PL2292736T3 - Identyfikacja i izolacja komórek multipotencjalnych z tkanki mezenchymalnej niebędącej chrzęstnokostną - Google Patents

Identyfikacja i izolacja komórek multipotencjalnych z tkanki mezenchymalnej niebędącej chrzęstnokostną

Info

Publication number
PL2292736T3
PL2292736T3 PL10183073T PL10183073T PL2292736T3 PL 2292736 T3 PL2292736 T3 PL 2292736T3 PL 10183073 T PL10183073 T PL 10183073T PL 10183073 T PL10183073 T PL 10183073T PL 2292736 T3 PL2292736 T3 PL 2292736T3
Authority
PL
Poland
Prior art keywords
isolation
identification
multipotent cells
mesenchymal tissue
osteochondral mesenchymal
Prior art date
Application number
PL10183073T
Other languages
English (en)
Inventor
Castro Rosa Ana García
Miguel María Gema Fernández
Arranz Mariano García
De La Peña Manuel Angel González
Olmo Damián García
Original Assignee
Tigenix S A U
Univ Madrid Autonoma
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Family has litigation
First worldwide family litigation filed litigation Critical https://patents.darts-ip.com/?family=35457282&utm_source=google_patent&utm_medium=platform_link&utm_campaign=public_patent_search&patent=PL2292736(T3) "Global patent litigation dataset” by Darts-ip is licensed under a Creative Commons Attribution 4.0 International License.
Application filed by Tigenix S A U, Univ Madrid Autonoma filed Critical Tigenix S A U
Publication of PL2292736T3 publication Critical patent/PL2292736T3/pl

