PL2285811T3 - Pochodne 3-(3-pirymidyno-2-ylo-benzylo)-[1,2,4]-triazolo[4,3-b]pirydazynowe jako inhibitory kinazy met - Google Patents

Pochodne 3-(3-pirymidyno-2-ylo-benzylo)-[1,2,4]-triazolo[4,3-b]pirydazynowe jako inhibitory kinazy met

Info

Publication number
PL2285811T3
PL2285811T3 PL09765500T PL09765500T PL2285811T3 PL 2285811 T3 PL2285811 T3 PL 2285811T3 PL 09765500 T PL09765500 T PL 09765500T PL 09765500 T PL09765500 T PL 09765500T PL 2285811 T3 PL2285811 T3 PL 2285811T3
Authority
PL
Poland
Prior art keywords
triazolo
pyrimidin
benzyl
kinase inhibitors
met kinase
Prior art date
Application number
PL09765500T
Other languages
English (en)
Inventor
Dieter Dorsch
Oliver Schadt
Frank Stieber
Andree Blaukat
Original Assignee
Merck Patent Gmbh
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Merck Patent Gmbh filed Critical Merck Patent Gmbh
Publication of PL2285811T3 publication Critical patent/PL2285811T3/pl

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Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D487/00—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, not provided for by groups C07D451/00 - C07D477/00
    • C07D487/02—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, not provided for by groups C07D451/00 - C07D477/00 in which the condensed system contains two hetero rings
    • C07D487/04—Ortho-condensed systems
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P17/00—Drugs for dermatological disorders
    • A61P17/02—Drugs for dermatological disorders for treating wounds, ulcers, burns, scars, keloids, or the like
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P25/00—Drugs for disorders of the nervous system
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P27/00—Drugs for disorders of the senses
    • A61P27/02—Ophthalmic agents
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P29/00—Non-central analgesic, antipyretic or antiinflammatory agents, e.g. antirheumatic agents; Non-steroidal antiinflammatory drugs [NSAID]
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P3/00—Drugs for disorders of the metabolism
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P35/00—Antineoplastic agents
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P35/00—Antineoplastic agents
    • A61P35/02—Antineoplastic agents specific for leukemia
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P37/00—Drugs for immunological or allergic disorders
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P43/00—Drugs for specific purposes, not provided for in groups A61P1/00-A61P41/00
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P9/00—Drugs for disorders of the cardiovascular system
    • A61P9/10—Drugs for disorders of the cardiovascular system for treating ischaemic or atherosclerotic diseases, e.g. antianginal drugs, coronary vasodilators, drugs for myocardial infarction, retinopathy, cerebrovascula insufficiency, renal arteriosclerosis
PL09765500T 2008-06-18 2009-05-25 Pochodne 3-(3-pirymidyno-2-ylo-benzylo)-[1,2,4]-triazolo[4,3-b]pirydazynowe jako inhibitory kinazy met PL2285811T3 (pl)

Applications Claiming Priority (3)

Application Number Priority Date Filing Date Title
DE102008028905A DE102008028905A1 (de) 2008-06-18 2008-06-18 3-(3-Pyrimidin-2-yl-benzyl)-[1,2,4]triazolo[4,3-b]pyridazinderivate
PCT/EP2009/003675 WO2009152920A1 (de) 2008-06-18 2009-05-25 3-(3-pyrimidin-2-yl-benzyl)-[1,2,4]triazolo[4,3-b]pyridazin-derivative als met-kinase inhibitoren
EP09765500A EP2285811B1 (de) 2008-06-18 2009-05-25 3-(3-pyrimidin-2-yl-benzyl)-[1,2,4]-triazolo[4,3-b]pyridazin-derivative als met-kinase inhibitoren

Publications (1)

Publication Number Publication Date
PL2285811T3 true PL2285811T3 (pl) 2013-04-30

Family

ID=40973097

Family Applications (1)

Application Number Title Priority Date Filing Date
PL09765500T PL2285811T3 (pl) 2008-06-18 2009-05-25 Pochodne 3-(3-pirymidyno-2-ylo-benzylo)-[1,2,4]-triazolo[4,3-b]pirydazynowe jako inhibitory kinazy met

Country Status (19)

Country Link
US (1) US8497266B2 (pl)
EP (1) EP2285811B1 (pl)
JP (1) JP5662311B2 (pl)
KR (1) KR101661777B1 (pl)
CN (1) CN102066378B (pl)
AR (1) AR072860A1 (pl)
AU (1) AU2009259764B2 (pl)
BR (1) BRPI0915417B8 (pl)
CA (1) CA2728194C (pl)
DE (1) DE102008028905A1 (pl)
DK (1) DK2285811T3 (pl)
EA (1) EA019534B1 (pl)
ES (1) ES2400117T3 (pl)
IL (1) IL210063A (pl)
MX (1) MX2010013649A (pl)
PL (1) PL2285811T3 (pl)
PT (1) PT2285811E (pl)
WO (1) WO2009152920A1 (pl)
ZA (1) ZA201100437B (pl)

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DE102008028905A1 (de) 2008-06-18 2009-12-24 Merck Patent Gmbh 3-(3-Pyrimidin-2-yl-benzyl)-[1,2,4]triazolo[4,3-b]pyridazinderivate
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KR101663335B1 (ko) 2008-12-22 2016-10-06 메르크 파텐트 게엠베하 6-（1-메틸-1ｈ-피라졸-4-일）-2-｛3-［5-（2-모르폴린-4-일-에톡시）-피리미딘-2-일］-벤질｝-2ｈ-피리다진-3-온디히드로겐포스페이트의 신규한 다형체 및 이의 제조 방법
DE102008062825A1 (de) * 2008-12-23 2010-06-24 Merck Patent Gmbh 3-(3-Pyrimidin-2-yl-benzyl)-[1,2,4]triazolo [4,3-b]pyridazin-derivate
EP3010922B1 (en) * 2013-06-19 2017-03-15 Galapagos NV Novel compounds and pharmaceutical compositions thereof for the treatment of inflammatory disorders
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ES2946551T3 (es) 2017-10-17 2023-07-20 Palau Pharma S L U Síntesis de compuestos de 4-aminopirimidina

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Also Published As

Publication number Publication date
AU2009259764B2 (en) 2013-09-26
PT2285811E (pt) 2013-03-05
EP2285811A1 (de) 2011-02-23
MX2010013649A (es) 2010-12-21
ES2400117T3 (es) 2013-04-05
CN102066378B (zh) 2014-04-16
EP2285811B1 (de) 2012-12-05
KR20110031329A (ko) 2011-03-25
CA2728194C (en) 2016-11-29
US8497266B2 (en) 2013-07-30
CN102066378A (zh) 2011-05-18
EA201100031A1 (ru) 2011-08-30
BRPI0915417A2 (pt) 2015-11-03
WO2009152920A1 (de) 2009-12-23
CA2728194A1 (en) 2009-12-23
US20110092498A1 (en) 2011-04-21
KR101661777B1 (ko) 2016-09-30
ZA201100437B (en) 2011-09-28
AU2009259764A1 (en) 2009-12-23
JP2011524385A (ja) 2011-09-01
DE102008028905A1 (de) 2009-12-24
EA019534B1 (ru) 2014-04-30
DK2285811T3 (da) 2013-03-11
IL210063A (en) 2015-06-30
AR072860A1 (es) 2010-09-29
BRPI0915417B8 (pt) 2021-05-25
JP5662311B2 (ja) 2015-01-28
IL210063A0 (en) 2011-02-28
BRPI0915417B1 (pt) 2020-02-11

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