PL2679217T3 - Kompozycje farmaceutyczne toksyny botulinowej stabilizowane niebiałkową substancją - Google Patents

Kompozycje farmaceutyczne toksyny botulinowej stabilizowane niebiałkową substancją

Info

Publication number
PL2679217T3
PL2679217T3 PL13178507.3T PL13178507T PL2679217T3 PL 2679217 T3 PL2679217 T3 PL 2679217T3 PL 13178507 T PL13178507 T PL 13178507T PL 2679217 T3 PL2679217 T3 PL 2679217T3
Authority
PL
Poland
Prior art keywords
pharmaceutical compositions
clostridial toxin
toxin pharmaceutical
protein stabilized
stabilized clostridial
Prior art date
Application number
PL13178507.3T
Other languages
English (en)
Polish (pl)
Inventor
Terrence J. Hunt
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Family has litigation
First worldwide family litigation filed litigation Critical https://patents.darts-ip.com/?family=37527018&utm_source=google_patent&utm_medium=platform_link&utm_campaign=public_patent_search&patent=PL2679217(T3) "Global patent litigation dataset” by Darts-ip is licensed under a Creative Commons Attribution 4.0 International License.
Application filed filed Critical
Publication of PL2679217T3 publication Critical patent/PL2679217T3/pl

Links

Classifications

    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61KPREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K39/00Medicinal preparations containing antigens or antibodies
    • A61K39/02Bacterial antigens
    • A61K39/08Clostridium, e.g. Clostridium tetani
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61KPREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K38/00Medicinal preparations containing peptides
    • A61K38/16Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof
    • A61K38/43Enzymes; Proenzymes; Derivatives thereof
    • A61K38/46Hydrolases (3)
    • A61K38/48Hydrolases (3) acting on peptide bonds (3.4)
    • A61K38/4886Metalloendopeptidases (3.4.24), e.g. collagenase
    • A61K38/4893Botulinum neurotoxin (3.4.24.69)
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61KPREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K47/00Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient
    • A61K47/06Organic compounds, e.g. natural or synthetic hydrocarbons, polyolefins, mineral oil, petrolatum or ozokerite
    • A61K47/08Organic compounds, e.g. natural or synthetic hydrocarbons, polyolefins, mineral oil, petrolatum or ozokerite containing oxygen, e.g. ethers, acetals, ketones, quinones, aldehydes, peroxides
    • A61K47/10Alcohols; Phenols; Salts thereof, e.g. glycerol; Polyethylene glycols [PEG]; Poloxamers; PEG/POE alkyl ethers
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61KPREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K47/00Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient
    • A61K47/06Organic compounds, e.g. natural or synthetic hydrocarbons, polyolefins, mineral oil, petrolatum or ozokerite
    • A61K47/26Carbohydrates, e.g. sugar alcohols, amino sugars, nucleic acids, mono-, di- or oligo-saccharides; Derivatives thereof, e.g. polysorbates, sorbitan fatty acid esters or glycyrrhizin
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61KPREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K47/00Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient
    • A61K47/30Macromolecular organic or inorganic compounds, e.g. inorganic polyphosphates
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61KPREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K47/00Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient
    • A61K47/30Macromolecular organic or inorganic compounds, e.g. inorganic polyphosphates
    • A61K47/32Macromolecular compounds obtained by reactions only involving carbon-to-carbon unsaturated bonds, e.g. carbomers, poly(meth)acrylates, or polyvinyl pyrrolidone
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61KPREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K9/00Medicinal preparations characterised by special physical form
    • A61K9/0012Galenical forms characterised by the site of application
    • A61K9/0019Injectable compositions; Intramuscular, intravenous, arterial, subcutaneous administration; Compositions to be administered through the skin in an invasive manner
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61PSPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P21/00Drugs for disorders of the muscular or neuromuscular system
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61PSPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P21/00Drugs for disorders of the muscular or neuromuscular system
    • A61P21/02Muscle relaxants, e.g. for tetanus or cramps
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61PSPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P43/00Drugs for specific purposes, not provided for in groups A61P1/00-A61P41/00

