PL2578081T4 - Kompozycje, sposoby i urządzenia do leczenia chorób wątroby - Google Patents

Kompozycje, sposoby i urządzenia do leczenia chorób wątroby

Info

Publication number
PL2578081T4
PL2578081T4 PL12176014.4T PL12176014T PL2578081T4 PL 2578081 T4 PL2578081 T4 PL 2578081T4 PL 12176014 T PL12176014 T PL 12176014T PL 2578081 T4 PL2578081 T4 PL 2578081T4
Authority
PL
Poland
Prior art keywords
compositions
methods
devices
liver disease
treating liver
Prior art date
Application number
PL12176014.4T
Other languages
English (en)
Other versions
PL2578081T3 (pl
Inventor
Martin Yarmush
Biju Parekkadan
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed filed Critical
Publication of PL2578081T4 publication Critical patent/PL2578081T4/pl
Publication of PL2578081T3 publication Critical patent/PL2578081T3/pl

Links

Classifications

    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61M—DEVICES FOR INTRODUCING MEDIA INTO, OR ONTO, THE BODY; DEVICES FOR TRANSDUCING BODY MEDIA OR FOR TAKING MEDIA FROM THE BODY; DEVICES FOR PRODUCING OR ENDING SLEEP OR STUPOR
    • A61M1/00—Suction or pumping devices for medical purposes; Devices for carrying-off, for treatment of, or for carrying-over, body-liquids; Drainage systems
    • A61M1/34—Filtering material out of the blood by passing it through a membrane, i.e. hemofiltration or diafiltration
    • A61M1/3472—Filtering material out of the blood by passing it through a membrane, i.e. hemofiltration or diafiltration with treatment of the filtrate
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K35/00—Medicinal preparations containing materials or reaction products thereof with undetermined constitution
    • A61K35/12—Materials from mammals; Compositions comprising non-specified tissues or cells; Compositions comprising non-embryonic stem cells; Genetically modified cells
    • A61K35/28—Bone marrow; Haematopoietic stem cells; Mesenchymal stem cells of any origin, e.g. adipose-derived stem cells
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61M—DEVICES FOR INTRODUCING MEDIA INTO, OR ONTO, THE BODY; DEVICES FOR TRANSDUCING BODY MEDIA OR FOR TAKING MEDIA FROM THE BODY; DEVICES FOR PRODUCING OR ENDING SLEEP OR STUPOR
    • A61M1/00—Suction or pumping devices for medical purposes; Devices for carrying-off, for treatment of, or for carrying-over, body-liquids; Drainage systems
    • A61M1/34—Filtering material out of the blood by passing it through a membrane, i.e. hemofiltration or diafiltration
    • A61M1/3472—Filtering material out of the blood by passing it through a membrane, i.e. hemofiltration or diafiltration with treatment of the filtrate
    • A61M1/3486—Biological, chemical treatment, e.g. chemical precipitation; treatment by absorbents
    • A61M1/3489—Biological, chemical treatment, e.g. chemical precipitation; treatment by absorbents by biological cells, e.g. bioreactor
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61M—DEVICES FOR INTRODUCING MEDIA INTO, OR ONTO, THE BODY; DEVICES FOR TRANSDUCING BODY MEDIA OR FOR TAKING MEDIA FROM THE BODY; DEVICES FOR PRODUCING OR ENDING SLEEP OR STUPOR
    • A61M1/00—Suction or pumping devices for medical purposes; Devices for carrying-off, for treatment of, or for carrying-over, body-liquids; Drainage systems
    • A61M1/36—Other treatment of blood in a by-pass of the natural circulatory system, e.g. temperature adaptation, irradiation ; Extra-corporeal blood circuits
    • A61M1/3687—Chemical treatment
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61M—DEVICES FOR INTRODUCING MEDIA INTO, OR ONTO, THE BODY; DEVICES FOR TRANSDUCING BODY MEDIA OR FOR TAKING MEDIA FROM THE BODY; DEVICES FOR PRODUCING OR ENDING SLEEP OR STUPOR
    • A61M1/00—Suction or pumping devices for medical purposes; Devices for carrying-off, for treatment of, or for carrying-over, body-liquids; Drainage systems
    • A61M1/36—Other treatment of blood in a by-pass of the natural circulatory system, e.g. temperature adaptation, irradiation ; Extra-corporeal blood circuits
    • A61M1/3687—Chemical treatment
    • A61M1/3689—Chemical treatment by biological cells
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P1/00—Drugs for disorders of the alimentary tract or the digestive system
    • A61P1/16—Drugs for disorders of the alimentary tract or the digestive system for liver or gallbladder disorders, e.g. hepatoprotective agents, cholagogues, litholytics
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P37/00—Drugs for immunological or allergic disorders
    • C—CHEMISTRY; METALLURGY
    • C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12M—APPARATUS FOR ENZYMOLOGY OR MICROBIOLOGY; APPARATUS FOR CULTURING MICROORGANISMS FOR PRODUCING BIOMASS, FOR GROWING CELLS OR FOR OBTAINING FERMENTATION OR METABOLIC PRODUCTS, i.e. BIOREACTORS OR FERMENTERS
