PL2858986T3 - Pochodne piperydyny jako agoniści GPR119 - Google Patents
Pochodne piperydyny jako agoniści GPR119Info
- Publication number
- PL2858986T3 PL2858986T3 PL13804551T PL13804551T PL2858986T3 PL 2858986 T3 PL2858986 T3 PL 2858986T3 PL 13804551 T PL13804551 T PL 13804551T PL 13804551 T PL13804551 T PL 13804551T PL 2858986 T3 PL2858986 T3 PL 2858986T3
- Authority
- PL
- Poland
- Prior art keywords
- piperidine derivatives
- gpr119 agonists
- gpr119
- agonists
- piperidine
- Prior art date
Links
Classifications
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D211/00—Heterocyclic compounds containing hydrogenated pyridine rings, not condensed with other rings
- C07D211/04—Heterocyclic compounds containing hydrogenated pyridine rings, not condensed with other rings with only hydrogen or carbon atoms directly attached to the ring nitrogen atom
- C07D211/06—Heterocyclic compounds containing hydrogenated pyridine rings, not condensed with other rings with only hydrogen or carbon atoms directly attached to the ring nitrogen atom having no double bonds between ring members or between ring members and non-ring members
- C07D211/08—Heterocyclic compounds containing hydrogenated pyridine rings, not condensed with other rings with only hydrogen or carbon atoms directly attached to the ring nitrogen atom having no double bonds between ring members or between ring members and non-ring members with hydrocarbon or substituted hydrocarbon radicals directly attached to ring carbon atoms
- C07D211/18—Heterocyclic compounds containing hydrogenated pyridine rings, not condensed with other rings with only hydrogen or carbon atoms directly attached to the ring nitrogen atom having no double bonds between ring members or between ring members and non-ring members with hydrocarbon or substituted hydrocarbon radicals directly attached to ring carbon atoms with substituted hydrocarbon radicals attached to ring carbon atoms
- C07D211/20—Heterocyclic compounds containing hydrogenated pyridine rings, not condensed with other rings with only hydrogen or carbon atoms directly attached to the ring nitrogen atom having no double bonds between ring members or between ring members and non-ring members with hydrocarbon or substituted hydrocarbon radicals directly attached to ring carbon atoms with substituted hydrocarbon radicals attached to ring carbon atoms with hydrocarbon radicals, substituted by singly bound oxygen or sulphur atoms
- C07D211/22—Heterocyclic compounds containing hydrogenated pyridine rings, not condensed with other rings with only hydrogen or carbon atoms directly attached to the ring nitrogen atom having no double bonds between ring members or between ring members and non-ring members with hydrocarbon or substituted hydrocarbon radicals directly attached to ring carbon atoms with substituted hydrocarbon radicals attached to ring carbon atoms with hydrocarbon radicals, substituted by singly bound oxygen or sulphur atoms by oxygen atoms
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K31/00—Medicinal preparations containing organic active ingredients
- A61K31/33—Heterocyclic compounds
- A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
- A61K31/435—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with one nitrogen as the only ring hetero atom
- A61K31/44—Non condensed pyridines; Hydrogenated derivatives thereof
- A61K31/445—Non condensed piperidines, e.g. piperocaine
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K31/00—Medicinal preparations containing organic active ingredients
- A61K31/33—Heterocyclic compounds
- A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
- A61K31/435—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with one nitrogen as the only ring hetero atom