Landscapes

  • Health & Medical Sciences (AREA)
  • Chemical & Material Sciences (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Veterinary Medicine (AREA)
  • Public Health (AREA)
  • Medicinal Chemistry (AREA)
  • General Health & Medical Sciences (AREA)
  • Animal Behavior & Ethology (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Epidemiology (AREA)
  • Engineering & Computer Science (AREA)
  • General Chemical & Material Sciences (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Oil, Petroleum & Natural Gas (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Immunology (AREA)
  • Biochemistry (AREA)
  • Inorganic Chemistry (AREA)
  • Molecular Biology (AREA)
  • Organic Chemistry (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Gastroenterology & Hepatology (AREA)
  • Proteomics, Peptides & Aminoacids (AREA)
  • Dermatology (AREA)
  • Physical Education & Sports Medicine (AREA)
  • Orthopedic Medicine & Surgery (AREA)
  • Neurology (AREA)
  • Pain & Pain Management (AREA)
  • Microbiology (AREA)
  • Mycology (AREA)
  • Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)
  • Medicinal Preparation (AREA)
PL13178507.3T 2005-10-06 2006-10-04 Kompozycje farmaceutyczne toksyny botulinowej stabilizowane niebiałkową substancją PL2679217T3 (pl)

Applications Claiming Priority (2)

Application Number Priority Date Filing Date Title
US72512605P 2005-10-06 2005-10-06
US11/524,683 US8137677B2 (en) 2005-10-06 2006-09-21 Non-protein stabilized clostridial toxin pharmaceutical compositions

Publications (1)

Publication Number Publication Date
PL2679217T3 true PL2679217T3 (pl) 2016-11-30

Family

ID=37527018

Family Applications (1)

Application Number Title Priority Date Filing Date
PL13178507.3T PL2679217T3 (pl) 2005-10-06 2006-10-04 Kompozycje farmaceutyczne toksyny botulinowej stabilizowane niebiałkową substancją

Country Status (16)

Country Link
US (5) US8137677B2 (cg-RX-API-DMAC7.html)
EP (2) EP2679217B1 (cg-RX-API-DMAC7.html)
JP (4) JP5140595B2 (cg-RX-API-DMAC7.html)
KR (1) KR101314952B1 (cg-RX-API-DMAC7.html)
AU (1) AU2006299366B2 (cg-RX-API-DMAC7.html)
CA (1) CA2602926C (cg-RX-API-DMAC7.html)
CY (1) CY1117727T1 (cg-RX-API-DMAC7.html)
DK (1) DK2679217T3 (cg-RX-API-DMAC7.html)
ES (1) ES2580010T3 (cg-RX-API-DMAC7.html)
HU (1) HUE027810T2 (cg-RX-API-DMAC7.html)
MX (1) MX2007012062A (cg-RX-API-DMAC7.html)
NZ (1) NZ562033A (cg-RX-API-DMAC7.html)
PL (1) PL2679217T3 (cg-RX-API-DMAC7.html)
PT (1) PT2679217T (cg-RX-API-DMAC7.html)
SI (1) SI2679217T1 (cg-RX-API-DMAC7.html)
WO (1) WO2007041664A1 (cg-RX-API-DMAC7.html)