    • C12M29/00—Means for introduction, extraction or recirculation of materials, e.g. pumps
    • C12M29/16—Hollow fibers
    • C—CHEMISTRY; METALLURGY
    • C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
    • C12N5/00—Undifferentiated human, animal or plant cells, e.g. cell lines; Tissues; Cultivation or maintenance thereof; Culture media therefor
    • C12N5/06—Animal cells or tissues; Human cells or tissues
    • C12N5/0602—Vertebrate cells
    • C12N5/0652—Cells of skeletal and connective tissues; Mesenchyme
    • C12N5/0662—Stem cells
    • C12N5/0663—Bone marrow mesenchymal stem cells (BM-MSC)
    • C—CHEMISTRY; METALLURGY
    • C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
    • C12N5/00—Undifferentiated human, animal or plant cells, e.g. cell lines; Tissues; Cultivation or maintenance thereof; Culture media therefor
    • C12N5/06—Animal cells or tissues; Human cells or tissues
    • C12N5/0602—Vertebrate cells
    • C12N5/067—Hepatocytes
    • G—PHYSICS
    • G01—MEASURING; TESTING
    • G01N—INVESTIGATING OR ANALYSING MATERIALS BY DETERMINING THEIR CHEMICAL OR PHYSICAL PROPERTIES
    • G01N33/00—Investigating or analysing materials by specific methods not covered by groups G01N1/00 - G01N31/00
    • G01N33/48—Biological material, e.g. blood, urine; Haemocytometers
    • G01N33/50—Chemical analysis of biological material, e.g. blood, urine; Testing involving biospecific ligand binding methods; Immunological testing
    • G01N33/5005—Chemical analysis of biological material, e.g. blood, urine; Testing involving biospecific ligand binding methods; Immunological testing involving human or animal cells
    • G01N33/5008—Chemical analysis of biological material, e.g. blood, urine; Testing involving biospecific ligand binding methods; Immunological testing involving human or animal cells for testing or evaluating the effect of chemical or biological compounds, e.g. drugs, cosmetics
    • G01N33/5044—Chemical analysis of biological material, e.g. blood, urine; Testing involving biospecific ligand binding methods; Immunological testing involving human or animal cells for testing or evaluating the effect of chemical or biological compounds, e.g. drugs, cosmetics involving specific cell types
    • G01N33/5067—Liver cells
    • G—PHYSICS
    • G01—MEASURING; TESTING
    • G01N—INVESTIGATING OR ANALYSING MATERIALS BY DETERMINING THEIR CHEMICAL OR PHYSICAL PROPERTIES
    • G01N33/00—Investigating or analysing materials by specific methods not covered by groups G01N1/00 - G01N31/00
    • G01N33/48—Biological material, e.g. blood, urine; Haemocytometers
    • G01N33/50—Chemical analysis of biological material, e.g. blood, urine; Testing involving biospecific ligand binding methods; Immunological testing
    • G01N33/5005—Chemical analysis of biological material, e.g. blood, urine; Testing involving biospecific ligand binding methods; Immunological testing involving human or animal cells
    • G01N33/5008—Chemical analysis of biological material, e.g. blood, urine; Testing involving biospecific ligand binding methods; Immunological testing involving human or animal cells for testing or evaluating the effect of chemical or biological compounds, e.g. drugs, cosmetics
    • G01N33/5044—Chemical analysis of biological material, e.g. blood, urine; Testing involving biospecific ligand binding methods; Immunological testing involving human or animal cells for testing or evaluating the effect of chemical or biological compounds, e.g. drugs, cosmetics involving specific cell types
    • G01N33/5073—Stem cells
    • C—CHEMISTRY; METALLURGY
    • C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
    • C12N2502/00—Coculture with; Conditioned medium produced by
    • C12N2502/13—Coculture with; Conditioned medium produced by connective tissue cells; generic mesenchyme cells, e.g. so-called "embryonic fibroblasts"
    • C12N2502/1352—Mesenchymal stem cells
    • C12N2502/1358—Bone marrow mesenchymal stem cells (BM-MSC)
    • G—PHYSICS
    • G01—MEASURING; TESTING
    • G01N—INVESTIGATING OR ANALYSING MATERIALS BY DETERMINING THEIR CHEMICAL OR PHYSICAL PROPERTIES
    • G01N2500/00—Screening for compounds of potential therapeutic value
    • G—PHYSICS
    • G01—MEASURING; TESTING
    • G01N—INVESTIGATING OR ANALYSING MATERIALS BY DETERMINING THEIR CHEMICAL OR PHYSICAL PROPERTIES
    • G01N2800/00—Detection or diagnosis of diseases
    • G01N2800/08—Hepato-biliairy disorders other than hepatitis
    • G01N2800/085—Liver diseases, e.g. portal hypertension, fibrosis, cirrhosis, bilirubin

