) 2015-12-23
KR102252119B1 (ko) 2021-05-17
PT3157552T (pt) 2020-01-22
CN106456733B (zh) 2021-03-16
AU2015277460B2 (en) 2020-10-08
AU2019203442B2 (en) 2021-04-08
AU2021204594B2 (en) 2024-05-09
US20210047384A1 (en) 2021-02-18
IL266570B (en) 2020-06-30
HUE048076T2 (hu) 2020-07-28
PL3480213T3 (pl) 2020-05-18
EP3157552B1 (en) 2019-10-23
ES2770330T3 (es) 2020-07-01
CN113248624A (zh) 2021-08-13
TW202124435A (zh) 2021-07-01
EP3483179B1 (en) 2020-09-16
JP2022046544A (ja) 2022-03-23
EP3483179A1 (en) 2019-05-15
JP2020022491A (ja) 2020-02-13
CN113248624B (zh) 2025-02-07
HUE047255T2 (hu) 2020-04-28
TW201946933A (zh) 2019-12-16
CN106456733A (zh) 2017-02-22
JP6652932B2 (ja) 2020-02-26
US20180282392A1 (en) 2018-10-04
BR112016027897A2 (pt) 2017-10-24
KR20170030484A (ko) 2017-03-17
IL275307B (en) 2022-03-01
US20200377569A1 (en) 2020-12-03
WO2015195531A2 (en) 2015-12-23
IL248979B (en) 2020-06-30
JP6995151B2 (ja) 2022-02-21
JP2020072733A (ja) 2020-05-14
TWI795740B (zh) 2023-03-11
US20170058015A1 (en) 2017-03-02
EP3157552A4 (en) 2017-11-22
TWI722576B (zh) 2021-03-21
JP7331075B2 (ja) 2023-08-22
EP3480213B1 (en) 2019-11-13
AU2019203442A1 (en) 2019-06-06
DK3157552T3 (da) 2020-01-13
AU2015277460A1 (en) 2016-11-24
EP3480213A1 (en) 2019-05-08
ES2767259T3 (es) 2020-06-17
SG10202006338UA (en) 2020-08-28
IL275307A (en) 2020-07-30
SG11201609876TA (en) 2017-01-27
US20210238254A1 (en) 2021-08-05
AU2021204594A1 (en) 2021-07-29
TW201613966A (en) 2016-04-16
EP3157552A2 (en) 2017-04-26
IL266570A (en) 2019-07-31
JP6652680B2 (ja) 2020-02-26
WO2015195531A3 (en) 2016-02-25
IL248979A0 (en) 2017-01-31
DK3480213T3 (da) 2020-02-17
TWI696633B (zh) 2020-06-21
PT3480213T (pt) 2020-02-04
JP2017519491A (ja) 2017-07-20

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