JP5140595B2 - 非タンパク質安定化クロストリジウム毒素医薬組成物 - Google Patents

非タンパク質安定化クロストリジウム毒素医薬組成物 Download PDF

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Publication number
JP5140595B2
JP5140595B2 JP2008534672A JP2008534672A JP5140595B2 JP 5140595 B2 JP5140595 B2 JP 5140595B2 JP 2008534672 A JP2008534672 A JP 2008534672A JP 2008534672 A JP2008534672 A JP 2008534672A JP 5140595 B2 JP5140595 B2 JP 5140595B2
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JP
Japan
Prior art keywords
botulinum toxin
pharmaceutical composition
protein
toxin
botulinum
Prior art date
Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
Expired - Fee Related
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JP2008534672A
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English (en)
Japanese (ja)
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JP2009511485A (ja
JP2009511485A5 (cg-RX-API-DMAC7.html
Inventor
テレンス・ジェイ・ハント
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Allergan Inc
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Allergan Inc
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Publication of JP2009511485A5 publication Critical patent/JP2009511485A5/ja
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Classifications

    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K39/00—Medicinal preparations containing antigens or antibodies
    • A61K39/02—Bacterial antigens
    • A61K39/08—Clostridium, e.g. Clostridium tetani
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K38/00—Medicinal preparations containing peptides
    • A61K38/16—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof
    • A61K38/43—Enzymes; Proenzymes; Derivatives thereof
    • A61K38/46—Hydrolases (3)
    • A61K38/48—Hydrolases (3) acting on peptide bonds (3.4)
    • A61K38/4886—Metalloendopeptidases (3.4.24), e.g. collagenase
    • A61K38/4893—Botulinum neurotoxin (3.4.24.69)
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K47/00—Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient
    • A61K47/06—Organic compounds, e.g. natural or synthetic hydrocarbons, polyolefins, mineral oil, petrolatum or ozokerite
    • A61K47/08—Organic compounds, e.g. natural or synthetic hydrocarbons, polyolefins, mineral oil, petrolatum or ozokerite containing oxygen, e.g. ethers, acetals, ketones, quinones, aldehydes, peroxides
    • A61K47/10—Alcohols; Phenols; Salts thereof, e.g. glycerol; Polyethylene glycols [PEG]; Poloxamers; PEG/POE alkyl ethers
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K47/00—Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient
    • A61K47/06—Organic compounds, e.g. natural or synthetic hydrocarbons, polyolefins, mineral oil, petrolatum or ozokerite
    • A61K47/26—Carbohydrates, e.g. sugar alcohols, amino sugars, nucleic acids, mono-, di- or oligo-saccharides; Derivatives thereof, e.g. polysorbates, sorbitan fatty acid esters or glycyrrhizin
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K47/00—Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient
    • A61K47/30—Macromolecular organic or inorganic compounds, e.g. inorganic polyphosphates
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K47/00—Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient
    • A61K47/30—Macromolecular organic or inorganic compounds, e.g. inorganic polyphosphates
    • A61K47/32—Macromolecular compounds obtained by reactions only involving carbon-to-carbon unsaturated bonds, e.g. carbomers, poly(meth)acrylates, or polyvinyl pyrrolidone
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K9/00—Medicinal preparations characterised by special physical form
    • A61K9/0012—Galenical forms characterised by the site of application
    • A61K9/0019—Injectable compositions; Intramuscular, intravenous, arterial, subcutaneous administration; Compositions to be administered through the skin in an invasive manner
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P21/00—Drugs for disorders of the muscular or neuromuscular system
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P21/00—Drugs for disorders of the muscular or neuromuscular system
    • A61P21/02—Muscle relaxants, e.g. for tetanus or cramps
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P43/00—Drugs for specific purposes, not provided for in groups A61P1/00-A61P41/00

Landscapes

  • Health & Medical Sciences (AREA)
  • Chemical & Material Sciences (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Veterinary Medicine (AREA)
  • Public Health (AREA)
  • Medicinal Chemistry (AREA)
  • General Health & Medical Sciences (AREA)
  • Animal Behavior & Ethology (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Epidemiology (AREA)
  • Engineering & Computer Science (AREA)
  • General Chemical & Material Sciences (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Oil, Petroleum & Natural Gas (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Immunology (AREA)
  • Biochemistry (AREA)
  • Inorganic Chemistry (AREA)
  • Molecular Biology (AREA)
  • Organic Chemistry (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Gastroenterology & Hepatology (AREA)
  • Proteomics, Peptides & Aminoacids (AREA)
  • Dermatology (AREA)
  • Physical Education & Sports Medicine (AREA)
  • Orthopedic Medicine & Surgery (AREA)
  • Neurology (AREA)
  • Pain & Pain Management (AREA)
  • Microbiology (AREA)
  • Mycology (AREA)
  • Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)
  • Medicinal Preparation (AREA)
JP2008534672A 2005-10-06 2006-10-04 非タンパク質安定化クロストリジウム毒素医薬組成物 Expired - Fee Related JP5140595B2 (ja)

Applications Claiming Priority (5)