- A61K31/44—Non condensed pyridines; Hydrogenated derivatives thereof
- A61K31/445—Non condensed piperidines, e.g. piperocaine
- A61K31/452—Piperidinium derivatives
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K31/00—Medicinal preparations containing organic active ingredients
- A61K31/33—Heterocyclic compounds
- A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
- A61K31/435—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with one nitrogen as the only ring hetero atom
- A61K31/44—Non condensed pyridines; Hydrogenated derivatives thereof
- A61K31/445—Non condensed piperidines, e.g. piperocaine
- A61K31/4523—Non condensed piperidines, e.g. piperocaine containing further heterocyclic ring systems
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K31/00—Medicinal preparations containing organic active ingredients
- A61K31/33—Heterocyclic compounds
- A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
- A61K31/435—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with one nitrogen as the only ring hetero atom
- A61K31/44—Non condensed pyridines; Hydrogenated derivatives thereof
- A61K31/445—Non condensed piperidines, e.g. piperocaine
- A61K31/4523—Non condensed piperidines, e.g. piperocaine containing further heterocyclic ring systems
- A61K31/454—Non condensed piperidines, e.g. piperocaine containing further heterocyclic ring systems containing a five-membered ring with nitrogen as a ring hetero atom, e.g. pimozide, domperidone
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K31/00—Medicinal preparations containing organic active ingredients
- A61K31/33—Heterocyclic compounds
- A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
- A61K31/435—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with one nitrogen as the only ring hetero atom
- A61K31/44—Non condensed pyridines; Hydrogenated derivatives thereof
- A61K31/445—Non condensed piperidines, e.g. piperocaine
- A61K31/4523—Non condensed piperidines, e.g. piperocaine containing further heterocyclic ring systems
- A61K31/4545—Non condensed piperidines, e.g. piperocaine containing further heterocyclic ring systems containing a six-membered ring with nitrogen as a ring hetero atom, e.g. pipamperone, anabasine
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K31/00—Medicinal preparations containing organic active ingredients
- A61K31/33—Heterocyclic compounds
- A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
- A61K31/495—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with two or more nitrogen atoms as the only ring heteroatoms, e.g. piperazine or tetrazines
- A61K31/4965—Non-condensed pyrazines
- A61K31/497—Non-condensed pyrazines containing further heterocyclic rings
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K31/00—Medicinal preparations containing organic active ingredients
- A61K31/33—Heterocyclic compounds
- A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
- A61K31/495—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with two or more nitrogen atoms as the only ring heteroatoms, e.g. piperazine or tetrazines
- A61K31/4985—Pyrazines or piperazines ortho- or peri-condensed with heterocyclic ring systems
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K31/00—Medicinal preparations containing organic active ingredients
- A61K31/33—Heterocyclic compounds
- A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
- A61K31/495—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with two or more nitrogen atoms as the only ring heteroatoms, e.g. piperazine or tetrazines
- A61K31/505—Pyrimidines; Hydrogenated pyrimidines, e.g. trimethoprim
- A61K31/506—Pyrimidines; Hydrogenated pyrimidines, e.g. trimethoprim not condensed and containing further heterocyclic rings
