PL3009148T3 - Kompozycje oraz sposoby leczenia i diagnozowania nowotworu - Google Patents
Kompozycje oraz sposoby leczenia i diagnozowania nowotworuInfo
- Publication number
- PL3009148T3 PL3009148T3 PL15178099T PL15178099T PL3009148T3 PL 3009148 T3 PL3009148 T3 PL 3009148T3 PL 15178099 T PL15178099 T PL 15178099T PL 15178099 T PL15178099 T PL 15178099T PL 3009148 T3 PL3009148 T3 PL 3009148T3
- Authority
- PL
- Poland
- Prior art keywords
- compositions
- treating
- methods
- diagnosing cancer
- diagnosing
- Prior art date
Links
- 206010028980 Neoplasm Diseases 0.000 title 1
- 201000011510 cancer Diseases 0.000 title 1
- 239000000203 mixture Substances 0.000 title 1
Classifications
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K39/00—Medicinal preparations containing antigens or antibodies
- A61K39/395—Antibodies; Immunoglobulins; Immune serum, e.g. antilymphocytic serum
- A61K39/39533—Antibodies; Immunoglobulins; Immune serum, e.g. antilymphocytic serum against materials from animals
- A61K39/39558—Antibodies; Immunoglobulins; Immune serum, e.g. antilymphocytic serum against materials from animals against tumor tissues, cells, antigens
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K39/00—Medicinal preparations containing antigens or antibodies
- A61K39/395—Antibodies; Immunoglobulins; Immune serum, e.g. antilymphocytic serum
- A61K39/39533—Antibodies; Immunoglobulins; Immune serum, e.g. antilymphocytic serum against materials from animals
- A61K39/3955—Antibodies; Immunoglobulins; Immune serum, e.g. antilymphocytic serum against materials from animals against proteinaceous materials, e.g. enzymes, hormones, lymphokines
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K45/00—Medicinal preparations containing active ingredients not provided for in groups A61K31/00 - A61K41/00
- A61K45/06—Mixtures of active ingredients without chemical characterisation, e.g. antiphlogistics and cardiaca
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P35/00—Antineoplastic agents
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P43/00—Drugs for specific purposes, not provided for in groups A61P1/00-A61P41/00
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07K—PEPTIDES
- C07K14/00—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof
- C07K14/435—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from animals; from humans
- C07K14/705—Receptors; Cell surface antigens; Cell surface determinants
- C07K14/72—Receptors; Cell surface antigens; Cell surface determinants for hormones
- C07K14/723—G protein coupled receptor, e.g. TSHR-thyrotropin-receptor, LH/hCG receptor, FSH receptor
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07K—PEPTIDES
- C07K16/00—Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies
- C07K16/18—Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies against material from animals or humans
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07K—PEPTIDES
- C07K16/00—Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies
- C07K16/18—Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies against material from animals or humans
- C07K16/28—Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies against material from animals or humans against receptors, cell surface antigens or cell surface determinants
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07K—PEPTIDES
- C07K16/00—Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies
- C07K16/18—Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies against material from animals or humans
- C07K16/28—Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies against material from animals or humans against receptors, cell surface antigens or cell surface determinants
- C07K16/30—Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies against material from animals or humans against receptors, cell surface antigens or cell surface determinants from tumour cells
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K39/00—Medicinal preparations containing antigens or antibodies