Links

Classifications

    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K35/00—Medicinal preparations containing materials or reaction products thereof with undetermined constitution
    • A61K35/12—Materials from mammals; Compositions comprising non-specified tissues or cells; Compositions comprising non-embryonic stem cells; Genetically modified cells
    • A61K35/28—Bone marrow; Haematopoietic stem cells; Mesenchymal stem cells of any origin, e.g. adipose-derived stem cells
    • C—CHEMISTRY; METALLURGY
    • C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
    • C12N5/00—Undifferentiated human, animal or plant cells, e.g. cell lines; Tissues; Cultivation or maintenance thereof; Culture media therefor
    • C12N5/06—Animal cells or tissues; Human cells or tissues
    • C12N5/0602—Vertebrate cells
    • C12N5/0652—Cells of skeletal and connective tissues; Mesenchyme
    • C12N5/0662—Stem cells
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P19/00—Drugs for skeletal disorders
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P21/00—Drugs for disorders of the muscular or neuromuscular system
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P25/00—Drugs for disorders of the nervous system
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P43/00—Drugs for specific purposes, not provided for in groups A61P1/00-A61P41/00
    • C—CHEMISTRY; METALLURGY
    • C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
    • C12N5/00—Undifferentiated human, animal or plant cells, e.g. cell lines; Tissues; Cultivation or maintenance thereof; Culture media therefor
    • C12N5/06—Animal cells or tissues; Human cells or tissues
    • C12N5/0602—Vertebrate cells
    • C12N5/0607—Non-embryonic pluripotent stem cells, e.g. MASC
    • C—CHEMISTRY; METALLURGY
    • C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
    • C12N5/00—Undifferentiated human, animal or plant cells, e.g. cell lines; Tissues; Cultivation or maintenance thereof; Culture media therefor
    • C12N5/06—Animal cells or tissues; Human cells or tissues
    • C12N5/0602—Vertebrate cells
    • C12N5/0618—Cells of the nervous system
    • C12N5/0619—Neurons
    • C—CHEMISTRY; METALLURGY
    • C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
    • C12N5/00—Undifferentiated human, animal or plant cells, e.g. cell lines; Tissues; Cultivation or maintenance thereof; Culture media therefor
    • C12N5/06—Animal cells or tissues; Human cells or tissues
    • C12N5/0602—Vertebrate cells
    • C12N5/0652—Cells of skeletal and connective tissues; Mesenchyme
    • C—CHEMISTRY; METALLURGY
    • C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
    • C12N5/00—Undifferentiated human, animal or plant cells, e.g. cell lines; Tissues; Cultivation or maintenance thereof; Culture media therefor
    • C12N5/06—Animal cells or tissues; Human cells or tissues
    • C12N5/0602—Vertebrate cells
    • C12N5/0652—Cells of skeletal and connective tissues; Mesenchyme
    • C12N5/0654—Osteocytes, Osteoblasts, Odontocytes; Bones, Teeth
    • C—CHEMISTRY; METALLURGY
    • C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
    • C12N5/00—Undifferentiated human, animal or plant cells, e.g. cell lines; Tissues; Cultivation or maintenance thereof; Culture media therefor
    • C12N5/06—Animal cells or tissues; Human cells or tissues
    • C12N5/0602—Vertebrate cells
    • C12N5/0652—Cells of skeletal and connective tissues; Mesenchyme
    • C12N5/0658—Skeletal muscle cells, e.g. myocytes, myotubes, myoblasts
    • C—CHEMISTRY; METALLURGY
    • C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
    • C12N5/00—Undifferentiated human, animal or plant cells, e.g. cell lines; Tissues; Cultivation or maintenance thereof; Culture media therefor
    • C12N5/06—Animal cells or tissues; Human cells or tissues
    • C12N5/0602—Vertebrate cells
    • C12N5/0652—Cells of skeletal and connective tissues; Mesenchyme
    • C12N5/0662—Stem cells
    • C12N5/0667—Adipose-derived stem cells [ADSC]; Adipose stromal stem cells
    • G—PHYSICS
    • G01—MEASURING; TESTING
    • G01N—INVESTIGATING OR ANALYSING MATERIALS BY DETERMINING THEIR CHEMICAL OR PHYSICAL PROPERTIES
    • G01N33/00—Investigating or analysing materials by specific methods not covered by groups G01N1/00 - G01N31/00
    • G01N33/48—Biological material, e.g. blood, urine; Haemocytometers
    • G01N33/50—Chemical analysis of biological material, e.g. blood, urine; Testing involving biospecific ligand binding methods; Immunological testing
    • G01N33/5005—Chemical analysis of biological material, e.g. blood, urine; Testing involving biospecific ligand binding methods; Immunological testing involving human or animal cells
    • G01N33/5008—Chemical analysis of biological material, e.g. blood, urine; Testing involving biospecific ligand binding methods; Immunological testing involving human or animal cells for testing or evaluating the effect of chemical or biological compounds, e.g. drugs, cosmetics
    • C—CHEMISTRY; METALLURGY
    • C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
    • C12N2506/00—Differentiation of animal cells from one lineage to another; Differentiation of pluripotent cells
    • C12N2506/13—Differentiation of animal cells from one lineage to another; Differentiation of pluripotent cells from connective tissue cells, from mesenchymal cells
    • C12N2506/1346—Differentiation of animal cells from one lineage to another; Differentiation of pluripotent cells from connective tissue cells, from mesenchymal cells from mesenchymal stem cells
    • C12N2506/1384—Differentiation of animal cells from one lineage to another; Differentiation of pluripotent cells from connective tissue cells, from mesenchymal cells from mesenchymal stem cells from adipose-derived stem cells [ADSC], from adipose stromal stem cells
    • C—CHEMISTRY; METALLURGY
    • C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
    • C12N2510/00—Genetically modified cells