Landscapes

  • Health & Medical Sciences (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Engineering & Computer Science (AREA)
  • Biomedical Technology (AREA)
  • Chemical & Material Sciences (AREA)
  • General Health & Medical Sciences (AREA)
  • Heart & Thoracic Surgery (AREA)
  • Cell Biology (AREA)
  • Hematology (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Vascular Medicine (AREA)
  • Zoology (AREA)
  • Animal Behavior & Ethology (AREA)
  • Public Health (AREA)
  • Veterinary Medicine (AREA)
  • Immunology (AREA)
  • Biotechnology (AREA)
  • Molecular Biology (AREA)
  • Organic Chemistry (AREA)
  • Wood Science & Technology (AREA)
  • Anesthesiology (AREA)
  • Genetics & Genomics (AREA)
  • Biochemistry (AREA)
  • Microbiology (AREA)
  • General Chemical & Material Sciences (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Developmental Biology & Embryology (AREA)
  • Medicinal Chemistry (AREA)
  • Urology & Nephrology (AREA)
  • General Engineering & Computer Science (AREA)
  • Gastroenterology & Hepatology (AREA)
  • Cardiology (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Physics & Mathematics (AREA)
  • Tropical Medicine & Parasitology (AREA)
  • Food Science & Technology (AREA)
  • Analytical Chemistry (AREA)
  • Toxicology (AREA)
  • Pathology (AREA)
  • General Physics & Mathematics (AREA)
PL12176014.4T 2006-10-11 2007-10-11 Kompozycje, sposoby i urządzenia do leczenia chorób wątroby PL2578081T3 (pl)

Applications Claiming Priority (4)

Application Number Priority Date Filing Date Title
US85077806P 2006-10-11 2006-10-11
US85123406P 2006-10-12 2006-10-12
US92313807P 2007-04-12 2007-04-12
US99531607P 2007-09-26 2007-09-26

Publications (2)

Publication Number Publication Date
PL2578081T4 true PL2578081T4 (pl) 2016-09-30
PL2578081T3 PL2578081T3 (pl) 2016-09-30

Family

ID=39402354

Family Applications (1)