- A61K2039/505—Medicinal preparations containing antigens or antibodies comprising antibodies
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07K—PEPTIDES
- C07K2317/00—Immunoglobulins specific features
- C07K2317/10—Immunoglobulins specific features characterized by their source of isolation or production
- C07K2317/14—Specific host cells or culture conditions, e.g. components, pH or temperature
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07K—PEPTIDES
- C07K2317/00—Immunoglobulins specific features
- C07K2317/20—Immunoglobulins specific features characterized by taxonomic origin
- C07K2317/21—Immunoglobulins specific features characterized by taxonomic origin from primates, e.g. man
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07K—PEPTIDES
- C07K2317/00—Immunoglobulins specific features
- C07K2317/20—Immunoglobulins specific features characterized by taxonomic origin
- C07K2317/24—Immunoglobulins specific features characterized by taxonomic origin containing regions, domains or residues from different species, e.g. chimeric, humanized or veneered
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07K—PEPTIDES
- C07K2317/00—Immunoglobulins specific features
- C07K2317/70—Immunoglobulins specific features characterized by effect upon binding to a cell or to an antigen
- C07K2317/76—Antagonist effect on antigen, e.g. neutralization or inhibition of binding
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07K—PEPTIDES
- C07K2319/00—Fusion polypeptide
- C07K2319/30—Non-immunoglobulin-derived peptide or protein having an immunoglobulin constant or Fc region, or a fragment thereof, attached thereto
Landscapes
- Health & Medical Sciences (AREA)
- Chemical & Material Sciences (AREA)
- Life Sciences & Earth Sciences (AREA)
- Organic Chemistry (AREA)
- Medicinal Chemistry (AREA)
- Immunology (AREA)
- General Health & Medical Sciences (AREA)
- Genetics & Genomics (AREA)
- Proteomics, Peptides & Aminoacids (AREA)
- Molecular Biology (AREA)
- Biochemistry (AREA)
- Biophysics (AREA)
- Veterinary Medicine (AREA)
- Pharmacology & Pharmacy (AREA)
- Public Health (AREA)
- Animal Behavior & Ethology (AREA)
- Engineering & Computer Science (AREA)
- Epidemiology (AREA)
- Bioinformatics & Cheminformatics (AREA)
- Cell Biology (AREA)
- Endocrinology (AREA)
- Microbiology (AREA)
- Mycology (AREA)
- Gastroenterology & Hepatology (AREA)
- Toxicology (AREA)
- Zoology (AREA)
- General Chemical & Material Sciences (AREA)
- Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
- Chemical Kinetics & Catalysis (AREA)
- Oncology (AREA)
- Biomedical Technology (AREA)
- Peptides Or Proteins (AREA)
- Medicines Containing Antibodies Or Antigens For Use As Internal Diagnostic Agents (AREA)
- Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)
- Preparation Of Compounds By Using Micro-Organisms (AREA)
- Micro-Organisms Or Cultivation Processes Thereof (AREA)
- Investigating Or Analysing Biological Materials (AREA)
- Measuring Or Testing Involving Enzymes Or Micro-Organisms (AREA)
- Medicines Containing Material From Animals Or Micro-Organisms (AREA)
Applications Claiming Priority (4)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| US94761107P | 2007-07-02 | 2007-07-02 | |
| EP15178099.6A EP3009148B1 (en) | 2007-07-02 | 2008-07-02 | Compositions and methods for treating and diagnosing cancer |
| EP08779934.2A EP2173379B2 (en) | 2007-07-02 | 2008-07-02 | Compositions and methods for treating and diagnosing cancer |
| PCT/US2008/008210 WO2009005809A2 (en) | 2007-07-02 | 2008-07-02 | Compositions and methods for treating and diagnosing cancer |
Publications (1)
| Publication Number | Publication Date |
|---|---|
| PL3009148T3 true PL3009148T3 (pl) | 2019-03-29 |
Family
ID=40226729
Family Applications (2)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| PL15178099T PL3009148T3 (pl) | 2007-07-02 | 2008-07-02 | Kompozycje oraz sposoby leczenia i diagnozowania nowotworu |
| PL08779934T PL2173379T3 (pl) | 2007-07-02 | 2008-07-02 | Kompozycje oraz sposoby leczenia i diagnozowania nowotworu |