Families Citing this family (41)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US8632785B2 (en) * 2000-02-08 2014-01-21 Allergan, Inc. Clostridial toxin pharmaceutical composition containing a gelatin fragment
US7780967B2 (en) * 2000-02-08 2010-08-24 Allergan, Inc. Reduced toxicity Clostridial toxin pharmaceutical compositions
US7763663B2 (en) 2001-12-19 2010-07-27 University Of Massachusetts Polysaccharide-containing block copolymer particles and uses thereof
AU2005251676B2 (en) 2004-03-03 2011-09-29 Revance Therapeutics, Inc. Compositions and methods for topical diagnostic and therapeutic transport
US9211248B2 (en) 2004-03-03 2015-12-15 Revance Therapeutics, Inc. Compositions and methods for topical application and transdermal delivery of botulinum toxins
GB2416122A (en) 2004-07-12 2006-01-18 Ipsen Ltd Botulinum neurotoxin composition
CN102139099A (zh) * 2004-07-26 2011-08-03 莫茨药物股份两合公司 包含肉毒杆菌神经毒素的治疗组合物
US9180081B2 (en) * 2005-03-03 2015-11-10 Revance Therapeutics, Inc. Compositions and methods for topical application and transdermal delivery of botulinum toxins
JP5368793B2 (ja) 2005-07-18 2013-12-18 ユニバーシティ オブ マサチューセッツ ロウエル ナノエマルジョンを製造および使用するための組成物および方法
US8323666B2 (en) * 2005-08-01 2012-12-04 Allergan, Inc. Botulinum toxin compositions
US8137677B2 (en) 2005-10-06 2012-03-20 Allergan, Inc. Non-protein stabilized clostridial toxin pharmaceutical compositions
US8168206B1 (en) * 2005-10-06 2012-05-01 Allergan, Inc. Animal protein-free pharmaceutical compositions
WO2008045107A2 (en) 2005-12-01 2008-04-17 University Of Massachusetts Lowell Botulinum nanoemulsions
US9486408B2 (en) 2005-12-01 2016-11-08 University Of Massachusetts Lowell Botulinum nanoemulsions
SG179457A1 (en) 2006-12-01 2012-04-27 Anterios Inc Peptide nanoparticles and uses therefor
CN101848702B (zh) 2006-12-01 2013-07-17 安特里奥公司 两亲实体纳米粒子
CN101765423B (zh) 2007-05-31 2014-08-06 安特里奥公司 核酸纳米粒子和其用途
WO2009008595A1 (en) * 2007-07-10 2009-01-15 Medy-Tox, Inc. Pharmaceutical liquid composition of botulinum toxin with improved stability
HRP20180054T1 (hr) 2007-09-14 2018-02-09 Sanofi Pasteur Biologics, Llc Farmaceutski pripravci koji sadrže toksoide clostridium difficile a i b
US9107815B2 (en) * 2008-02-22 2015-08-18 Allergan, Inc. Sustained release poloxamer containing pharmaceutical compositions
CN102307571A (zh) * 2008-12-10 2012-01-04 阿勒根公司 梭菌毒素药物组合物
KR102179926B1 (ko) 2008-12-31 2020-11-17 레반스 테라퓨틱스, 아이엔씨. 주사용 보툴리눔 독소 제제
EP2248518B1 (en) * 2009-04-17 2013-01-16 Merz Pharma GmbH & Co. KGaA Formulation for stabilizing proteins, peptides or mixtures thereof.
US8591884B2 (en) 2009-06-24 2013-11-26 CNSS IP Holdings, Inc Compositions and methods for enhancing metal ion dependent drug therapies
MX366344B (es) 2009-06-25 2019-07-05 Revance Therapeutics Inc Formulaciones de toxina botulinica libres de albumina.
WO2011057246A1 (en) * 2009-11-09 2011-05-12 Enerdel, Inc. Scalable battery module
ES2639617T3 (es) * 2010-10-12 2017-10-27 Merz Pharma Gmbh & Co. Kgaa Formulación adecuada para estabilizar proteínas, que carece de excipientes de mamíferos
MX355771B (es) * 2011-03-31 2018-04-30 Medy Tox Inc Preparacion liofilizada de toxinas de botulismo.
KR20140147950A (ko) * 2013-06-20 2014-12-31 서울대학교산학협력단 필러와 보틀리눔 독소를 포함하는 피부 주름, 노화 개선 또는 신경근육 관련 질환 치료용 조성물
US9480731B2 (en) 2013-12-12 2016-11-01 Medy-Tox, Inc. Long lasting effect of new botulinum toxin formulations
GB201407525D0 (en) * 2014-04-29 2014-06-11 Syntaxin Ltd Manufacture of recombinant clostridium botulinum neurotoxins
WO2016007537A1 (en) 2014-07-07 2016-01-14 Mast Therapeutics, Inc. A poloxamer composition free of long circulating material and methods for production and uses thereof
MX380066B (es) 2014-12-23 2025-03-11 Merz Pharma Gmbh & Co Kgaa Recipiente precargado con toxina botulinica.
WO2017179775A1 (en) * 2016-04-12 2017-10-19 Hugel Inc. Microstructure formulation techniques for botulinum toxin
PL3432916T3 (pl) * 2016-09-13 2020-04-30 Allergan, Inc. Niebiałkowo stabilzowane kompozycje toksyny clostridium
CA3044219A1 (en) 2016-11-21 2018-05-24 Eirion Therapeutics, Inc. Transdermal delivery of large agents
EP3470054B1 (en) * 2017-10-11 2023-09-20 Hugel Inc. Microstructure formulation techniques for botulinum toxin
US10525111B2 (en) 2017-10-12 2020-01-07 Hugel, Inc. Microstructure formulation techniques for botulinum toxin
US10792400B2 (en) 2017-10-12 2020-10-06 Hugel Inc. Microstructure formulation techniques for botulinum toxin
US20190185837A1 (en) 2017-12-20 2019-06-20 Allergan, Inc. Botulinum toxin cell binding domain polypeptides and methods of use for treatments of fibrosis associated disorders
KR20250124258A (ko) * 2018-09-13 2025-08-19 알레간 인코포레이티드 클로스트리디움 독소-히알루론산 조성물