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P3/00—Drugs for disorders of the metabolism
- A61P3/08—Drugs for disorders of the metabolism for glucose homeostasis
- A61P3/10—Drugs for disorders of the metabolism for glucose homeostasis for hyperglycaemia, e.g. antidiabetics
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P43/00—Drugs for specific purposes, not provided for in groups A61P1/00-A61P41/00
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D211/00—Heterocyclic compounds containing hydrogenated pyridine rings, not condensed with other rings
- C07D211/04—Heterocyclic compounds containing hydrogenated pyridine rings, not condensed with other rings with only hydrogen or carbon atoms directly attached to the ring nitrogen atom
- C07D211/06—Heterocyclic compounds containing hydrogenated pyridine rings, not condensed with other rings with only hydrogen or carbon atoms directly attached to the ring nitrogen atom having no double bonds between ring members or between ring members and non-ring members
- C07D211/36—Heterocyclic compounds containing hydrogenated pyridine rings, not condensed with other rings with only hydrogen or carbon atoms directly attached to the ring nitrogen atom having no double bonds between ring members or between ring members and non-ring members with hetero atoms or with carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, e.g. ester or nitrile radicals, directly attached to ring carbon atoms
- C07D211/40—Oxygen atoms
- C07D211/42—Oxygen atoms attached in position 3 or 5
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D211/00—Heterocyclic compounds containing hydrogenated pyridine rings, not condensed with other rings
- C07D211/04—Heterocyclic compounds containing hydrogenated pyridine rings, not condensed with other rings with only hydrogen or carbon atoms directly attached to the ring nitrogen atom
- C07D211/06—Heterocyclic compounds containing hydrogenated pyridine rings, not condensed with other rings with only hydrogen or carbon atoms directly attached to the ring nitrogen atom having no double bonds between ring members or between ring members and non-ring members
- C07D211/36—Heterocyclic compounds containing hydrogenated pyridine rings, not condensed with other rings with only hydrogen or carbon atoms directly attached to the ring nitrogen atom having no double bonds between ring members or between ring members and non-ring members with hetero atoms or with carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, e.g. ester or nitrile radicals, directly attached to ring carbon atoms
- C07D211/60—Carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, e.g. ester or nitrile radicals
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D211/00—Heterocyclic compounds containing hydrogenated pyridine rings, not condensed with other rings
- C07D211/04—Heterocyclic compounds containing hydrogenated pyridine rings, not condensed with other rings with only hydrogen or carbon atoms directly attached to the ring nitrogen atom
- C07D211/06—Heterocyclic compounds containing hydrogenated pyridine rings, not condensed with other rings with only hydrogen or carbon atoms directly attached to the ring nitrogen atom having no double bonds between ring members or between ring members and non-ring members
- C07D211/36—Heterocyclic compounds containing hydrogenated pyridine rings, not condensed with other rings with only hydrogen or carbon atoms directly attached to the ring nitrogen atom having no double bonds between ring members or between ring members and non-ring members with hetero atoms or with carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, e.g. ester or nitrile radicals, directly attached to ring carbon atoms
- C07D211/60—Carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, e.g. ester or nitrile radicals