Family Applications After (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| PL08779934T PL2173379T3 (pl) | 2007-07-02 | 2008-07-02 | Kompozycje oraz sposoby leczenia i diagnozowania nowotworu |
Country Status (14)
| Country | Link |
|---|---|
| US (10) | US8158757B2 (OSRAM) |
| EP (3) | EP2173379B2 (OSRAM) |
| JP (3) | JP5931336B2 (OSRAM) |
| AU (1) | AU2008270972B2 (OSRAM) |
| CA (1) | CA2691378A1 (OSRAM) |
| CY (1) | CY1116967T1 (OSRAM) |
| DK (1) | DK2173379T3 (OSRAM) |
| ES (2) | ES2694018T3 (OSRAM) |
| HR (1) | HRP20151261T1 (OSRAM) |
| HU (1) | HUE027154T2 (OSRAM) |
| PL (2) | PL3009148T3 (OSRAM) |
| PT (1) | PT2173379E (OSRAM) |
| SI (1) | SI2173379T1 (OSRAM) |
| WO (1) | WO2009005809A2 (OSRAM) |
Families Citing this family (56)
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| DK2157192T3 (da) | 2003-10-10 | 2013-11-25 | Deutsches Krebsforsch | Sammensætninger til diagnose og terapi af sygdomme forbundet med afvigende ekspression af futriner (R-spondiner) |
| CA2664828A1 (en) | 2006-10-20 | 2008-04-24 | Deutsches Krebsforschungszentrum Stiftung Des Offentlichen Rechts | Rspondins as modulators of angiogenesis and vasculogenesis |
| HRP20151261T1 (hr) | 2007-07-02 | 2016-01-01 | Oncomed Pharmaceuticals, Inc. | Sastavi i postupci za lijeäśenje i dijagnosticiranje raka |
| CN102112492B (zh) | 2007-11-14 | 2015-02-25 | 中外制药株式会社 | 使用抗gpr49抗体的癌症的诊断和治疗 |
| WO2010016766A2 (en) * | 2008-08-08 | 2010-02-11 | Koninklijke Nederlandse Akademie Van Wetenschappen | Antibodies recognizing endogenous human lgr5 and/or lgr6 |
| US8652843B2 (en) | 2008-08-12 | 2014-02-18 | Oncomed Pharmaceuticals, Inc. | DDR1-binding agents and methods of use thereof |
| WO2010033553A2 (en) * | 2008-09-16 | 2010-03-25 | University Of Florida Research Foundation Inc. | Gene expression related to preeclampsia |
| US9752124B2 (en) | 2009-02-03 | 2017-09-05 | Koninklijke Nederlandse Akademie Van Wetenschappen | Culture medium for epithelial stem cells and organoids comprising the stem cells |
| EP3061808B1 (en) | 2009-02-03 | 2020-08-12 | Koninklijke Nederlandse Akademie van Wetenschappen | Culture medium for epithelial stem cells and organoids comprising said stem cells |
| EP2412800A1 (en) | 2010-07-29 | 2012-02-01 | Koninklijke Nederlandse Akademie van Wetenschappen | Liver organoid, uses thereof and culture method for obtaining them |
| US8563307B2 (en) | 2009-02-24 | 2013-10-22 | James Wang | Treatment of immunosuppression-related disorders |
| WO2011056644A2 (en) * | 2009-10-28 | 2011-05-12 | Centocor Ortho Biotech Inc. | Anti-glp-1r antibodies and their uses |
| WO2011078301A1 (ja) | 2009-12-25 | 2011-06-30 | ファーマロジカルズ・リサーチ プライベート リミテッド | Nog樹立癌細胞株が移植された非ヒト動物モデルを用いた抗癌剤ターゲット探索及びスクリーニング法 |
| US8679474B2 (en) | 2010-08-04 | 2014-03-25 | StemBios Technologies, Inc. | Somatic stem cells |
| WO2012046797A1 (ja) | 2010-10-06 | 2012-04-12 | ファーマロジカルズ・リサーチ プライベート リミテッド | 癌幹細胞集団及びその作製方法 |
| GB201106395D0 (en) | 2011-04-14 | 2011-06-01 | Hubrecht Inst | Compounds |
| US9057096B2 (en) | 2011-05-20 | 2015-06-16 | Board Of Regents Of The University Of Texas System | Regulation of Wnt/beta-catenin signaling |
| BR112014000765A2 (pt) * | 2011-07-15 | 2017-06-13 | Oncomed Pharm Inc | agentes de ligação a rspo e seus usos |
| AU2013204484B2 (en) * | 2011-07-15 | 2016-05-12 | Oncomed Pharmaceuticals, Inc. | RSPO binding agents and uses thereof |
| EP2749641B1 (en) | 2011-09-07 | 2021-06-02 | Chugai Seiyaku Kabushiki Kaisha | Cancer stem cell isolation |
| TWI571513B (zh) | 2011-09-28 | 2017-02-21 | 幹細胞生物科技股份有限公司 | 體幹細胞及其製備方法 |
| EP3653222A1 (en) | 2011-10-14 | 2020-05-20 | Novartis AG | Antibodies and methods for wnt pathway-related diseases |
| JP6291254B2 (ja) | 2011-10-28 | 2018-03-14 | 中外製薬株式会社 | 癌幹細胞特異的分子 |
| US9220774B2 (en) | 2011-11-01 | 2015-12-29 | Bionomics Inc. | Methods of treating cancer by administering anti-GPR49 antibodies |
| AU2012332587B2 (en) * | 2011-11-01 | 2017-02-23 | Bionomics, Inc. | Antibodies and methods of treating cancer |