Application Number Title Priority Date Filing Date
PL12176014.4T PL2578081T3 (pl) 2006-10-11 2007-10-11 Kompozycje, sposoby i urządzenia do leczenia chorób wątroby

Country Status (7)

Country Link
US (3) US8172784B2 (pl)
EP (2) EP2076116A4 (pl)
DK (1) DK2578081T3 (pl)
ES (1) ES2583371T3 (pl)
PL (1) PL2578081T3 (pl)
PT (1) PT2578081E (pl)
WO (1) WO2008060788A2 (pl)

Families Citing this family (35)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
GB0329449D0 (en) * 2003-12-19 2004-01-28 Omnicyte Ltd Stem cells
PT2578081E (pt) 2006-10-11 2016-06-17 Massachusetts Inst Technology Composições, métodos e dispositivos para o tratamento de doenças hepáticas
WO2010037092A1 (en) 2008-09-29 2010-04-01 University Of Pittsburgh-Of The Commonwealth System Of Higher Education Self-regulating device for modulating inflammation
GB0818725D0 (en) 2008-10-13 2008-11-19 Habib Nagy A Pharmaceutical composition
WO2011156338A2 (en) 2010-06-07 2011-12-15 University Of Pittsburgh - Of The Commonwealth System Of Higher Education Methods for modeling hepatic inflammation
CN102641297B (zh) * 2011-02-21 2016-02-24 杨子江 治疗外周动脉粥样硬化引起的缺血性疾病的制剂及其制备方法
CN102641292B (zh) * 2011-02-21 2015-11-25 杨子江 促血管及周边组织修复或再生的制剂及其制备方法
CN102641293B (zh) * 2011-02-21 2016-02-24 杨子江 用于治疗缺血性脑血管疾病的制剂及其制备方法
ES2629502T3 (es) * 2011-03-11 2017-08-10 Children's Medical Center Corporation Métodos y composiciones relacionados con exosomas de células madre mesenquimales
EP2508607A1 (en) * 2011-04-07 2012-10-10 Helmholtz-Zentrum für Infektionsforschung GmbH Medicament for liver regeneration and for treatment of liver failure
RS57886B1 (sr) 2011-11-30 2019-01-31 Astellas Inst For Regenerative Medicine Mezenhimalne stromalne ćelije i primene vezane za njih
WO2014011407A2 (en) 2012-07-12 2014-01-16 Imstem Biotechnology, Inc. Mesenchymal-like stem cells derived from human embryonic stem cells, methods and uses thereof
ES2526816B1 (es) * 2013-06-14 2015-10-27 Fundación Pública Andaluza Progreso Y Salud Composiciones para el tratamiento del daño hepático
DK3016665T3 (da) 2013-07-05 2019-11-25 Univ Catholique Louvain Konditioneret medium fra humane voksne leverstamceller og dets anvendelse i behandlingen af leverlidelser
WO2015179227A1 (en) 2014-05-18 2015-11-26 Children's Medical Center Corporation Methods and compositions relating to exosomes
ES2573354B1 (es) * 2014-11-06 2017-03-24 Servicio Andaluz De Salud Lisados de células madre mesenquimales para el tratamiento de lesiones músculo esqueléticas
ES2890123T3 (es) 2015-04-01 2022-01-17 Sanbio Inc Métodos y composiciones para la estimulación de la proliferación celular y el suministro de mezclas biológicamente activas de isoformas FGF2
ES2906161T3 (es) 2015-06-03 2022-04-13 Aelan Cell Tech Inc Métodos complementarios para terapias basadas en IL-2 y terapias basadas en células madre mesenquimales
US11291689B2 (en) 2015-06-03 2022-04-05 Aelan Cell Technologies, Inc. Methods and devices for the production and delivery of beneficial factors from adipose-derived stem cells
CN108289916A (zh) * 2015-06-15 2018-07-17 生命治疗有限公司 用于诱导细胞的抗细胞凋亡、存活或增殖的组合物和方法
WO2017019986A1 (en) * 2015-07-29 2017-02-02 Indiana University Research And Technology Corporation Materials and methods for treating and evaluating ischemic and/or reperfusion-injured tissue and/or tissue susceptible to same
US10328122B2 (en) * 2015-09-15 2019-06-25 Zhejiang University Method of treating fulminant hepatic failure using DLL4 cytokine
GB201521101D0 (en) 2015-11-30 2016-01-13 Koninklijke Nederlandse Akademie Van Wetenschappen Transduction buffer
WO2018025622A1 (ja) 2016-08-02 2018-02-08 エンゼルプレイングカード株式会社 検査システム及び管理システム
US20190350192A1 (en) * 2016-10-28 2019-11-21 Vital Therapies, Inc. Use of conditioned media from extracorporeal blood detoxifying system to supplement organ perfusion solutions
JP6950887B2 (ja) * 2017-04-28 2021-10-13 米満　吉和 体外型の人工肝臓、及び体外型の人工肝臓用又は肝細胞培養用の器具
GB2568928B (en) * 2017-12-01 2023-03-08 Young Cell Biomedical Tech Inc Neuroprotective composition, preparation process thereof and medical uses thereof
GB2585538B (en) * 2018-02-20 2024-01-10 Emulate Inc Human microphysiological cell system for liver disease
EP3876906A4 (en) * 2018-11-09 2022-08-10 Figene, LLC MEANS AND METHODS TO PREVENT OR REVERSE AGING
CN119215068A (zh) * 2019-11-20 2024-12-31 万能溶剂有限公司 用于肝再生的血浆级分
EP4036221A1 (en) * 2021-01-29 2022-08-03 Baer, Hans Ulrich Method for stimulating cell growth and proliferation of cells of interest, and method for preparing a liver or pancreas implant
CN113016778A (zh) * 2021-02-08 2021-06-25 广东乾晖生物科技有限公司 基于间充质干细胞的离体器官灌注保存系统
CN113082337A (zh) * 2021-02-23 2021-07-09 广东乾晖生物科技有限公司 基于胎盘间充质干细胞生物反应器的生物人工肝支持系统
CN119061124A (zh) * 2021-08-30 2024-12-03 四川大学 一种利用生物埃米孔检测核苷酸的方法
JPWO2023190448A1 (pl) 2022-03-29 2023-10-05