Family Cites Families (50)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
DE3682047D1 (de) * 1985-07-09 1991-11-21 Quadrant Bioresources Ltd Beschuetzung von proteinen und aehnlichem.
DE3603444A1 (de) * 1986-02-05 1987-08-06 Thomae Gmbh Dr K Pharmazeutische zubereitungsformen zur stabilisierung von interferon alpha
US5215743A (en) * 1988-04-13 1993-06-01 Maninder Singh Tumor necrosis factor formulations
US5945098A (en) * 1990-02-01 1999-08-31 Baxter International Inc. Stable intravenously-administrable immune globulin preparation
AU4646393A (en) 1992-06-23 1994-01-24 Interactive Biologics Associates Pharmaceutical composition containing botulinum b complex
US5756468A (en) 1994-10-13 1998-05-26 Wisconsin Alumni Research Foundation Pharmaceutical compositions of botulinum toxin or botulinum neurotoxin and methods of preparation
US5512547A (en) 1994-10-13 1996-04-30 Wisconsin Alumni Research Foundation Pharmaceutical composition of botulinum neurotoxin and method of preparation
US5556771A (en) * 1995-02-10 1996-09-17 Gen-Probe Incorporated Stabilized compositions of reverse transcriptase and RNA polymerase for nucleic acid amplification
AU6034396A (en) 1995-06-06 1996-12-24 L. Bruce Pearce Improved compositions and methods for chemodenervation using neurotoxins
JPH0952844A (ja) * 1995-08-10 1997-02-25 Amano Pharmaceut Co Ltd 酵素含有内服液剤
US8828432B2 (en) * 1996-10-28 2014-09-09 General Mills, Inc. Embedding and encapsulation of sensitive components into a matrix to obtain discrete controlled release particles
IL122732A0 (en) * 1997-01-15 1998-08-16 Akzo Nobel Nv Liquid gonadotropin-containing formulation its preparation and a device containing same
US6638621B2 (en) * 2000-08-16 2003-10-28 Lyotropic Therapeutics, Inc. Coated particles, methods of making and using
CN1073626C (zh) 1997-10-18 2001-10-24 卫生部兰州生物制品研究所 A型肉毒结晶毒素的生产工艺及生产该毒素所需的冻干保护液
CA2319113A1 (en) * 1998-01-26 1999-07-29 University Of Massachusetts Biologically active hemagglutinin from type a clostridium botulinum and methods of use
TW574036B (en) 1998-09-11 2004-02-01 Elan Pharm Inc Stable liquid compositions of botulinum toxin
IL126182A0 (en) 1998-09-11 1999-05-09 Nun Yehoshua Ben Cryosurgical instrument
US20050147690A1 (en) * 1998-09-25 2005-07-07 Masters David B. Biocompatible protein particles, particle devices and methods thereof
IL149778A0 (en) 1999-11-22 2002-11-10 Universal Preservation Technologies Inc Preservation of sensitive biological material
CA2400318C (en) * 2000-02-08 2005-06-14 Allergan, Inc. Botulinum toxin pharmaceutical compositions
US20030118598A1 (en) 2000-02-08 2003-06-26 Allergan, Inc. Clostridial toxin pharmaceutical compositions
US6306423B1 (en) 2000-06-02 2001-10-23 Allergan Sales, Inc. Neurotoxin implant
US6653062B1 (en) * 2000-07-26 2003-11-25 Wisconsin Alumni Research Foundation Preservation and storage medium for biological materials
US7255865B2 (en) 2000-12-05 2007-08-14 Allergan, Inc. Methods of administering botulinum toxin
US20030104996A1 (en) * 2001-08-30 2003-06-05 Tiansheng Li L-methionine as a stabilizer for NESP/EPO in HSA-free formulations
US20040161776A1 (en) * 2001-10-23 2004-08-19 Maddon Paul J. PSMA formulations and uses thereof