Landscapes

  • Health & Medical Sciences (AREA)
  • Engineering & Computer Science (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Biomedical Technology (AREA)
  • Chemical & Material Sciences (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Organic Chemistry (AREA)
  • Biotechnology (AREA)
  • Zoology (AREA)
  • Genetics & Genomics (AREA)
  • Wood Science & Technology (AREA)
  • General Health & Medical Sciences (AREA)
  • Cell Biology (AREA)
  • Biochemistry (AREA)
  • Microbiology (AREA)
  • General Engineering & Computer Science (AREA)
  • Developmental Biology & Embryology (AREA)
  • Rheumatology (AREA)
  • Medicinal Chemistry (AREA)
  • Immunology (AREA)
  • Animal Behavior & Ethology (AREA)
  • Veterinary Medicine (AREA)
  • Public Health (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Neurology (AREA)
  • General Chemical & Material Sciences (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Hematology (AREA)
  • Molecular Biology (AREA)
  • Urology & Nephrology (AREA)
  • Orthopedic Medicine & Surgery (AREA)
  • Neurosurgery (AREA)
  • Physical Education & Sports Medicine (AREA)
  • General Physics & Mathematics (AREA)
  • Food Science & Technology (AREA)
  • Physics & Mathematics (AREA)
  • Analytical Chemistry (AREA)
  • Toxicology (AREA)
  • Pathology (AREA)
PL10183073T 2004-10-04 2005-10-04 Identyfikacja i izolacja komórek multipotencjalnych z tkanki mezenchymalnej niebędącej chrzęstnokostną PL2292736T3 (pl)

Applications Claiming Priority (3)

Application Number Priority Date Filing Date Title
ES200402355A ES2313805B1 (es) 2004-10-04 2004-10-04 Identificacion y aislamiento de celulas multipotentes de tejido mesenquimal no osteocondral.
EP05796904A EP1812558A1 (en) 2004-10-04 2005-10-04 Identification and isolation of multipotent cells from non-osteochondral mesenchymal tissue
EP10183073.5A EP2292736B1 (en) 2004-10-04 2005-10-04 Identification and isolation of multipotent cells from non-osteochondral mesenchymal tissue

Publications (1)

Publication Number Publication Date
PL2292736T3 true PL2292736T3 (pl) 2015-07-31

Family

ID=35457282

Family Applications (1)

Application Number Title Priority Date Filing Date
PL10183073T PL2292736T3 (pl) 2004-10-04 2005-10-04 Identyfikacja i izolacja komórek multipotencjalnych z tkanki mezenchymalnej niebędącej chrzęstnokostną

Country Status (17)

Country Link
US (3) US20060073124A1 (pl)
EP (5) EP2292736B1 (pl)
JP (2) JP2008515413A (pl)
KR (1) KR20070085294A (pl)
CN (1) CN101056974B (pl)
AU (1) AU2005291353A1 (pl)
CA (1) CA2583151C (pl)
CY (1) CY1116198T1 (pl)
DK (1) DK2292736T3 (pl)
ES (2) ES2313805B1 (pl)
HU (1) HUE025155T2 (pl)
IL (1) IL182441A (pl)
PL (1) PL2292736T3 (pl)
PT (1) PT2292736E (pl)
SG (2) SG158853A1 (pl)
SI (1) SI2292736T1 (pl)
WO (1) WO2006037649A1 (pl)