Family Cites Families (44)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US4522811A (en) 1982-07-08 1985-06-11 Syntex (U.S.A.) Inc. Serial injection of muramyldipeptides and liposomes enhances the anti-infective activity of muramyldipeptides
US4833083A (en) * 1987-05-26 1989-05-23 Sepragen Corporation Packed bed bioreactor
US5605835A (en) * 1988-05-23 1997-02-25 Regents Of The University Of Minnesota Bioreactor device with application as a bioartificial liver
US5602026A (en) * 1988-10-14 1997-02-11 The General Hospital Corporation Culturing liver cells between two supports
DE69118690T2 (de) * 1990-05-16 1997-01-09 Baylor College Medicine Eine permanente menschliche hepatogene zellinie und seine verwendung in der unterstützung der leberfunktion
US5270192A (en) 1991-02-07 1993-12-14 Monsanto Company Biological artificial liver
US5549674A (en) * 1992-03-02 1996-08-27 The Regents Of The University Of Michigan Methods and compositions of a bioartificial kidney suitable for use in vivo or ex vivo
AU7959494A (en) 1992-09-11 1996-04-19 Xenogenex, Inc. Artificial liver apparatus and method
US5866420A (en) * 1993-10-08 1999-02-02 The United States Of America As Represented By The Secretary Of Agriculture Artificial liver device
US6472200B1 (en) * 1999-07-23 2002-10-29 Yissum Research Development Company Of The Hebrew University Of Jerusalem Device and method for performing a biological modification of a fluid
ES2227607T3 (es) * 1995-10-06 2005-04-01 Academisch Ziekenhuis Bij De Universiteit Van Amsterdam Soporte solido para uso en cultivo celular, especialmente para el cultivo de celulas hepaticas, reactor biologico que contiene dicho soporte solido y su uso en un sistema de higado bioartificial.
US6287558B1 (en) 1997-08-01 2001-09-11 Biohybrio Technologies Llc Devices containing cells or tissue and an agent that inhibits damage by a host cell molecule
US6429012B1 (en) * 1997-10-06 2002-08-06 Viacell, Inc. Cell population containing non-fetal hemangioblasts and method for producing same
AUPP108597A0 (en) * 1997-12-22 1998-01-22 Sheil, A G R Prof. Liver support system
DK1066052T3 (da) 1998-03-18 2006-06-12 Osiris Therapeutics Inc Mesenchymstamceller til forebyggelse og behandling af immunreaktioner ved transplantationer
US6060364A (en) * 1999-03-02 2000-05-09 Advanced Micro Devices, Inc. Fast Mosfet with low-doped source/drain
AU759854C (en) * 1999-04-23 2004-01-08 Cytopherx, Inc. Extracorporeal circuit and related methods
US7759113B2 (en) 1999-04-30 2010-07-20 The General Hospital Corporation Fabrication of tissue lamina using microfabricated two-dimensional molds
US6372494B1 (en) * 1999-05-14 2002-04-16 Advanced Tissue Sciences, Inc. Methods of making conditioned cell culture medium compositions
EP1203075B1 (en) 1999-06-21 2007-09-12 The General Hospital Corporation Cell culture systems and methods for organ assist devices
US6562616B1 (en) * 1999-06-21 2003-05-13 The General Hospital Corporation Methods and devices for cell culturing and organ assist systems
US7838289B2 (en) * 2001-02-14 2010-11-23 Abt Holding Company Assay utilizing multipotent adult stem cells