JP4648002B2 (ja) * 2002-06-21 2011-03-09 ノボ ノルディスク ヘルス ケア アクチェンゲゼルシャフト 第vii因子ポリペプチドの安定化された固体組成物
WO2004043534A1 (en) * 2002-11-12 2004-05-27 Collegium Pharmaceutical, Inc. Inertial drug delivery system
US20060002862A1 (en) * 2002-12-17 2006-01-05 Medimmune Vaccines, Inc. High pressure spray-dry of bioactive materials
CA2510058C (en) 2002-12-20 2010-03-16 Botulinum Toxin Research Associates, Inc. Improved pharmaceutical botulinum toxin compositions
US20040204471A1 (en) * 2003-03-20 2004-10-14 Pharmacia Corporation Treatment and prevention of otic disorders with Cox-2 inhibitors alone or in combination with otic agents
DE10333317A1 (de) * 2003-07-22 2005-02-17 Biotecon Therapeutics Gmbh Formulierung für Proteinarzneimittel ohne Zusatz von humanem Serumalbumin (HSA)
CA2537315C (en) * 2003-08-26 2015-12-08 Gel-Del Technologies, Inc. Protein biomaterials and biocoacervates and methods of making and using thereof
EP1691746B1 (en) * 2003-12-08 2015-05-27 Gel-Del Technologies, Inc. Mucoadhesive drug delivery devices and methods of making and using thereof
US20050214325A1 (en) * 2004-03-26 2005-09-29 Vvii Newco 2003, Inc. Compositions and methods to increase the effect of a neurotoxin treatment
US20090181083A1 (en) * 2004-06-28 2009-07-16 Lifebycle Pharmas A/S Porous tablets as carriers for liquid formulations
GB2416122A (en) * 2004-07-12 2006-01-18 Ipsen Ltd Botulinum neurotoxin composition
CN102139099A (zh) * 2004-07-26 2011-08-03 莫茨药物股份两合公司 包含肉毒杆菌神经毒素的治疗组合物
EP1776137B1 (en) * 2004-08-04 2014-11-26 Ipsen Biopharm Limited Pharmaceutical composition containing botulinum neurotoxin a2
US7560100B2 (en) * 2004-09-09 2009-07-14 Yeda Research And Development Co., Ltd. Mixtures of polypeptides, compositions containing and processes for preparing same, for treating neurodegenerative diseases
US9504658B2 (en) * 2004-11-09 2016-11-29 Board Of Regents, The University Of Texas System Stabilized HME composition with small drug particles
HRP20110803T1 (hr) * 2005-09-16 2011-11-30 Merial Ltd. Stabilizatori za cjepiva osušena zamrzavanjem
US8137677B2 (en) * 2005-10-06 2012-03-20 Allergan, Inc. Non-protein stabilized clostridial toxin pharmaceutical compositions
US8168206B1 (en) * 2005-10-06 2012-05-01 Allergan, Inc. Animal protein-free pharmaceutical compositions
EP2829282B1 (en) * 2007-03-22 2017-10-25 The Regents of The University of Colorado, A Body Corporate Method of preparing an immunologically-active adjuvant-bound dried vaccine composition
EP1985276A1 (en) * 2007-04-26 2008-10-29 Merz Pharma GmbH & Co. KGaA Treatment of movement disorders by a combined use of a chemodenervating agent and automated movement therapy
WO2010037402A1 (en) * 2008-10-02 2010-04-08 Dako Denmark A/S Molecular vaccines for infectious disease
EP2248518B1 (en) * 2009-04-17 2013-01-16 Merz Pharma GmbH & Co. KGaA Formulation for stabilizing proteins, peptides or mixtures thereof.
DE212011100034U1 (de) * 2010-01-20 2012-07-04 Theracoat Ltd. Material zur Behandlung von inneren Hohlräumen
ES2639617T3 (es) * 2010-10-12 2017-10-27 Merz Pharma Gmbh & Co. Kgaa Formulación adecuada para estabilizar proteínas, que carece de excipientes de mamíferos

