PL2440562T3 - Otrzymywanie 6-alfa-amino-N-podstawionych morfinanów w wyniku katalitycznego przeniesienia wodoru - Google Patents

Otrzymywanie 6-alfa-amino-N-podstawionych morfinanów w wyniku katalitycznego przeniesienia wodoru

Info

Publication number
PL2440562T3
PL2440562T3 PL10724967T PL10724967T PL2440562T3 PL 2440562 T3 PL2440562 T3 PL 2440562T3 PL 10724967 T PL10724967 T PL 10724967T PL 10724967 T PL10724967 T PL 10724967T PL 2440562 T3 PL2440562 T3 PL 2440562T3
Authority
PL
Poland
Prior art keywords
alpha
amino
preparation
hydrogen transfer
catalytic hydrogen
Prior art date
Application number
PL10724967T
Other languages
English (en)
Polish (pl)
Inventor
Christopher W. Grote
Gary L. Cantrell
Joseph P. Mcclurg
Catherine E. Thomasson
Frank W. Moser
Original Assignee
Mallinckrodt Llc
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Mallinckrodt Llc filed Critical Mallinckrodt Llc
Publication of PL2440562T3 publication Critical patent/PL2440562T3/pl

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D489/00—Heterocyclic compounds containing 4aH-8, 9 c- Iminoethano-phenanthro [4, 5-b, c, d] furan ring systems, e.g. derivatives of [4, 5-epoxy]-morphinan of the formula:
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P25/00—Drugs for disorders of the nervous system
    • A61P25/04—Centrally acting analgesics, e.g. opioids

Landscapes

  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • Health & Medical Sciences (AREA)
  • Medicinal Chemistry (AREA)
  • Pain & Pain Management (AREA)
  • Neurology (AREA)
  • Neurosurgery (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • General Chemical & Material Sciences (AREA)
  • Engineering & Computer Science (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Biomedical Technology (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Animal Behavior & Ethology (AREA)
  • General Health & Medical Sciences (AREA)
  • Public Health (AREA)
  • Veterinary Medicine (AREA)
  • Low-Molecular Organic Synthesis Reactions Using Catalysts (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Catalysts (AREA)
PL10724967T 2009-06-11 2010-06-10 Otrzymywanie 6-alfa-amino-N-podstawionych morfinanów w wyniku katalitycznego przeniesienia wodoru PL2440562T3 (pl)

Applications Claiming Priority (2)

Application Number Priority Date Filing Date Title
US18609109P 2009-06-11 2009-06-11
EP10724967.4A EP2440562B1 (fr) 2009-06-11 2010-06-10 Préparation de morphinanes 6-alpha-amino n-substitués par transfert catalytique d'hydrogène

Publications (1)

Publication Number Publication Date
PL2440562T3 true PL2440562T3 (pl) 2017-07-31

Family

ID=42357348

Family Applications (1)

Application Number Title Priority Date Filing Date
PL10724967T PL2440562T3 (pl) 2009-06-11 2010-06-10 Otrzymywanie 6-alfa-amino-N-podstawionych morfinanów w wyniku katalitycznego przeniesienia wodoru

Country Status (8)

Country Link
US (1) US8519133B2 (fr)
EP (1) EP2440562B1 (fr)
JP (2) JP5697215B2 (fr)
CN (1) CN102803267A (fr)
CA (1) CA2764915C (fr)
ES (1) ES2598496T3 (fr)
PL (1) PL2440562T3 (fr)
WO (1) WO2010144641A1 (fr)

Families Citing this family (14)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US8946419B2 (en) 2009-02-23 2015-02-03 Mallinckrodt Llc (+)-6-hydroxy-morphinan or (+)-6-amino-morphinan derivatives
EP2440561B1 (fr) * 2009-06-11 2014-04-30 Mallinckrodt LLC Amination reductrice de 6-ceto normorphinanes par transfert catalytique d'hydrogene
WO2010144641A1 (fr) * 2009-06-11 2010-12-16 Mallinckrodt Inc. Préparation de morphinanes 6-alpha-amino n-substitués par transfert catalytique d'hydrogène
WO2011009020A2 (fr) 2009-07-16 2011-01-20 Mallinckrodt Inc. Composés et compositions pour une utilisation en photothérapie et dans le traitement d'une maladie néovasculaire oculaire et de cancers
WO2011009015A1 (fr) * 2009-07-16 2011-01-20 Mallinckrodt Inc. (+)–morphinanes en tant qu'antagonistes du récepteur de type toll 9 et utilisations thérapeutiques de celles-ci
US10363251B2 (en) 2009-07-16 2019-07-30 Mallinckrodt Llc (+)-morphinans as antagonists of toll-like receptor 9 and therapeutic uses thereof
US9901540B2 (en) 2010-05-10 2018-02-27 Euro-Celtique S.A. Combination of active loaded granules with additional actives
CN102946870A (zh) 2010-05-10 2013-02-27 欧洲凯尔特公司 包含氢吗啡酮和纳洛酮的药物组合物
EP2568968B1 (fr) 2010-05-10 2017-07-12 Euro-Celtique S.A. Fabrication de granules libres de principes actifs et comprimés les contenant
CA2768199C (fr) * 2010-07-16 2018-08-28 Mallinckrodt Llc (+)-morphinanes en tant qu'antagonistes des recepteurs de type toll-9 et leurs utilisations therapeutiques
MX2013013634A (es) * 2011-06-09 2013-12-12 Mallinckrodt Llc Aminacion reductiva de 6-ceto-morfinanos por transfrencia catalitica de hidrogeno.
WO2015071380A1 (fr) 2013-11-13 2015-05-21 Euro-Celtique S.A. Hydromorphone et naloxone utilisées pour le traitement de la douleur et du syndrome de dysfonctionnement intestinal dû aux opioïdes
ES2940904T3 (es) 2014-07-10 2023-05-12 SpecGx LLC Procedimiento para preparar fenilalcanos sustituidos
US11214577B2 (en) * 2019-03-29 2022-01-04 Humanwell Pharmaceutical US Morphinans useful for treating medical disorders

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Also Published As

Publication number Publication date
JP5697215B2 (ja) 2015-04-08
ES2598496T3 (es) 2017-01-27
US20100317683A1 (en) 2010-12-16
WO2010144641A1 (fr) 2010-12-16
CN102803267A (zh) 2012-11-28
CA2764915A1 (fr) 2010-12-16
JP2012529533A (ja) 2012-11-22
JP2015057448A (ja) 2015-03-26
EP2440562A1 (fr) 2012-04-18
EP2440562B1 (fr) 2016-08-10
US8519133B2 (en) 2013-08-27
CA2764915C (fr) 2017-07-11

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