WO2001040448A1 (en) * 1999-12-02 2001-06-07 The General Hospital Corporation Methods for removal, purification, and concentration of viruses, and methods of therapy based thereupon
AU3869501A (en) * 2000-02-26 2001-09-03 Artecel Sciences Inc Pleuripotent stem cells generated from adipose tissue-derived stromal cells and uses thereof
CN100363066C (zh) 2000-10-12 2008-01-23 肾脏治疗公司 在体液体外处理中用于体液流动控制的装置和方法
US7311905B2 (en) * 2002-02-13 2007-12-25 Anthrogenesis Corporation Embryonic-like stem cells derived from post-partum mammalian placenta, and uses and methods of treatment using said cells
US6582955B2 (en) * 2001-05-11 2003-06-24 Spectrum Laboratories, Inc. Bioreactor with application as blood therapy device
US6607501B2 (en) * 2001-05-14 2003-08-19 Reynolds G. Gorsuch Process and apparatus for utilization of in vivo extracted plasma with tissue engineering devices, bioreactors, artificial organs, and cell therapy applications
US6620630B2 (en) 2001-09-24 2003-09-16 Extraction Systems, Inc. System and method for determining and controlling contamination
US20050008626A1 (en) * 2001-12-07 2005-01-13 Fraser John K. Methods of using adipose tissue-derived cells in the treatment of cardiovascular conditions
US6855542B2 (en) * 2001-12-21 2005-02-15 Organogenesis Inc. Chamber with adjustable volume for cell culture and organ assist
AU2003228348A1 (en) * 2002-03-20 2003-10-08 John T. Fassett Induction of hepatocyte proliferation in vitro by inhibition of cell cycle inhibitors
US7160719B2 (en) * 2002-06-07 2007-01-09 Mayo Foundation For Medical Education And Research Bioartificial liver system
CA2784829C (en) 2003-04-01 2015-10-06 United States Of America Department Of Veteran's Affairs Stem-cell, precursor cell, or target cell-based treatment of multi-organ failure and renal dysfunction
EP1669441A1 (en) * 2003-08-27 2006-06-14 Renomedix Institute Inc. Method of differentiating mesenchymal stem cell into liver cell and artificial human liver cell
WO2006050091A2 (en) 2004-10-28 2006-05-11 Medivas, Llc Bioactive wound dressings and implantable devices and methods of use
US7338461B2 (en) * 2004-02-02 2008-03-04 The General Hospital Corporation Modified organ support devices
US7622108B2 (en) * 2004-04-23 2009-11-24 Bioe, Inc. Multi-lineage progenitor cells
ATE506431T1 (de) * 2004-04-23 2011-05-15 Bioe Llc Mehrfachlinien-vorläuferzellen
NZ550826A (en) * 2004-04-27 2011-09-30 Vital Therapies Inc Metabolic detoxification system and method
BRPI0520280A2 (pt) 2005-05-10 2009-04-28 Us Of America Dept Of Veteran terapia de disfunÇÕes renais e falÊncia méltipla de àrgços com cÉlulas-tronco mesenquimais e meio condicionado por exposiÇço a cÉlulas-tronco mesenquimais
US20070065415A1 (en) * 2005-09-16 2007-03-22 Kleinsek Donald A Compositions and methods for the augmentation and repair of defects in tissue
US8455250B2 (en) * 2005-12-29 2013-06-04 Anthrogenesis Corporation Co-culture of placental stem cells and stem cells from a second source
PT2578081E (pt) 2006-10-11 2016-06-17 Massachusetts Inst Technology Composições, métodos e dispositivos para o tratamento de doenças hepáticas