| AU2012332588B2 (en) * | 2011-11-01 | 2017-09-07 | Bionomics, Inc. | Methods of blocking cancer stem cell growth |
| WO2013067060A1 (en) * | 2011-11-01 | 2013-05-10 | Bionomics, Inc. | Anti-gpr49 antibodies |
| WO2013119923A1 (en) | 2012-02-09 | 2013-08-15 | The Regents Of The University Of Michigan | Different states of cancer stem cells |
| BR112014019741A2 (pt) | 2012-02-11 | 2020-12-22 | Genentech, Inc | Usos de um antagonista da via wnt, uso de uma terapia anticâncer, método de identificação de um indivíduo com câncer, métodos para prever, método de inibição da proliferação de uma célula de câncer, uso de um antagonista da translocação de r-spondina e antagonista da translocação de r-spondina isolado |
| AR090549A1 (es) | 2012-03-30 | 2014-11-19 | Genentech Inc | Anticuerpos anti-lgr5 e inmunoconjugados |
| MX2015000565A (es) * | 2012-07-13 | 2015-04-10 | Oncomed Pharm Inc | Agentes de union de proteina de r-espondina humana (rspo3) y usos de los mismos. |
| US20140017721A1 (en) * | 2012-07-13 | 2014-01-16 | The Research Foundation Of State University Of New York | Spontaneously immortalized prostate cancer cell line |
| JP6495174B2 (ja) | 2012-12-06 | 2019-04-03 | ステムバイオス テクノロジーズ,インコーポレイテッド | Lgr5+体性幹細胞 |
| EP2746770A1 (en) | 2012-12-21 | 2014-06-25 | Stembios Technologies, Inc. | Method for evaluating effect of action on subject based on stem celldynamics |
| CA2913924A1 (en) | 2013-05-30 | 2014-12-04 | Order-Made Medical Research Inc. | Reagent including anti-lgr6 antibodies for detection and diagnosis of cancer |
| HK1218124A1 (zh) | 2013-09-17 | 2017-02-03 | 豪夫迈.罗氏有限公司 | 使用抗lgr5抗体的方法 |
| WO2015108203A1 (ja) | 2014-01-15 | 2015-07-23 | 株式会社オーダーメードメディカルリサーチ | 抗slc6a6抗体を用いたがん治療用医薬組成物 |
| JP6967853B2 (ja) | 2014-02-28 | 2021-11-17 | メルス ナムローゼ フェンノートシャップ | ErbB−2およびErbB−3に結合する抗体 |
| WO2015130172A1 (en) | 2014-02-28 | 2015-09-03 | Merus B.V. | Antibodies that bind egfr and erbb3 |
| EP3126397B1 (en) | 2014-04-04 | 2020-01-29 | Bionomics, Inc. | Humanized antibodies that bind lgr5 |
| CN110436419A (zh) * | 2014-05-05 | 2019-11-12 | 塞尼斯有限责任公司 | 经纯化的过氧化氢气体发生方法和装置 |
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| JP2017528523A (ja) * | 2014-09-16 | 2017-09-28 | オンコメッド ファーマシューティカルズ インコーポレイテッド | 線維性疾患の治療 |
| WO2016057629A1 (en) * | 2014-10-07 | 2016-04-14 | Duke University | Methods and therapeutics relating to human r-spondin protein and leucine-rich repeat-containing g protein-coupled receptor protein |
| MA41123A (fr) * | 2014-12-02 | 2017-10-10 | Oncomed Pharm Inc | Polythérapie pour le traitement du cancer |
| WO2017040660A1 (en) * | 2015-08-31 | 2017-03-09 | Oncomed Pharmaceuticals, Inc. | Combination therapy for treatment of disease |
| SG11201803359VA (en) | 2015-10-23 | 2018-05-30 | Merus Nv | Binding molecules that inhibit cancer growth |
| CN105274061A (zh) * | 2015-10-26 | 2016-01-27 | 无锡傲锐东源生物科技有限公司 | 抗lgr5蛋白单克隆抗体杂交瘤细胞及其产生的抗lgr5单克隆抗体和应用 |
| AU2017239038B2 (en) * | 2016-03-22 | 2024-06-27 | Bionomics Inc | Administration of an anti-LGR5 monoclonal antibody |
| JP2019529418A (ja) | 2016-09-16 | 2019-10-17 | バイオノミックス リミテッド | 抗体およびチェックポイント阻害剤の併用療法 |
| MA46952A (fr) | 2016-12-01 | 2019-10-09 | Regeneron Pharma | Anticorps anti-pd-l1 radiomarqués pour imagerie immuno-pet |
| US11780925B2 (en) | 2017-03-31 | 2023-10-10 | Merus N.V. | ErbB-2 and ErbB3 binding bispecific antibodies for use in the treatment of cells that have an NRG1 fusion gene |
| BR112019024230A2 (pt) | 2017-05-17 | 2020-06-09 | Merus N.V. | combinação de um anticorpo bispecífico erbb-2 / erbb-3 com terapia endócrina para câncer de mama |
| SG11202001050PA (en) | 2017-08-09 | 2020-03-30 | Merus Nv | Antibodies that bind egfr and cmet |
| US20250346890A1 (en) * | 2019-12-19 | 2025-11-13 | Deutsches Krebsforschungszentrum | Leukemia treatment |
| US20230338466A1 (en) * | 2020-06-03 | 2023-10-26 | Children's Hospital Medical Center | Compositions and methods comprising r-spondins for treatment of tumors |
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