- C07D211/62—Carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, e.g. ester or nitrile radicals attached in position 4
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D401/00—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom
- C07D401/02—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom containing two hetero rings
- C07D401/12—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom containing two hetero rings linked by a chain containing hetero atoms as chain links
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D401/00—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom
- C07D401/14—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom containing three or more hetero rings
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D405/00—Heterocyclic compounds containing both one or more hetero rings having oxygen atoms as the only ring hetero atoms, and one or more rings having nitrogen as the only ring hetero atom
- C07D405/02—Heterocyclic compounds containing both one or more hetero rings having oxygen atoms as the only ring hetero atoms, and one or more rings having nitrogen as the only ring hetero atom containing two hetero rings
- C07D405/12—Heterocyclic compounds containing both one or more hetero rings having oxygen atoms as the only ring hetero atoms, and one or more rings having nitrogen as the only ring hetero atom containing two hetero rings linked by a chain containing hetero atoms as chain links
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D409/00—Heterocyclic compounds containing two or more hetero rings, at least one ring having sulfur atoms as the only ring hetero atoms
- C07D409/02—Heterocyclic compounds containing two or more hetero rings, at least one ring having sulfur atoms as the only ring hetero atoms containing two hetero rings
- C07D409/12—Heterocyclic compounds containing two or more hetero rings, at least one ring having sulfur atoms as the only ring hetero atoms containing two hetero rings linked by a chain containing hetero atoms as chain links
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D487/00—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, not provided for by groups C07D451/00 - C07D477/00
- C07D487/02—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, not provided for by groups C07D451/00 - C07D477/00 in which the condensed system contains two hetero rings
- C07D487/04—Ortho-condensed systems
Applications Claiming Priority (3)
Application Number | Priority Date | Filing Date | Title |
---|---|---|---|
KR20120062784 | 2012-06-12 | ||
PCT/KR2013/005096 WO2013187646A1 (fr) | 2012-06-12 | 2013-06-11 | Dérivés de pipéridine agonistes de gpr119 |
EP13804551.3A EP2858986B1 (fr) | 2012-06-12 | 2013-06-11 | Dérivés de pipéridine agonistes de gpr119 |
Publications (1)
Publication Number | Publication Date |
---|---|
PL2858986T3 true PL2858986T3 (pl) | 2020-03-31 |
Family
ID=49758419
Family Applications (1)
Application Number | Title | Priority Date | Filing Date |
---|---|---|---|
PL13804551T PL2858986T3 (pl) | 2012-06-12 | 2013-06-11 | Pochodne piperydyny jako agoniści GPR119 |
Country Status (18)
Country | Link |
---|---|
US (1) | US9944600B2 (fr) |
EP (1) | EP2858986B1 (fr) |
JP (3) | JP2015522559A (fr) |
KR (1) | KR101535954B1 (fr) |
CN (1) | CN104364246B (fr) |
BR (1) | BR112014031091A2 (fr) |
CA (1) | CA2867114C (fr) |
DK (1) | DK2858986T3 (fr) |
ES (1) | ES2759010T3 (fr) |
HR (1) | HRP20200141T1 (fr) |
IN (1) | IN2014MN02380A (fr) |
MX (1) | MX365108B (fr) |
NZ (1) | NZ630488A (fr) |
PH (1) | PH12014502567A1 (fr) |
PL (1) | PL2858986T3 (fr) |
PT (1) | PT2858986T (fr) |
RU (1) | RU2603346C2 (fr) |
WO (1) | WO2013187646A1 (fr) |
Families Citing this family (13)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