Also Published As

Publication number Publication date
EP2679217A1 (en) 2014-01-01
EP1931306B2 (en) 2021-09-22
MX2007012062A (es) 2007-12-04
US20120141619A1 (en) 2012-06-07
EP1931306B1 (en) 2013-07-31
EP1931306A1 (en) 2008-06-18
US20100279953A1 (en) 2010-11-04
HK1192710A1 (en) 2014-08-29
JP5758856B2 (ja) 2015-08-05
ES2580010T3 (es) 2016-08-18
CA2602926C (en) 2010-12-21
JP2017088611A (ja) 2017-05-25
KR101314952B1 (ko) 2013-10-04
US20200330564A1 (en) 2020-10-22
EP2679217B1 (en) 2016-04-06
JP2014139229A (ja) 2014-07-31
SI2679217T1 (sl) 2016-08-31
US8642047B2 (en) 2014-02-04
PT2679217T (pt) 2016-07-15
JP6235176B2 (ja) 2017-11-22
NZ562033A (en) 2011-12-22
HUE027810T2 (en) 2016-11-28
JP5140595B2 (ja) 2013-02-06
JP2012197320A (ja) 2012-10-18
CA2602926A1 (en) 2007-04-12
JP2009511485A (ja) 2009-03-19
KR20080052510A (ko) 2008-06-11
DK2679217T3 (en) 2016-07-25
WO2007041664A1 (en) 2007-04-12
US20240226252A1 (en) 2024-07-11
AU2006299366A1 (en) 2007-04-12
CY1117727T1 (el) 2017-05-17
US8137677B2 (en) 2012-03-20
AU2006299366B2 (en) 2012-01-12
US20140112908A1 (en) 2014-04-24

Similar Documents

Publication Publication Date Title
SI2679217T1 (sl) Farmacevtske sestave neproteinskega stabiliziranega klostridijskega toksina
GB0524962D0 (en) Topical pharmaceutical compositions
GB0513692D0 (en) Novel pharmaceutical compositions
EP1988922A4 (en) PROTEIN FORMULATIONS
PL1917072T3 (pl) Formulacja witaminowa
PL1884242T3 (pl) Kompozycja farmaceutyczna zawierająca lurasidon
ZA200803150B (en) Topical Formulations
ZA200708705B (en) Pharmaceutical composition
IL188352A0 (en) Pharmaceutical compositions
ZA200804103B (en) Pharmaceutical compositions
IL192091A0 (en) Pharmaceutical compositions
IL192824A (en) Peptide compounds, pharmaceuticals containing them and their use
GB0522045D0 (en) Pharmaceutical compositions
EP1953227A4 (en) BINDER OF LIPOPOLYSACCHARIDE OR LIPID A, AND NEW PEPTIDE
EP1845944A4 (en) PHARMACEUTICAL COMPOSITIONS
GB0512246D0 (en) Novel pharmaceutical
ZA200803566B (en) Pharmaceutical compositions
GB0514259D0 (en) Pharmaceutical compositions
ZA200805355B (en) Pharmaceutical compositions containing protein NMA0939
GB0612556D0 (en) Topical pharmaceutical formulations
GB0525269D0 (en) Pharmaceutical compositions
GB0515306D0 (en) Pharmaceutical compositions
GB0513693D0 (en) Novel pharmaceutical compositions
GB0513440D0 (en) Novel pharmaceutical compositions
GB0512202D0 (en) Novel pharmaceutical compositions