Also Published As

Publication number Publication date
EP2578081A3 (en) 2013-04-24
EP2076116A4 (en) 2010-04-07
US10363276B2 (en) 2019-07-30
ES2583371T3 (es) 2016-09-20
WO2008060788A3 (en) 2008-12-04
PT2578081E (pt) 2016-06-17
US20120225130A1 (en) 2012-09-06
US20160331784A1 (en) 2016-11-17
EP2076116A2 (en) 2009-07-08
EP2578081A2 (en) 2013-04-10
US8172784B2 (en) 2012-05-08
WO2008060788A2 (en) 2008-05-22
US20080145442A1 (en) 2008-06-19
DK2578081T3 (en) 2016-06-27
EP2578081B1 (en) 2016-03-09
PL2578081T3 (pl) 2016-09-30

Similar Documents

Publication Publication Date Title
PL2578081T3 (pl) Kompozycje, sposoby i urządzenia do leczenia chorób wątroby
IL291175A (en) Compositions and methods for treating collagen-mediated diseases
IL257681A (en) Methods and compositions for the treatment of cancer
EP1959929A4 (en) COMPOSITIONS AND METHODS FOR TREATING DERMATOLOGICAL SUFFERING
IL195619A0 (en) Compositions and methods for joininig non-conjoined iumens
IL193014A0 (en) Methods and compositions for treating schizophrenia
EP2170309A4 (en) METHOD AND COMPOSITIONS FOR THE TREATMENT OF DISEASES
EP2192913A4 (en) COMPOSITIONS AND METHODS OF TREATING DEMODEX CASES
GB0601143D0 (en) Uses, methods and compositions
AP2011005681A0 (en) Methods and formulations for treating chronic liver disease.
ZA200900140B (en) Methods and compositions for treating biofilms
EP2101731A4 (en) PROCESSES AND COMPOSITIONS WITH END OXIFES
HUP0700369D0 (en) Pharmaceutical compositions and method for treating schizofrenia
EP1855662A4 (en) METHODS AND COMPOSITIONS FOR TREATING CANCER
ZA200806361B (en) Methods and compositions for treating feline hyperthyroidism
GB0718918D0 (en) Compositions and methods for treating skin conditions
IL196638A0 (en) Methods and compositions for treating disease
EP2094279A4 (en) METHOD AND COMPOSITIONS FOR THE TREATMENT OF INFLUENZA
GB0712671D0 (en) Compounds, compositions and processes
EP2068629A4 (en) COMPOSITIONS AND METHODS FOR TREATING CANCER
ZA200807049B (en) Compositions and methods for treating collagen-mediated diseases
HK1123731A (en) Methods and compositions for treating conditions
GB0507963D0 (en) Composition and method for treating disease
GB0522732D0 (en) Composition and method for treating disease
GB0607565D0 (en) Methods and compositions