Families Citing this family (56)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
WO2004069172A2 (en) 2003-01-30 2004-08-19 The Government of the United States of America as represented by the Department of Veterans Affairs Multilineage-inducible cells and uses thereof
DE602004027479D1 (de) * 2003-04-24 2010-07-15 Koninkl Philips Electronics Nv Eingriffsfreie links-herzkammervolumenbestimmung
US7266519B2 (en) * 2003-06-30 2007-09-04 Qualcomm Incorporated Billing system with authenticated wireless device transaction event data
ITRM20030376A1 (it) * 2003-07-31 2005-02-01 Univ Roma Procedimento per l'isolamento e l'espansione di cellule staminali cardiache da biopsia.
US20060045872A1 (en) * 2004-08-25 2006-03-02 Universidad Autonoma De Madrid Ciudad Universitaria de Cantoblanco Use of adipose tissue-derived stromal stem cells in treating fistula
ES2313805B1 (es) 2004-10-04 2009-12-23 Cellerix, S.L. Identificacion y aislamiento de celulas multipotentes de tejido mesenquimal no osteocondral.
US11660317B2 (en) 2004-11-08 2023-05-30 The Johns Hopkins University Compositions comprising cardiosphere-derived cells for use in cell therapy
CA2585980C (en) * 2004-11-08 2017-09-26 The Johns Hopkins University Cardiac stem cells
SI1926813T2 (sl) 2005-09-23 2019-11-29 Tigenix S A U Celična populacija z imunoregulatorno aktivnostjo, postopek za izolacijo in uporabe
US20090208464A1 (en) * 2006-01-24 2009-08-20 Centeno Christopher J Mesenchymal stem cell isolation and transplantation method and system to be used in a clinical setting
US20080025953A1 (en) * 2006-07-25 2008-01-31 Kiminobu Sugaya Vigor Enhancement of Animals Via Administration of Stem Cells
KR100827660B1 (ko) 2006-10-25 2008-05-07 대한민국 (식품의약품안전청장) Ｃｄ9를 발현하는 인간 중간엽 줄기세포의 선별 및배양방법
CA2913024A1 (en) * 2006-11-03 2008-05-08 Aastrom Biosciences, Inc. Mixed cell populations for tissue repair and separation technique for cell processing
US20100093089A1 (en) * 2006-11-09 2010-04-15 Eduardo Marban Dedifferentiation of adult mammalian cardiomyocytes into cardiac stem cells
FR2918073B1 (fr) * 2007-06-27 2012-10-19 Univ Paris Curie Cellules fixatrices de cellules tumorales.
US9095562B2 (en) * 2007-07-05 2015-08-04 Regenerative Sciences, Inc. Methods and compositions for optimized expansion and implantation of mesenchymal stem cells
WO2009085969A2 (en) 2007-12-19 2009-07-09 Regenerative Sciences, Llc Compositions and methods to promote implantation and engrafment of stem cells
EP2257176B1 (en) 2008-03-14 2013-09-18 Regenerative Sciences, LLC Compositions and methods for cartilage repair
AU2015268704B2 (en) * 2008-08-04 2017-08-10 Consejo Superior De Investigaciones Cientificas Uses of mesenchymal stem cells
GB0814249D0 (en) * 2008-08-04 2008-09-10 Cellerix Sa Uses of mesenchymal stem cells
KR101713343B1 (ko) * 2008-08-18 2017-03-22 메소블라스트, 아이엔씨. 단일 클론 항체 ｓｔｒｏ-4
US20110245804A1 (en) 2008-12-05 2011-10-06 Regenerative Sciences, Llc Methods and Compositions to Facilitate Repair of Avascular Tissue
US20100168022A1 (en) * 2008-12-11 2010-07-01 Centeno Christopher J Use of In-Vitro Culture to Design or Test Personalized Treatment Regimens
US20110054929A1 (en) * 2009-09-01 2011-03-03 Cell Solutions Colorado Llc Stem Cell Marketplace
JP5810435B2 (ja) * 2009-09-30 2015-11-11 国立大学法人 熊本大学 内胚葉細胞、腸管細胞又は膵細胞の検出方法
US9113950B2 (en) 2009-11-04 2015-08-25 Regenerative Sciences, Llc Therapeutic delivery device
US9845457B2 (en) 2010-04-30 2017-12-19 Cedars-Sinai Medical Center Maintenance of genomic stability in cultured stem cells
US9249392B2 (en) 2010-04-30 2016-02-02 Cedars-Sinai Medical Center Methods and compositions for maintaining genomic stability in cultured stem cells
US10130736B1 (en) 2010-05-14 2018-11-20 Musculoskeletal Transplant Foundation Tissue-derived tissuegenic implants, and methods of fabricating and using same