PL2858986T3 (pl) | 2012-06-12 | 2020-03-31 | Chong Kun Dang Pharmaceutical Corp. | Pochodne piperydyny jako agoniści GPR119 |
NZ720304A (en) * | 2013-11-26 | 2017-08-25 | Chong Kun Dang Pharmaceutical Corp | Amide derivatives for gpr119 agonist |
WO2015167309A1 (fr) * | 2014-05-02 | 2015-11-05 | 현대약품 주식회사 | Dérivé de cyclohexène, son procédé de préparation et composition pharmaceutique pour prévenir ou traiter des maladies métaboliques, contenant celui-ci comme principe actif |
KR101651505B1 (ko) * | 2014-05-02 | 2016-08-29 | 현대약품 주식회사 | 싸이클로 헥센 유도체, 이의 제조방법 및 이를 유효성분으로 함유하는 대사성 질환의 예방 또는 치료용 약학적 조성물 |
US10723699B2 (en) | 2015-11-04 | 2020-07-28 | Hyundai Pharm Co., Ltd. | Cyclohexene derivative, preparation method thereof, and pharmaceutical composition for preventing or treating metabolic disease comprising the same as active ingredient |
US10954229B2 (en) | 2016-04-08 | 2021-03-23 | Mankind Pharma Ltd. | GPR119 agonist compounds |
US10526345B2 (en) | 2016-04-08 | 2020-01-07 | Mankind Pharma Ltd. | Compounds as GPR119 agonists |
US10208030B2 (en) * | 2016-04-08 | 2019-02-19 | Mankind Pharma Ltd. | GPR119 agonist compounds |
JP2019517563A (ja) * | 2016-06-09 | 2019-06-24 | プラマーナ ファーマシューティカルズ インコーポレイテッド | ベンゾ[d][1,3]オキサチオール、ベンゾ[d][1,3]オキサチオール3−オキシドまたはベンゾ[d][1,3]オキサチオール3,3−ジオキシドを含有する化合物およびGタンパク質共役型受容体119のアゴニストとしてのその方法/使用 |
KR102112173B1 (ko) * | 2017-02-28 | 2020-05-19 | 한국화학연구원 | 피페리딘-아릴 유도체 또는 이의 약학적으로 허용 가능한 염, 이의 제조방법, 및 이를 유효성분으로 함유하는 약제학적 조성물 |
US11358956B2 (en) | 2017-11-30 | 2022-06-14 | Pramana Pharmaceuticals Inc. | Compounds containing polysubstituted benzo[d][1,3]oxathiole, benzo[d][1,3]oxathiole 3-oxide or benzo[d][1,3]oxathiole 3,3-dioxide and methods/uses thereof as agonists of G protein-coupled receptor 119 |
WO2019151274A1 (fr) * | 2018-02-01 | 2019-08-08 | 日本たばこ産業株式会社 | Composé amide hétérocyclique azoté et son utilisation à des fins médicales |
GB201905520D0 (en) | 2019-04-18 | 2019-06-05 | Modern Biosciences Ltd | Compounds and their therapeutic use |
Family Cites Families (24)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
US5109002A (en) * | 1989-09-08 | 1992-04-28 | Du Pont Merck Pharmaceutical Company | Antipsychotic 1-cycloalkylpiperidines |
DK1167326T4 (da) * | 2000-06-26 | 2008-03-17 | Saudi Basic Ind Corp | Dimerisering af isobuten |
US7060331B2 (en) | 2000-07-13 | 2006-06-13 | Merck Patent Gmbh | Chiral compounds 1 |
DE60104014T2 (de) | 2000-10-20 | 2005-08-11 | Merck Patent Gmbh | Chirale binaphtol-verbindungen |
DE102004037515A1 (de) * | 2003-08-22 | 2005-03-17 | Merck Patent Gmbh | Verfahren zur Herstellung von Aldehyden |
US20080103123A1 (en) | 2006-08-30 | 2008-05-01 | Biovitrum | New compounds |
EA015835B1 (ru) * | 2006-12-06 | 2011-12-30 | Смитклайн Бичем Корпорейшн | Производные 4-окса(тиа)метилпиперидина и их применение в качестве противодиабетических средств |
JP2010514828A (ja) | 2007-01-04 | 2010-05-06 | プロシディオン・リミテッド | ピペリジンgpcrアゴニスト |
BRPI0814294A2 (pt) | 2007-07-19 | 2015-02-03 | Metabolex Inc | Agonistas de receptor heterocíclico ligado a n para o tratamento do diabetes e de desordens metabólicas. |
EP2197873B1 (fr) | 2007-09-20 | 2014-07-16 | Irm Llc | Composés et compositions en tant que modulateurs de l'activité de gpr119 |
WO2009106565A1 (fr) * | 2008-02-27 | 2009-09-03 | Biovitrum Ab (Publ) | Agonistes du gpr119 |
WO2009106561A1 (fr) | 2008-02-27 | 2009-09-03 | Biovitrum Ab (Publ) | Composés pyrazines pour le traitement de troubles apparentés à gpr119 |
JP5309216B2 (ja) * | 2008-07-11 | 2013-10-09 | アイアールエム・リミテッド・ライアビリティ・カンパニー | Gpr119活性のモジュレーターとしての4−フェノキシメチルピペリジン類 |
WO2010048149A2 (fr) * | 2008-10-20 | 2010-04-29 | Kalypsys, Inc. | Modulateurs hétérocycliques de gpr119 pour le traitement d'une maladie |