Application Number Priority Date Filing Date Title
US72512605P 2005-10-06 2005-10-06
US60/725,126 2005-10-06
US11/524,683 2006-09-21
US11/524,683 US8137677B2 (en) 2005-10-06 2006-09-21 Non-protein stabilized clostridial toxin pharmaceutical compositions
PCT/US2006/038913 WO2007041664A1 (en) 2005-10-06 2006-10-04 Non-protein stabilized clostridial toxin pharmaceutical compositions

Related Child Applications (1)

Application Number Title Priority Date Filing Date
JP2012162277A Division JP5758856B2 (ja) 2005-10-06 2012-07-23 非タンパク質安定化クロストリジウム毒素医薬組成物

Publications (3)

Publication Number Publication Date
JP2009511485A JP2009511485A (ja) 2009-03-19
JP2009511485A5 JP2009511485A5 (cg-RX-API-DMAC7.html) 2009-11-26
JP5140595B2 true JP5140595B2 (ja) 2013-02-06

Family

ID=37527018

Family Applications (4)

Application Number Title Priority Date Filing Date
JP2008534672A Expired - Fee Related JP5140595B2 (ja) 2005-10-06 2006-10-04 非タンパク質安定化クロストリジウム毒素医薬組成物
JP2012162277A Active JP5758856B2 (ja) 2005-10-06 2012-07-23 非タンパク質安定化クロストリジウム毒素医薬組成物
JP2014075596A Pending JP2014139229A (ja) 2005-10-06 2014-04-01 非タンパク質安定化クロストリジウム毒素医薬組成物
JP2017010322A Expired - Fee Related JP6235176B2 (ja) 2005-10-06 2017-01-24 非タンパク質安定化クロストリジウム毒素医薬組成物

Family Applications After (3)

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JP2012162277A Active JP5758856B2 (ja) 2005-10-06 2012-07-23 非タンパク質安定化クロストリジウム毒素医薬組成物
JP2014075596A Pending JP2014139229A (ja) 2005-10-06 2014-04-01 非タンパク質安定化クロストリジウム毒素医薬組成物
JP2017010322A Expired - Fee Related JP6235176B2 (ja) 2005-10-06 2017-01-24 非タンパク質安定化クロストリジウム毒素医薬組成物

Country Status (16)

Country Link
US (5) US8137677B2 (cg-RX-API-DMAC7.html)
EP (2) EP2679217B1 (cg-RX-API-DMAC7.html)
JP (4) JP5140595B2 (cg-RX-API-DMAC7.html)
KR (1) KR101314952B1 (cg-RX-API-DMAC7.html)
AU (1) AU2006299366B2 (cg-RX-API-DMAC7.html)
CA (1) CA2602926C (cg-RX-API-DMAC7.html)
CY (1) CY1117727T1 (cg-RX-API-DMAC7.html)
DK (1) DK2679217T3 (cg-RX-API-DMAC7.html)
ES (1) ES2580010T3 (cg-RX-API-DMAC7.html)
HU (1) HUE027810T2 (cg-RX-API-DMAC7.html)
MX (1) MX2007012062A (cg-RX-API-DMAC7.html)
NZ (1) NZ562033A (cg-RX-API-DMAC7.html)
PL (1) PL2679217T3 (cg-RX-API-DMAC7.html)
PT (1) PT2679217T (cg-RX-API-DMAC7.html)
SI (1) SI2679217T1 (cg-RX-API-DMAC7.html)
WO (1) WO2007041664A1 (cg-RX-API-DMAC7.html)

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Also Published As

Publication number Publication date
EP2679217A1 (en) 2014-01-01
EP1931306B2 (en) 2021-09-22
MX2007012062A (es) 2007-12-04
US20120141619A1 (en) 2012-06-07
EP1931306B1 (en) 2013-07-31
EP1931306A1 (en) 2008-06-18
US20100279953A1 (en) 2010-11-04
HK1192710A1 (en) 2014-08-29
JP5758856B2 (ja) 2015-08-05
ES2580010T3 (es) 2016-08-18
PL2679217T3 (pl) 2016-11-30
CA2602926C (en) 2010-12-21
JP2017088611A (ja) 2017-05-25
KR101314952B1 (ko) 2013-10-04
US20200330564A1 (en) 2020-10-22
EP2679217B1 (en) 2016-04-06
JP2014139229A (ja) 2014-07-31
SI2679217T1 (sl) 2016-08-31
US8642047B2 (en) 2014-02-04
PT2679217T (pt) 2016-07-15
JP6235176B2 (ja) 2017-11-22
NZ562033A (en) 2011-12-22
HUE027810T2 (en) 2016-11-28
JP2012197320A (ja) 2012-10-18
CA2602926A1 (en) 2007-04-12
JP2009511485A (ja) 2009-03-19
KR20080052510A (ko) 2008-06-11
DK2679217T3 (en) 2016-07-25
WO2007041664A1 (en) 2007-04-12
US20240226252A1 (en) 2024-07-11
AU2006299366A1 (en) 2007-04-12
CY1117727T1 (el) 2017-05-17
US8137677B2 (en) 2012-03-20
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US20140112908A1 (en) 2014-04-24

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