US9352003B1 (en) 2010-05-14 2016-05-31 Musculoskeletal Transplant Foundation Tissue-derived tissuegenic implants, and methods of fabricating and using same
US8883210B1 (en) 2010-05-14 2014-11-11 Musculoskeletal Transplant Foundation Tissue-derived tissuegenic implants, and methods of fabricating and using same
US8834928B1 (en) 2011-05-16 2014-09-16 Musculoskeletal Transplant Foundation Tissue-derived tissugenic implants, and methods of fabricating and using same
AU2012275335B2 (en) 2011-06-29 2017-04-20 Biorestorative Therapies, Inc. Brown fat cell compositions and methods
DK2634195T3 (en) * 2012-03-01 2017-02-27 Miltenyi Biotec Gmbh Separation of living pristine neurons
JP2015521054A (ja) 2012-06-05 2015-07-27 カプリコール，インコーポレイテッド 心臓組織から心臓幹細胞を作製するための最適化方法および心臓治療におけるそれらの使用
JP6433896B2 (ja) 2012-08-13 2018-12-05 シーダーズ−サイナイ・メディカル・センターＣｅｄａｒｓ−Ｓｉｎａｉ Ｍｅｄｉｃａｌ Ｃｅｎｔｅｒ 組織再生のためのエキソソームおよびマイクロリボ核酸
EP2986714B1 (en) 2013-04-19 2021-01-06 Biorestorative Therapies, Inc. Human brown adipose derived stem cells and uses
CA2919374C (en) 2013-07-30 2019-12-03 Musculoskeletal Transplant Foundation Acellular soft tissue-derived matrices and methods for preparing same
BR102013033827B1 (pt) * 2013-12-27 2021-09-08 Regenera - Medicina Veterinária Avançada Ltda. Concentrado multipotente e imunocompatível de células-tronco e biofármaco e forma de dosagem que o compreendem
AU2015327812B2 (en) 2014-10-03 2021-04-15 Cedars-Sinai Medical Center Cardiosphere-derived cells and exosomes secreted by such cells in the treatment of muscular dystrophy
US10531957B2 (en) 2015-05-21 2020-01-14 Musculoskeletal Transplant Foundation Modified demineralized cortical bone fibers
US10912864B2 (en) 2015-07-24 2021-02-09 Musculoskeletal Transplant Foundation Acellular soft tissue-derived matrices and methods for preparing same
US11052175B2 (en) 2015-08-19 2021-07-06 Musculoskeletal Transplant Foundation Cartilage-derived implants and methods of making and using same
EP3381458B1 (en) 2015-11-24 2023-06-07 Rohto Pharmaceutical Co., Ltd. Therapeutic agent for liver disease containing stromal cells derived from adipose tissue and method for producing the same
US11518982B2 (en) * 2015-12-01 2022-12-06 Adiposeeds, Inc. Method for manufacturing mesenchymal cell line derived from vertebrate animal adipose tissue
EP3402543B1 (en) 2016-01-11 2021-09-08 Cedars-Sinai Medical Center Cardiosphere-derived cells and exosomes secreted by such cells in the treatment of heart failure with preserved ejection fraction
GB201604304D0 (en) * 2016-03-14 2016-04-27 Tigenix S A U Adipose tissue-derived stromal stem cells for use in treating refractory complex perianal fistulas in crohn's disease
US11351200B2 (en) 2016-06-03 2022-06-07 Cedars-Sinai Medical Center CDC-derived exosomes for treatment of ventricular tachyarrythmias
JP6994021B2 (ja) 2016-08-26 2022-01-14 ジュノー セラピューティクス インコーポレイテッド 細胞組成物中に存在する粒子を計数する方法
WO2018057542A1 (en) 2016-09-20 2018-03-29 Cedars-Sinai Medical Center Cardiosphere-derived cells and their extracellular vesicles to retard or reverse aging and age-related disorders
EP3612191A4 (en) 2017-04-19 2020-12-30 Cedars-Sinai Medical Center METHODS AND COMPOSITIONS FOR TREATING SKELETAL MUSCLE DYSTROPHY
EP3417888A1 (de) * 2017-06-25 2018-12-26 co.don AG Verfahren zum herstellen von transplantierbarem knorpelgewebe
EP3727351A4 (en) 2017-12-20 2021-10-06 Cedars-Sinai Medical Center MODIFIED EXTRACELLULAR VESICLES FOR IMPROVED TISSUE DELIVERY
CN111405898B (zh) 2018-01-29 2022-09-13 中国科学院动物研究所 一种破坏细胞机械稳态以及促进组织器官的再生修复的方法及其应用
CN110090300A (zh) * 2018-01-29 2019-08-06 中国科学院动物研究所 一种促进组织器官的再生修复的方法及其应用
ES2957507A1 (es) * 2022-06-09 2024-01-19 Fundacion Instituto De Investig Sanitaria Fundacion Jimenez Diaz Tratamiento de la disfuncion de las glandulas de meibomio