AR077642A1 (es) | 2009-07-09 | 2011-09-14 | Arena Pharm Inc | Moduladores del metabolismo y el tratamiento de trastornos relacionados con el mismo |
AR077638A1 (es) | 2009-07-15 | 2011-09-14 | Lilly Co Eli | Compuesto de (metanosulfonil -piperidin )-( alcoxi-aril) -tetrahidro- piridina , composicion farmaceutica que lo comprende y su uso para preparar un medicamento util para el tratamiento de diabetes u obesidad |
CN102918027A (zh) | 2010-04-06 | 2013-02-06 | 艾尼纳制药公司 | Gpr119受体调节剂和对与所述受体有关的障碍的治疗 |
WO2011145718A1 (fr) | 2010-05-21 | 2011-11-24 | 田辺三菱製薬株式会社 | Nouveau composé de pyrrolo[2,3-d]pyrimidine |
TW201202230A (en) | 2010-05-24 | 2012-01-16 | Mitsubishi Tanabe Pharma Corp | Novel quinazoline compound |
CN102432598A (zh) * | 2010-09-29 | 2012-05-02 | 江苏恒瑞医药股份有限公司 | 三环化合物、其制备方法及其在医药上的应用 |
CA2818050A1 (fr) * | 2010-11-26 | 2012-05-31 | Lupin Limited | Modulateurs de gpr119 bicycliques |
WO2012077655A1 (fr) | 2010-12-07 | 2012-06-14 | 塩野義製薬株式会社 | Dérivé spiro présentant une activité agoniste de gpr119 |
JP2014159376A (ja) | 2011-06-17 | 2014-09-04 | Taisho Pharmaceutical Co Ltd | アザスピロアルカン化合物 |
PL2858986T3 (pl) | 2012-06-12 | 2020-03-31 | Chong Kun Dang Pharmaceutical Corp. | Pochodne piperydyny jako agoniści GPR119 |
-
2013
- 2013-06-11 PL PL13804551T patent/PL2858986T3/pl unknown
- 2013-06-11 PT PT138045513T patent/PT2858986T/pt unknown
- 2013-06-11 RU RU2014142328/04A patent/RU2603346C2/ru active
- 2013-06-11 BR BR112014031091A patent/BR112014031091A2/pt not_active Application Discontinuation
- 2013-06-11 WO PCT/KR2013/005096 patent/WO2013187646A1/fr active Application Filing
- 2013-06-11 KR KR1020130066224A patent/KR101535954B1/ko active IP Right Grant
- 2013-06-11 CN CN201380030772.3A patent/CN104364246B/zh not_active Expired - Fee Related
- 2013-06-11 MX MX2014015057A patent/MX365108B/es active IP Right Grant
- 2013-06-11 ES ES13804551T patent/ES2759010T3/es active Active
- 2013-06-11 CA CA2867114A patent/CA2867114C/fr not_active Expired - Fee Related
- 2013-06-11 JP JP2015515954A patent/JP2015522559A/ja active Pending
- 2013-06-11 NZ NZ630488A patent/NZ630488A/en not_active IP Right Cessation
- 2013-06-11 EP EP13804551.3A patent/EP2858986B1/fr active Active
- 2013-06-11 IN IN2380MUN2014 patent/IN2014MN02380A/en unknown
- 2013-06-11 US US14/407,214 patent/US9944600B2/en not_active Expired - Fee Related
- 2013-06-11 DK DK13804551T patent/DK2858986T3/da active
-
2014
- 2014-11-18 PH PH12014502567A patent/PH12014502567A1/en unknown
-
2017
- 2017-01-06 JP JP2017000926A patent/JP2017105785A/ja active Pending
-
2019
- 2019-02-01 JP JP2019017078A patent/JP2019104741A/ja not_active Ceased
-
2020
- 2020-01-29 HR HRP20200141TT patent/HRP20200141T1/hr unknown
Also Published As
Publication number | Publication date |
---|---|
MX365108B (es) | 2019-05-23 |
NZ630488A (en) | 2016-07-29 |
EP2858986B1 (fr) | 2019-10-30 |
KR101535954B1 (ko) | 2015-07-10 |
PH12014502567B1 (en) | 2015-01-21 |
CA2867114C (fr) | 2016-02-23 |
JP2015522559A (ja) | 2015-08-06 |
PT2858986T (pt) | 2019-11-29 |
RU2014142328A (ru) | 2016-07-27 |
US9944600B2 (en) | 2018-04-17 |
AU2013275090A1 (en) | 2014-09-25 |
JP2019104741A (ja) | 2019-06-27 |
CN104364246B (zh) | 2018-05-22 |
EP2858986A1 (fr) | 2015-04-15 |
BR112014031091A2 (pt) | 2017-08-22 |
WO2013187646A1 (fr) | 2013-12-19 |
EP2858986A4 (fr) | 2015-11-11 |
KR20130139176A (ko) | 2013-12-20 |
PH12014502567A1 (en) | 2015-01-21 |
MX2014015057A (es) | 2015-06-05 |
DK2858986T3 (da) | 2019-11-25 |
ES2759010T3 (es) | 2020-05-07 |
RU2603346C2 (ru) | 2016-11-27 |
JP2017105785A (ja) | 2017-06-15 |
US20150166480A1 (en) | 2015-06-18 |
CA2867114A1 (fr) | 2013-12-19 |
IN2014MN02380A (fr) | 2015-08-14 |
CN104364246A (zh) | 2015-02-18 |
HRP20200141T1 (hr) | 2020-04-03 |
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