Family Cites Families (21)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US5811094A (en) 1990-11-16 1998-09-22 Osiris Therapeutics, Inc. Connective tissue regeneration using human mesenchymal stem cell preparations
US6294346B1 (en) 1991-07-08 2001-09-25 Neurospheres Holdings, Ltd. Use of multipotent neural stem cells and their progeny for the screening of drugs and other biological agents
WO1997041208A1 (en) 1996-04-26 1997-11-06 Case Western Reserve University Skin regeneration using mesenchymal stem cells
WO1999011287A1 (en) 1997-09-04 1999-03-11 Osiris Therapeutics, Inc. Ligands that modulate differentiation of mesenchymal stem cells
PT1066052E (pt) 1998-03-18 2006-06-30 Osiris Therapeutics Inc Celulas estaminais mesenquimatosas para a prevencao e tratamento
US5958767A (en) 1998-08-14 1999-09-28 The Children's Medical Center Corp. Engraftable human neural stem cells
KR100968165B1 (ko) * 1999-03-10 2010-07-06 더 리전츠 오브 더 유니버시티 오브 캘리포니아 지방 유래 간세포 및 격자
US20030082152A1 (en) * 1999-03-10 2003-05-01 Hedrick Marc H. Adipose-derived stem cells and lattices
US20050153442A1 (en) * 1999-03-10 2005-07-14 Adam Katz Adipose-derived stem cells and lattices
US7670628B2 (en) * 1999-07-07 2010-03-02 Angioblast Systems, Inc. Mesenchymal precursor cell
AU2001238695B2 (en) * 2000-02-26 2005-11-24 Artecel Sciences, Inc. Pleuripotent stem cells generated from adipose tissue-derived stromal cells and uses thereof
US7749710B2 (en) * 2002-06-14 2010-07-06 Xintela Ab Marker for stem cells and its use
JP4603883B2 (ja) * 2002-07-31 2010-12-22 サントル・ナショナル・ドゥ・ラ・レシェルシュ・サイエンティフィーク−セ・エン・エール・エス− 脂肪組織由来の幹細胞および前記細胞から分化した細胞
ES2265199B1 (es) * 2003-06-12 2008-02-01 Cellerix, S.L. Celulas madre adultas multipotentes procedentes de condrocitos desdiferenciados y sus aplicaciones.
KR20060036933A (ko) * 2003-10-07 2006-05-02 바이오마스터 인코포레이티드 지방-유래 전구세포의 세포 분화
DE602004030823D1 (de) * 2003-11-04 2011-02-10 Biomaster Inc Verfahren und system zur herstellung von stammzellen aus fettgewebe
EP2298862B1 (en) 2004-03-22 2017-08-30 Mesoblast International Sàrl Mesenchymal stem cells and uses therefor
RU2252252C1 (ru) * 2004-04-09 2005-05-20 Тепляшин Александр Сергеевич Способ выделения мезенхимальных стволовых клеток
ES2313805B1 (es) 2004-10-04 2009-12-23 Cellerix, S.L. Identificacion y aislamiento de celulas multipotentes de tejido mesenquimal no osteocondral.
ES2264862B8 (es) 2004-08-25 2017-01-20 Cellerix, S.L. Biomaterial para sutura.
GB0814249D0 (en) * 2008-08-04 2008-09-10 Cellerix Sa Uses of mesenchymal stem cells

Also Published As

Publication number Publication date
WO2006037649A1 (en) 2006-04-13
PT2292736E (pt) 2015-04-29
US10729726B2 (en) 2020-08-04
CY1116198T1 (el) 2017-02-08
ES2535042T3 (es) 2015-05-04
EP1812558A1 (en) 2007-08-01
EP3342857A1 (en) 2018-07-04
EP2862925A1 (en) 2015-04-22
SG158853A1 (en) 2010-02-26
HUE025155T2 (en) 2016-03-29
EP2292736A2 (en) 2011-03-09
CN101056974A (zh) 2007-10-17
ES2313805A1 (es) 2009-03-01
US20070248580A1 (en) 2007-10-25
EP2292736A3 (en) 2011-06-15
CA2583151A1 (en) 2006-04-13
JP2013013411A (ja) 2013-01-24
EP3165601A1 (en) 2017-05-10
IL182441A0 (en) 2007-07-24
AU2005291353A1 (en) 2006-04-13
CA2583151C (en) 2015-09-15
SI2292736T1 (sl) 2015-05-29
ES2313805B1 (es) 2009-12-23
JP5732011B2 (ja) 2015-06-10
US20170296585A1 (en) 2017-10-19
KR20070085294A (ko) 2007-08-27
US20060073124A1 (en) 2006-04-06
IL182441A (en) 2015-08-31
EP2292736B1 (en) 2015-01-21
JP2008515413A (ja) 2008-05-15
SG192459A1 (en) 2013-08-30
DK2292736T3 (en) 2015-04-20
CN101056974B (zh) 2015-11-25

Similar Documents

Publication Publication Date Title
IL182441A0 (en) Identification and isolation of multipotent cells from non-osteochondral mesenchymal tissue
GB2432835B (en) Culturing human embryonic stem cells
AP2010005102A0 (en) Multipotent/pluripotent cells and methods
HK1200866A1 (en) Very small embryonic-like (vsel) stem cells and methods of isolating and using the same (vsel)
GB0812222D0 (en) Direct differancntiation of cardiomyocytes from human embryonic stem cells
AU2003220424A8 (en) Adipose stromal stem cells for tissue and vascular modification
EP1732462A4 (en) ELECTROMAGNETIC TREATMENT OF TISSUE AND CELLS
IL166332A0 (en) Isolation and identification of t cells
GB0803474D0 (en) Compositions and methods for growth of pluripotent cells
HK1080483A1 (en) Rapid extraction of rna from cells and tissues
IL177540A0 (en) Analysis of cell morphology and motility
TWI341679B (en) Isolation of transmit and receive signals
EP1917348A4 (en) ISOLATION OF MULTIPLE LINE STEM CELLS
HK1164919A1 (en) Method and kit for rapid isolation of human foxp3 treg cells foxp3 treg
EP1708757A4 (en) USE OF PLURIPOTENTIAL CELLS TAKEN FROM HUMAN CORDIAL BLOOD BLOOD FOR THE TREATMENT OF DISEASE
EP1687411A4 (en) IDENTIFICATION AND ISOLATION OF HEMATOPOIETIC STEM CELLS
EP1557461A4 (en) COMPOSITION FOR THE CULTURE OF PLURIPOTENT STEM CELLS AND THE USE THEREOF
IL177647A0 (en) Use of enzyme
EP1802737A4 (en) TISSUE SYSTEM AND USE METHOD
EP1697715A4 (en) IDENTIFICATION, INSULATION AND ELIMINATION OF CANCER STEM CELLS
EP1685237A4 (en) NEW MULTIPOTENT STEM CELLS
GB0610836D0 (en) The preparation of multipotent stem cells and the use thereof
GB0426182D0 (en) Photoporation of cells
EP1627071A4 (en) MULTICELLULAR COMPOSITIONS OF HUMAN PLURIPOTENT EMBRYONIC STEM CELLS AND CANCER CELLS
ZA200702966B (en) Cryopreservation of cells